Individual Differences In Neuroticism Research Articles

Context-dependent effect of mood: The differential-processual approach

The present study explores the influence of the context-dependent effect of mood as well as individual differences in neuroticism and action vs. state/volatility orientation on the predecisional processing in a multiattribute choice task. Participants ( N = 120) acquired information about choice options presented in a computerized information board after filling personality questionnaires. Their performance was analyzed by means of a process-oriented method. Results showed that participants in positive mood process the information longer in enjoy than in done-enough context. In turn, participants in negative mood process the information more selectively in enjoy than in done-enough context. Moreover, neuroticism and action vs. state/volatility orientation of a participant impact the strength of the context-dependent effect of mood. In particular, the effect is reinforced for participants with low neuroticism and volatility orientation, while it is weakened for those with low neuroticism and action orientation. The results are interpreted in accordance with the transactional approach.

The neural correlates of worry in association with individual differences in neuroticism.

The tendency to worry is a facet of neuroticism that has been shown to mediate the relationship between neuroticism and symptoms of depression and anxiety. The aim of the current study was to investigate the neural correlates of state worry in association with neuroticism. One-hundred twenty participants were selected from an initially recruited sample of 240 women based on their neuroticism score. First, participants completed a questionnaire to assess the excessiveness and uncontrollability of pathological worry. Second, we measured brain activation with functional magnetic resonance imaging (fMRI) while participants were randomly presented with 12 worry-inducing sentences and 12 neutral sentences in a mood induction paradigm. Individuals scoring higher on neuroticism reported to worry more in daily life and to have generated more worry-related thoughts after the presentation of a worry-inducing sentence. Furthermore, imaging results showed the involvement of default mode and emotional brain areas during worry, previously associated with self-related processing and emotion regulation. Specifically, cortical midline structures and the anterior insula showed more activation during worry, when individuals indicated to have generated more worry-related thoughts. Activation in the retrosplenial and visual cortex was decreased in individuals scoring higher on neuroticism during worry, possibly suggesting reduced autobiographical specificity and visual mental imagery. In the literature, both these processes have been related to the cognitive avoidance of emotional distress. Excessive worry features in a number of emotional disorders and results from studies that elucidate its neural basis may help explain how and why neuroticism contributes to vulnerability for psychopathology.

Understanding the Costs of Support Transactions in Daily Life

The benefits of close relationships for mental and physical health are well documented. One of the mechanisms presumed to underlie these effects is social support, whereby close others provide practical and emotional assistance in times of need. Although there is no doubt that generalized perceptions of support availability are beneficial, research examining actual instances of support receipt has found unexpectedly mixed results. Receiving support sometimes has positive effects, but null or even negative effects are common. In this article, we review our multimethod program of research that seeks to understand and explain the costs of receiving social support. We focus on reductions in the recipient's sense of relationship equity and self-efficacy as mechanisms of this effect and examine a number of other moderating factors. Although we have found that receiving support incurs costs on average, there is considerable variability yet to be explained. Using diary data from 312 persons preparing to take a challenging exam, we examined the potential of individual differences in neuroticism, agreeableness, and attachment insecurity to explain variability in experienced support costs. We close with new questions about why received support may be beneficial or benign in some situations while being especially toxic in others.

When Being Discrepant from One's Ideal or Ought Selves Hurts: The Moderating Role of Neuroticism

Self–discrepancy theory posits that people experience emotional consequences when they perceive discrepancies between their actual and possible selves. However, the extent to which people react emotionally to these self–discrepancies (i.e. ideal, ought and undesired) may be a function of individual differences in neuroticism. Across both experimental (Study 1; N = 155) and correlational designs (Study 2; N = 139) involving college students, the authors demonstrated that neuroticism moderated the discrepancy–emotion associations such that high–neuroticism individuals showed elevated depression and anxiety symptoms when their self–discrepancies were activated. The heightened symptoms were maintained over time. Negative repetitive thoughts (i.e. rumination and worry) were examined as potential mediating mechanisms between the discrepancy × neuroticism interaction and symptoms. Partial support was obtained in that rumination mediated between undesired discrepancy × neuroticism interaction and anxious/depressive symptoms. Implications and possible theoretical extensions for self–discrepancy theory are discussed. Copyright © 2012 John Wiley & Sons, Ltd.

Role of Neuroticism and Coping Strategies in Psychological Reactions to a Racist Incident Among African American University Students

A total of 562 African American university students provided data on individual differences in neuroticism; coping with a recent experience being the target of prejudice, racism, and/or discrimination; and psychological reactions to the incident. Higher negative affect, lower positive affect, more intrusive thoughts about the incident, and lack of forgiveness for the perpetrator were used to index distress in response to the racist incident. Using factor analyses, we determined the factor structure of the Brief COPE in our sample. Using structural equation modeling, we then examined neuroticism and each coping factor as unique predictors of reactions to the race-related incident. We documented that there were direct and indirect associations (via the selection of coping strategies) between neuroticism and the outcome measures. Neuroticism also moderated the association between particular coping strategies and reactions to the racist incident. There was also evidence for direct associations between various coping strategies and the outcome measures. The research, though preliminary, suggests the importance of neuroticism and coping strategies in understanding psychological reactions to being the target of racism.

Neural basis of contagious itch and why some people are more prone to it

Watching someone scratch himself can induce feelings of itchiness in the perceiver. This provides a unique opportunity to characterize the neural basis of subjective experiences of itch, independent of changes in peripheral inputs. In this study, we first established that the social contagion of itch is essentially a normative response (experienced by most people), and that the degree of contagion is related to trait differences in neuroticism (i.e., the tendency to experience negative emotions), but not to empathy. Watching video clips of someone scratching (relative to control videos of tapping) activated, as indicated by functional neuroimaging, many of the neural regions linked to the physical perception of itch, including anterior insular, primary somatosensory, and prefrontal (BA44) and premotor cortices. Moreover, activity in the left BA44, BA6, and primary somatosensory cortex was correlated with subjective ratings of itchiness, and the responsivity of the left BA44 reflected individual differences in neuroticism. Our findings highlight the central neural generation of the subjective experience of somatosensory perception in the absence of somatosensory stimulation. We speculate that the habitual activation of this central "itch matrix" may give rise to psychogenic itch disorders.

Schizotypy and Behavioural Adjustment and the Role of Neuroticism

ObjectiveIn the present study the relationship between behavioural adjustment following cognitive conflict and schizotypy was investigated using a Stroop colour naming paradigm. Previous research has found deficits with behavioural adjustment in schizophrenia patients. Based on these findings, we hypothesized that individual differences in schizotypy, a personality trait reflecting the subclinical expression of the schizophrenia phenotype, would be associated with behavioural adjustment. Additionally, we investigated whether such a relationship would be explained by individual differences in neuroticism, a non-specific measure of negative trait emotionality known to be correlated with schizotypy.Methods106 healthy volunteers (mean age: 25.1, 60% females) took part. Post-conflict adjustment was measured in a computer-based version of the Stroop paradigm. Schizotypy was assessed using the Schizotypal Personality Questionnaire (SPQ) and Neuroticism using the NEO-FFI.ResultsWe found a negative correlation between schizotypy and post-conflict adjustment (r = −.30, p<.01); this relationship remained significant when controlling for effects of neuroticism. Regression analysis revealed that particularly the subscale No Close Friends drove the effect.ConclusionPrevious findings of deficits in cognitive control in schizophrenia patients were extended to the subclinical personality expression of the schizophrenia phenotype and found to be specific to schizotypal traits over and above the effects of negative emotionality.

The error-related negativity relates to sadness following mood induction among individuals with high neuroticism

The error-related negativity (ERN) is an event-related potential (ERP) that indexes error monitoring. Research suggests that the ERN is increased in internalizing disorders, such as depression and anxiety. Although studies indicate that the ERN is insensitive to state-related fluctuations in anxiety, few studies have carefully examined the effect of state-related changes in sadness on the ERN. In the current study, we sought to determine whether the ERN would be altered by a sad mood induction using a between-subjects design. Additionally, we explored if this relationship would be moderated by individual differences in neuroticism-a personality trait related to both anxiety and depression. Forty-seven undergraduate participants were randomly assigned to either a sad or neutral mood induction prior to performing an arrow version of the flanker task. Participants reported greater sadness following the sad than neutral mood induction; there were no significant group differences on behavioral or ERP measures. Across the entire sample, however, participants with a larger increase in sad mood from baseline to post-induction had a larger (i.e. more negative) ERN. Furthermore, this effect was larger among individuals reporting higher neuroticism. These data indicate that neuroticism moderates the relationship between the ERN and changes in sad mood.

Routine cognitive errors: A trait-like predictor of individual differences in anxiety and distress

Five studies (N=361) sought to model a class of errors—namely, those in routine tasks—that several literatures have suggested may predispose individuals to higher levels of emotional distress. Individual differences in error frequency were assessed in choice reaction-time tasks of a routine cognitive type. In Study 1, it was found that tendencies toward error in such tasks exhibit trait-like stability over time. In Study 3, it was found that tendencies toward error exhibit trait-like consistency across different tasks. Higher error frequency, in turn, predicted higher levels of negative affect, general distress symptoms, displayed levels of negative emotion during an interview, and momentary experiences of negative emotion in daily life (Studies 2–5). In all cases, such predictive relations remained significant with individual differences in neuroticism controlled. The results thus converge on the idea that error frequency in simple cognitive tasks is a significant and consequential predictor of emotional distress in everyday life. The results are novel, but discussed within the context of the wider literatures that informed them.

Experiential, autonomic, and neural responses during threat anticipation vary as a function of threat intensity and neuroticism

Anticipatory emotional responses play a crucial role in preparing individuals for impending challenges. They do this by triggering a coordinated set of changes in behavioral, autonomic, and neural response systems. In the present study, we examined the biobehavioral impact of varying levels of anticipatory anxiety, using a shock anticipation task in which unpredictable electric shocks were threatened and delivered to the wrist at variable intervals and intensities (safe, medium, strong). This permitted investigation of a dynamic range of anticipatory anxiety responses. In two studies, 95 and 51 healthy female participants, respectively, underwent this shock anticipation task while providing continuous ratings of anxiety experience and electrodermal responding (Study 1) and during fMRI BOLD neuroimaging (Study 2). Results indicated a step-wise pattern of responding in anxiety experience and electrodermal responses. Several brain regions showed robust responses to shock anticipation relative to safe trials, including the hypothalamus, periaqueductal gray, caudate, precentral gyrus, thalamus, insula, ventrolateral PFC, dorsomedial PFC, and ACC. A subset of these regions demonstrated a linear pattern of increased responding from safe to medium to strong trials, including the bilateral insula, ACC, and inferior frontal gyrus. These responses were modulated by individual differences in neuroticism, such that those high in neuroticism showed exaggerated anxiety experience across the entire task, and reduced brain activation from medium to strong trials in a subset of brain regions. These findings suggest that individual differences in neuroticism may influence sensitivity to anticipatory threat and provide new insights into the mechanism through which neuroticism may confer risk for developing anxiety disorders via dysregulated anticipatory responses.

Neuroticism and Responsiveness to Error Feedback: Adaptive Self-Regulation Versus Affective Reactivity

Responsiveness to negative feedback has been seen as functional by those who emphasize the value of reflecting on such feedback in self-regulating problematic behaviors. On the other hand, the very same responsiveness has been viewed as dysfunctional by its link to punishment sensitivity and reactivity. The present 4 studies, involving 203 undergraduate participants, sought to reconcile such discrepant views in the context of the trait of neuroticism. In cognitive tasks, individuals were given error feedback when they made mistakes. It was found that greater tendencies to slow down following error feedback were associated with higher levels of accuracy at low levels of neuroticism but lower levels of accuracy at high levels of neuroticism. Individual differences in neuroticism thus appear crucial in understanding whether behavioral alterations following negative feedback reflect proactive versus reactive mechanisms and processes. Implications for understanding the processing basis of neuroticism and adaptive self-regulation are discussed.

The Five-Factor Model of Personality and Borderline Personality Disorder: A Genetic Analysis of Comorbidity

Recently, the nature of personality disorders and their relationship with normal personality traits has received extensive attention. The five-factor model (FFM) of personality, consisting of the personality traits neuroticism, extraversion, openness to experience, agreeableness, and conscientiousness, is one of the proposed models to conceptualize personality disorders as maladaptive variants of continuously distributed personality traits. The present study examined the phenotypic and genetic association between borderline personality and FFM personality traits. Data were available for 4403 monozygotic twins, 4425 dizygotic twins, and 1661 siblings from 6140 Dutch, Belgian, and Australian families. Broad-sense heritability estimates for neuroticism, agreeableness, conscientiousness, extraversion, openness to experience, and borderline personality were 43%, 36%, 43%, 47%, 54%, and 45%, respectively. Phenotypic correlations between borderline personality and the FFM personality traits ranged from .06 for openness to experience to .68 for neuroticism. Multiple regression analyses showed that a combination of high neuroticism and low agreeableness best predicted borderline personality. Multivariate genetic analyses showed the genetic factors that influence individual differences in neuroticism, agreeableness, conscientiousness, and extraversion account for all genetic liability to borderline personality. Unique environmental effects on borderline personality, however, were not completely shared with those for the FFM traits (33% is unique to borderline personality). Borderline personality shares all genetic variation with neuroticism, agreeableness, conscientiousness, and extraversion. The unique environmental influences specific to borderline personality may cause individuals with a specific pattern of personality traits to cross a threshold and develop borderline personality.

The Devil You Know

Individuals differ in the extent to which they respond negatively to uncertainty. Although some individuals feel little discomfort when facing the unknown, those high in neuroticism find it aversive. We examined neurophysiological responses to uncertainty using an event-related potential framework. Participants completed a time-estimation task while their neural activity was recorded via electroencephalography. The feedback-related negativity (FRN), an evoked potential that peaks approximately 250 ms after the receipt of feedback information, was examined under conditions of positive, negative, and uncertain feedback. The magnitude of these responses was then analyzed in relation to individual differences in neuroticism. As expected, a larger FRN was observed after negative feedback than after positive feedback for all participants. For individuals who scored highly on trait neuroticism, however, uncertain feedback produced a larger neural response than did negative feedback. These results are discussed in terms of affective responses to uncertainty among neurotic individuals.

The influence of personality on neural mechanisms of observational fear and reward learning

Fear and reward learning can occur through direct experience or observation. Both channels can enhance survival or create maladaptive behavior. We used fMRI to isolate neural mechanisms of observational fear and reward learning and investigate whether neural response varied according to individual differences in neuroticism and extraversion. Participants learned object-emotion associations by observing a woman respond with fearful (or neutral) and happy (or neutral) facial expressions to novel objects. The amygdala–hippocampal complex was active when learning the object-fear association, and the hippocampus was active when learning the object-happy association. After learning, objects were presented alone; amygdala activity was greater for the fear (vs. neutral) and happy (vs. neutral) associated object. Importantly, greater amygdala–hippocampal activity during fear (vs. neutral) learning predicted better recognition of learned objects on a subsequent memory test. Furthermore, personality modulated neural mechanisms of learning. Neuroticism positively correlated with neural activity in the amygdala and hippocampus during fear (vs. neutral) learning. Low extraversion/high introversion was related to faster behavioral predictions of the fearful and neutral expressions during fear learning. In addition, low extraversion/high introversion was related to greater amygdala activity during happy (vs. neutral) learning, happy (vs. neutral) object recognition, and faster reaction times for predicting happy and neutral expressions during reward learning. These findings suggest that neuroticism is associated with an increased sensitivity in the neural mechanism for fear learning which leads to enhanced encoding of fear associations, and that low extraversion/high introversion is related to enhanced conditionability for both fear and reward learning.

Neuroticism influences pupillary responses during an emotional interference task

We used behavioral and pupillary measures during an analogical reasoning task to investigate the processing of conceptual and emotional relations as well as their interaction. In particular, we examined how mental resource consumption is modulated by individual differences in neuroticism in healthy participants during conditions with emotional interference. Two word pairs were presented simultaneously, each with a conceptual and an emotional relation. In one experimental block, participants had to decide whether conceptual relations between the two word pairs were corresponding ( conceptual task). In the other block, participants had to decide whether emotional relations were corresponding ( emotional task). When participants had to focus on the correspondence of emotional relations, they were faster, more accurate, and showed greater pupillary responses than during the conceptual task. Moreover, participants with comparably higher neuroticism scores showed increased pupillary responses during conditions with emotional interference (i.e., during the conceptual task when they had to ignore incongruent information on the correspondence provided by the task-irrelevant emotional relations). These results demonstrate that affective aspects of stimuli (here: emotional relations) are preferentially selected for information processing. Moreover, increased mental resource consumption due to emotional interference in participants with comparably higher neuroticism scores might reflect a possible mechanism making these individuals more vulnerable to mood or anxiety disorders.

Catechol- O-Methyltransferase Contributes to Genetic Susceptibility Shared Among Anxiety Spectrum Phenotypes

Catechol-O-methyltransferase (COMT) has been investigated for its possible role in a wide range of psychiatric phenotypes. In particular, several studies support association of this gene with panic disorder and other anxiety-related traits. We examined the COMT gene for association with genetic risk across a range of anxiety spectrum phenotypes. We used multivariate structural equation modeling to select twin pairs scoring at the extremes of a latent genetic risk factor shared by neuroticism, several anxiety disorders, and major depression from a large population-based twin sample. With one member from each of these pairs, the resulting sample of 589 cases and 539 control subjects were entered into a two-stage association study in which genetic markers were screened in stage 1, the positive results of which were tested for replication in stage 2. The functional val158met polymorphism (rs4680) plus nine other single nucleotide polymorphism markers selected to capture the major allelic variation across the COMT locus were analyzed for differences between cases and control subjects. Although the val (G) allele of rs4680 showed marginally significant association in our combined stage 1 plus stage 2 sample, a high-risk haplotype of this allele with the A allele of rs165599 was significantly over-represented in cases (p = 1.97e-5, odds ratio = 1.95). This haplotype also predicted individual differences in neuroticism and risk for several anxiety disorders and major depression. Consistent with prior studies, our findings are female-specific. Variations in the COMT gene contribute to genetic risk shared across a range of anxiety-related phenotypes.

Neuroticism, Side Effects, and Health Perceptions Among HIV-Infected Individuals on Antiretroviral Medications

Side effects from antiretroviral therapy (ART) for HIV disease can deter treatment, impact quality of life, and impede medication adherence. Individual differences in neuroticism may account for variations in the experience of side effects and perceptions of health status. Cross-sectional assessments were conducted with 258 HIV-infected participants with confirmed HIV infection and current ART regimen. Structural equation modeling (SEM) was used to evaluate a model of self-reported ART side effect frequency and severity and perceived health status, as related to symptoms of neuroticism. Symptoms of neuroticism were associated with greater reports of ART side effects and poorer perceived health but unrelated to reported CD4 count and viral load. A structural model was supported in which greater symptoms of neuroticism are linked to poorer perceived health through greater side effect frequency and severity. Individual differences in symptoms of neuroticism can explain variations in side effect reporting and consequential impairments in perceived health in the context of HIV treatment. Identification and intervention with individuals high in symptoms of neuroticism may be warranted to alleviate side effect-related concerns and maximize treatment benefit.

Neuroticism and brain responses to anticipatory fear.

Personality is known to influence cognitive and affective functioning as well as the risk of psychiatric disorders. Exploration of the neurobiological correlates of personality traits has the potential to enhance understanding of their significance in development of related psychopathological states. The authors examined the association between individual differences in neuroticism and brain activity in response to threat of electric shocks. Fourteen right-handed healthy men underwent functional MRI during a 5-min experiment that involved repeated presentations of two 30-s alternating conditions. In 1 of these conditions, subjects were told to expect mild but painful electric shocks; there was no possibility of receiving shocks in the other condition. The results revealed that neuroticism correlated positively with the ratings of fear of shock and negatively (indicating suppression) with brain activity from safe to shock conditions in the anterior and posterior cingulate, superior/middle temporal gyrus extending to the hippocampus, precuneus, putamen, thalamus, and middle occipital gyrus. The observations support recent psychophysiological research that has demonstrated reduced processing of pain in subjects with higher levels of neuroticism, especially the anxiety component of this trait.

Neurotic contentment: A self-regulation view of neuroticism-linked distress.

The present hypotheses were guided by four premises, which were systematically examined in six studies involving 409 undergraduate participants. The first premise, established by prior work, is that trait neuroticism is closely associated with avoidance-related goals. The second premise, however, is that neuroticism may be uncorrelated with cognitive tendencies to recognize threats as they occur, and subsequently to down-regulate them. In support of this point, all six studies found that neuroticism was unrelated to post-error behavioral adjustments in choice reaction time. The third premise is that post-error reactivity would nonetheless predict individual differences in threat-recognition (Studies 1 and 2) and its apparent mitigation (Study 3), independently of trait neuroticism. These predictions were supported. The fourth premise is that individual differences in neuroticism and error-reactivity would interact with each other in predicting everyday experiences of distress. In support of such predictions, Studies 4-6 found that higher levels of error-reactivity were associated with less negative affect at high levels of neuroticism, but more negative affect at low levels of neuroticism. The findings are interpreted in terms of trait-cognition self-regulation principles.

Neuroticism and affective priming: Evidence for a neuroticism-linked negative schema

Neuroticism has been hypothesized to systematically relate to semantic memory networks favoring negative affect, but no studies using affective priming tasks have established this link. The present two studies, involving 145 undergraduate participants, sought to provide initial evidence along these lines. Study 1 used a task in which participants were asked to judge their emotions in the past, whereas Study 2 used a perceptual identification task in which participants merely had to identify the word in question. In both studies, neuroticism was positively correlated with negative affective priming, but not positive affective priming. The studies suggest that neuroticism systematically relates to the inter-connectivity of negative affect within semantic memory systems, whether involving the self-concept (Study 1) or not (Study 2). These results are novel and important in understanding individual differences in neuroticism and their affective processing correlates.