Indoor air quality (IAQ) is crucial to environmental health significantly impacting on the well-being and productivity of building occupants. Several studies have explored various aspects of IAQ in non-tropical regions but there is limited information on how seasonal variations affect IAQ in hot-humid climates like Enugu, Nigeria. This study investigated seasonal changes in key indoor air parameters including CO, CO2, HCHO, TVOC, temperature, RH, PM2.5, and AQI across rainy and dry seasons in 58 government offices in Enugu, and evaluated how these fluctuations relate to architectural features of the offices. Using a mixed-methods approach, data collection involved qualitative assessments of building design attributes alongside quantitative IAQ measurements taken with the BOSEAN T-Z01Pro detector. Seasonal variations were analyzed using paired T-tests, ANOVA, and regression models. The results revealed a marked increase in pollutant concentrations during the dry season (p < 0.001-0.005), resulting in a poorer air quality index compared to the rainy season. Architectural features accounted for 68.5% of the variability in AQI (R2 = 0.685, p = 0.000), with casement windows being significantly associated with better air quality (Exp B = -4.217, p = 0.013) These shows that the dry season poses a greater risk to IAQ which is worsened in offices where projecting windows were used, potentially impacting health and productivity. The study emphasizes the need to address seasonal IAQ differences when designing office buildings in tropical regions. Design architects can help reduce seasonal air quality challenges and support healthier, more productive indoor environments by incorporating ventilation strategies, such as the use of casement windows. Further research should include long-term monitoring across various settings and additional IAQ parameters for better understanding of IAQ dynamics.