The current study examines the relationships between hitters' neural activity and their in-game hitting performance. Collegiate baseball players completed a computerized video task assessing whether thrown pitches were balls or strikes while their neural activity was recorded. In addition, each player's hitting statistics were collected for the following baseball season. Results showed that neural activity during the computerized task was associated with in-game hitting performance, even after accounting for other individual difference variables. These findings indicate that players' neural activity measured in a laboratory environment shows a translational relationship with in-game hitting performance over time. Neural activity provides a more objective analysis of players' ongoing self-regulatory processes during hitting and a better understanding of the cognitive processes associated with hitting performance. Self-regulatory cognitive control is adaptable and trainable, and this research advances the measurement of cognitive variables related with in-game hitting performance in baseball.