BackgroundCalcium (Ca) can complex with free fatty acids in the gastrointestinal tract (GIT), leading to the formation of insoluble unabsorbable Ca-fatty acid soaps, contributing to the proposed effect of Ca on weight loss in humans. ObjectivesWe determined the effect of dietary Ca concentration and the individual long-chain fatty acids on Ca-fatty acid soap formation and fatty acid digestibility. MethodsNine-week-old crossbreed male pigs (n = 144; mean ± SD body weight: 21.7 ± 0.15 kg) were used as an animal model for digestion in the adult human. The animals received purified diets containing 4 Ca concentrations (0, 2, 4, and 6 g/kg diet) and 4 fat sources (tallow, palmolein oil, soybean oil, and olive oil) in a completely randomized design. Fatty acids, Ca, and Ca-fatty acid soaps were determined in feces (n = 9 per diet). ResultsIncreasing dietary Ca led to a 4-fold increase (P ≤ 0.05) in excreted palmitic and stearic acid when diets contained tallow or palmolein oil as the major fat source. More than 80% of these excreted fatty acids were present as soaps. For the tallow-based diets, increasing dietary Ca led to a decrease in stearic acid digestibility from 91% to 66% (P ≤ 0.01) and in palmitic acid digestibility from 96% to 83% (P ≤ 0.01). For the olive oil- and soybean oil-based diets dietary Ca did not (P > 0.05) influence fatty acid excretion. ConclusionsCa-fatty acid soap formation led to decreased fat absorption in the GIT of growing pigs, which supports the hypothesis that higher dietary Ca concentrations reduce fat absorption.