ObjectiveThis study aimed to develop and implement a program-wide active learning framework to guide active learning and assessment efforts in an entry-to-practice competency-based Doctor of Pharmacy program. MethodsThe development of the framework involved 3 stages: creation of a framework aligned with the program’s guiding principles, provision of training and support to faculty and students, and evaluation of the students’ and academic staff satisfaction using an online survey over 2 academic years (2022–2023). Data from this survey were analyzed descriptively. ResultsAn active learning framework that was aligned with the program’s guiding principles while allowing flexibility for individual teaching styles was developed. It consisted of 4 stages: preclass preparation, in-class work, prelaboratory preparation, and in-laboratory activities (emphasizing knowledge acquisition and competency development). Academic staff surveys reported higher satisfaction of staff in year 2 than year 3 of the program, with indications of further training on specific modalities. Students’ satisfaction improved from year 2 to 3, particularly, in areas related to class objectives, learning environment, and feedback. ConclusionThe transformation of a curriculum that includes the evolution of the teaching and learning strategy is a complex, long-term project that deserves continuing attention. Having frameworks in place helps the management, instructors, and students to understand the global direction, stay focused, and support the implementation of competency-based education and student-centered learning.