You have accessJournal of UrologyKidney Cancer: Advanced (including Drug Therapy) II (PD39)1 Apr 2020PD39-12 UROLOGIST-LEVEL UTILIZATION PATTERNS OF CYTOREDUCTIVE SURGERY FOR METASTATIC RENAL CELL CARCINOMA Joseph Cheaib*, Julia Wainger, Hiten Patel, Mitchell Huang, Meredith Metcalf, Michael Biles, Russell Becker, Joseph Canner, Michael Johnson, Mohamad Allaf, and Phillip Pierorazio Joseph Cheaib*Joseph Cheaib* More articles by this author , Julia WaingerJulia Wainger More articles by this author , Hiten PatelHiten Patel More articles by this author , Mitchell HuangMitchell Huang More articles by this author , Meredith MetcalfMeredith Metcalf More articles by this author , Michael BilesMichael Biles More articles by this author , Russell BeckerRussell Becker More articles by this author , Joseph CannerJoseph Canner More articles by this author , Michael JohnsonMichael Johnson More articles by this author , Mohamad AllafMohamad Allaf More articles by this author , and Phillip PierorazioPhillip Pierorazio More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000918.012AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Cytoreductive surgery (CS) has been integral in the multimodal management of patients with metastatic renal cell carcinoma (mRCC) in the tyrosine kinase inhibitor (TKI) era. Its role, however, has recently come into question with the release of data from prospective trials. Accordingly, reporting current urologist-level patterns of utilization of CS would be important to evaluate the impact of such findings on future CS implementation. METHODS: We performed a population-based study of patients diagnosed with mRCC from 2004 to 2013 using the linked Surveillance, Epidemiology, and End Results (SEER)-Medicare database. Patients were assigned to a specific primary urologist using Medicare physician specialty codes. A multivariable mixed-effects logistic model was fit to evaluate the association between the use of CS and select patient characteristics, assuming a urologist-level random intercept to account for correlation among urologists. From the model, the predicted probability of using CS was obtained for each urologist. RESULTS: A total of 4226 patients with mRCC and 1964 primary urologists were identified. On average, each urologist saw 3 patients (range: 1-35 patients). Overall, 1370 (32%) patients underwent CS for mRCC; CS included radical nephrectomy (N=1285, 94%), partial nephrectomy (N=55, 4%), and thermal ablation (N=30, 2%). Median age was 75 years (IQR: 70-81 years), and median tumor size was 7.3 cm (IQR: 5-10 cm). Table 1 shows the patient characteristics and predictors of CS. At the individual urologist level, the estimated probability of using CS varied from 26.9% to 38.7% (mean: 32.2%) (Figure 1). Of the 1964 urologists, 1077 (55%) never offered CS. CONCLUSIONS: Significant variation exists in the utilization of CS, with 27-39% of patients undergoing CS and 55% of urologists never offering CS to patients with mRCC in the TKI era. These data serve as a benchmark to measure continued changes in the use of CS in the contemporary era, with randomized clinical trials demonstrating little benefit to CS in patients with poor-risk mRCC. Source of Funding: None © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e813-e814 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Joseph Cheaib* More articles by this author Julia Wainger More articles by this author Hiten Patel More articles by this author Mitchell Huang More articles by this author Meredith Metcalf More articles by this author Michael Biles More articles by this author Russell Becker More articles by this author Joseph Canner More articles by this author Michael Johnson More articles by this author Mohamad Allaf More articles by this author Phillip Pierorazio More articles by this author Expand All Advertisement PDF downloadLoading ...
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