Individual Differences In Sensitivity Research Articles

Vagal Flexibility Moderates the Links between Observed Sensitive Caregiving in Infancy and Externalizing Behavior Problems in Middle Childhood.

This study explored how patterns of physiological stress reactivity underpin individual differences in sensitivity to early rearing experiences and childhood risk for psychopathology. To examine individual differences in parasympathetic functioning, past research has largely relied on static measures of stress reactivity (i.e., residual and change scores) in infancy which may not adequately capture the dynamic nature of regulation across contexts. Using data from a prospective longitudinal study of 206 children (56% African Americans) and their families, this study addressed these gaps by employing the latent basis growth curve model to characterize the dynamic, non-linear patterns of change in infants' respiratory sinus arrhythmia (i.e., vagal flexibility) across the Face-to-Face Still-Face Paradigm. Furthermore, it investigated whether and how infants' vagal flexibility moderates the links between sensitive parenting, observed during a free play task when children were 6 months of age, and parent-report of children's externalizing problems at 7 years of age. Results of the structural equation models revealed that infants' vagal flexibility moderates the predictive relations between sensitive parenting in infancy and children's later externalizing problems. Simple slope analyses revealed that low vagal flexibility, characterized by less suppression and flatter recovery patterns, exacerbated risk for externalizing psychopathology in the context of insensitive parenting. Children with low vagal flexibility also benefited most from sensitive parenting, as indicated by the lower number of externalizing problems. Findings are interpreted in the light of the biological sensitivity to context model and provide evidence for vagal flexibility as a biomarker of individual's sensitivity to early rearing contexts.

Intolerance of Uncertainty and Cognition in Breast Cancer Survivors: The Mediating Role of Anxiety.

Cancer-related cognitive impairment (CRCI) is one of the most prevalent symptoms that breast cancer survivors experience. While cancer treatments are established contributors to CRCI, inter-individual differences in CRCI are not well understood. Individual differences in sensitivity to uncertainty are potential contributors to CRCI; however, no prior studies have attempted to examine this link in the context of breast cancer. To address the gap, we used preliminary findings from an ongoing cross-sectional study. A total of 38 women with stage I-III breast cancer (1-4 years post-treatment) were included in this study. Intolerance of uncertainty (IU) was assessed using the Intolerance of Uncertainty Scale. Self-reported cognitive function was assessed with the Neuro-QoL questionnaire. Anxiety was assessed using the Patient-Reported Outcomes Measurement System Bank. From this study, we found that anxiety mediates the association between IU and cognitive function of survivors. In other words, among post-menopausal breast cancer survivors, those with higher IU showed higher anxiety and consequently had lower cognitive function. This finding suggests that assessing IU may help predict the risk of CRCI. This study expands the current knowledge that addresses the importance of IU as a factor associated with cognitive health.

Individuals with low arithmetic abilities are sensitive to interference during knowledge retrieval from long-term memory across different domains

ABSTRACT Individuals show large individual differences in arithmetic abilities, especially in arithmetic facts. However, it is still unclear if individual differences in these abilities can be explained through individual differences in sensitivity to interference during retrieval from the associative network, and whether this sensitivity to interference is domain-general. To this end, we compared 18 adults with low arithmetic abilities with 18 intelligence matched individuals with high arithmetic abilities in two arithmetic and one lexico-semantic task. While individuals with low arithmetic abilities performed worse (longer response time and lower accuracy) on related lures, where interference occurs, individuals with high arithmetic abilities performed equally well on related and unrelated lures. This pattern of results emerged in the arithmetic tasks as well as in the lexico-semantic task. This finding indicates that sensitivity to interference is a domain-general construct hindering the selective retrieval of information from long-term memory in individuals with low arithmetic abilities.

Evidence for Different Roles of Inhibitory and Prospective Intolerance of Uncertainty During Threat Discrimination Learning

Uncertainty is a core component of threat and associated learning processes. One methodological factor impacting uncertainty in threat learning paradigms is the threat reinforcement rate, which refers to the proportion of times a cue is reinforced with an aversive stimulus. This study tested the effect of partial vs continuous threat reinforcement on threat / safety discrimination learning, as indexed by skin conductance response (SCR). Using a within-participants design, fifty-nine participants completed a task in which three colored shapes were paired with electric shock at reinforcement schedules of 100% (CS+), 50% (CS+) and 0% (CS-). In addition, the study examined the relationship between the Intolerance of Uncertainty scale (IU) and two subscales – inhibitory and prospective IU – with threat discrimination learning. The data show heightened SCR in the continuous vs partial reinforcement condition to all stimuli, but limited evidence of enhanced discrimination learning. Furthermore, no association was observed between total IU score and threat-safety discrimination. However, using a two-factor model of IU, findings showed higher inhibitory IU and higher prospective IU were associated with diminished and heightened threat discrimination, respectively. These results contribute to a fast-growing literature exploring how the uncertainty inherent to predictors of threat, individual differences in sensitivity to uncertainty, and interactions between these two factors, can shape the acquisition of threat memory.

Sensory Processing Sensitivity and Children Development in the Context of Environmental Sensitivity

Studies proved that people vary greatly in their sensitivity to the environment, and some are more sensitive than others. Aron et al. proposed the Sensory Processing Sensitivity (SPS) model to explain individual differences in sensitivity from the perspective of environmental information processing depth, which has recently been incorporated within a meta-framework of Environmental Sensitivity. In the field of children development research, children’s SPS is gradually understood as an important marker of children’s environmental sensitivity, and about 30% of children have a high-sensitive trait characterized by deeper processing of environmental information, increased emotional and physiological reactivity, greater awareness of environmental subtleties, and ease to be overstimulated. Recently, SPS and the highly sensitive child have gained great popularity in public and academia. This article reviews the theoretical framework and measurements of SPS of children, summarizing the relationship between SPS and children’s development outcomes and the moderating role SPS plays in children’s development. Future research needs to focus on the prevention and intervention of negative effects related to SPS and harness its positive potential to promote children’s well-being.

Heightened motor impairment as a protective factor against heavy drinking in individuals with high alcohol-induced disinhibition.

Behavioral disinhibition and motor impairment are both acutely elevated following alcohol consumption, and individual differences in sensitivity to alcohol-induced increases in these effects are associated with drinking habits. Specifically, high alcohol-induced disinhibition and low motor impairment have been identified as separate markers for alcohol-related problems. This study tested the degree to which alcohol-induced disinhibition and motor impairment jointly predict heavy drinking. We hypothesized that heavier drinkers would exhibit a combination of high sensitivity to alcohol-induced disinhibition and low sensitivity to its motor impairing effect. Data from three studies were aggregated to comprise a sample of 96 young adults. Participants' motor coordination (grooved pegboard) and behavioral disinhibition (cued go/no-go) were assessed following consumption of 0.65 g/kg alcohol and a placebo during separate sessions. As BAC was ascending, alcohol increased motor impairment and disinhibition compared to placebo. Combined effects at this time of alcohol on motor impairment and disinhibition predicted typical drinking habits. Specifically, a combination of high sensitivity to alcohol's disinhibiting effect and low sensitivity to its motor impairing effect was associated with heavy drinking. As BAC was descending, only reduced sensitivity to motor impairment remained as a predictor of heavy drinking. The findings suggest that although motor impairment following alcohol consumption is associated with certain negative outcomes (e.g., increased risk for physical injury and motor vehicle accidents), such heightened motor impairment from alcohol may actually serve as a protective factor against the excessive drinking that can accompany the disinhibiting effect of alcohol.

Theoretical background of high sensitivity ‒ systematic review

Aim The aim of the article is to systematize the knowledge regarding the theoretical background of the notion referred to in numerous studies as high sensitivity. The basis for the undertaken analyses is the concept of sensory processing sensitivity, which is important for the theoretical development of the issue of environmental sensitivity. Due to its application value, the concept is used in applied studies of individual differences in sensitivity to environmental stimuli. Based thereon, psychometric tools are developed to measure sensitivity, understood as a phenotypic trait in adults and children. Method The article presents qualitative research that was carried out using a systematic literature review (PRISMA) as part of the project “High sensitivity ‒ innovative module in human sciences” (HSP) No. 2020-1-PL01-KA203-082261. The study was conducted using the following databases: PubMed, ScienceDirect and Scopus. Results As part of the systematic review, 821 articles were identified containing the keywords “sensory processing sensitivity” OR “highly sensitive person” AND “theory” OR “theoretical background”. After eliminating duplicating articles (n = 33), titles and abstracts were analysed. In the next step, 705 articles were removed in line with the adopted exclusion criteria, and after analysing the full text, another 74 articles were excluded. Eventually, 12 articles were included in the review. Conclusions The obtained results indicate that in the context of the research conducted in this field, three main concepts are mentioned: Differential Sensitivity, Sensory Processing Sensitivity and Biological Sensitivity to Context. Research proves the independence of the sensory processing sensitivity trait from other traits, such as neuroticism or introversion. The concept of environmental sensitivity demonstrates its application value, and psychometric tools are developed within its framework.

"Sensitivity to the disinhibiting effect of alcohol: The role of trait impulsivity and sex differences": Clarification.

Higher trait impulsivity is associated with more impulsive responding on certain behavioral measures of disinhibition. Additionally, behavioral disinhibition is acutely elevated following alcohol consumption. The present study examined the possibility that trait impulsivity may predict individual differences in sensitivity to the disinhibiting effect of alcohol. Specifically, the present study tested the hypothesis that those with elevated trait impulsivity also experience heightened sensitivity to the disinhibiting effect of alcohol, which might further compound their tendency toward impulsive action. To test this hypothesis, data from six studies were aggregated to comprise a sample of 190 young adults. Participants completed the Barratt Impulsiveness Scale-11 (BIS-11), and behavioral disinhibition was assessed using a cued go/no-go task following consumption of 0.65 g/kg alcohol and a placebo. Alcohol increased disinhibition overall, but higher impulsivity did not predict increased sensitivity to alcohol-induced disinhibition. In men, higher levels of trait impulsivity predicted heightened disinhibition in the unintoxicated state following placebo, but this relationship was not present in women. These findings suggest significant sex differences in the relationship between trait impulsivity and disinhibition. This sex difference may explain inconsistent research findings in studies assessing links between trait and behavioral measures of impulsivity. The data also point to trait impulsivity and sensitivity to alcohol-induced disinhibition as independent constructs. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Sensitivity to the disinhibiting effect of alcohol: The role of trait impulsivity and sex differences.

To test this hypothesis, data from six studies were aggregated to comprise a sample of 190 young adults. Participants completed the Barratt Impulsiveness Scale-11 (BIS-11), and behavioral disinhibition was assessed using a cued go/no-go task following consumption of 0.65 g/kg alcohol and a placebo. Alcohol increased disinhibition overall, but higher impulsivity did not predict increased sensitivity to alcohol-induced disinhibition. In men, higher levels of trait impulsivity predicted heightened disinhibition in the unintoxicated state following placebo, but this relationship was not present in women. These findings suggest significant sex differences in the relationship between trait impulsivity and disinhibition. This sex difference may explain inconsistent research findings in studies assessing links between trait and behavioral measures of impulsivity. The data also point to trait impulsivity and sensitivity to alcohol-induced disinhibition as independent constructs. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Individual differences in sensitivity to bitterness focusing on oat and pea preparations

Growing interest in plant-based alternative products offers hope for a more sustainable future. Oat and pea are among the most potential raw materials, due to their nutritional value and their widespread growth. However, one of the key issues with the development of such products is their bitter off-taste due to ingredients like saponins, amino acids, and fatty acids. The perception of bitterness varies between compounds and depends on physiological differences among individuals, which also complicates the development of plant-based alternatives. This study aimed to investigate individual differences in bitterness sensitivity, with a particular focus on pea and oat products. Sensory evaluations (n = 12) and consumer tests (n = 100) showed that people were generally more sensitive to the bitterness of peas than oats. No statistically significant difference was observed in bitterness perception based on diet habits. Furthermore, findings demonstrated that no general standard for assessing a variety of product groups can be recommended for sensory analysis. Well-established bitter standards such as PROP, quinine, and caffeine, were not correlating with other bitter stimuli. Thus, the choice of the bitter standards to be used in sensory analysis depends on the purpose of the study and the samples included.

Music engagement is negatively correlated with depressive symptoms during the COVID-19 pandemic via reward-related mechanisms.

The COVID-19 pandemic has deeply affected the mental health of millions of people. We assessed which of many leisure activities correlated with positive mental health outputs, with particular attention to music, which has been reported to be important for coping with the psychological burden of the pandemic. Questionnaire data from about 1000 individuals primarily from Italy, Spain, and the United States during May-June 2020 show that people picked music activities (listening to, playing, singing, etc.) most often as the leisure experiences that helped them the most to cope with psychological distress related with the pandemic. During the pandemic, hours of engagement in music and food-related activities were associated with lower depressive symptoms. The negative correlation between music and depression was mediated by individual differences in sensitivity to reward, whereas the correlation between food-related activities and improved mental health outputs was explained by differences in emotion suppression strategies. Our results, while correlational, suggest that engaging in music activities could be related to improved well-being with the underlying mechanism being related to reward, consistent with neuroscience findings. Our data have practical significance in pointing to effective strategies to cope with mental health issues beyond those related to the COVID-19 pandemic.

Thumbs up or thumbs down: neural processing of social feedback and links to social motivation in adolescent girls.

Adolescence is a period of rapid biological and psychological development, characterized by increasing emotional reactivity and risk-taking, especially in peer contexts. Theories of adolescent neural development suggest that the balance in sensitivity across neural threat, reward and regulatory systems contributes to these changes. Building on previous research, this study used a novel social feedback task to explore activation and functional connectivity in the context of social threat and reward in a sample of mid-adolescent girls (n = 86, Mage = 16.32). When receiving negative peer feedback, adolescents showed elevated activation in, and amygdala connectivity with, social processing regions [e.g. medial prefrontal cortex (mPFC) and temporoparietal junction (TPJ)]. When receiving positive feedback, adolescents showed elevated activation in social and reward (e.g. mPFC and ventromedial prefrontal cortex) processing regions and less striatum-cerebellum connectivity. To understand the psychological implications of neural activation and co-activation, we examined associations between neural processing of threat and reward and self-reported social goals. Avoidance goals predicted elevated amygdala and striatum connectivity with social processing regions [e.g. medial temporal gyrus (MTG)], whereas approach goals predicted deactivation in social processing regions (e.g. MTG/TPJ and precuneus), highlighting the importance of considering individual differences in sensitivity to social threat and reward in adolescence.

Long-term delayed emergence after remimazolam-based general anesthesia: a case report

BackgroundRemimazolam is an ultra-short-acting benzodiazepine anesthetic that is antagonized by flumazenil, and it is typically expected to be applied in anesthesia with the purpose of ensuring early postoperative recovery. We report a case of long-term delayed emergence with re-sedation even after three times of flumazenil administration.Case presentationA 71-year-old man was scheduled for a robotic-assisted laparoscopic radical prostatectomy for prostate cancer. We used remimazolam for anesthetic induction and maintenance. The intraoperative bispectral index (BIS) was 30–50. Flumazenil was administered as patient emergence was delayed after surgery; however, re-sedation was observed. This finding persisted till 12 h after surgery, and the patient awakened on postoperative day 2.ConclusionsRemimazolam is a short-acting anesthetic, but long-term delayed emergence with re-sedation may occur even after flumazenil administration. Anesthesia using remimazolam requires anesthesia management that takes into account the individual differences in sensitivity and metabolism, with BIS as the indicator.

The neural basis of smile authenticity judgments and the potential modulatory role of the oxytocin receptor gene (OXTR)

Accurate perception of genuine vs. posed smiles is crucial for successful social navigation in humans. While people vary in their ability to assess the authenticity of smiles, little is known about the specific biological mechanisms underlying this variation. We investigated the neural substrates of smile authenticity judgments using functional magnetic resonance imaging (fMRI). We also tested a preliminary hypothesis that a common polymorphism in the oxytocin receptor gene (OXTR) rs53576 would modulate the behavioral and neural indices of accurate smile authenticity judgments. A total of 185 healthy adult participants (Neuroimaging arm: N = 44, Behavioral arm: N = 141) determined the authenticity of dynamic facial expressions of genuine and posed smiles either with or without fMRI scanning. Correctly identified genuine vs. posed smiles activated brain areas involved with reward processing, facial mimicry, and mentalizing. Activation within the inferior frontal gyrus and dorsomedial prefrontal cortex correlated with individual differences in sensitivity (d’) and response criterion (C), respectively. Our exploratory genetic analysis revealed that rs53576 G homozygotes in the neuroimaging arm had a stronger tendency to judge posed smiles as genuine than did A allele carriers and showed decreased activation in the medial prefrontal cortex when viewing genuine vs. posed smiles. Yet, OXTR rs53576 did not modulate task performance in the behavioral arm, which calls for further studies to evaluate the legitimacy of this result. Our findings extend previous literature on the biological foundations of smile authenticity judgments, particularly emphasizing the involvement of brain regions implicated in reward, facial mimicry, and mentalizing.

Individual differences in sensitivity to positive home environment among children "at risk" for attention-deficit/hyperactivity disorder: A review.

Although the evidence for the genetic basis of attention-deficit/hyperactivity disorder (ADHD) is strong, environmental factors, such as the quality of parenting or the home environment, may moderate such genetic liability. The plausible negative effect of a low-quality home environment and negative parenting on child outcomes is well-established; however, the positive effect of a high-quality environment and positive parenting remained largely uninvestigated. Due to the presence of genetic, temperamental, or physiological factors, children who were traditionally considered at-risk for ADHD may be more sensitive to aspects of their environment compared to children who are not at such risk. Therefore, they would be more affected by their environmental experience, either for good or bad. Under supportive environmental conditions, such at-risk individuals might actually outperform their non-vulnerable peers, suggesting that these individual factors might be considered susceptibility factors rather than risk factors. Little is known regarding the positive effect of the environment in the ADHD literature, but it has been demonstrated in cognitive functions that are closely associated with ADHD, such as executive functions (EF). We review this literature and examine the extant empirical support for sensitivity to aspects of the home environment and parenting in the case of ADHD and EF. Moreover, we review factors that could help identify the specific aspects of the home environment and parenting that these children might be more susceptible to. Such knowledge could be valuable when designing preventive interventions and identifying those children that are especially sensitive and could benefit from such interventions. Recommendations for future studies are discussed as well.

Trait sensitivity to negative feedback determines the intensity of compulsive alcohol seeking and taking in male rats.

Background:Alcohol use disorder is one of the most common psychiatric disorders, and it is a leading cause of mortality worldwide. It has been demonstrated previously that people with alcohol use disorder are less sensitive to the negative outcomes of their actions and less able to use negative feedback to guide and adjust their ongoing behaviour. However, far less is known about the aberrant processing of negative feedback before the onset of alcohol use disorder. In this study, we investigated the theoretical claim that sensitivity to negative feedback — as a stable and enduring behavioural trait — can predict vulnerability to the development of compulsive alcohol consumption in rats.Methods:We trained and tested rats in a series of probabilistic reversal learning tests, and based on this “negative feedback sensitivity screening,” we classified each rat as more or less sensitive to negative feedback. Then, in the intermittent-access 2-bottle choice paradigm, we measured alcohol consumption in the animals classified above. In the next step, using the instrumental second-order chained schedule of alcohol reinforcement task, we examined the influence of sensitivity to negative feedback on the development of compulsive alcohol seeking behaviour. Finally, we measured how trait sensitivity to negative feedback affected the extinction and reinstatement of alcohol seeking after a period of abstinence.Results:Trait sensitivity to negative feedback predicted the vulnerability of rats to the development of compulsive alcohol seeking and consumption. We also found significant differences between the more sensitive and less sensitive groups in their propensity to extinguish alcohol seeking behaviours when the alcohol was no longer available.Limitations:The findings from our study did not answer the question of whether individual differences in sensitivity to negative feedback have a genetic basis or develop in response to postnatal experiences.Conclusion:The results of our study suggest that negative feedback sensitivity screening could be used to evaluate individual vulnerability to the development and maintenance of alcohol use disorder.

Changes in the Prevalence of Thin Bodies Bias Young Women’s Judgments About Body Size

Body dissatisfaction is pervasive among young women in Western countries. Among the many forces that contribute to body dissatisfaction, the overrepresentation of thin bodies in visual media has received notable attention. In this study, we proposed that prevalence-induced concept change may be one of the cognitive mechanisms that explain how beauty standards shift. We conducted a preregistered online experiment with young women (N = 419) and found that when the prevalence of thin bodies in the environment increased, the concept of being overweight expanded to include bodies that would otherwise be judged as “normal.” Exploratory analyses revealed significant individual differences in sensitivity to this effect, in terms of women’s judgments about other bodies as well as their own. These results suggest that women’s judgments about other women’s bodies are biased by an overrepresentation of thinness and lend initial support to policies designed to increase size-inclusive representation in the media.

Task-irrelevant auditory metre shapes visuomotor sequential learning

The ability to learn and reproduce sequences is fundamental to every-day life, and deficits in sequential learning are associated with developmental disorders such as specific language impairment. Individual differences in sequential learning are usually investigated using the serial reaction time task (SRTT), wherein a participant responds to a series of regularly timed, seemingly random visual cues that in fact follow a repeating deterministic structure. Although manipulating inter-cue interval timing has been shown to adversely affect sequential learning, the role of metre (the patterning of salience across time) remains unexplored within the regularly timed, visual SRTT. The current experiment consists of an SRTT adapted to include task-irrelevant auditory rhythms conferring a sense of metre. We predicted that (1) participants’ (n = 41) reaction times would reflect the auditory metric structure; (2) that disrupting the correspondence between the learned visual sequence and auditory metre would impede performance; and (3) that individual differences in sensitivity to rhythm would predict the magnitude of these effects. Altering the relationship via a phase shift between the trained visual sequence and auditory metre slowed reaction times. Sensitivity to rhythm was predictive of reaction times over all. In an exploratory analysis, we, moreover, found that approximately half of participants made systematically different responses to visual cues on the basis of the cues’ position within the auditory metre. We demonstrate the influence of auditory temporal structures on visuomotor sequential learning in a widely used task where metre and timing are rarely considered. The current results indicate sensitivity to metre as a possible latent factor underpinning individual differences in SRTT performance.

Quantifying the regularities between orthography and semantics and their impact on group- and individual-level behavior.

Statistical views of reading highlight the link between proficient literacy and the assimilation of various regularities embedded in writing systems, including those in the mapping between print and meaning. Still, orthographic-semantic (O-S) regularities remain relatively understudied, with open questions regarding 3 issues: (a) how O-S regularities should be quantified, (b) how they impact the behavior of proficient readers, and (c) whether individual differences in sensitivity to these regularities predict reading skills. The goal of the current article is to address these questions. We start by reviewing previous studies estimating print-meaning regularities, where orthography-to-semantics consistency (OSC) is defined as the mean semantic similarity between a word and its orthographic neighbors. While we adopt this general strategy, we identify a potential confound in previous operational definitions. We therefore offer a modified measure, which we use to examine group-level OSC effects in available data sets of single word recognition and reading for comprehension. Our findings validate the existence of OSC effects but reveal variation across tasks, with OSC effects emerging more strongly in tasks involving a direct mapping of print to meaning. Next, we present a reanalysis of word naming data from 399 second through fifth graders, where we examine individual differences in reliance on O-S regularities and their relation to participants' reading skills. We show that early readers whose naming accuracy is more influenced by OSC (i.e., those who rely more on O-S) have better passage comprehension abilities. We conclude by discussing the role of O-S regularities in proficient reading and literacy acquisition. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Development of a Nonhuman Primate Model of Resistance to Punishment of Ethanol Choice

Several of the diagnostic criteria for alcohol use disorder (AUD) reflect the fact that some people continue to drink despite negative consequences. That is, vulnerable individuals are resistant to punishment. A better understanding of the behavioral and neurobiological factors that underlie this characteristic will lead to better preventive and treatment approaches to AUD. The objective of this study was to extend rodent studies by developing and validating a model of resistance to punishment of alcohol drinking in nonhuman primates. To increase translational relevance, the study was conducted in the context of an ethanol‐water choice procedure. Each day two 800‐ml bottles were hung on the monkey’s home cage for three hours, one containing a 4% ethanol solution and the other containing water. The primary dependent variable was ethanol choice (ml of ethanol consumed divided by total ml consumed x 100). When choice was stable (±10% of the 3‐day mean with no upward or downward trend), several manipulations were made. Experiment 1 characterized choice of several concentrations of ethanol (0%‐8%) versus water by substituting other ethanol concentrations for the 4% solution until choice again stabilized. The relationship between the available ethanol concentration and ethanol choice was characterized by an inverted U‐shaped function. In Experiment 2, the alternative (water) was manipulated to further validate the procedure as a model of choice. For monkeys in whom choice of the 4% ethanol solution was relatively low (<30%), the bitter tastant quinine (0.01‐1.0 g/L) was added to the water solution. For monkeys with higher choice of 4% ethanol (>70%), sucrose (1.0‐5.0%) was added to the water solution. These manipulations predictably increased and decreased, respectively, choice of the 4% ethanol solution. Finally, in Experiment 3, consumption of the 4% ethanol solution was punished by adding quinine (0.01‐5.6 g/L) to the ethanol solution. Increasing quinine concentrations decreased ethanol choice and ethanol intake in all monkeys without decreasing the total volume of fluid consumed. Individual differences were observed in the potency of quinine which can be interpreted as individual differences in sensitivity to punishment. These studies established and validated a novel nonhuman primate model of punishment of ethanol choice which can be used to characterize factors that underlie susceptibility versus resistance to punishing effects of adverse consequences of alcohol drinking.