The coverage of Covid-19 vaccination in Kendari City reached 237.735 (89.66%) in the first dose, 147.430 (55.60%) in the second dose and 3.518 (84.75%) in the third dose. Meanwhile, at the Puuwatu Health Center, the coverage of vaccination doses 2nd was 10.874 (34%). The low-vaccine program is influenced by individual perceptions and desires to vaccinate. This study aims to determine the factors associated with acceptance of the Covid-19 vaccine based on the health belief model theory. The research design used was a cross-sectional study. The population in this study were the people who were in the working area of the Puuwatu Health Center as many as 36.521 people, while the sample was 110 respondents. The sampling technique used was accidental sampling. Research data were analyzed using the chi-square test. The results of the study showed perceived vulnerability (p=0.000), perceived severity (p=0.000), perceived benefits (p=0.001), perceived obstacles (p=0.000), and cues to act (p=0.000). It can be concluded that perception is related to public acceptance of the covid-19 vaccine.