Individual Territories Research Articles

Regional Development Of Municipalities With A Population Of 10 To 30 Thousand In The North-Eastern And South-Eastern Planning Regions Of Bulgaria

This article is devoted to assessing and analyzing the development of municipalities from 10 to 30 thousand people in the Bulgarian Northeast and Southeast regions on level 2. At the beginning, a characterization of the ongoing processes and the importance of the regionalization process for the spatial development of individual territories is presented, the purpose of the article is formed, and the leading task is to make a statistical analysis of leading socio-ideographic indicators that bring to the fore the characteristics of these territorial units and present to our attention their state. It is important to be able, based on the assessment of the situation and the reference to expert assessment, to take the appropriate measures and sets of actions to promote the regional economic development of these municipalities. Comparing municipalities in these two regions, the southwest and south-central areas of the country emerge as the richest and most developed regions regarding household income, techno-social equipment, and endowed and economic potential. The analyses revealed several detailed aspects of the typology of problems specific to the various municipalities, which can be examined in more detail in another study. The conclusion draws relevant recommendations for improving regional development in these territories.

Migration processes in the Republic of Kazakhstan: current situation and consequences

Rural population migration is an objective process that affects the economic, environmental, social and demographic development of countries and their individual territories. Regulation and supervision of the migration process is one of the priority tasks of the state. The aim is to the scale and direction of migration flows in rural areas of the republic, the reasons for migration and the degree of influence on the labor market in rural areas are considered. Methods - comparisons to determine quantitative indicators characterizing the level of resettlement of economically active citizens. Assessment of the dynamics of those who arrived and left the RS was carried out by the methods of grouping and graphical analysis. Generalization method - in formulating the main aspects of resettlement. Results - the authors state that it is necessary to improve the mechanisms of legal labor migration, explanation and counseling, legal protection and organizational measures for those arriving and departing. Special attention should be paid to the development of infrastructure, creation of new jobs, career opportunities, high income, social conditions in rural settlements (RS) with high levels of local displacement. Based on the study, it is concluded that even positive trends and sustainable growth in production do not suppress the incentives for outflow to the city both for permanent residence and in search of temporary work. Conclusions - the location of rural areas near the regional center, the location of agricultural enterprises and farms, favorable natural and climatic conditions have a great impact on the attraction of migrants to rural areas. Based on the above, the key factor contributing to the reduction of migration loss of population can be called diversification of the economy in rural areas, further development of existing and creation of new production facilities.

THE ROLE OF FREE ECONOMIC ZONES IN THE ECONOMIC GROWTH OF UZBEKISTAN A CASE STUDY OF THE SOUTH KOREAN EXPERIENCE

In the era of the globalizing world, when states are becoming more and more dependent on each other, Uzbekistan, which continues the transition to the principles of a market economy, has also entered this path. One of the main conditions for ensuring stable economic growth in individual territories is an increase in investment activity based on the widespread involvement of domestic and foreign investors. To accomplish this task and an intensive transition to the principles of an open market economy, there is a need to create free economic zones (FEZ). There are already 23 free economic zones in Uzbekistan, 21 of which specialize in industry, 2 in agriculture, where industrial goods are produced for the domestic market and for export. However, the study revealed that there are several problems in the free economic zones in Uzbekistan that need to be addressed. To verify these objectives correlation, and regression analysis conducted. The analysis revealed that out of six factors, the two factors of FEZ export and FEZ investment are the major factors that directly impacted economic growth

Administrative-territorial transformations in the Kursk region in the mid 1940s – early 1960s: main practices and results

Relevance. Issues of intraregional administrative and territorial transformations, including in the Kursk region, currently remain practically unstudied. This is due, on the one hand, to the specifics of the source base of the problem, which is a set of official legal documents, statistics and regulations, and, on the other hand, to insufficient interest on the part of researchers. Meanwhile, studying the specifics of the implementation of various administrative-territorial transformations in the post-war period using the example of a specific region has serious scientific significance: it allows us to detail the features of the socio-economic development of territories, demographic and migration aspects, etc., which creates the opportunity to take a slightly different look at history of the Kursk region.The purpose. Reveal the features of the dynamics of the administrative-territorial structure of the Kursk region in the mid-1940s – early 1960s.Objectives: based on the study of a complex of historical sources, show the prerequisites, logic and course of intraregional administrative and territorial transformations of the Kursk region in the period indicated above.Methodology. When writing the work, the authors relied on the fundamental methods of historical science (the principles of historicism and objectivity), as well as on a number of specific historical and general scientific methods (analytical, comparative historical, genetic, etc.).Results. Currently, in local historiography there are no scientific works on the history of the administrative-territorial structure of the Kursk region. The reference publications available to historians are replete with inaccuracies and errors. This work partly identifies these errors, and also shows the mechanisms for changing the administrative-territorial structure of the Kursk region in the mid-1940s – early 1960s.Conclusion. The administrative and territorial transformations that took place in the Kursk region in the mid1940s – early 1960s had a predominantly socio-economic basis. The rapid development of individual territories required changes in the network of village councils, districts, the creation of new regions, as well as the abolition of ineffective administrative-territorial units. The party and state leadership of the region and the country in most cases responded quite quickly to these needs, however, as practice has shown, not all of them were consolidated in practice.

A CLUSTER APPROACH TO ASSESSING THE RELATIONSHIP BETWEEN THE INTENSIFICATION OF AGRICULTURAL LAND USE AND THE CONTENT OF HUMUS IN SOILS

Introduction. Today, global agricultural production is focused on obtaining a quick profit, despite the consequences of harmful anthropogenic influence on the state of land. First of all, this is manifested in the intensification of the crop industry, which is oriented towards increasing the acreage under energy agricultural crops. A similar situation is also typical for Ukraine and is aimed at increasing the energy potential of the crop industry. Methods. The methodological basis of the conducted research is a dialectical approach. It allows to assess the effect of economic laws in the direction of establishing trends and patterns of development of social and natural phenomena and processes. The cluster approach was used as a tool for targeted management of the ecological and economic components of the regional system of land use in the agricultural sector. A wide range of statistical analysis methods are used in the work, administrative regions are grouped into clusters according to the conducted research. The results of the conducted studies were evaluated using the Statistica 10.0 software package. The abstract-logical method was used to form conclusions and make theoretical generalizations. Results. The article examines the influence of intensification of agricultural activity on the quality of the soil, reveals the dependence of the humus content in the soil on the dynamics of the technically available energy potential of agricultural crops grown in Ukraine regionally, as well as the volume of production of organic fertilizers as a result of raising farm animals. Discussion. Research data reveal a high correlation coefficient of the studied indicators within individual territories. The results are expected to be used for planning the necessary measures in order to increase the ecological and economic efficiency of the agricultural land use system. Keywords: humus level, intensification, energy potential, organic fertilizers, soil quality, agricultural land use.

REGIONAL SPECIFICITY OF THE TRANSFORMATION OF SETTLEMENTS IN THE FACE OF THE CHALLENGES OF WAR

The article deals with the problematic aspects of the development of the General Scheme of Planning of the Territory of Ukraine, programs and projects for the restoration and further development of settlements, based on the historically developed specifics of the regions and the features of individual territories of Ukraine, which arose, as a result, of Russian military aggression. The typological features of different groups of settlements and the territory of the country are formulated, namely, settlements subject to complex reconstruction and located: A typology is proposed and typological features of different groups of settlements in the country are formulated, based on the differentiation of territories according to the scale of damage and the conditions for further restoration and balanced development. Namely, a) in the occupied territories; b) on the brink of combat and were totally destroyed during active hostilities; c) in the buffer zone of 50–100 km along the border with Russia; d) received significant flows of internal migration; e) were in relative "safety" and were subjected only to the destruction of local urban objects; e) in territories subjected to total mining and construction of a developed network of fortifications.

DONETSK PROVINCE: ABOUT ORIGINS OF THE FORMATION

This article deals with the problems of the formation of the predecessor of the modern Donetsk People’s Republic - Donetsk province and traces its incorporation into the RSFSR, and then the transition to the Ukrainian SSR. April 26, 1920 should be recognized as the date of the entry of Donbass into the Russian Soviet Republic, when the RSFSR recognized the decision of the Soviet government on the allocation of the new province borders. Nowadays, archival data allow us to conclude that there is no legal transfer of the Donetsk province of the Ukrainian SSR. At the end of 1920, the territory of Donetsk province was politically recognized by the Bolsheviks as Soviet Ukraine, without observing the constitutional procedure for the region’s withdrawal from the Russian Federation. The Ukrainian SSR received its political recognition as a national republic - the Ukrainian people exercised their right to secede. Donbass emerged on the basis of self-determination of the workers of this region, who fought for independence and Soviet power. The author shows which variants of the borders of the Donetsk province were originally intended and on what principles the inclusion of individual territories in its composition was based.

Development of Transport Logistics in Kyrgyzstan

The article explores the possibilities of the Kyrgyz Republic in solving logistics problems, primarily in the framework of the development of transnational projects, cooperation of modes of transport in mixed traffic and identifying their competitive advantages, as well as by developing modern multimodal transport hubs, using the economic and geographical features of the regions. An attempt is made to show how the development of international transport corridors affects the development of individual territories on the example of the continental and border regions.

Assessing the Feasibility of Establishing special Economic Zones: Geo-economic Mapping Method

The purpose of the study is to systematize factors of successful and sustainable functioning of special economic zones, as well as to develop tools to map of zones on a map of a country with the competitive advantages of individual territories identified therein in order to make recommendations for improving the zonal policy. The relevance of the study is due to the fact that in the context of global shocks, a special preferential regime, flexible governance models of special economic zones are not determinants of their successful application in order to promote national investment strategies. The geo-economic advantages of the territories within which the special economic zones operate come to the fore. Such advantages are the basis for the formation of poles of economic, commercial, industrial and innovative growth. The use of methods of theoretical (analysis, synthesis, generalization) and empirical (comparison, measurement) research allowed the authors to reveal the content of effects associated with the functioning of special zones, to highlight the problems of their measurement; to generalize the features of preferential regimes of Russia; to systematize the geo-economic factors of successful and sustainable operation of special zones. The method of geo-economic mapping was used to identify the correspondence between the competitive advantages of territories and special zones created within their borders. As a result, it is proposed to classify key geo-economic factors that determine the potential successful functioning of special zones into three groups: spatial, economic and organizational. These groups of factors, according to the authors, should be considered in terms of formation and retention of geo-economic advantages: general, caused by public management and specialized. The method of geo-economic mapping identifies regions whose special zones correspond to the level of development of the identified geo-economic advantages, as well as those whose conditions are most likely not to maximize the effect of the special zones localized in their territory. It is recommended to establish a system for monitoring the conformity of specialization of regions with the profile of special economic zones established within their borders.

Toolkit for increasing the efficiency of land resource use in the territorial communities' management

The article examines the main tools for achieving more efficient and sustainable use of land resources in managing territorial communities. The place of use of land resources in the management of territorial communities is analyzed. In this context, land resources are objects of the management of territorial communities, which include the territory, the air space above it, soils, vegetation, and natural resources that have material form and monetary value and can also potentially participate in the production of agricultural or industrial products, performing works, providing services, and bringing income to their owners in the form of land rent. It was emphasized that Ukraine is currently facing numerous problems caused by the war, particularly insufficient funding at the disposal of territorial communities, and therefore, the main goal is the most efficient use of all available resources, in particular land resources, to ensure development and increase their independence. Primarily financial, maximizing the potential of individual territories. The main tools for increasing the efficiency of the use of land resources in the management of territorial communities are identified the implementation of geo-information systems, economic mechanisms, land development, and zoning planning, the establishment of environmental standards, public involvement in the process of land resource management, and raising the level of awareness and education in the field of effective land use. Having analyzed the management of land resources in Ukraine, especially in the context of new territorial communities, it was noted the presence of several significant problems, in particular, such as: insufficiently defined boundaries of the territory of the community, restrictions on the use of land outside settlements, insufficient income to the local budget from land payments, limited possibility of making strategic plans due to lack of information about land resources, problems of land pollution, refusal to grant land to citizens, difficulties in attracting investors and business development in the territory of the community, underestimation and incorrect reservation of promising territories for development, low quality of maintenance of reclamation systems and problems with illegal use of forest resources. Keywords: land resources, management of land resources, territorial communities, efficiency of use of land resources, decentralization.

МОДИФИКАЦИЯ И ВНЕДРЕНИЕ ПАРАМЕТРОВ ОБЪЕКТИВИЗАЦИИ ПОКАЗАТЕЛЯ ОЖИДАЕМОЙ ПРОДОЛЖИТЕЛЬНОСТИ ЗДОРОВОЙ ЖИЗНИ

The search for a universal indicator of population health, which gives an estimate of one value and is devoid of subjectivity, continues to this day [1-4]. Mortality, which strictly records the fact and causes of the end of human life, can have different content, and age-related detailing of death gives, although interesting, but a large number of indicators [5-7]. It was possible to collect the influence of all age–related mortality rates into one generalized estimate in an integral indicator – “life expectancy” (hereinafter – life expectancy). However, with this approach, the issue of assessing the state of health of living people remains unresolved [8, 9], and the answer should be the indicator “healthy life expectancy” (hereinafter referred to as the life expectancy index). Attempts have been made to introduce the HPP indicator since the 1960s and 1970s, but it was only at the end of the twentieth century that it was adopted by WHO. Changes in social conditions of life and the quality of health care are now aimed not only at increasing the BWF, but also the BWF. And more and more countries and WHO have started using it as the main target. Domestic statistics practically do not calculate [10] and do not publish the GPR in official statistical collections. The calculations made for countries and regions are not extended to individual territories of the regions. The existing approaches are based on a subjective assessment of the health of certain age categories [8, 10] and do not use the collected statistical information. Goal. To develop an improved methodology for calculating the integrated indicator of “healthy life expectancy” in conditions of limited statistical information and introduce it into the practice of assessing the health of the population. Tasks: 1. To analyze the existing calculation of the indicator “healthy life expectancy”. 2. To summarize the existing approaches to calculating the indicator of “healthy life expectancy” and comment on the methodology for determining the life expectancy. 3. To develop an improved methodology for calculating the indicator of “healthy life expectancy”. Research methods: literary review and expert opinion. Conclusion: The HPA indicator should be implemented, as there is a need for this assessment of population health. However, the use of HPE requires a unified interpretation of the degree of loss of health in various diseases, as well as the introduction of an age (five-year) breakdown of sick and disabled citizens into domestic official statistics.

Mobile app for household eco-activism

The article substantiates the development of a mobile application for the installation of communications in the public to solve the problem of sustainable environmental development of individual territories of settlements and attracting attention to current environmental problems. The use of structural analysis and synthesis methods made it possible to establish all the key actors and processes of the problem area. Based on this, using the methods of information modelling, a model describing all the functional features of the implementation of information processes necessary for programming the modules of the software product was developed. Using the methods of object-orientated programming, a mobile application was created that allows us to generate a list of environmental events in which anyone can take part and get access to resources related to ecology.

Пріоритети податкової політики соціально-економічного розвитку територіальних громад

The article formulates the priorities of the tax policy of socioeconomic development of territorial communities under the influence of endo- and exogenous factors of its implementation. In the course of the study, general scientific and special research methods were used: analysis and synthesis, the method of causal analysis, methods of systematization and logical generalization, as well as the method of SWOT analysis. Their application made it possible to identify and systematize the problems of implementation of tax policy in the context of ensuring the socioeconomic development of territorial communities in Ukraine, taking into account the regulatory, organizational, economic, managerial and regulatory aspects. The method of SWOT analysis identifies obstacles and opportunities, weaknesses and strengths of the implementation of tax policy aimed at the development of individual territories of the country. According to its results, the priorities of the tax policy of socioeconomic development of territorial communities are determined. It is proposed that the implementation of these priorities of the tax policy of socioeconomic development of territorial communities of Ukraine, taking into account its administrative-territorial structure and differences in the natural-resource, production-sectoral and socioeconomic provision of individual territories, should take place primarily at the local level, which will help to form «development centers», the economic growth of which, according to the principle of diffusion, will spread to the regional and national levels. It is expected that the identified priorities will help to improve the existing tax policy, contributing to increasing the tax potential of budgets of cities, the formation of a business environment, and improving the tax culture both at the level of the population and at the level of competent local authorities, as well as the growth of social awareness and participation in the economic development of territorial communities.

Assessment of opportunities for the development of organic agriculture in municipal areas

Purpose: of the research is to develop a methodology for assessing the development opportunities of organic agriculture in municipal areas based on their clustering.Methods: within the framework of the study, methods of comparing averages, grouping, clustering based on Kohonen's self-organizing neural network were used. The study was conducted on the materials of the Penza region, the complex of analyzed indicators was formed on the basis of official statistical data on municipal districts of the region. The applied approach assumes the possibility of carrying out similar calculations based on the materials from other subjects of the Russian Federation.Results: the study proposes a system of indicators characterizing the development potential of the production of certain types of organic agricultural products on the territory of municipal districts. Clustering of districts was carried out, as a result, 6 clusters were identified, characterized by various combinations of the values of the analyzed factors. The characteristics of each cluster in terms of opportunities for the development of organic agriculture are given. The areas of activity with the best potential are indicated, as well as the main unfavorable factors. 2 clusters have been identified that can be considered as pilot ones for the implementation of the regional program for the development of organic agriculture.Conclusions and Relevance: at the initial stage of the development of the organic production sector, it is important to identify growth points, types of agricultural activities in certain areas that may be the most promising within the framework of the introduction of the principles of organic farming. Given the diversity and high variability of the values of indicators that determine the potential for the development of organic agriculture in individual territories, clustering can be an effective method that allows differentiating and increasing the targeting of state support measures for the relevant producers. The application of efforts for the development of organic agriculture, taking into account the peculiarities of the formed clusters, will be more effective.

MODERN ECONOMIC GROWTH - CONDITIONS AND FACTORS OF DEVELOPMENT

The focus of this paper is on economic growth and the conditions that influence its importance for the regional economy. We define its framework, philosophy and possibilities to influence the development processes of individual territories. Also important are the conditions and growth factors, which are discussed separately. Endogenous and exogenous factors of territorial and spatial development are given a special place in the exposition. The concepts and features of spatial and territorial development are discussed in terms of the functioning of the national economy and the measurement of growth. Special attention is paid to the factors and conditions that, in theoretical order, form the model of regional economic growth. Comparative analysis of processes and phenomena that bring out the specifics and peculiarities of regional economic growth and its significance for regional development is made. In conclusion, relevant conclusions and recommendations are made regarding the importance of regional economic growth for the development of regions and national spaces.

On the identity of the species Pulsatilla astragalifolia (Ranunculaceae)

Pulsatilla is a genus of early-flowering, ornamental, partly medicinal plants, characterized by a high level of hybridization. In this connection, many of them are rare and endemic to individual territories. Several different nomenclature combinations have been made over the extensive history of the genus revising, which often causes debates between scientists. One of the cases is the taxon Pulsatilla astragalifolia Pobed. To try to solve this issue, ITS fragments of nuclear DNA of three close species (Pulsatilla bungeana C. A. Mey. ex Ledeb., P astragalifolia Pobed., P tenuiloba (Hayek) Juz.) were sequenced. Another group is formed by several clades with samples of P. bungeana and P. astragalifolia, According to the results obtained, the studied samples were divided into several groups. One group consists of two clades: the first - P. tenuiloba samples, the second - P. astragalifolia samples. Which may indicate the presence of several forms of these species. Subsequently, it is planned to study new occurrences of these species, as well as the analysis of the other DNA fragments. However, the findings indicate that Pulsatilla astragalifolia is a separate species, having both morphological and genetic differences from related species.

Public-private partnership in the Russian Federation at the present stage: Trends and problems of development

Aim. To generalize the trends and problems of public-private partnership (PPP) development in the Russian Federation (RF) at the present stage.Objectives. To perform a brief review of the history of PPP development in Russia; to disclose the essence of theoretical provisions regarding the features and principles of PPP; to analyze the data characterizing the development of PPP in 2018–2022 in terms of the number and types of projects, the amount of financing raised, the levels of their implementation (federal, regional, municipal); to study the features of the implementation of the concept of “PPP for the benefit of people” in modern Russian practice.Methods. With the help of general methods of scientific cognition in various aspects, the authors have considered the features, trends and problems of PPP development in Russia, characteristic of the current state, as well as determined the general directions of their solution.Results. PPP is a modern method of attracting private capital to solve socio-economic problems of development of industries and territories. Its features are revealed through economic, social, financial, legal, managerial, political sides. The actual set of principles includes expediency, efficiency, legality, priority of public interests, responsibility of the parties to obligations, information transparency. The world practice has accumulated experience in the use of various PPP projects. The modern trend is the inclusion of sustainable development goals in the PPP development concept, which significantly modernizes approaches to the selection of PPP projects. The main trends of PPP development in Russia include the predominance of PPP projects implemented by type (concession agreements), number (municipal level projects), financing volumes (regional level projects), specific financial capacity (federal level projects); expansion of the range of sectors, objects, introduction of new measures, tools and mechanisms for the development and modernization of social infrastructure, ensuring technological sovereignty. The multiplicity of problems of PPP development in Russia is caused by legal, macroeconomic, personnel, political, managerial factors, which determines the need for continuous improvement of organizational, legal, financial and economic mechanisms.Conclusions. The study of trends and problems of PPP development in Russia allows not only to identify the national specifics of attracting private capital to solve problems of socio-economic development, but also to identify ways, directions of improving the welfare of the population, the growth of competitiveness of individual territories on the basis of a fuller use of entrepreneurial potential of regions.

Assessment of landslide hazard risks on the example of the land cadastre of Kosiv district

The purpose of the research presented in this article is to analyse landslide hazards by assessing the impact of the natural component of factors on land use within the Kosiv district of the Ivano-Frankivsk region. The increasing number of negative consequences of landslide processes in the study area, and especially in the Carpathian region of Ukraine, requires the creation of new approaches to land resource assessment and civil engineering to reduce the negative impact of landslides on the environment and human activities. Methods. Landslide processes were studied using geophysical methods, GPS and geostatistical methods of data analysis. Based on the created mapping layer of the land cadastre and the landslide hazard map for Kosiv district, a vector analysis was performed to assess the risk in each area according to its cadastral number. Results. The environmental and geological risk of the natural component of landslide hazard factors was calculated using geoinformatics and geostatistical analysis tools with the use of QGIS. An important result of the research is the creation of landslide risk maps of land plots based on data from the State Land Cadastre using the Kadastr.Live Toolbar plugin. Scientific novelty. For the first time an analysis of the natural component of landslide hazard risks for the territory of Kosiv district was carried out as a basis for the assessment of such risks for individual cadastral zones. The regulatory and monetary assessments were clarified based on individual territories, for conducting economic activities that require hydrogeological research or changing the intended use of land.. Practical significance. By applying the methodology of dividing landslide risk assessment factors into natural and anthropogenic components, it becomes possible to identify areas within the study area with the highest probability of landslide development and activation. This method helps to study the characteristics of natural factors and is useful in assessing the risk of landslides..

The ivy sign as a radiological marker for follow-up of postoperative cerebral perfusion status in adult moyamoya disease.

Little is known about the relationship between postoperative changes in cerebral perfusion and the ivy sign representing leptomeningeal collateral burden in moyamoya disease (MMD). This study aimed to investigate the usefulness of the ivy sign in evaluating cerebral perfusion status following bypass surgery in patients with adult MMD. Two hundred thirty-three hemispheres in 192 patients with adult MMD undergoing combined bypass between 2010 and 2018 were retrospectively enrolled. The ivy sign was represented as the ivy score on FLAIR MRI in each territory of the anterior, middle, and posterior cerebral arteries. Ivy scores, as well as clinical and hemodynamic states on SPECT, were semiquantitatively compared both preoperatively and at 6 months after surgery. Clinical status improved at 6 months after surgery (p < 0.01). On average, ivy scores in whole and individual territories were decreased at 6 months (all p values < 0.01). Cerebral blood flow (CBF) postoperatively improved in three individual vascular territories (all p values ≤ 0.03) except for the posterior cerebral artery territory (PCAt), and cerebrovascular reserve (CVR) improved in those areas (all p values ≤ 0.04) except for the PCAt. Postoperative changes in ivy scores and CBF were inversely correlated in all territories (p ≤ 0.02), except for the PCAt. Furthermore, changes in ivy scores and CVR were only correlated in the posterior half of the middle cerebral artery territory (p = 0.01). The ivy sign was significantly decreased after bypass surgery, which was well correlated with postoperative hemodynamic improvement in the anterior circulation territories. The ivy sign is believed to be a useful radiological marker for postoperative follow-up of cerebral perfusion status.

Long-term prognostic value of [15O]H2O PET imaging in patients suspected for cerebral hemodynamic insufficiency

ObjectivesQuantitative regional cerebral perfusion (rCBF) measurements using [15O]H2O PET with arterial cannulation and acetazolamide (ACZ) challenge have been reserved to identify high-risk patients that are candidates for by-pass operation. We aimed to assess the prognostic value of various parameters in quantitative [15O]H2O PET measurements in patients not subsequently undergoing surgery. MethodsWe identified 32 eligible patients who underwent [15O]H2O brain PET imaging for suspicion of hemodynamic insufficiency between 2009 and 2020. Cerebrovascular events were defined as new ischemic lesions on MRI, stroke, transient ischemic attack, vascular dementia. Follow-up period was 91 months (range: 26-146). rCBF before (rCBFbase) and after (rCBFacz) ACZ challenge and the relative increase (CVR), were examined in the anterior (ACA), middle (MCA), and posterior (PCA) cerebral artery territories of the affected hemisphere, and the most recent MRI scans were scored for infarcts and white matter lesions. ResultsReceiver operating characteristic (ROC) curve analysis showed higher prognostic accuracy for rCBFacz(AUC:0.82) compared to CVR (AUC:0.72) and rCBFbase (AUC:0.77). ROC AUC, optimal thresholds (and corresponding sensitivity/specificity/accuracy) for rCBFacz after ACZ in individual territories were 0.79 and 37.8 mL 100g−1 min−1 (0.81/0.63/0.72) for the ACA, 0.84 and 32 mL 100g−1 min−1 (0.81/0.75/0.78) for the MCA, and 0.70 and 43.9 ml/(mL 100g−1 min−1 (0.81/0.43/0,62) for the PCA. Kaplan Meier survival curve showed longer event-free survival in patients with rCBFacz below cut-off (p=0.007). In multivariate analysis rCBFacz remained a significant predictor when correcting for age. ConclusionQuantitative rCBF measurements after ACZ challenge with [15O]H2O PET provided high prognostic value for future cerebrovascular events.