Indonesian Traditional Medicine Research Articles

Socialization of Natural Medicines and New Perspectives on Traditional Indonesian Medicine for Pharmaceutical Workers

Treatment traditional Indonesian herbs, which have been There is during centuries, now get increasing attention big in the middle change paradigm global health towards a more approach holistic and natural. Socialization about treatment traditional This important done for give perspective new that puts forward value and potential drug made from nature. Through activity socialization, society invited for understand more in about various available herbal concoctions, how to its use, as well as benefit for health. Knowledge This No only support sustainability practice treatment traditional, but also integrate it with modern medicine. In the context of modern health, proper understanding about treatment potion traditional can answer challenge in field health, such as increasing request to treatment natural and issues resistance medicine. Through socialization of a nature educational, community can empowered in choose alternative more treatment safe and effective, and contribute to preservation culture local. In addition, socialization this also becomes bridge connecting knowledge traditional and research scientific, encouraging research more carry on about efficacy herbs drug material nature. With Thus, socialization This expected can strengthen position treatment traditional Indonesian herbs as one of the pillars in system better health inclusive and sustainable.

Network Pharmacology and Molecular Mechanism of Traditional Indonesian Medicine in Hypertension Treatment

Network Pharmacology and Molecular Mechanism of Traditional Indonesian Medicine in Hypertension Treatment

Spiro-meroterpenoids, Syzygioblanes D-H, Isolated from Indonesian Medicinal Plant Syzygium oblanceolatum.

Syzygioblanes A-C (1-3), isolated from the Indonesian traditional herbal medicine Syzygium oblanceolatum (S. oblanceolatum), are meroterpenoids with a spiro ring formed through a [4 + 2] cycloaddition of the flavanone desmethoxymatteucinol with cyclic sesquiterpenoids. Our ongoing phytochemical investigation of S. oblanceolatum resulted in the isolation of five additional spiro-meroterpenoids, syzygioblanes D-H (4-8), which are hybrids of the same flavanone with eudesmane/cadinane-type sesquiterpenoids. A possible biosynthetic pathway involves enzymatic dearomative hydroxylation of desmethoxymatteucinol followed by [4 + 2] cyclization of the resulting diene with a cyclic sesquiterpene containing an exocyclic methylene to form the unique spiro ring in the syzygioblane molecule. The isolated syzygioblanes F (6) and G (7) demonstrated collateral sensitivity by inhibiting the growth of multidrug-resistant tumor cell lines more than the related chemosensitive tumor cell lines.

Household resilience of women migrant worker sellers of Jamu Gendong.

The selling of Jamu Gendong (an Indonesian traditional herbal medicine), is closely associated with the informal work of women who migrate to different regions. In Sukoharjo Regency and Wonogiri Regency, Central Java Province, the pressing need to meet household necessities in their places of origin compels women to assume the role of breadwinners. Therefore, this research aimed to identify the livelihood capital and resilience of migrant women selling jamu gendong. The study was conducted in Ciamis Regency, West Java Province, Indonesia, in November 2022, using quantitative and qualitative methods. Primary data were collected through structured questionnaires and in-depth interviews. The sample comprised 51 women selected through snowball sampling and actively involved in selling Jamu Gendong, along with six key individuals from relevant agencies. The research findings indicate that the households of migrant women who sell jamu gendong can survive and adapt during their migration to prevent poverty by implementing diverse livelihood strategies. They are the only ones who move without their family members renting a place to live with them. This research has identified various capital sources, including productive age and skills in preparing jamu gendong; physical capital, including road infrastructure, markets, and access to health and education facilities; and natural, social, and financial capital. This research provides an in-depth understanding of women's roles in family economic resilience, diversification of life strategies, the importance of social capital in migrant networks, economic empowerment through migration, and the influence of cultural values on livelihood strategies. The findings contribute to a comprehensive understanding of the resilience demonstrated by migrant women selling jamu gendong. However, further research should be conducted in areas beyond the city center to obtain a holistic view of their resilience.

The determinant of reconsumption intention: a study of Indonesian traditional herbal medicine consumers

The determinant of reconsumption intention: a study of Indonesian traditional herbal medicine consumers

Household resilience of women migrant worker sellers of Jamu Gendong

Background The selling of Jamu Gendong (an Indonesian traditional herbal medicine), is closely associated with the informal work of women who migrate to different regions. In Sukoharjo Regency and Wonogiri Regency, Central Java Province, the pressing need to meet household necessities in their places of origin compels women to assume the role of breadwinners. Therefore, this research aimed to identify the livelihood capital and resilience of migrant women selling jamu gendong. Methods The study was conducted in Ciamis Regency, West Java Province, Indonesia, in November 2022, using quantitative and qualitative methods. Primary data were collected through structured questionnaires and in-depth interviews. The sample comprised 51 women selected through snowball sampling and actively involved in selling Jamu Gendong, along with six key individuals from relevant agencies. Results The research findings indicate that the households of migrant women who sell jamu gendong can survive and adapt during their migration to prevent poverty by implementing diverse livelihood strategies. They are the only ones who move without their family members renting a place to live with them. This research has identified various capital sources, including productive age and skills in preparing jamu gendong; physical capital, including road infrastructure, markets, and access to health and education facilities; and natural, social, and financial capital. This research provides an in-depth understanding of women’s roles in family economic resilience, diversification of life strategies, the importance of social capital in migrant networks, economic empowerment through migration, and the influence of cultural values on livelihood strategies. Conclusions The findings contribute to a comprehensive understanding of the resilience demonstrated by migrant women selling jamu gendong. However, further research should be conducted in areas beyond the city center to obtain a holistic view of their resilience.

Isolation and Inhibitory Activity Testing of Alpha-Glucosidase Enzyme from Endophytic Bacteria in Kumis Kucing (Orthosiphon aristatus (Blume) Miq.) Leaves

Orthosiphon aristatus (Blume) Miq., commonly known as kumis kucing, is frequently used in traditional Indonesian medicine to treat diabetes, hypertension, rheumatism, gout, and as a diuretic. However, large-scale production of medicinal products from natural sources requires significant raw material and land, creating a need for alternative methods. This study explores the potential of isolating endophytic bacteria from kumis kucing leaves to serve as α-glucosidase enzyme inhibitors, offering a more sustainable approach. Eight bacterial endophytes were isolated and tested using bioautography assays and IC50 measurements to assess their inhibitory activity. Four isolates—KK 1, KK 3, KK 4, and KK 5—demonstrated significant α-glucosidase inhibition, with IC50 values of 41.35 µg/mL, 57.04 µg/mL, 56.70 µg/mL, and 164.16 µg/mL, respectively. Molecular testing identified KK 1 as Priestia aryabhattai, while KK 3 and KK 5 were identified as Priestia megaterium. These findings suggest that endophytic bacteria isolated from Orthosiphon aristatus leaves have the potential to be developed as natural sources of α-glucosidase inhibitors, which are beneficial for diabetes management.

Development of Indonesian Original Medicines Study of Standardized Herbal Medicine Products "Antangin JRG" as Traditional Medicine

This study aims to examine the potential for the development of indigenous Indonesian medicines based on traditional medicinal plants. Herbal medicine has been used for generations in Indonesia and has great potential to be developed into more standardized and modern products. This study covers various aspects ranging from product name, content, class, composition, efficacy claims, empirical data, standardization of raw materials, preclinical tests, toxicity tests, to clinical trials. The results of the study show that with proper processing and standardization, Indonesian traditional medicine can compete with modern pharmaceutical products.

Pharmacognosic Study and Determination of Marker Compounds Soursop Leaves (Annona muricata)

Soursop (Annona muricata) is reported to have great efficacy in traditional medicine in Indonesia so it is very vulnerable to being faked or sold as low quality. Apart from having a delicious fruit taste, Soursop leaves have also been used as an effective cancer medicine by the public and have been scientifically proven so that Soursop can be used as a phytopharmaceutical product. Therefore, it is necessary to carry out research to determine pharmacognosy parameters and marker compounds as ingredients needed to obtain the authenticity of simplicia and plant extracts. This research includes macroscopic and microscopic examination of leaves, macroscopic and microscopic examination of simplicia, fluorescence characteristics of simplicia, determining the solubility of methanol extract in various non-polar and polar solvents as well as the characteristics of marker compounds that can be used as alternatives to existing marker compounds from Soursop (Annona muricata). The research results obtained are important information as a stage for the identification and standardization of soursop leaves (Annona muricata) as a raw material for herbal medicine.

Karakter Morfologi Dan Hubungan Kekerabatan Pada Tanaman Jahe (Zingiber officinale) di Kabupaten Garut

Ginger (Zingiber officinale) is one of the spice plants used for cooking or traditional medicine in Indonesia. Ginger variations are highly diverse in the Garut region, hence there is a need for the characterization of ginger plants to identify the germplasm present in the Garut area. This research was conducted at several points in the Garut region by observing the morphological characteristics of ginger based on Union for the Protection of New Varieties of Plants. The morphological characteristics observed include overall plant morphology, including stem, leaves, and rhizomes. After the data were collected based on predetermined criteria according to descriptors, the data were processed using NTSYS 2.1 to determine the relatedness of the ginger varieties found. Based on the analysis of the dendrogram results, it is shown that among the red ginger varieties (A1 and A5), there is a coefficient value of 0.65, indicating a high similarity in properties. Elephant ginger (A3, A2) and emprit ginger (A6) have a coefficient value of 0.45, indicating a close relatedness between elephant ginger and red ginger, while elephant ginger (A4 and A7) has a coefficient value of 0.50, indicating close relatedness.

A systematic review of Indonesian traditional Jamu medicine

A systematic review of Indonesian traditional Jamu medicine

Analysis Of Iron (Fe) And Zinc Content (Zn) From Bay Leaves (Syzygium Polyanthum)

Background: Anemia is a nutritional problem in children, pregnant women, teenagers, and women of childbearing age. The prevalence of anemia in Indonesia in 2018 among young women was 48.9%. Bay leaves are widely known in various culinary and traditional medicine in Indonesia. Objective: This study analyzes the iron (Fe) and zinc (Zn) content in bay leaves (Syzygium polyanthum) growing in Karanganyar, Indonesia. Method: This research is an observational descriptive experiment with a laboratory approach carried out through a series of experiments. An Atomic Absorption Spectrophotometer (AAS) is used to analyze iron levels. Results: This research shows that the average concentration of Fe in bay leaves growing in Karanganyar is 294.28 mg/L per 100 grams of bay leaves. Meanwhile, the average concentration of Zn in bay leaves is 15.19 mg/L per 100 grams of bay leaves. According to TKPI 2017, bay leaves contain around 44.1 mg of iron per 100 g. Apart from that, the results of research conducted by Suharni 2021 show that 100 g of bay leaf extract contains around 30.09 mg of iron. Comparison with other plants shows that bay leaves contain much more iron and zinc. Higher than plants such as Moringa leaves. As an example of another plant that is often consumed, Moringa leaves have a lower iron and zinc content, namely 6 mg Fe/100 grams of Moringa leaves and 0.6mg/100 grams of zinc. In addition, this research opens up opportunities for application to experimental animals such as mice, which can be given bay leaf powder to understand its impact on iron and zinc levels in their bodies. Conclusion: The average test concentration of Fe in bay leaves is 294.28 mg/L. Meanwhile, the average concentration of Zn in bay leaves is 15.19 mg/L.

Analysis of Aspects of Legal Protection for Patients Regarding Traditional Medicine in Law Number 17 of 2023 Concerning Health

This research examines legal protection for patients who are victims of traditional medical malpractice based on Law Number 17 of 2023 concerning Health. In the context of the increasing use of traditional medicine in Indonesia, it is important to understand existing legal protection mechanisms and how effective these regulations are in protecting patients' rights. This study uses a qualitative approach with literature study methods and analysis of related laws and regulations. The research results show that Law Number 17 of 2023 has provided a clearer legal framework in regulating traditional healing practices and provides protection mechanisms for patients. However, implementation in the field still faces various challenges, including a lack of effective supervision, limited public knowledge about their rights as patients, and differences in service quality in various regions. This research also identifies the important role of local governments in supervising and coaching traditional medicine service providers, as well as the need to increase education and outreach to the community regarding patient rights. In conclusion, although Law Number 17 of 2023 has provided a significant legal basis, there is still room for improvement in the implementation of this regulation to ensure optimal protection for traditional medicine patients in Indonesia.

The Prospect of Indonesian Herbal as An Alternative Treatment for Covid-19 Patient: A Literature-Based Study

Coronavirus disease 2019 (COVID-19) is a new disease caused by a novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The disease has several symptoms from mild to severe and could lead to death for comorbidities and the elderly. Therefore, the infections and mortality cases keep growing day by day, moreover many authorities are trying to suppress it by applying several health protocols, including medicines. Several studies were conducted on drug discovery from plants to cure the disease. The article aimed to do a narrative review about the prospect of JAMU becoming an alternative medicine to cure COVID-19 by mapping the literature deposited on PubMed which reported medicinal plants as an alternative medicine for COVID-19 by using a text mining program. There are approximately 30,191 articles on PUBMED related to COVID-19 and medicine. Medicinal plants with antiviral and anti-inflammatory activities are the best plants for COVID-19. JAMU, an Indonesian traditional medicine, has an outstanding possibility to be applied in the COVID-19 strategy to recover patients and prevent infections.

Sosialisasi Pemanfaatan Tanaman Toga dalam Meningkatkan Pendapatan Ibu-Ibu TP PKK Desa Lenteng Timur

Herbal medicine is one type of traditional Indonesian medicine made from natural ingredients and is a cultural heritage passed down from generation to generation. One of the problems is the lack of knowledge about the benefits of TOGA plants, which are not only used as kitchen spices but can also be utilized as powdered herbal drinks. The main objective of this community service activity is to train and disseminate information on the education and production of powdered herbal drinks that can be sold to the PKK women in Lenteng Timur village, providing additional income for their families. The aim of this research is to determine whether TOGA plants can help the PKK women in Lenteng Timur village earn more income. The methods of socialization, education, training, and evaluation are used in this study. The findings show that before the training, 77.5% of the PKK women in Lenteng Timur village only knew about the use of TOGA plants as powdered herbal drinks; however, after the training, their knowledge increased by 22.5%.

Integration of Traditional Medicine in the Perspective of Islamic Law and Positive Law

Traditional medicine in Indonesia, as part of the archipelago's cultural heritage, has been the main choice in curing people's illnesses. Despite the growth of modern medical services, many still rely on traditional medicine, including reflexology, herbal drinks, aromatherapy, chiropractic therapy, cupping, and acupuncture. This study aims to examine and discuss traditional medicine in Indonesia, focusing on Battra (traditional medicine) and various types of traditional medicine such as reflexology, herbal drinks, aromatherapy, chiropractic therapy, cupping, acupuncture, as well as traditional medicine in the context of Islamic law. This research uses a descriptive qualitative approach through literature study. The results show that there is a link between the social relationship between traditional healers and patients as a legal relationship in terms of their respective interests. In addition, traditional medicine in Indonesia is not only seen as a cheap alternative, but also as an inseparable part of cultural identity and ancestral heritage that needs to be preserved. Health law also plays a role in regulating and protecting traditional medicine to prevent abuse and harmful practices.

Cyclic Sesquiterpene-Flavanone [4+2] Hybrids, Syzygioblanes A-C, Found in an Indonesian Traditional Medicine, "Jampu Salo" (Syzygium oblanceolatum).

A plant used in an Indonesian traditional herbal medicine as a diabetes treatment and known locally as "Jampu Salo" was collected on Sulawesi Island, Indonesia. It was identified as Syzygium oblanceolatum (C. B. Rob.) Merr. (Myrtaceae) and found for the first time in Sulawesi; it was previously reported only in the eastern Philippines and Borneo. A phytochemical study of S. oblanceolatum led to the isolation of three unprecedented meroterpenoids, syzygioblanes A-C (1-3, respectively). These compounds might be biosynthesized through [4+2] cycloaddition of various germacrane-based cyclic sesquiterpenoids with the flavone desmethoxymatteucinol to form a spiro skeleton. The unique and complex structures were elucidated by microcrystal electron diffraction analysis in addition to general analytical techniques such as high-resolution mass spectrometry, various nuclear magnetic resonance methods, and infrared spectroscopy. Synchrotron X-ray diffraction and calculations of electronic circular dichroism spectra helped to determine the absolute configurations. The newly isolated compounds exhibited collateral sensitivity to more strongly inhibit the growth of a multidrug resistant tumor cell line compared to a chemosensitive tumor cell line.

Evaluation of the antiplasmodial and anti-Toxoplasma activities of several Indonesian medicinal plant extracts

Ethnopharmacological relevanceMalaria, caused by Plasmodium parasites, remains a significant global health challenge, particularly in tropical and subtropical regions. At the same time, the prevalence of toxoplasmosis has been reported to be 30% worldwide. Traditional medicines have long played a vital role in discovering and developing novel drugs, and this approach is essential in the face of increasing resistance to current antimalarial and anti-Toxoplasma drugs. In Indonesian traditional medicine, various plants are used for their therapeutic properties. This study focuses on eleven medicinal plants from which nineteen extracts were obtained and screened for their potential medicinal benefits against malaria and toxoplasmosis. Aims of the studyThe aim of this study was to evaluate the efficacy of extracts from Indonesian medicinal plants to inhibit Plasmodium falciparum, a parasite responsible for malaria, and Toxoplasma gondii, an opportunistic parasite responsible for toxoplasmosis. MethodsNineteen extracts from eleven plants were subjected to in vitro screening against P. falciparum 3D7 (a chloroquine-sensitive strain) and the T. gondii RH strain. In vitro treatments were conducted on P. falciparum 3D7 and K1 (multidrug-resistant strains) using the potent extracts, and in vivo assessments were carried out with mice infected with P. yoelii 17XNL. LCMS analysis was also conducted to identify the main components of the most effective extract. ResultsSeven extracts showed significant antiplasmodial activity (>80% inhibition) at a concentration of 100 μg/ml. These extracts were obtained from Dysoxylum parasiticum (Osbeck) Kosterm., Elaeocarpus glaber (Bl.) Bijdr., Eleutherine americana Merr., Kleinhovia hospita L., Peronema canescens Jack, and Plectranthus scutellarioides (L.) R.Br. Notably, the D. parasiticum ethyl acetate extract exhibited high selectivity and efficacy both in vitro and in vivo. Herein, the key active compounds oleamide and erucamide were identified, which had IC50 values (P. falciparum 3D7/K1) of 17.49/23.63 μM and 32.49/51.59 μM, respectively. ConclusionsThe results of this study highlight the antimalarial potential of plant extracts collected from Indonesia. Particularly, extracts from D. parasiticum EtOH and EtOAc stood out for their low toxicity and strong antiplasmodial properties, with the EtOAc extract emerging as a notably promising antimalarial candidate. Key compounds identified within this extract demonstrate the complexity of extracts' action against malaria, potentially targeting both the parasite and the host. This suggests a promising approach for developing new antimalarial strategies that tackle the multifaceted challenges of drug resistance and disease management. Future investigations are necessary to unlock the full therapeutic potential of these extracts.

Ciplukan (Physalis angulata Linn) Bioactivity against Bleomycin-Induced Pulmonary Fibrosis in Mice by reducing Subpleural Fibrosis, KL-6 Level and Anti-Inflammatory properties

Pulmonary fibrosis is a fatal lung disease with unknown pathogenesis and limited treatment options. Herbal medicine began to be developed as an antifibrosis drug for this disease. Ciplukan plant (Physalis angulata Linn.), is a wild plant that has been widely used for generations as traditional Indonesian medicine for various diseases; but has never been studied as an antifibrosis. This study aimed to determine Ciplukan herb ethanol extract (CPL) bioactivity as antifibrosis in pulmonary fibrosis disorders in experimental mice model induced by bleomycin. A total of 35 male mice and 35 female mice of the ddy strain was divided into 7 groups respectively with 1 normal control group and 6 experimental animal models of pulmonary fibrosis induced by bleomycin groups. For the pulmonary fibrosis model, bleomycin (BLM) was injected subcutaneously 8 times with a frequency of twice a week for 4 weeks. Furthermore, the mice were given CPL orally starting at week 6 of treatment with 2 different doses, 1.95mg (CPL-1) and 3.9mg (CPL) every day for 4 weeks. Pulmonary fibrosis histopathology was analyzed using HE and MT staining methods. Serum IL-6, KL-6, and TGF-β1 levels determination was carried out using the ELISA method. The administration of CPL significantly reduced the fibrosis score from 2.80±1.095 to 1.67±0.577µm (p=0.026). The CPL also showed anti-inflammatory activity by reducing IL-6 levels from 1916.20±594.27 to 16.81±17.07pg/mL (p=0.003); TGF-β1 levels from 51.25±2.25 to 22.48±0.93ng/mL (p=0.021); and KL-6 levels from 28.09±2.25 to 13.99±0.93ng/mL (p=0.000). CPL was proven to have pulmonary antifibrotic activity in experimental mice model. The pulmonary antifibrotic effect was evidenced by a decrease in pulmonary fibrosis scores also a decrease in KL-6 levels, IL-6 levels, and TGF-β1. The administration of CPL-1 and CPL-2 can provide recovery of pulmonary fibrosis induced by bleomycin.

Antioxidant potential and polyphenol content in different parts of Graptophyllum pictum extracts.

The antioxidant potential of Graptophyllum pictum (wungu leaves), an indigenous shrub plant extensively used in traditional medicine in Indonesia, was investigated in this study. The research focused on a comprehensive evaluation of total phenolic content (TPC), total flavonoid content (TFC), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and ferric-reducing antioxidant power (FRAP) across various plant parts, including roots, stems, and flowers, which had been underexplored in prior studies. The ethanol extract derived from wungu flowers and leaves demonstrated notable antioxidant potential, characterized by elevated TPC (12.22 ± 0.31 mg GAE/g DW) and FRAP (37.73 ± 1.08 μmol TEAC/g DW) in the ethanol extract of wungu flowers. Similarly, the ethanol extract of wungu leaves showcased a substantial TFC (2.31 ± 0.18 mg QE/g DW) and DPPH (1.12 ± 0.05 μmol TEAC/g DW), surpassing other parts of the wungu plant in the same or different extracts. These findings suggested that ethanol extracts were a promising foundation for herbal medicines with antioxidant properties, highlighting their potential applications in plant breeding programs. Furthermore, the correlation data underscored the significance of the ethyl acetate and ethanol extracts, revealing a robust correlation between TPC, TFC, and FRAP compared to the n-hexane extract.