The aims of this study were to compare the goodness of fit and the concurrent validity of three regression models of the force–velocity relationship in a unilateral knee extension exercise. The force–velocity relationship and the one-repetition-maximum load in the dominant and non-dominant leg were obtained in 24 male sports sciences students by a progressive protocol. Additionally, the maximum voluntary contraction (MVC) of the knee extensor muscles was recorded. Individual force–velocity relationships were obtained by the linear, quadratic polynomial and exponential regression models. Although the adjusted coefficients of determination of all three models were high, the polynomial model’s coefficient was slightly but significantly higher than the rest of the models (p < 0.05), while the standard error of estimate was slightly higher for the linear than for polynomial model (p = 0.001). MVC was underestimated by F 0 calculated from the linear and polynomial models, while the maximum power was accurately estimated by the linear model. In summary, while the polynomial model revealed somewhat better fit, the linear model more accurately estimates the maximum power and provides the parameters of apparent physiological meaning. Therefore, we recommend using the linear model in research and routine testing of mechanical capacities of knee extensors.