Indirect Method Research Articles

Development of an indirect measurement method for the Contact Tube to Workpiece Distance (CTDW) in the Direct Energy Deposition – Arc (DED-ARC) process for different arc types

During the layer-by-layer build-up in the Direct Energy Deposition (DED) - Arc additive manufacturing (AM) process, the distance between the contact tube and the workpiece, effectively the welded layer, changes. Since the weld paths are predefined by the path planning software, a constant Contact Tube to Workpiece Distance (CTWD) and weld bead height is assumed. However, even small changes in geometry, such as crossovers of weld paths, result in higher weld beads than assumed. Similarly, an incorrectly assumed bead height as input to the path planning will result in a change in the CTWD. The sum of the deviations of the real weld geometries from the assumed ones in the path planning can greatly influence the CTWD. This implies that the dimensional accuracy may be significantly compromised. This research presents an approach for a general indirect measurement method using the welding current to obtain the CTWD during the actual welding process. A real-time process control method is implemented and validated using the mechanically controlled short arc and the pulsed arc process. Varying process parameters are used to validate the general applicability for a specific material. For the mechanically controlled short arc process, the model underestimates the measured CTWD by a mean error of 3.4 mm. The pulse process is overestimated by a mean error of 2.2 mm. The standard deviation for the pulse process with 1.3 mm is slightly smaller than for the short arc process with 1.7 mm.

Estimation of unfrozen water content of saturated sandstones using nuclear magnetic resonance, mercury intrusion porosimetry, and ultrasonic tests

The unfrozen water content (UWC) is a crucial parameter that affects the strength and thermal properties of rocks in relation to engineering construction and geological disasters in cold regions. In this study, three different methods were employed to test and estimate the UWC of saturated sandstones, including nuclear magnetic resonance (NMR), mercury intrusion porosimetry (MIP), and ultrasonic methods. The NMR method enabled the direct measurement of the UWC of sandstones using the free induction decay (FID). The MIP method was used to analyze the pore structures of sandstones, with the UWC subsequently calculated based on pore ice crystallization. Therefore, the MIP test constituted an indirect measurement method. Furthermore, a correlation was established between the P-wave velocity and the UWC of these sandstones based on the mixture theory, which could be employed to estimate the UWC as an empirical method. All methods demonstrated that the UWC initially exhibited a rapid decrease from 0 °C to –5 °C and then generally became constant beyond –20 °C. However, these test methods had different characteristics. The NMR method was used to directly and accurately calculate the UWC in the laboratory. However, the cost and complexity of NMR equipment have precluded its use in the field. The UWC can be effectively estimated by the MIP test, but the estimation accuracy is influenced by the ice crystallization process and the pore size distribution. The P-wave velocity has been demonstrated to be a straightforward and practical empirical parameter and was utilized to estimate the UWC based on the mixture theory. This method may be more suitable in the field. All methods confirmed the existence of a hysteresis phenomenon in the freezing-thawing process. The average hysteresis coefficient was approximately 0.538, thus validating the Gibbs–Thomson equation. This study not only presents alternative methodologies for estimating the UWC of saturated sandstones but also contribute to our understanding of the freezing-thawing process of pore water.

Electrical measurement method of static friction force on rough surface

Friction plays a key role in the assessment of the safety and stability of mechanical systems (such as superconducting magnet quench explosion, aerospace vehicle bearing wear, etc.). Due to the closeness of the interfaces in engineering structures and the randomness of the contact surfaces, existing methods for measuring static friction force are unable to measure it at the contact interfaces of engineering structures under service conditions. In this paper, a new method for measuring the static friction force at the interface based on electrical signals is proposed. This method enables the measurement of the static friction force at interfaces of complex engineering structures under service conditions solely through electrical signals. The results indicate that the contact resistance gradually decreases with the increase in tangential load during the static friction stage until a monotonic behavior of macroscopic sliding occurs. The evolution of contact resistance is linked to the evolution of the real contact area, and this monotonic behavior can be explained as the deformation form of contact points. The accuracy of the proposed electrical measurement method is verified by comparison with experimental results (with an error of less than 9%). The indirect measurement method of friction force proposed in this paper can effectively measure the static friction force at the interfaces of engineering structures under service conditions, and it is expected to be applied to the detection of friction performance at engineering structure interfaces in extreme service environments.

Development of a Gaussia luciferase immunoprecipitation assay for detecting Schistosoma japonicum infection

Timely and accurate diagnosis of Schistosoma infection is important to adopt effective strategies for schistosomiasis control. Previously, we demonstrated that Schistosoma japonicum can secret extracellular vesicles and their cargos may serve as a novel type of biomarkers for diagnosing schistosomiasis. Here, we developed a Gaussia luciferase immunoprecipitation assay combined with S. japonicum extracellular vesicle (SjEV) protein to evaluate its potential for diagnosing schistosomiasis. A saposin-like protein (SjSLP) identified from SjEVs was fused to the Gaussia luciferase as the diagnostic antigen. The developed method showed good capability for detecting S. japonicum infection in mice and human patients. We also observed that the method could detect schistosome infection in mice as early as 7 days of post-infection, which showed better sensitivity than that of indirect ELISA method. Overall, the developed method showed a good potential for detecting Schistosoma infection particularly for early stage, which may provide an alternative strategy for identify Schistosoma infection for disease control.

Effectiveness of 13-valent pneumococcal conjugate vaccine for prevention of invasive pneumococcal disease among children in the United States between 2010 and 2019: An indirect cohort study

BackgroundA U.S. case-control study (2010–2014) demonstrated vaccine effectiveness (VE) for ≥ 1 dose of the thirteen-valent pneumococcal conjugate vaccine (PCV13) against vaccine-type (VT) invasive pneumococcal disease (IPD) at 86 %; however, it lacked statistical power to examine VE by number of doses and against individual serotypes. MethodsWe used the indirect cohort method to estimate PCV13 VE against VT-IPD among children aged < 5 years in the United States from May 1, 2010 through December 31, 2019 using cases from CDC’s Active Bacterial Core surveillance, including cases enrolled in a matched case-control study (2010–2014). Cases and controls were defined as individuals with VT-IPD and non-PCV13-type-IPD (NVT-IPD), respectively. We estimated absolute VE using the adjusted odds ratio of prior PCV13 receipt (1-aOR x 100 %). ResultsAmong 1,161 IPD cases, 223 (19.2 %) were VT cases and 938 (80.8 %) were NVT controls. Of those, 108 cases (48.4 %; 108/223) and 600 controls (64.0 %; 600/938) had received > 3 PCV13 doses; 23 cases (17.6 %) and 15 controls (2.4 %) had received no PCV doses. VE ≥ 3 PCV13 doses against VT-IPD was 90.2 % (95 % Confidence Interval75.4–96.1 %), respectively. Among the most commonly circulating VT-IPD serotypes, VE of ≥ 3 PCV13 doses was 86.8 % (73.7–93.3 %), 50.2 % (28.4–80.5 %), and 93.8 % (69.8–98.8 %) against serotypes 19A, 3, and 19F, respectively. ConclusionsAt least three doses of PCV13 continue to be effective in preventing VT-IPD among children aged < 5 years in the US. PCV13 was protective against serotypes 19A and 19F IPD; protection against serotype 3 IPD did not reach statistical significance.

On the importance of the experimental setup design in hydrodynamic journal bearing friction measurement

Improving operating conditions and reducing the friction-related power losses of hydrodynamic journal bearings could lower emissions and contribute to efforts for a faster green transition. Experimental studies play an important role in evaluating and improving the performance of plain journal bearings. The concept of the experimental setup for friction measurements of journal bearings is well defined in the relevant standards, but the actual design is always left to the researchers conducting a particular study. Our study reveals that common practical assumptions about the frictional power losses caused by components of the experimental setup can lead to misleading conclusions about the measured coefficient of friction. The research premises were tested on the developed experimental setup using two methods for measuring the coefficient of friction and different load interfaces. In particular, the direct torque measurement using strain gauges on the shaft demonstrated the strongest correlation with theoretical values. However, the result was affected by the correct evaluation of the frictional losses of the support ball bearings. Conversely, the Stribeck curves showed that the combination of the indirect cantilever method and load interface with direct radial force application led to inferior results. The intricate interactions between setup components and unknown frictional conditions made straightforward geometric corrections challenging. The study encourages researchers in the field to critically assess their experimental setups and to rely on their own assessment of frictional losses.

Indirect Spectrophotometric Method Based on a Selective Reaction Between Bicinchoninic Acid and Copper(I) for the Determination of Metal Ions

Indirect Spectrophotometric Method Based on a Selective Reaction Between Bicinchoninic Acid and Copper(I) for the Determination of Metal Ions

Maglumi X3 fully automated chemiluminescent immunoassay for islet cell autoantibodies. Analytical performance and comparability to indirect immunofluorescence method

Maglumi X3 fully automated chemiluminescent immunoassay for islet cell autoantibodies. Analytical performance and comparability to indirect immunofluorescence method

Joint stress of a hinged platform composed of eight boxes

The box-type hinged platform has important applications in ocean engineering. In this paper, a multi-module assembled box-type platform is described. The mid-section load of the platform is numerically simulated based on the three-dimensional velocity potential theory and the indirect time-domain method through the hydrodynamic module AQWA in ANSYS. The stress of the hinged joints of platforms was performed using finite element analysis software in ANSYS software. The results show that: (1) In irregular waves, the shear force and bending moment in the middle section of the platform increases with the increase of the significant wave height; (2) Under the same towing scheme, the stress of the hinged joints between box platforms shows an increasing trend with the increase of wave level. Under the same wave working condition, the stress at the uniaxial nut of the hinged joints is relatively high, which is prone to fracture.

A Remaining Useful Life Indirect Prediction Method for Lithium-Ion Batteries Based on SA-DBN

To solve the issue that the battery capacity cannot be directly measured in practice, a more practical indirect remaining useful life (RUL) prediction method is proposed. First, the battery state characteristic parameters are analyzed and the time interval of equal discharge voltage drop (TIE-DVD) is selected as the indirect health factor. Second, the degradation relationship model is established by using back propagation (BP) neural network. Then, the deep belief network (DBN) model is used to establish the indirect health factor prediction model. Finally, to verify the adaptability of the proposed method to different types of batteries with different aging levels, both datasets from our own laboratory and the datasets from NASA Ames Research Center are used for experimental validations. The comparative experiments demonstrate that the proposed RUL prediction method is simple, accurate, and practical.

Seismic Response of Utility Tunnel in Trapezoidal Backfilled Soil Under P Wave and Amplification Effect of Ground Motion

ABSTRACT For the seismic risk of utility tunnel in trapezoidal backfilled soil and its possible amplification effect of ground motion, the seismic response of utility tunnel in trapezoidal backfilled soil under P wave is studied by a high-precision indirect boundary element method (IBEM) with the idea of “partition fit.” The results show that the peak surface displacement appears on the backfill surface, and the softer the backfilled soil, the greater the peak surface displacement; the peak vertical displacement at oblique incidence is generally smaller than that at vertical incidence; the existence of utility tunnel can restrain the incidence wave to a certain extent, especially for the low-frequency wave; the peak displacement and stress of utility tunnel in the soft backfilled soil are all greater than that in stiff backfilled soil; the peak stress of utility tunnel at oblique incidence is greater than that at vertical incidence; the stress concentration occurs at the axillary corner; and the stress in the inner wall of utility tunnel is greater than that in the outer wall. The similar conclusions could be further confirmed from the time history analysis. The research results can provide some reference for the seismic design of utility tunnel in the backfill site and the evaluation of seismic performance of near surface pipeline, etc.

Applying indirect reference interval method for the reference interval appropriateness assessment: A retrospective study from a medical center

Applying indirect reference interval method for the reference interval appropriateness assessment: A retrospective study from a medical center

Influence of different pre-treatments on the resin infiltration depth into enamel of teeth affected by molar-incisor hypomineralization (MIH)

ObjectivesThis in vitro pilot study aimed to evaluate whether different pre-treatments (demineralization, deproteinization, (chemo-)mechanical reduction of the surface layer) influence the penetration depth of a resin infiltrant into MIH-affected enamel compared to initial carious lesions. MethodsThirty extracted human permanent molars with non-cavitated initial carious lesions (n = 5) or MIH (n = 25) were chosen and randomly assigned to six experimental groups: IC: initial caries; M: MIH; MN: MIH, 5.25% sodium hypochlorite; MM: MIH, microabrasion; MA: MIH, air abrasion; MAN: MIH, air abrasion and 5.25% sodium hypochlorite. A modified indirect dual fluorescence staining method was adopted to assess the penetration depth (PD) of the resin infiltrant and the lesion depth (LD) by confocal laser scanning microscopy (CLSM). Exemplarily, scanning electron microscopic (SEM) images were captured. The relationship between group assignment and penetration/lesion depth was estimated using a linear mixed model incorporating the tooth as random effect (two observations/tooth). The significance level was set at p < 0.05. ResultsFor MIH-affected molars, the mean PD (in µm; median, [minimum-maximum]) were M (178.2 [32.5–748.9]), MN (275.6 [105.3–1131.0]), MM (48.7 [0.0–334.4]), MA (287.7 [239.4–491.7]), and MAN (245.4 [76.1–313.5]). Despite the observed differences in PD between the groups, these could not be statistically verified (Bonferroni, p = 0.322). The percentage penetration was significantly higher for IC than for MIH groups (Bonferroni, p < 0.05). SignificanceCompared to IC, resin infiltration into MIH-affected enamel ist more variable. Different pre-treatments influence the resin penetration into developmentally hypomineralized enamel to a fluctuating level.

An approach for end-to-end optimization of low-thrust interplanetary trajectories using collinear libration points

This article presents an approach to solve the problem of end-to-end optimization of the low-thrust interplanetary trajectory. At first, the problem of optimizing low-thrust interplanetary trajectory, which passes through the collinear libration points near the planets of departure and arrival is considered. The obtained solutions from this problem can be used as an initial guess to solve the end-to-end optimization problem, i.e., to calculate interplanetary low-thrust trajectories that satisfy the necessary optimality conditions at the match points of the heliocentric and planetocentric segments of trajectory. The minimum-fuel problem is considered. An indirect method based on the maximum principle, and the continuation method is applied to optimize interplanetary spacecraft trajectories. Numerical examples of trajectories from the Earth orbit to the orbit around the destination planet (Mars and Jupiter) are given. The possibility of a significant reduction in the required characteristic velocity is shown in comparison with the estimates obtained by using the zero-radius sphere of influence model.

A New Attempt to Estimate Underground Soil Leakage through High-Density, Fixed-Point Monitoring in a Typical Karst Rocky Desertification Region

Understanding soil loss pathways in karst regions is crucial for erosion control. Combining high-density measurements of grid points with runoff plot monitoring, we attempt to use a new indirect method to study the characteristics of soil loss in karst rocky desertification areas of Salaxi Town, Guizhou province. One cycle year monitoring data of 12640 grid points were applied in the soil loss analysis. This study identifies underground leakage as the primary pathway of soil loss, with an mean soil leakage of 21.51 kg in potential areas, accounting for 83.12%, and an average leakage of 22.69 kg in in mild karst rocky desertification areas accounting for 81.48%. Mixed vegetation types (forest, shrub, and grass) were better at preventing surface soil loss but increased underground leakage compared to single vegetation types. The rainy season significantly influences soil erosion, accounting for 67.88% of total loss, with slight variations among different karst rocky desertification grades and vegetation types. Mean underground leakage rates during the rainy and dry seasons are 63.34% and 36.66%, respectively. Although this method still has certain limitations, it plays a positive role in revealing the mechanism of soil erosion processes in karst regions.

Large electrocaloric effect across the non-hysteretic electrostructural phase transition in lead-free (Ba0.88Ca0.12)(Ti0.94Sn0.06)O3 ceramics

Structural, dielectric, and electrocaloric properties were investigated in Pb-free ceramic (Ba0.88Ca0.12)(Ti0.94Sn0.06)O3 (BCST), synthesized using solid-state sintering method. Rietveld refinement of room temperature XRD data revealed the existence of pure perovskite tetragonal (P4mm) phase. Temperature-dependent XRD analyses confirmed a structural transition from tetragonal to cubic phase near 380 K. Temperature-dependent dielectric constant (εr) and specific heat capacity (Cp) confirmed the presence of thermal hysteresis in two phase transitions near 233±10K and 254±10K, and a non-hysteretic behavior at the Curie temperature (TC∼373±10K). A comprehensive Raman study corroborated the existence of phase transitions. Electrocaloric properties were determined using indirect method utilizing the non-hysteretic nature acrossTC. A large adiabatic temperature change of |∆T| = 0.52 K, isotropic entropy change |∆S| = 0.68 J/kg.K, electrocaloric coefficients, |∆T/∆E |= 0.311 K.mm/kV and |∆S/∆E| = 0.41 J.mm/K.kg.kV were obtained at 380 K for an electric field of 16.7 kV/cm. Obtained value of |∆T/∆E| is relatively good, reported among other BaTiO3-based ceramics.

Indirect measurement of process parameters in peripheral end milling based on acoustic emission signals

In machining, current methods for online estimation of cutting parameters heavily rely on piezoelectric dynamometers. Albeit their high precision, integration into industrial environments is limited due to high cost and practical machine mounting constraints. To address this challenge, this study presents an indirect measurement method of the cutting depths in peripheral milling based on acoustic emission sensors. The proposed method involves extracting time-based features from a tailor-made envelope of the acoustic emission signal, identifying transitions between cutting phases from its waveform, and using these features to estimate radial and axial depths of cut through a geometric model of the tool-workpiece contact zone. Experiments show that this method can achieve relative errors below 5% in measuring the depths of cut, approaching the precision levels of piezoelectric dynamometers. This suggests that acoustic emission is an alternative process variable, enriching the spectrum of monitoring systems traditionally dependent on the measurement of cutting forces.

A differential-based method for correcting ultra-short baseline positioning results

The primary factors influencing the positional accuracy of an ultra-short baseline (USBL) system are errors in sound speed, delay, installation deviation, and the bending of sound rays. Premised on the USBL positioning model, an error contribution model including ranging error, delay error, sound speed error and array element installation deviation was constructed. In parallel, an indirect difference correction method with additional coefficients was proposed based on the geometric correlation of the error function model. Specifically, a reference beacon was deployed on the seabed, and differential correction was achieved by directly computing target coordinates, integrating them with the positional data from the reference beacon. The proposed method demonstrated efficacy in mitigating errors associated with gradual variations or pronounced geometric correlations, including discrepancies in sound speed, bending of sound rays, and deviations in the installation of array elements. The correction method was applied to the USBL positioning, and the simulation results show that the proposed method notably enhanced both accuracy and consistency in positioning, particularly in shallow water environments characterised by significant sound speed errors. The sea trial data from the R/V Dayang Yihao in the Western Pacific demonstrate that the proposed method can effectively mitigate the errors induced by sound ray bending in deep-sea environments. The mean absolute error (MAE) and standard deviation (STD) were reduced by 51.3% and 55.3%, respectively, compared with the results of the USBL direct solution.

Indirect temperature protection of an asynchronous generator by stator winding resistance measurement with superimposition of high-frequency pulse signals

Indirect temperature protection of an asynchronous generator by stator winding resistance measurement with superimposition of high-frequency pulse signals

Catastrophic costs for tuberculosis patients in India: Impact of methodological choices.

As financial risk protection is one of the goals towards universal health coverage, detailed information on costs, catastrophic costs and other economic consequences related to any disease are required for designing social protection measures. End Tuberculosis (TB) Strategy set a milestone of achieving zero catastrophic cost by 2020. However, a recent literature review noted that 7%-32% TB affected households in India faced catastrophic cost. Studies included in the review were small scale cross-sectional. We followed a cohort of 1482 notified drug-susceptible TB patients from four states in India: Assam, Maharashtra, Tamil Nadu, and West Bengal to provide a comprehensive picture of economic burden associated with TB treatment. Treatment cost was calculated using World Health Organization guidelines on TB patient cost survey and both human capital and output approaches of indirect cost (time, productivity, and income loss related to an episode) calculation were used to provide the range of households currently facing catastrophic cost. Depending on choice of indirect cost calculation method, 30%-61% study participants faced catastrophic cost. For over half of them, costs became catastrophic even before starting TB treatment as there was average 7-9 weeks delay from symptom onset to treatment initiation which was double the generally accepted delay of 4 weeks. During that period, they made average 8-11 visits to different providers and spent money on consultations, drugs, tests, and travel. Following the largest cohort of drug-susceptible TB patients till date, the study concluded that a significant proportion of study participants faced catastrophic cost and the proportion was much higher when income loss was considered as indirect cost calculation method. Therefore, ensuring uninterrupted livelihood during TB treatment is an absolute necessity. Another reason of high cost was the delay in diagnosis and costs incurred during pre-diagnosis period. This delay and consequently, economic burden, can be reduced by both supply side (intense private sector engagement, rapid diagnosis) and demand side (community engagement) initiatives. Reimbursement of expenses incurred before treatment initiation could be used as short-term measure for mitigating financial hardship.