This article details a current perspective and accurate anatomical three-dimensional descriptions of the ligaments of the wrist. The carpometacarpal ligaments, the intercarpal ligaments, and the radiocarpal ligaments are described and illustrated using a unique combination of detailed dissection, computed tomography, and a three-dimensional digitization technique. Detailed information is also provided about the ligamentous attachments of the carpometacarpal joints, the carpal bones, and the distal radius. This study improves knowledge and understanding of the normal anatomy and mechanics of the radiocarpal and intercarpal ligaments and the carpometacarpal joints, and it should help in the assessment of radiographic images and treatment of various injuries and degenerative changes seen in the wrist. The knowledge of the ligaments will further serve as a foundation for understanding the anatomy of the ligaments, the biomechanics of the wrist, and the function of the individual ligaments and their roles in joint motion and stability.