Individual Representations Research Articles

Enrollment of Spanish-speaking Latinx adults in clinical trials: Five lessons learned from a randomized study in substance use treatment

Latinx individuals are the largest ethnic minoritized group in the United States (US) at 19% of the population. However, they remain underrepresented in clinical research, accounting for less than 8% of clinical trial participants. Consideration of cultural values could help overcome barriers to inclusion in clinical trials and result in better recruitment and retention of Latinx individuals. In this commentary, we describe general guidance on culturally responsive modifications to facilitate the successful recruitment and retention of Spanish-speaking Latinx participants in Randomized Clinical Trials (RCTs) for substance use. We identify five culturally responsive strategies to help enroll participants in RCTs: 1. Create an ethnically diverse research team, 2. Assess available community partners, 3. Familiarize oneself with the target community, 4. Establish confianza (trust) with participants, and 5. Remain visible to participants and staff from recruitment sites. Representation of Latinx individuals in clinical trials is essential to ensure treatments are responsive to their needs and equitydriven. Some of these strategies can further research in helping to promote the participation of Latinx individuals experiencing substance use concerns, including outreach to those not seeking treatment.

Understanding Ethnic Disparities in Lethal Police Incidents in the Netherlands Between 2016 and 2020

This Research Note outlines a novel approach to studying the role of ethnicity in lethal police incidents (LPI). We take data from the Netherlands, between 2016 and 2020, to show—first—that the representation of individuals with minority ethnic backgrounds in LPI is 350% of what would be expected based on their proportion of the population. Comparisons with other indicators (prison population; homicide) showed that the proportion of individuals with minority ethnic backgrounds was particularly high in outcomes that meet two conditions: (1) the outcome is more serious (vs. less serious), and (2) the authorities are involved (vs. not involved). These findings generate relevant recommendations for future work on lethal police incidents.

Inclusion of Subjects who are Obese in Drug Development: Current Status and Opportunities.

The prevalence of obesity has grown tremendously in recent years and this population has an increased risk of disease comorbidities. The presence of disease comorbidities requires treatment interventions and proper dosing guidelines. However, drug development programs often do not have adequate representation of individuals who are obese in clinical trials, leaving gaps in the understanding of treatment response leading to a lack of adequate individualization options. Based on a recent survey of approved drug product package inserts, very few approved products included specific dosing based on obesity, in both adults and pediatrics. Reasons for the limited information on patients who are obese may include the under-reporting of information regarding such patients and a lack of clinical trial diversity in enrolling patient groups in whom obesity or obesity-related comorbidities are more prevalent. An inadvertent impact of the practice of exclusion of subsets of patients with some comorbidities in clinical trials may play a role in the reduced enrollment of individuals who are obese. Recently, regulatory authorities have taken specific initiatives to promote clinical trial diversity, including engaging with stakeholders and publishing regulatory guidance. These guidance documents highlight the need to enroll diverse clinical trial populations and provide recommendations on concepts related to drug development for obese populations. Such efforts will help to address the gap in information regarding drug response and dosing in patients who are obese.

The Visual Representation of Chinese and Thai Women in the Contemporary Media

In recent years, the role of women has become a heated topic, dominating the trend of gender studies in many academic studies in sociology and anthropology, and the question of whether or not women have completed their role change and broken the mould of traditional styles has become one of the cultural connotations of multimedia on the Internet. As large Asian countries, China and Thailand are both growing countries in which traditional agrarian societies are gradually moving towards new technologies. This paper makes an exploration of the power and image of Chinese and Thai females in different magazines, media and films over time, including the media representation of Asian women in western countries and the local media effects. Whereas, further expansion of the definition of femininity as distinct from biological sex, in different countries, religious regions, technological means and other multifaceted individual representations, a deeper perspective on the culturally unfolding nature of gender definitions, promoting an extension of the fixed term feminine.

Ophthalmology Faculty Diversity Trends in the US

Enhancing the diversity of ophthalmologists can potentially contribute to diminishing disparities in eye care. To investigate longitudinal trends in the representation of individuals underrepresented in medicine (URiM) and women among ophthalmology faculty compared with other specialties and to assess disparities between ophthalmology faculty demographic characteristics and the US population. In this cross-sectional study, a comprehensive analysis of Association of American Medical Colleges Faculty Roster data between 2000 and 2021 was conducted, using data from the US Medical School Faculty report on 56 438 ophthalmology faculty members. The data set was used to differentiate ophthalmology faculty members by gender, rank, and designation as a URiM individual. Outcome measures included changes in URiM and non-URiM faculty proportions, faculty rank, gender, department chair positions, and the US population between 2000 and 2021. A total of 56 438 ophthalmology faculty members (37 511 men [66.5%]) were included in the study. The number of ophthalmology faculty increased from 1820 in 2000 to 3151 in 2021. Across all years, URiM female faculty represented 3.1% of ophthalmologists (1733 of 56 438), while URiM men accounted for 3.5% (1983 of 56 438). Overall, non-URiM men constituted 63.0% of ophthalmologists (35 528 of 56 438), and non-URiM women accounted for 30.5% (17 194 of 56 438). The proportion of URiM male faculty remained stable from 2000 to 2021 (63 of 1820 [3.5%] vs 104 of 3151 [3.3%]), with a small increase in URiM women faculty at junior faculty positions (2000, 40 of 1820 [2.2%]; 2021, 129 of 3151 [4.1%]; difference, 1.9% [95% CI, 0.9%-2.9%]). Proportions of non-URiM men decreased from 71.2% (1295 of 1820) in 2000 to 55.3% (1743 of 3151) in 2021 (difference, 15.8% [95% CI, 13.1%-18.6%]) and proportions of non-URiM women increased from 23.2% (422 of 1820) in 2000 to 37.3% (1175 of 3151) in 2021 (difference, 14.1% [95% CI, 11.5%-16.7%]). In terms of faculty rank, there were increases in representation of women from 2000 to 2021 at assistant professor (from 11.2% [203 of 1819] to 19.7% [622 of 3165]; difference, 8.5% [95% CI, 6.5%-10.5%]), associate professor (from 4.6% [83 of 1819] to 8.6% [271 of 3165]; difference, 4.0% [95% CI, 2.6%-5.4%]), and professor levels (from 2.8% [51 of 1819] to 7.1% [223 of 3165]; difference, 4.3% [95% CI, 3.9%-6.1%]). URiM representation remained stable at most ranks. Compared with other specialties, ophthalmology had among the lowest percentage change in URiM faculty. The expansion of ophthalmology's URiM faculty representation was less than one-third that of the diverse US population. These findings highlight substantial growth in ophthalmology faculty and an increase in women's representation across several faculty ranks. However, URiM representation has remained largely unchanged, despite an increase at the associate professor level. This finding emphasizes the need for continued efforts to enhance diversity in academic ophthalmology.

Sismondi's principles of liberty and economic progress

AbstractThe Swiss‐born liberal thinker Jean‐Charles‐Léonard Simonde de Sismondi (1773–1842) rejected metaphysical systems of thought in favour of historical and social analysis. However, in his mature writings, he offered an organising, although a never explicit, set of principles guiding his political and economic disquisitions. I identify Sismondi's essential principles of social study, namely, the effect of political organisation on the character of the people, the need for a ‘national reason’, along with the weight of tradition over individual representation. Subordinate principles of liberty are examined, such as respect for minorities, freedom of public debate, and engagement in local affairs. I argue that, when the political idea of a slowly matured national reason guiding the constitutional progress of liberty is applied to a rapidly changing economic domain, tension is created within Sismondi's understanding of social sciences.

Reprezentacije odnosa obitelji i osnovne škole u nacionalnim dokumentima, zakonima i podzakonskim aktima

The aim of this research is to describe how family and school relations are represented in national documents, laws, and sub-legal acts that organise the primary education sector. The research is based on a qualitative research paradigm and documentation analysis procedure. A reflexive thematic analysis was carried out on 17 documents, laws and sublegal acts relevant to primary school education in the Republic of Croatia, which resulted in four basic representations of the relations between family and school, placed in the context of humanistic, legalistic, procedural and patronising constructions of their relations. Further analysis revealed examples of incongruity in the generated representations of family and school relations within documents, as well as the deviation of individual representations from recent knowledge about the optimal positioning of family and school relations. The conclusion discusses the practical implications of the obtained findings and potential directions of an empirical approach to the described problem.

Legal Aid with regard to Right to Fair Trial in Pakistani and International Law: A Comparative Approach

The key objective of this article is to analyze the concept of legal aid, its significance, challenges, and potential solutions. This article by using the doctrinal research methodology, presents a comparative analysis of legal aid “in the context of international law” and Pakistani law, highlighting “the” similarities and dissimilarities between the two systems. Access to justice and legal representation are fundamental principles in international and national legal frameworks, ensuring that individuals have adequate assistance in navigating the legal system's complexities. This article examines the relevant provisions in international instruments, such as the Universal Declaration of Human Rights and the International Covenant on Civil and Political Rights, which underscore the importance of legal aid. Additionally, this article explores the role of international organizations, such as the European Court of Human Rights, in providing legal aid to individuals involved in international criminal proceedings. On the other hand, Pakistani law recognizes the importance of legal aid as well, albeit with its own unique features and challenges. This article examines the constitutional provisions and statutory laws in Pakistan that guarantee the right to legal representation for individuals, particularly those who are economically disadvantaged. By understanding the similarities and dissimilarities between these systems, policymakers, legal practitioners, and scholars can identify potential areas for improvement and enhance access to justice for individuals, irrespective of their economic or social status. This article concludes that international law recognizes legal aid as a universal right and various international treaties make it mandatory for states (i.e., Pakistan) to ensure access to legal aid for those who cannot afford it.

Digital 3D facial approximation of the Petralona skull. Methodological issues and applications

The human face is a highly specialized anatomical entity. Its appearance is a result of evolutionary processes that include biomechanical, physiological, and social influences. The facial approximation is based on the relevance of skeletal and soft tissue anatomy and aims to reconstruct a person's face from the anatomical features of the skull. In forensics, the technique focuses on the estimation of the facial characteristics of unidentified individuals. In archaeological contexts, it has been widely used for the representation of hominins, prehistoric and historic periods individuals. For the facial approximation of the Petralona man, we digitized a cast of the original skull with an Artec Spider 3D scanner of metrological accuracy up to 0.05mm. A digital model of the Mauer mandible (Germany), the holotype of Homo heidelbergensis, was used to virtually complement the skeletal anatomy of the face. Cinema4D (Maxon) was used to place soft tissue depth markers according to standard nomenclature. The digital reconstruction of facial anatomy and skin texture was developed in ZBrush (Pixologic). The facial features were approximated with the use of techniques that are based on anatomical and/or statistical evidence. The facial approximation of the Petralona skull aims to disseminate scientific information and contribute to the public understanding of evolutionary science.

Racial Disparities in End-Stage Kidney Disease Outcomes among Asians and Native Hawaiians and Other Pacific Islanders across Geographic Residence

Introduction: While Asian and Native Hawaiian and other Pacific Islander (NHOPI) patients have a high prevalence of kidney disease risk factors, there are sparse data examining their end-stage kidney disease (ESKD) outcomes. As Hawaii has high representation of Asian and NHOPI individuals, we compared their ESKD outcomes based on residence in the mainland USA versus Hawaii/Pacific Islands (PIs). Materials and Methods: Using United States Renal Data System data, we examined the impact of geographic residence in the mainland versus Hawaii/PIs on race-mortality associations among incident ESKD patients transitioning to dialysis over January 1, 2000–December 31, 2016 using Cox regression. We examined likelihood of post-dialysis kidney transplantation using Cox models and cumulative incidence curves. Results: Compared with White patients in the mainland, Asian and NHOPI patients in the mainland had lower mortality: adjusted HRs (95% CIs) 0.67 (0.66–0.67) and 0.72 (0.70–0.73), respectively. When examining Asian and NHOPI patients in Hawaii/PIs, survival benefit was attenuated in Asian and diminished to the null in NHOPI patients (ref: mainland White patients). Cumulative incidence curves comparing Asian, NHOPI, and White patients showed Asian and NHOPI patients in the mainland had the highest likelihood of transplantation, whereas NHOPI and Asian patients in Hawaii/PIs had the lowest likelihood. Conclusion: In the mainland, Asian and NHOPI patients had lower mortality versus White patients, whereas in Hawaii/PIs, this survival benefit was diminished in Asian and mitigated in NHOPI patients. NHOPI and Asian patients in Hawaii/PIs had less transplantation versus those in the mainland. Further research is needed to uncover factors contributing to differential ESKD outcomes among Asian and NHOPI patients across geographic residence.

Toward a simple topological model of a three-phase transformer including deep saturation conditions

PurposeThis paper aims to propose a method of parametrizing topological transformer model at high flux densities in the core.Design/methodology/approachThe approach proposed is based on terminal voltages and currents measured in a special purpose saturation test whose data are combined with typical saturation curves of grain-oriented electrical steels; the modeling is carried out in the ATPDraw program.FindingsThe authors corroborate experimentally the necessity of dividing the zero sequence impedance between all transformer phases and propose a method of the individual representation of the legs and yokes. This eliminates the use of nonexistent leakage inductances of primary and secondary windings.Practical implicationsThe presented modeling approach can be used for predicting inrush current events and in the evaluation of the impact caused by geomagnetically induced currents (GICs).Originality/valueThe proposed approach is completely original and will contribute to a better understanding of the transients occurring in a transformer under abnormal conditions, such as inrush current events and GICs.

What We Teach About Race and Gender: Representation in Images and Text of Children’s Books

Abstract Books shape how children learn about society and norms, in part through representation of different characters. We use computational tools to characterize representation in children’s books widely read in homes, classrooms, and libraries over the past century and describe economic forces that may contribute to these patterns. We introduce new artificial intelligence methods for systematically converting images into data. We apply these tools, alongside text analysis methods, to measure skin color, race, gender, and age in the content of these books, documenting what has changed and what has endured over time. We find underrepresentation of Black and Latinx people in the most influential books, relative to their population shares, though representation of Black individuals increases over time. Females are also increasingly present but appear less often in text than in images, suggesting greater symbolic inclusion in pictures than substantive inclusion in stories. Characters in these influential books have lighter average skin color than in other books, even after conditioning on race, and children are depicted with lighter skin color than adults on average. We present empirical analysis of related economic behavior to better understand the representation we find in these books. On the demand side, we show that people consume books that center their own identities and that the types of children’s books purchased correlate with local political beliefs. On the supply side, we document higher prices for books that center nondominant social identities and fewer copies of these books in libraries that serve predominantly White communities.

Scaling-up RADseq methods for large datasets of non-invasive samples: Lessons for library construction and data preprocessing.

Genetic non-invasive sampling (gNIS) is a critical tool for population genetics studies, supporting conservation efforts while imposing minimal impacts on wildlife. However, gNIS often presents variable levels of DNA degradation and non-endogenous contamination, which can incur considerable processing costs. Furthermore, the use of restriction-site-associated DNA sequencing methods (RADseq) for assessing thousands of genetic markers introduces the challenge of obtaining large sets of shared loci with similar coverage across multiple individuals. Here, we present an approach to handling large-scale gNIS-based datasets using data from the spotted hyena population inhabiting the Ngorongoro Crater in Tanzania. We generated 3RADseq data for more than a thousand individuals, mostly from faecal mucus samples collected non-invasively and varying in DNA degradation and contamination level. Using small-scale sequencing, we screened samples for endogenous DNA content, removed highly contaminated samples, confirmed overlap fragment length between libraries, and balanced individual representation in a sequencing pool. We evaluated the impact of (1) DNA degradation and contamination of non-invasive samples, (2) PCR duplicates and (3) different SNP filters on genotype accuracy based on Mendelian error estimated for parent-offspring trio datasets. Our results showed that when balanced for sequencing depth, contaminated samples presented similar genotype error rates to those of non-contaminated samples. We also showed that PCR duplicates and different SNP filters impact genotype accuracy. In summary, we showed the potential of using gNIS for large-scale genetic monitoring based on SNPs and demonstrated how to improve control over library preparation by using a weighted re-pooling strategy that considers the endogenous DNA content.

Health Digital Twins in Life Science and Health Care Innovation.

Health digital twins (HDTs) are virtual representations of real individuals that can be used to simulate human physiology, disease, and drug effects. HDTs can be used to improve drug discovery and development by providing a data-driven approach to inform target selection, drug delivery, and design of clinical trials. HDTs also offer new applications into precision therapies and clinical decision making. The deployment of HDTs at scale could bring a precision approach to public health monitoring and intervention. Next steps include challenges such as addressing socioeconomic barriers and ensuring the representativeness of the technology based on the training and validation data sets. Governance and regulation of HDT technology are still in the early stages.

Genetics of Alzheimer's Disease in the African American Population.

Black/African American (AA) individuals have a higher risk of Alzheimer's disease (AD) than White non-Hispanic persons of European ancestry (EUR) for reasons that may include economic disparities, cardiovascular health, quality of education, and biases in the methods used to diagnose AD. AD is also heritable, and some of the differences in risk may be due to genetics. Many AD-associated variants have been identified by candidate gene studies, genome-wide association studies (GWAS), and genome-sequencing studies. However, most of these studies have been performed using EUR cohorts. In this paper, we review the genetics of AD and AD-related traits in AA individuals. Importantly, studies of genetic risk factors in AA cohorts can elucidate the molecular mechanisms underlying AD risk in AA and other populations. In fact, such studies are essential to enable reliable precision medicine approaches in persons with considerable African ancestry. Furthermore, genetic studies of AA cohorts allow exploration of the ways the impact of genes can vary by ancestry, culture, and economic and environmental disparities. They have yielded important gains in our knowledge of AD genetics, and increasing AA individual representation within genetic studies should remain a priority for inclusive genetic study design.

Handphone and Students Growing in the example of Covid- 19; Lesson from Indigenous People in Limbungan, Lombok Timur, Indonesia

The pandemic has changed how students learn, including accepting technology in indigenous peoples' environments which is commonly unrevealed. This research discusses 1) how is students' literacy towards using smartphone technology in the context of learning before and after the pandemic in education units? 2) How do indigenous peoples understand modernization amid the substantial inheritance of ancestral traditions still practiced? Is it acceptance or rejection? To answer these research questions, ethnographic studies used Symbolic Interactionism analysis to observe changes in population behavior. There are two purposively selected sample groups; groups of students in indigenous environments, community leaders, and some randomly selected individual representations. Participatory observations, in-depth interviews, and related literature reviews were utilized to collect data supplemented by questionnaires disseminated through the help of google forms submitted to groups of students. The findings conclude that the Limbungan community is open to accepting technological media. Private television broadcasts after the fall of the new order regime contributed to campaigning for the importance of schools. This prompted the emergence of a wave of Limbungan people attending school. The pandemic has significantly improved digital literacy among indigenous peoples, even though most tribes in some areas have refused. School-age children are quite adaptive when using mobile phones to study during the pandemic. It can be said that indigenous groups in Indonesia do not always reject technology and the changes brought about in children's learning methods.

The spatiotemporal neural dynamics of Braille letter representations in individuals with congenital blindness

The spatiotemporal neural dynamics of Braille letter representations in individuals with congenital blindness

Exploring the Potential of Comics for Science Communication: A Study on Conveying COVID-19 Vaccine Safety Information to Black Americans

This study examined the effectiveness of using comics to communicate scientific information on COVID-19 vaccine safety to Black Americans. Although the effects of comics on interest, recall, and information sharing intention were not significant compared to expository texts and infographics, comics featuring abstract, racially ambiguous characters facilitated greater learning among participants with lower knowledge of COVID-19 vaccines, as opposed to comics with realistic representations of Black individuals. Furthermore, the effects of comics varied depending on individuals’ interest in comic reading. These findings highlight the potential of comics in science communication, but their design and target audience should be carefully considered.

Race and the Mental Representation of Individuals Diagnosed with Oppositional Defiant Disorder: Implications for Diagnosis

Introduction: This research investigates the possible role of racial and gender stereotypes in diagnosing children with Oppositional Defiant Disorder (ODD). ODD is diagnosed more readily in boys and Black children, although the factors producing differential diagnosis rates are unclear. The authors conducted six studies investigating the possibility that overlap between racial and gender stereotypes with ODD diagnostic criteria might contribute to gaps in its judged prevalence across groups. Method: Participants completed reverse correlation procedures to determine whether mental representations of children expected versus unexpected to be diagnosed with ODD differed in facial characteristics. Separate participants viewed these images and judged the likelihood that each person depicted had been diagnosed with ODD. Results: Classification images (CIs) showed that the children selected as having ODD appeared more prototypically Black in facial appearance than children not chosen as having ODD. No differences emerged in the gendered appearance of the two group-level CIs. Judged rates of ODD were higher for the children who appeared to be Black. However, diagnostic judgments of clinical trainees and practitioners were unaffected by appearance factors, suggesting that formal clinical training might attenuate the influence of stereotypes on judgment. Discussion: These results indicate that an overlap in Black stereotypes and diagnostic criteria for ODD might contribute to elevated diagnosis of ODD in African American children.

Linking information from multiple representations: an eye-tracking study

Eye tracking can provide valuable insights into how students use different representations to solve problems and can be a useful tool for measuring the integration of information from multiple representations. In this study, we measured the eye movements of 60 university students while solving two PISA items that contain graphs taken from mathematics and science assessments with the aim of studying the difference in visual attention between students who correctly and incorrectly identify graphs from a verbal description. We were particularly interested in the differences in the integration of information from different representations (text, graphs, and picture) between students who were successful or unsuccessful in solving items. The results suggest that students who solved the items correctly tend to solve the items longer than their counterparts who did not solve the items correctly. Analysis of eye tracking data suggests that students who solved science item correctly analyzed the graph for significantly longer time and had significantly longer average fixation time. This finding suggests that a careful analysis of graphs is crucial for the correct solution of PISA items used in this study. Furthermore, the results showed that students who solved the mathematics item correctly had significantly higher number of transitions between graphs and picture, which indicates a greater integration of information from two different representations. This indicates that these types of items require a lot of time and effort to complete, probably because solving them requires a lot of steps, which is cognitively demanding. We also found that the average fixation durations for different representations may vary for different items, indicating that it is not always equally difficult to extract necessary information from different types of representations. The results of this study suggest that instructors may be able to improve their teaching methods by considering the importance of individual representations (e.g., texts, graphs, and pictures) and the integration of information from multiple sources.