Individual Subjects Research Articles

Building deservingness and fairness with discourse: how states construct the social legitimacy of pension schemes

ABSTRACT How do modern states legitimize and frame their redistributive social policies in promoting policy changes to the public? This article studies pension reform in China, using quantitative text analysis of articles from official newspapers to investigate the state’s efforts in framing and crafting the social legitimacy – particularly deservingness and fairness – of its then-new pension schemes from 1978 to 2008. The results demonstrate that the state made efforts to reconstruct social knowledge on fairness and deservingness in pension reforms through both the social values and individual subjectivities. The state’s strategies for reconstructing public expectations for pension benefit redistribution and welfare responsibility allocation differ for retrenchment and expansive reforms, even though these strategies both target recrafting and reframing the principles of reciprocity based on ‘contribution and rewards’ and ‘rights and obligations’. The state also builds images of deserving and undeserving social groups by blurring the distinction between merit and equity and ultimately reshaping individual subjectivity as a self-regulated and self-motivated ‘socialized self’.

Polysubjectivity as a Factor of Social Development in the Context of Dialogization and Differentiation of Center–Region Relations in the Federal State

The article explores the phenomenon of polysubjectivity as a factor of social development from the perspective of post-non-classical scientific methodology. The author proposes conceptualizing polysubjectivity (multiple subjectivity) as a category describing the multifaceted nature, diversity, and dynamics of the social environment. This environment is formed through the dialogue of managed subjects who are bearers of diverse value-goal structures, possess certain resources, and are interconnected with other subjects of social action. Attention is drawn to the dual nature of poly-subjectivity. On one hand, it is viewed as the subjectivity of multiple individuals and social groups united within a localized social environment, for example, in the context of interactions between government and business, authorities and the population, or the federal center and regions. On the other hand, polysubjectivity is interpreted as the multifaceted and plural subjectivity of an individual. The author draws upon the methodology for analyzing sociocultural modernization of regions (N.I. Lapin), the activity-structural paradigm (A.V. Tikhonov), concepts of mediation and sociocultural dialogue (A.S. Akhiezer, A.P. Davydov), and the subject-oriented approach in social systems management (V.E. Lepskiy). Special attention is given to the role of the polysubjective approach in the context of differentiation among Russian regions and the implementation of their socio-economic development strategies. The article argues that the objective complexity of the Russian Federation's regional composition and the unevenness of modernization necessitate a polysubjective approach to structuring relations between the center and regions. Invoking W.R. Ashby’s law of requisite variety, it is demonstrated that effective management of regional system diversity requires a corresponding diversity of management approaches at the central level. Barriers to the formation of polysubjectivity are analyzed, particularly the absence of genuine dialogue between the center and regions. The conclusion posits that polysubjectivity can serve as a key characteristic of a certain stage in the institutionalization of post-industrial type management and as a form of interaction that ensures an adequate measure of collaboration among representatives of government, business, science, and various communities.

Happy people are always similar: The evidence from brain morphological and functional inter-subject correlations

A fundamental question in the study of happiness is whether there is neural evidence to support a well-known hypothesis that happy people are always similar while unfortunate people have their own misfortunes. To investigate this, we employed several happiness-related questionnaires to identify potential components of happiness, and further investigated and confirmed their associations with personality, mood, aggressive behaviors, and amygdala reactivity to fearful faces within a substantial sample size of college students (n = 570). Additionally, we examined the functional and morphological similarities and differences among happy individuals using the inter-subject representational similarity analysis (IS-RSA). IS-RSA emphasizes the geometric properties in a high-dimensional space constructed by brain or behavioral patterns and focuses on individual subjects. Our behavioral findings unveiled two factors of happiness: individual and social, both of which mediated the effect of personality traits on individual aggression. Subsequently, mood mediated the impact of happiness on aggressive behaviors across two subgroup splits. Functional imaging data revealed that individuals with higher levels of happiness exhibited reduced amygdala reactivity to fearful faces, as evidenced by a conventional face-matching task (n = 104). Moreover, IS-RSA demonstrated that these participants manifested similar neural activation patterns when processing fearful faces within the visual pathway, but not within the emotional network (e.g., amygdala). Morphological observations (n = 425) indicated that individuals with similar high happiness levels exhibited comparable gray matter volume patterns within several networks, including the default mode network, fronto-parietal network, visual network, and attention network. Collectively, these findings offer early neural evidence supporting the proposition that happy individuals may share common neural characteristics.

The relationship between event boundary strength and pattern shifts across the cortical hierarchy during naturalistic movie-viewing.

Our continuous experience is spontaneously segmented by the brain into discrete events. However, the beginning of a new event (an event boundary) is not always sharply identifiable: phenomenologically, event boundaries vary in salience. How are the response profiles of cortical areas at event boundaries modulated by boundary strength during complex, naturalistic movie-viewing? Do cortical responses scale in a graded manner with boundary strength, or do they merely detect boundaries in a binary fashion? We measured "cortical boundary shifts" as transient changes in multi-voxel patterns at event boundaries with different strengths (weak, moderate, and strong), determined by across-subject agreement. Cortical regions with different processing timescales were examined. In auditory areas, which have short timescales, cortical boundary shifts exhibited a clearly graded profile both in group-level and individual-level analyses. In cortical areas with long timescales, including the default mode network, boundary strength modulated pattern shift magnitude at the individual subject level. We also observed a positive relationship between boundary strength and the extent of temporal alignment of boundary shifts across different levels of the cortical hierarchy. Additionally, hippocampal activity was highest at event boundaries for which cortical boundary shifts were most aligned across hierarchical levels. Overall, we found that event boundary strength modulated cortical pattern shifts strongly in sensory areas and more weakly in higher-level areas, and that stronger boundaries were associated with greater alignment of these shifts across the cortical hierarchy.

Negotiating politics on campus: dynamic (de-)politicization among student activists in post-2011 Egypt

ABSTRACT This article examines processes of (de-) politicization among Egyptian student activists in the post-2011 context. Based on ethnographic observation, interviews and focus groups, I argue that the rapid and successive political changes – with the revolution in 2011 then the coup d’état in 2013 – made the boundaries separating institutional, contentious and prefigurative politics fluid. As student activists debated if their claims and activities were ‘student-related’ or ‘political’, several conceptions of politics and political action coexisted among them and their understanding of politics fluctuated. These evolving conceptions created gaps and contradictions allowing for the negotiation of the meaning of their various activities. The negotiation of politics is a collective pattern but was also reflected in, and reflective of evolving individual subjectivities. As young students lived through the revolution, entered university and joined or left a group, their perceptions of their roles and of the political meaning of their present and past activities changed. The rising repression in 2013/14 shaped the activists’ tactics, as well as their perceived priorities and the meaning of activities, thus amplifying the negotiation of politics.

Cognitive Workload Estimation in Conditionally Automated Vehicles Using Transformer Networks Based on Physiological Signals

Though driving automation promises to improve driving safety, drivers are still required to be ready to retake control in conditionally automated vehicles, which are defined by the Society of Automotive Engineers (SAE) as SAE L3 vehicles. Thus, drivers’ states can still affect driving safety in SAE L3 vehicles. Previous research found that a high cognitive load may impair drivers’ takeover performance. Thus, it is still necessary to estimate drivers’ cognitive load in SAE L3 vehicles. However, existing driver cognitive load estimation algorithms mostly focus on vehicles with a lower level of driving automation (e.g., SAE L0), which may not be relevant when estimating driver states in SAE L3 vehicles, given that drivers’ responsibilities are different, and several commonly used measures (e.g., driving performance) are unavailable when drivers are not continuously controlling the vehicle. Further, previous driver cognitive load estimation algorithms rarely considered the temporal information in the input features. Thus, we proposed a deep-learning algorithm to estimate driver cognitive load in SAE L3 vehicles, which integrated multiple physiological features (i.e., electrocardiogram, electrodermal activity, respiration) and considered the temporal correlation of the data using a transformer-encoder-based network. The performance of our algorithm was compared with baseline models on an open data set. Results showed that our algorithm outperformed baseline models and achieved an accuracy of 94.4% using within-subject data partition (proportionally splitting data from the same subject into the training and testing data sets) and an accuracy of 89% using across-subjects data partition (dividing the training and testing data sets based on individual subjects).

Neural basis of cognitive control signals in anterior cingulate cortex during delay discounting.

Cognitive control involves allocating cognitive effort according to internal needs and task demands and the Anterior Cingulate Cortex (ACC) is hypothesized to play a central role in this process. We investigated the neural basis of cognitive control in the ACC of rats performing an adjusting-amount delay discounting task. Decision-making in this this task can be guided by using either a lever-value tracking strategy, requiring a 'resource-based' form of cognitive effort or a lever-biased strategy requiring a 'resistance-based' form of cognitive effort. We found that ACC ensembles always tightly tracked lever value on each trial, indicative of a resource-based control signal. These signals were prevalent in the neural recordings and were influenced by the delay. A shorter delay was associated with devaluing of the immediate option and a longer delay was associated with overvaluing of the immediate option. In addition, ACC theta (6-12Hz) oscillations were observed at the choice point of rats exhibiting a resistance-based strategy. These data provide candidates of neural activity patterns in the ACC that underlie the use of 'resource-based' and 'resistance-based' cognitive effort. Furthermore, these data illustrate how strategies can be engaged under different conditions in individual subjects.

A Frente pela Vida e a atualização do Movimento da Reforma Sanitária Brasileira

ABSTRACT This paper examined the Front for Life (Frente pela Vida, FpV), a movement of organised civil society in the health field, which sought to achieve political impact in response to the health crisis caused by the COVID-19 pandemic in the context of the Bolsonaro administration. Information was obtained through a document review of FpV publications, participant observation in meetings, demonstrations, livestreams and events in which the front participated or organised, as well as interviews of participants in its operating group. The analytical categories used were origin, trajectory, movements, management, the relationship between the FpV and the health sector reform movement, sustainability, challenges and the FpV’s prospects. The results showed that the FpV has led a large policy network of individual and collective subjects, scientific entities and organisations representing various segments of civil society to update the health sector movement and expand its social support base. Its trajectory has involved mainly technical, scientific and political action in multiple areas, working with the Executive, Judiciary and Legislative branches of government, as well as civil society. In conclusion, the FpV has proved to be an important social movement pressing the State to defend life and the universal right to health and to expand and strengthen Brazil’s Unified Health System, the SUS.

The National Competency-Based Catalogue of Learning Objectives for Medicine 2.0 for the subject Physical and Rehabilitative Medicine, Naturopathic Medicine. Consensus of Scientific Medical Societies

The learning objectives in the current cross-sectional subject "Rehabilitation, Physical Medicine, Naturopathic Medicine" have been revised as part of the further development of the National Competency-Based Catalogue of Learning Objectives for Medicine (NKLM) to its new version 2.0. Since the NKLM is designed as an interdisciplinary catalogue, a subject assignment seemed necessary from the point of view of various stakeholders. Thus, the German Association of Scientific Medical Societies (AWMF) and the German medical faculties initiated a subject assignment process. The assignment process for the subject "Physical and Rehabilitative Medicine, Naturopathic Medicine" (PRM-NHV; according to the subject list of the first draft of the planned novel medical license regulations from 2020) is presented in this paper. The AWMF invited its member societies to participate in the assignment of learning objectives of chapters VI, VII, and VIII of the NKLM 2.0 to the individual subjects to which they consider to contribute in teaching. For "PRM-NHV", representatives of the societies for rehabilitation sciences (DGRW), physical and rehabilitation medicine (DGPRM), orthopaedics and traumatology (DGOU), as well as for naturopathy (DGNHK) participated. In a structured consensus process according to the DELPHI methodology, the learning objectives were selected and consented. Subsequently, subject recommendations were made by the AWMF for each learning objective. From the NKLM 2.0, a total of 100 competency-based learning objectives of chapters VII and VIII for the subject "PRM-NHV" were consented by the representatives of the involved societies for presentation on the NKLM 2.0 online platform. In the context of the revision process of medical studies in Germany and under the umbrella of the AWMF and the German medical faculties, a broad consensus of competency-based learning objectives in the subject "PRM-NHV" could be achieved. This provides an important orientation for all medical faculties both for the further development of teaching in the cross-sectional subject "Rehabilitation, Physical Medicine, Naturopathic Medicine" according to the 9th revision of the medical license regulations, which has been valid for twenty years, and for the preparation of the corresponding subjects in the draft bill of the novel license regulations.

Making Sense of the Political in Twentieth-Century China

Abstract At the opening of the twentieth century, some believed that there was a lack of political consciousness among the Chinese people. They introduced foreign political theories, attempting to engage Chinese citizenry with the political. Yet what the political entails remains an unresolved issue even in China today. This article traces the history of Chinese translation of the political through a dynamic process of language adaptation and cultural appropriation. It argues that two competing legacies, one that promises the politicization as a way to liberate individual subjectivity in a modernizing society and another that calls for the order and organization that subject individual will to the collective power of the state, have exerted combined influences on shaping the modern Chinese conception of the political. As a result, to many Chinese today, politics is not just about the daily business of people's affairs but also an orderly society with a centralized authority.

Housekeeping protein-coding genes interrogated with tissue and individual variations

Housekeeping protein-coding genes are stably expressed genes in cells and tissues that are thought to be engaged in fundamental cellular biological functions. They are often utilized as normalization references in molecular biology research and are especially important in integrated bioinformatic investigations. Prior studies have examined human housekeeping protein-coding genes by analyzing various gene expression datasets. The inclusion of different tissue types significantly impacted the discovery of housekeeping genes. In this report, we investigated particularly individual human subject expression differences in protein-coding genes across different tissue types. We used GTEx V8 gene expression datasets obtained from more than 16,000 human normal tissue samples. Furthermore, the Gini index is utilized to investigate the expression variations of protein-coding genes between tissue and individual donor subjects. Housekeeping protein-coding genes found using Gini index profiles may vary depending on the tissue subtypes investigated, particularly given the diverse sample size collections across the GTEx tissue subtypes. We subsequently selected major tissues and identified subsets of housekeeping genes with stable expression levels among human donors within those tissues. In this work, we provide alternative sets of housekeeping protein-coding genes that show more consistent expression patterns in human subjects across major solid organs. Weblink: https://hpsv.ibms.sinica.edu.tw.

КОМУНІКАЦІЙНІ СТРАТЕГІЇ В ПУБЛІЧНОМУ УПРАВЛІННІ ТА АДМІНІСТРУВАННІ

The article shows that communication in administrative systems has a public and legal purpose and regulates the movement of individual administrative subjects to the social community while preserving a certain degree of autonomy, independence, self-determination, and individuality of these subjects. The authors emphasize that regardless of the form of communication, the communication process plays a vital role in public administration. It was found that communication processes in public administration include elements such as administrative bodies and communities, communications, messages, information barriers, and feedback. It was determined that if the external communication of state administration is aimed at influencing civil society, receiving recommendations from society representatives, and adjusting positions, internal communication absorbs the entire administrative system from the inside and is the primary driving force in making major management decisions. It turned out to be a key driving force in management decision-making. This article analyzes the properties of communications in public administration. It is noted that communication is the exchange of information between two subjects. For public administration bodies, feedback is an essential element of communication activity, which emphasizes the transition from one-way notification of citizens about government actions to two-way communication - "civil society - government - civil society". It has been demonstrated that communication should ensure the effective exchange of information between the subject of management and the object of management, establish communication channels for the exchange of information between individual personnel and groups, adjust and arrange information flows to improve relations between communication subjects at different levels in the process of information exchange. It is emphasized that there are many different communication channels in the administrative system, and it is difficult to determine which are the most important and necessary.

Reliability of the quality of life-aged care consumers (QOL-ACC) and EQ-5D-5L among older people using aged care services at home

PurposeThe Quality of Life-Aged Care Consumers (QOL-ACC), a valid preference-based instrument, has been rolled out in Australia as part of the National Quality Indicator (QI) program since April 2023 to monitor and benchmark the quality of life of aged care recipients. As the QOL-ACC is being used to collect quality of life data longitudinally as one of the key aged care QI indicators, it is imperative to establish the reliability of the QOL-ACC in aged care settings. Therefore, we aimed to assess the reliability of the QOL-ACC and compare its performance with the EQ-5D-5L.MethodsHome care recipients completed a survey including the QOL-ACC, EQ-5D-5L and two global items for health and quality of life at baseline (T1) and 2 weeks later (T2). Using T1 and T2 data, the Gwet’s AC2 and intra-class correlation coefficient (ICC) were estimated for the dimension levels and overall scores agreements respectively. The standard error of measurement (SEM) and the smallest detectable change (SDC) were also calculated. Sensitivity analyses were conducted for respondents who did not change their response to global item of quality of life and health between T1 and T2.ResultsOf the 83 respondents who completed T1 and T2 surveys, 78 respondents (mean ± SD age, 73.6 ± 5.3 years; 56.4% females) reported either no or one level change in their health and/or quality of life between T1 and T2. Gwet’s AC2 ranged from 0.46 to 0.63 for the QOL-ACC dimensions which were comparable to the EQ-5D-5L dimensions (Gwet’s AC2 ranged from 0.52 to 0.77). The ICC for the QOL-ACC (0.85; 95% CI, 0.77–0.90) was comparable to the EQ-5D-5L (0.83; 95% CI, 0.74–0.88). The SEM for the QOL-ACC (0.08) was slightly smaller than for the EQ-5D-5L (0.11). The SDC for the QOL-ACC and the EQ-5D-5L for individual subjects were 0.22 and 0.30 respectively. Sensitivity analyses stratified by quality of life and health status confirmed the base case results.ConclusionsThe QOL-ACC demonstrated a good test-retest reliability similar to the EQ-5D-5L, supporting its repeated use in aged care settings. Further studies will provide evidence of responsiveness of the QOL-ACC to aged care-specific interventions in aged care settings.

The insecure subjects: battlefield experiences of the soldiers in Apocalypse Now (2001; 1979) and Don’t Burn (2009)

This paper continues the discussions on landscape and subjectivity in war films from a comparative perspective. By juxtaposing the battlefield experiences of the soldier as subjects in two films, Apocalypse Now Redux (2001; 1979) and Don’t Burn (2009), the article demonstrates how the landscape contributes to the creation of insecure subjects with experiences of strangeness and danger, where their desires and hopes are shattered. In contrast to previous studies on Vietnam War films that primarily focus on genre, theme, Vietnamese imagery, gender, and ideology, this article employs the theoretical lens of subjectivity as rooted in Deleuze and Guattari to explore the connections that constitute subjects through sensory perceptions, memories, dreams, traumas, and fears manifested through the battlefield landscape as experienced by the characters in the films. This comparative perspective not only challenges previous notions of Don’t Burn [2009] as a film that reflects the views and policies of the state, wherein individual subjectivity is emphasised to promote nationalism as a propagandistic purpose, but also offers multidimensional reflections on the Vietnam War while deeply questioning the ideological system constructed by state institutions within the context of the Cold War.

Less-lethal weapons: ocular trauma in Chile as psychosocial trauma. Challenges from a human rights and comprehensive perspective.

In October 2019 in Chile, massive protests broke out in the so-called social uprising. The repressive response of the armed forces and Carabineros (Police) resulted in serious and mas-sive violations of human rights, with between 400 and 500 victims of ocular trauma caused mainly by shots from anti-riot shotguns, constituting the largest number of cases in the world linked to a single event. It is proposed to evaluate the different dimensions of the impact of ocular trauma due to state violence, using the concept of psychosocial trauma and a support model that integrates the medical-psychological and social dimensions. Human rights violations of the period are described, focusing on cases of ocular trauma, and state and civil society responses. The requests of a survivors' organisations regarding truth, justice and reparation is presented. A clinical case of ocular trauma treated in our centre is analyzed. Survivors of ocular trauma manifest post-traumatic reactions regardless of the severity of their ocular injuries. The impact on the mental health of survi-vors of ocular trauma due to state violence is a phenomenon where the psychic and psychosocial im-pact of trauma due to socio-political violence intersects with the short- and long-term mental health effects. The impact of sociopolitical trauma must be understood considering both the in-dividual and social subject, considering their cultural, socioeconomic and political reality. Recovery from traumatic psychological injury must be addressed in its medical, sensory rehabilitation, psycho-logical and psychosocial dimensions, including processes of social recognition, search for justice and comprehensive reparation of damage. In contexts of impunity, a model is proposed that integrates rehabilitation with psycho-legal support, promotion of agency and organisation, within the frame-work of commitment to the movement and principles of human rights.

On the Re-Alienation Experiences of the Amateur Runners in Istanbul

In contemporary mass culture, individuals are increasingly subjected to standardization, homogenization, and objectification, leading to experiences of alienation within the societal framework shaped by it. Despite efforts to fortify connections with oneself, the environment, society, and meaning, individuals may still find themselves immersed in alienation within the societal structure they inhabit. Through heightened awareness, individuals strive to reclaim their authentic identities, utilizing various means to distance themselves from alienation. However, this pursuit may paradoxically result in renewed ruptures in connections, as individuals encounter re-alienation, finding themselves ontologically identical yet formally distinct within the alienation process. Amidst the complexities of modern life, individuals often seek self-realization through recreational pursuits like running. Hence, this study endeavors to examine the phenomenon of re-alienation, particularly among amateur runners. By conducting semi-structured, in-depth interviews with runners in Istanbul, the study explores both the process of distancing from alienation and the experience of encountering re-alienation through running. Through its investigation, the study aims to contribute to scholarly discourse on alienation, self-realization, and re-alienation with the lens of critical communication studies. By analyzing the lived experiences of individuals, the research seeks to deepen our understanding of the intricate dynamics of alienation and resilience in contemporary society. Research findings show that running as a recreational activity strengthens individuals' connections with themselves, nature, their social environment, meaning, and values, thereby allowing for a sense of autonomy to be achieved; however, due to social infrastructure and individual psychological tendencies, subject and object fetishes can be developed in relation to running activities, leading to experiences of re-alienation. Keywords: alienation, self-realization, mass culture, sports and recreational studies, critical communication studies

CONCEPT AND MEANS OF FORMALIZING ACTIVITIES IN THE FIELD OF CRIMINAL JUSTICE

Introduction. At the current stage of development of criminal procedure and forensic science, the sphere of criminal justice is often considered from the perspective of an activity-based approach, i.e., as the activities of individual subjects (investigator, prosecutor, suspect (accused), defense counsel, investigating judge, court, etc.) and their interaction. Similarly, a large number of proposals in the literature are related to the improvement or optimization of their activities with regard to the general principles of criminal proceedings. This article is no exception and is aimed at clarifying the approaches to understanding the activities in the field of criminal justice and their regulation (formalization). Summary of the research results. The article makes an attempt to summarize the existing views on the content of such concepts as criminal procedural activity, activity of an investigator, a prosecutor, an investigating judge and other participants to criminal proceedings. The author proposes the term "activity in the field of criminal justice" as a generalized term which reveals the social nature of the activity of investigation and trial of criminal offenses. The author also proposes an approach whereby regulatory and legal regulation, other types of social regulation and organizational and tactical recommendations are considered as means of formalizing activities in the field of criminal justice, i.e., those aimed at streamlining them and bringing them to a certain standard. At the same time, it is proposed to differentiate these measures depending on the degree (rigidity) of formalization. Conclusions. Based on the results of the study, the author concludes that formalization of activities in the field of criminal justice should be understood as the process of streamlining the actions and decisions of participants to criminal proceedings through their legal regulation, established ethical norms, and also such means as planning of activities by the subject and application of the rules of a recommendatory nature which are concentrated in the provided algorithms and programs. These means of formalization have different legal nature, but they can still be considered in the same order in accordance with their function in the field of criminal justice, which provides for the possibility of their grouping.

#1429 Daily urinary potassium excretion is not a fixed percentage of daily potassium intake

Abstract Background and Aims High potassium intake is associated with a lower blood pressure and lower incidence of chronic kidney disease. Since a significant amount of potassium is lost via stool, the World Health Organization advices to multiply 24-hour renal potassium excretion by 1.3 for estimation of dietary intake. We analyzed whether this 1.3 factor for potassium intake varies in healthy volunteers and evaluated whether factors associated with tissue cation storage, namely sodium intake, aldosterone, cortisol and urine volume, affect the renal potassium excretion. Method We performed a post-hoc analysis of the long-term sodium balance studies Mars105 and Mars520. Ten healthy male participants consumed a fixed amount of salt (6, 9 and 12 grams/day for >29 days) and potassium (4 grams/day) for 105 (n = 4) and 205 days (n = 6). During the entire study period all urine was collected in 24-hour aliquots. We calculated the percentage of potassium intake that was excreted in the corresponding 24-hour urine collection during steady-state. We assessed whether this percentage was associated with sodium intake, potassium intake, urinary aldosterone, urinary cortisol and urine volume using a multivariable mixed-effects model. Results Overall, the median renal potassium excretion was 80% of potassium intake (IQR 65-97%; range 24-304%). This corresponds to a conversion factor of 1.25 (IQR 1.03-1.54). Within individual subjects we also observed a marked day-to-day variation in the percentage of renal potassium excretion: the average intraperson width of the IQR was 25%. A higher sodium intake was associated with an increased percentage of renal potassium excretion, whereas a higher potassium intake was associated with a decreased percentage of renal potassium excretion. A significant positive interaction between the effects of sodium and potassium intake was present (P < .001; Fig. A). Furthermore, urinary aldosterone (Fig. B), urinary cortisol (Fig. C) and urine volume (Fig. D) were positively associated with the percentage of renal potassium excretion. Conclusion The percentage of consumed potassium that is excreted via urine shows considerable intra- and inter-subject variability. During steady-state this percentage is independently affected by sodium intake, potassium intake, urinary aldosterone, urinary cortisol, and urine volume. Our results suggest that the WHO's fixed 1.3 conversion factor may lead to inaccurate estimations of potassium intake.

In vivo bioluminescence imaging revealed the change of the time window of BDNF expression in the brain elicited by a single bout of exercise following repeated exercise

Exercise increases the expression of brain-derived neurotrophic factor (BDNF) in the brain and contributes to cognitive and sensorimotor functions. This study aimed to elucidate how repeated exercise modifies BDNF expression elicited by a single bout of exercise in the brain using in vivo bioluminescence imaging (BLI). Bdnf-luciferase (Luc) mice with the firefly luciferase gene inserted at the translation start point of the Bdnf gene were used for BLI to monitor changes in BDNF expression in the brain. The treadmill exercise at a speed of 10 m/s for 60 min was repeated 5 days a week for 4 weeks. BLI in individual subjects was repeated four times: before the exercise intervention, on the first exercise day, and 14 and 28 days after the start of the intervention. Each BLI was performed after a single bout of exercise and monitored for 8 h after exercise. Repetitive BLI showed that the exercise regimen enhanced BDNF expression in the brain, specifically at 4–8 h after a single bout of exercise. Repeated exercise for 2 weeks accelerated the start of enhancement after a single bout of exercise, but not after 4 weeks of repeated exercise. This study showed that repeated exercise modulated the time window of exercise-enhanced BDNF expression, suggesting that repeated exercise could change the sensitivity of gene expression to a single bout of exercise. These findings can be attributed to the advantages of in vivo BLI, which allowed us to precisely measure the time course of BDNF expression after repeated exercise in individual subjects.

Altered static and dynamic functional network connectivity in primary angle-closure glaucoma patients.

To explore altered patterns of static and dynamic functional brain network connectivity (sFNC and dFNC) in Primary angle-closure glaucoma (PACG) patients. Clinically confirmed 34 PACG patients and 33 age- and gender-matched healthy controls (HCs) underwent evaluation using T1 anatomical and functional MRI on a 3T scanner. Independent component analysis, sliding window, and the K-means clustering method were employed to investigate the functional network connectivity (FNC) and temporal metrics based on eight resting-state networks. Differences in FNC and temporal metrics were identified and subsequently correlated with clinical variables. For sFNC, compared with HCs, PACG patients showed three decreased interactions, including SMN-AN, SMN-VN and VN-AN pairs. For dFNC, we derived four highly structured states of FC that occurred repeatedly between individual scans and subjects, and the results are highly congruent with sFNC. In addition, PACG patients had a decreased fraction of time in state 3 and negatively correlated with IOP (p < 0.05). PACG patients exhibit abnormalities in both sFNC and dFNC. The high degree of overlap between static and dynamic results suggests the stability of functional connectivity networks in PACG patients, which provide a new perspective to understand the neuropathological mechanisms of optic nerve damage in PACG patients.