The purpose of this study was to investigate the relationship between mental health and self-reported itch in patients with burns across a 6 month time period and to test the hypothesis that poorer mental health outcomes are associated with increased severity of itch. MethodA quantitative study with three time points for data collection was conducted. Participants (232) completed assessments at 1 month, 3 months, and 6 months after burn injury. The Patient and Observer Scar Assessment Scale (POSAS) was used to report itch and the Short Form Health Survey (SF-36) provided an assessment of mental health across time. Only data from the itch and mental health subscales were used in the analysis. To analyze the data a quantile regression model was used. ResultsMental health is significantly associated with itch after adjusting for variation in itch over time (p=0.001). The regression coefficient indicates that as mental health increases by one unit, itch decreases by 0.03. Of importance, the relationship remained significant after adjusting for total burn surface area (p<0.001). ConclusionThese findings suggest there is a relationship between mental health and itch. Given the powerful impact itch can have on an individual's wellbeing health professionals can begin to further investigate itch from a bio-psychosocial perspective. Further research to investigate causal relationships between mental health and itch is important.