Indigenous Medicinal Plants Research Articles

Evaluation of Anti-malarial Activity of Brassica Juncea, Glinus Oppositifolius, and Barringtonia Acutangular Against Plasmodium Falciparum Strain

Malaria, caused by the Plasmodium parasite, contributes to a significant global health burden that disproportionally affects those living in developing nations. The majority of cases are caused by the species P. falciparum and responsible for the a million deaths each year worldwide. The aim of the present study was to evaluate extracts of three indigenous medicinal plants- Raishorisha, Brassica juncea; Gimma shak, Glinus oppositifolius and Hijal, Barringtonia acutangula In vitro anti-plasmodial activities against the 3D7 laboratory strain of Plasmodium falciparum, which is sensitive to all drug was tested. HRP2 ELISA assay was used to evaluate the in vitro inhibitory activity of the extracts. Plant extracts showed moderate to good anti parasitic effects. Highly promising anti-plasmodial activity was found in the extract of Brassica juncea. 50% inhibitory concentration (IC50) 3D7: 0.00905 μg/ml (methanol extract), and Glinus oppositifolius had a good activity (IC50) 3D7: 13.8 μg/ml (methanol extract). A moderate activity (23.8 μg/ml) was found in the methanol extracts of B. acutangula. These results demonstrate that methanol extracts of B. juncea and G. oppositifolius may have antimalarial agents even in their crude form. The isolation of compounds from these two plants seems to be of special interest for further anti-malarial studies. Bangladesh J. Zool. 51(2): 205-216, 2023

Medicinal Importance of Solanum nigrum Linn; A Review

Solanum nigrum (Black nightshade) is an indigenous medicinal plant that has been utilized in traditional medical systems for ages. S. nigrum includes bioactive substances such as alkaloids, flavonoids, steroids, and saponins, according to phytochemical research. Extracts and isolated chemicals indicate antioxidant, anti-inflammatory, antibacterial, antifungal, anti-diabetic, anti-cancer, immune-stimulating, therapeutic, and heart-protective effects. S. nigrum extracts, in particular, limit cancer cell growth, minimize chemically induced organ damage, alter immunological function, and provide protection against oxidative stress, according to animal and cell culture studies. S. nigrum has traditionally been used for the prevention of symptoms such as discomfort, inflammation, infections, and problems with the gastrointestinal tract. Overall, this comprehensive study reveals the varied therapeutic qualities of S. nigrum that demand further exploration.

Influence of Traditional Medicine as Initiative for Rural Tourism and Poverty Reduction Strategy Tanzania: A Case of Kisarawe District

Despite recent scientific advancement and globalization, traditional medicines and complementary/alternative medicine are still primary sources of health care, livelihoods and income generation among local communities falling under Rural Tourism (RT). This study assessed the influence of traditional medicine initiative as a rural tourism strategy inter alia for poverty reduction in Kisarawe district in Tanzania. The main objective was to examine the local community perception on traditional medicine administered by traditional healers whether it has impact in promoting community health compared to modern medicines; but also, as eco-tourism strategy for poverty reduction; while sustaining environmental protection and conservation of various bio-diversities. The study employed mixed methods included structured questionnaires, key informants’ interviews, application of Likert scale range from 1 to 7 in data collection from a sample size of 100 respondents. Other methods entailed direct field observation and reviews of relevant literature. SPSS software version 20 was used to analyze multivariate analysis. Results showed willingness of community members to undergo training on improvement of knowledge on traditional medicines supported by tourism programmes, government policies and regulations for sustainable RT, poverty reduction, environmental protection and conservation. The study concluded that, community perception on traditional medicine positively moderates the relationship between rural tourism development and poverty reduction; however, there was limited co-ordination of tourism activities; and insufficient collaboration between the public and private sector. It recommended that; future research should network with traditional healers in order to know more indigenous medicinal plant species in order to formalize their application in public health while promoting eco-tourism for social economic development of local communities in Kisarawe district.

Exploring Indigenous Medicinal Plants for Managing Diabetes Mellitus in Uganda: Ethnobotanical Insights, Pharmacotherapeutic Strategies, and National Development Alignment

Diabetes Mellitus (DM) stands as a pressing global health concern, particularly in Uganda, where its prevalence mirrors global trends driven by urbanization, lifestyle changes, and genetic predispositions. This study delves into Uganda's rich heritage of medicinal plants, investigating their use in managing DM within local communities. A comprehensive review was conducted, exploring the epidemiology and pathophysiology of DM in Uganda, emphasizing genetic predispositions, lifestyle factors, and the healthcare landscape. The study unveils indigenous medicinal plants employed for DM management, detailing their usage, preparation, and potential therapeutic properties. Additionally, the pharmacotherapeutic landscape for DM management, encompassing oral hypoglycemic agents, injectable therapies, and adjunctive medications, is scrutinized in alignment with Uganda's healthcare policies. Moreover, the study aligns strategies for DM management with Uganda's National Development Plan (NDP), outlining an integrative approach for healthcare infrastructure, primary care strengthening, sustainable financing, health information systems, and collaborative partnerships. Keywords: Diabetes Mellitus, Medicinal Plants, Uganda, Ethnobotany, Pharmacological Evaluation, National Development Plan, Integrated Healthcare Strategies

Exploring Indigenous Medicinal Plants for Managing Diabetes Mellitus in Uganda: Ethnobotanical Insights, Pharmacotherapeutic Strategies, and National Development Alignment

Diabetes Mellitus (DM) stands as a pressing global health concern, particularly in Uganda, where its prevalence mirrors global trends driven by urbanization, lifestyle changes, and genetic predispositions. This study delves into Uganda's rich heritage of medicinal plants, investigating their use in managing DM within local communities. A comprehensive review was conducted, exploring the epidemiology and pathophysiology of DM in Uganda, emphasizing genetic predispositions, lifestyle factors, and the healthcare landscape. The study unveils indigenous medicinal plants employed for DM management, detailing their usage, preparation, and potential therapeutic properties. Additionally, the pharmacotherapeutic landscape for DM management, encompassing oral hypoglycemic agents, injectable therapies, and adjunctive medications, is scrutinized in alignment with Uganda's healthcare policies. Moreover, the study aligns strategies for DM management with Uganda's National Development Plan (NDP), outlining an integrative approach for healthcare infrastructure, primary care strengthening, sustainable financing, health information systems, and collaborative partnerships. Keywords: Diabetes Mellitus, Medicinal Plants, Uganda, Ethnobotany, Pharmacological Evaluation, National Development Plan, Integrated Healthcare Strategies

Ethnopharmacology of medicinal plants used by the Tenggerese community in Bromo Tengger Semeru National Park, Indonesia

Abstract. Bhagawan WS, Ekasari W, Agil M. 2023. Ethnopharmacology of medicinal plants used by the Tenggerese community in Bromo Tengger Semeru National Park, Indonesia. Biodiversitas 24: 5464-5477. Bromo Tengger Semeru National Park is a repository of biodiversity with profound cultural significance. The Tenggerese community residing within the park possesses rich ethnopharmacological knowledge, using medicinal plants for various ailments. This study aims to comprehensively explore the medicinal plant diversity, traditional uses, and potential pharmacological activities among the Tenggerese people. Ethnopharmacological data was gathered through interviews with informants in seven Tenggerese villages. Ethnopharmacological indices like Species Use Value (SUV) and Fidelity Level (FL) were calculated to identify the most important medicinal plants. Phytochemical analysis of selected medicinal plants was conducted using UPLC-QTOF-MS/MS, and its pharmacological potential was assessed through antibacterial tests. A total of 124 medicinal plant species from 54 families were documented. The Tenggerese community utilizes plants to treat diverse diseases, with reproductive healthcare being prominently featured. Elaeocarpus longifolius emerged as a key species with high SUV and FL values. Phytochemical analysis identified 25 compounds, including major and minor compounds, already known for their pharmacological activities elsewhere. Elaeocarpus longifolius extract showed inhibitor activity against both gram-positive and gram-negative bacteria. The findings contribute to bridging traditional knowledge and modern scientific research, offering potential avenues for the development of drug candidates from indigenous medicinal plants.

An Insight on Use of Indigenous Medicinal Plants to Cure Common Communicable Diseases and Chronic Non-Communicable Diseases in West Champaran District, Bihar, India

An Insight on Use of Indigenous Medicinal Plants to Cure Common Communicable Diseases and Chronic Non-Communicable Diseases in West Champaran District, Bihar, India

Antimicrobial Activities of Some Constituents Isolated from a Kenyan Medicinal Plant, Capparis fascicularis DC

Background of the Study. Capparis fascicularis DC. is an indigenous medicinal plant belonging to the family Capparaceae found in Nyandarua County, Nairobi, Kenya, and many parts of Africa. It is a shrub whose roots are used traditionally to treat colds. Aim. The aim of the present study is to carry out antimicrobial activities of solvent extracts of different parts of Capparis fascicularis, characterize the phytochemical constituents of the most active extract, and identify the most active compounds. Place and Duration of the Study. All the experiments were carried out in the departments of Chemistry and Microbiology, Kenyatta University, Nairobi, Kenya. Methodology. Petroleum ether, ethyl acetate, methanol, and water extracts from the leaves, stem bark, and root bark of C. fascicularis were screened against selected strains of both Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Salmonella typhimurium and Escherichia coli) bacteria using disc diffusion and tube dilution methods. Fractionation of the most active crude extract was carried out by column chromatography, and the fractions together with the most active crude extract were screened against the selected bacterial strains. The most active fraction was further fractionated, and the subfractions were screened against the bacterial strains to test for possible synergistic effects between the subfractions and their constituents. The most active fraction was then analysed by GC-MS and LC-ESI-MS methods to identify the major constituents. Results. The ethyl acetate extract of C. fascicularis root bark (CFR2) showed a significant in vitro antibacterial activity. From the seven fractions of CFR2 obtained, fraction 2 (F2) had the lowest MIC value and was thus most active. Moreover, F2 was found to be more active compared to the four subfractions obtained from it. This suggested that constituents of F2 worked in synergy. Fraction 2 contained phenols, terpenes, and flavonoids. Two compounds were identified by GC-MS as 2,4-di-tert-butylphenol and (E,E)-2,4-decadienal, while three compounds were identified by LC-ESI-MS as tanshinone II A, cryptotanshinone, and danshensu. Conclusion. The study revealed that CFR2 is the most active extract on bacteria, suggesting that most antimicrobial compounds are concentrated in the roots of C. fascicularis. A follow-up study is directed towards chromatographic separations to obtain the other chemical constituents and screen them against various strains of bacteria.

EVALUATION AND CONSERVATION OF BIODIVERSITY OF PLANTS USED FOR MEDICINAL PURPOSE

India is a very rich hub of plant biodiversity, many of those are therapeutically and medicinally useful. The rich resources are disappearing at an alarming state because of over-exploitation. Some of the endangered medicinal plants are Saussaurea lappa, Picrorrhiza kurroa, Swertia chirata, Holostemma annnularis, Rauwolfia serpenti-na. Normally there are two methods of conservation: in situ and ex situ conservation. Many techniques were also followed in ancient times to conserve or cultivate plants. There is a need to conserve the medicinal plants to prevent their total extinction from the natural flora. The expanding trade in medicinal plants has implications for the survival of several plant species. Growing demand for therapeutic products from indigenous medicinal plants, itself has positive effect of increased interest in cultivation, which seems a perfect option for improving smallholder farmers’ livelihoods, as well as sustaining the availability of these resources for future generations. Cultivation of medicinal plants provides feasible solutions to pharmaceutical organization, while effectively con-serving threatened indigenous biodiversity. The purpose of this paper is to justify and emphasize the need for the evaluation and cultivation of medicinal plants.

Optimizing extraction of Pelargonium sidoides roots: Impact of ethanol concentration on biological activity of extracts

Pelargonium sidoides DC. (Geraniaceae) is an important indigenous medicinal plant in South Africa, historically employed by various ethnic groups to treat respiratory and gastrointestinal ailments. The proprietary herbal tincture, Umckaloabo®, utilizes an ethanolic extract (EPs® 7630) from the roots of P. sidoides, and has demonstrated effectiveness in alleviating symptoms of respiratory infections.P. sidoides roots contain numerous highly oxygenated coumarins and phenolic metabolites, notably the marker compound umckalin. While Umckaloabo® is prepared using 11 % ethanol extraction, the South African commercial market predominantly employs 60 % ethanol extraction due to its consistent umckalin yield and antimicrobial activity. The effects of these extraction methods on chemical composition and in vitro pharmacological activity remain poorly understood.This study confirmed superior antibacterial and antifungal activity in the 60 % ethanol extracts prepared from six root samples compared to the 11 % ethanol extracts. MIC values for both Gram-negative and Gram-positive bacteria ranged from 0.078 to 2.5 mg/mL in the 60 % extracts. Remarkably, two of the root extracts exhibited excellent to very good activity against C. albicans and C. neoformans with MIC values of 0.039 and 0.078 mg/mL, respectively.A positive correlation was identified between total minimum inhibitory concentration (MIC) levels and polyphenol content, rather than umckalin levels. The influence of these extracts on the pro-inflammatory cytokine IL-6 was assessed. Both 60 % and 11 % root extracts of P. sidoides at 100 µg/mL significantly reduced IL-6 production, with the 60 % extracts demonstrating a more pronounced effect (p = 0.008).Statistical analysis revealed significant differences between 11 % and 60 % ethanol extractions in terms of average MIC overall, average Gram-negative MIC, average Gram-positive MIC, fungal MIC, and IL-6 levels. Extracts with higher polyphenol values exhibited superior antimicrobial activity and antioxidant potential, suggesting that polyphenol content may serve as a more reliable indicator of antimicrobial activity than umckalin levels. Additionally, polyphenol levels in the roots may vary with altitude and other environmental factors, warranting further research.

Phytochemical profiles and novel biofunctions of Dillenia ovata Wall. ex Hook.f. et Thomson: A Vietnamese indigenous medicinal plant

Phytochemical profiles and novel biofunctions of Dillenia ovata Wall. ex Hook.f. et Thomson: A Vietnamese indigenous medicinal plant

Potential of Selected African Medicinal Plants as Alternative Therapeutics against Multi-Drug-Resistant Bacteria.

Antimicrobial resistance is considered a "One-Health" problem, impacting humans, animals, and the environment. The problem of the rapid development and spread of bacteria resistant to multiple antibiotics is a rising global health threat affecting both rich and poor nations. Low- and middle-income countries are at highest risk, in part due to the lack of innovative research on the surveillance and discovery of novel therapeutic options. Fast and effective drug discovery is crucial towards combatting antimicrobial resistance and reducing the burden of infectious diseases. African medicinal plants have been used for millennia in folk medicine to cure many diseases and ailments. Over 10% of the Southern African vegetation is applied in traditional medicine, with over 15 species being partially or fully commercialized. These include the genera Euclea, Ficus, Aloe, Lippia. And Artemisia, amongst many others. Bioactive compounds from indigenous medicinal plants, alone or in combination with existing antimicrobials, offer promising solutions towards overcoming multi-drug resistance. Secondary metabolites have different mechanisms and modes of action against bacteria, such as the inhibition and disruption of cell wall synthesis; inhibition of DNA replication and ATP synthesis; inhibition of quorum sensing; inhibition of AHL or oligopeptide signal generation, broadcasting, and reception; inhibition of the formation of biofilm; disruption of pathogenicity activities; and generation of reactive oxygen species. The aim of this review is to highlight some promising traditional medicinal plants found in Africa and provide insights into their secondary metabolites as alternative options in antibiotic therapy against multi-drug-resistant bacteria. Additionally, synergism between plant secondary metabolites and antibiotics has been discussed.

Indigenous medicinal plants used in folk medicine for malaria treatment in Kwara State, Nigeria: an ethnobotanical study

BackgroundFolk medicine is crucial to healthcare delivery in the underdeveloped countries. It is frequently used as a primary treatment option or as a complementary therapy for malaria. Malaria is a deadly disease which greatly threatens global public health, claiming incredible number of lives yearly. The study was aimed at documenting the medicinal plants used for malaria treatment in folk medicine in Kwara State, Nigeria.MethodsEthnobotanical information was collected from selected consenting registered traditional medicine practitioners (TMPs) through oral face-to-face interviews using in-depth, semi-structured interview guide. The ethnobotanical data were analysed, and descriptive statistical methods were used to compile them.ResultsSixty-two indigenous medicinal plants, including 13 new plants, used for malaria treatment were identified in this study. The TMPs preferred decoction in aqueous solvent (34%) and steeping in decaffeinated soft drink (19%) for herbal preparations. Oral administration (74%) was the main route of administration, while leaves (40%) and stem barks (32%) were the most dominant plant parts used in herbal preparations. The most cited families were Fabaceae (15%) and Rutaceae (6%), while Mangifera indica (77.14%), Enantia chlorantha (65.71%), Alstonia boonei (57.14%) followed by Cymbopogon citratus (54.29%) were the most used plants. Besides, the antimalarial activities of many of the plants recorded and their isolated phytocompounds have been demonstrated. Furthermore, the conservation status of 4 identified plants were Vulnerable.ConclusionThe study showed strong ethnobotanical knowledge shared by the TMPs in the State and provides preliminary information that could be explored for the discovery of more potent antimalarial compounds.

Characterization and antimicrobial evaluation of biomimetically synthesized silver nanoparticles using aqueous leaf extract of Morinda lucida Benth. (Rubiaceae)

Silver nanoparticles (AgNPs) are silver atom masses that are attracting widespread interest due to their diverse applications, particularly their activity as antimicrobial agents. Physico-chemical methods of AgNP synthesis are associated with high costs, high temperatures and toxic byproducts. Thus, the plant mediated pathway represents a better option. The indigenous medicinal plant Morinda lucida was employed in the fabrication of AgNPs. The nanoparticles were characterized using different analytical techniques and also evaluated for their antimicrobial potential. Phytochemical screening of the plant was also carried out. For the synthesis, 10 ml of aqueous M. lucida leaf extract was added to 90 ml of freshly prepared 3 mM silver nitrate (AgNO3) solution in a flask. The mixture was allowed to stand at ambient temperature, in a dark cupboard for 48 hours. Positive AgNP synthesis, indicated by a colour change from red to brown was further validated by UV-vis spectroscopy wherein an absorption peak at 460.51 nm was recorded. The utilitarian aspects of the particles were further characterized using scanning electron microscopy (SEM), fourier transform infrared (FTIR) spectroscopy, dynamic light scattering (DLS), X-ray diffraction (XRD) and energy dispersive X-ray spectroscopy (EDX). The SEM images showed that particles were round to irregular in shape. Amide, amine, alkene and alkynes were the most occurring functional groups from the FTIR spectra. Quantitative phytochemical analysis revealed the presence of flavonoids, terpenoids, phenols, reducing sugars and alkaloids in varying amounts, which play a significant role in the synthesis and stabilization of the AgNPs. The XRD diffractogram of AgNPs showed two peaks at 45.53° and 77.17° that correspond to miller indices of (200) and (311) respectively and an average crystalline size of 62.60 nm obtained using the Debye-Scherrer’s formula. The DLS result indicated a Z–average size of 235.1 nm and a polydispersity index (PDI) of 0.4. EDX analysis showed that elemental silver (Ag) had the highest atomic concentration of 64.50 %. Using the agar well diffusion assay, the nanoparticles exhibited antimicrobial activity against P. aeruginosa (bacteria) and A. flavus (fungi). It can be concluded that M. lucida is capable of synthesizing stable, small-sized AgNPs with antimicrobial potential.

Network pharmacology combined with molecular docking and in vitro verification reveals the therapeutic potential of Delphinium roylei munz constituents on breast carcinoma.

Delphinium roylei Munz is an indigenous medicinal plant to India where its activity against cancer has not been previously investigated, and its specific interactions of bioactive compounds with vulnerable breast cancer drug targets remain largely unknown. Therefore, in the current study, we aimed to evaluate the anti-breast cancer activity of different extracts of D. roylei against breast cancer and deciphering the molecular mechanism by Network Pharmacology combined with Molecular Docking and in vitro verification. The experimental plant was extracted with various organic solvents according to their polarity index. Phytocompounds were identified by High resolution-liquid chromatography-mass spectrometry (HR-LC/MS) technique, and SwissADME programme evaluated their physicochemical properties. Next, target(s) associated with the obtained bioactives or breast cancer-related targets were retrieved by public databases, and the Venn diagram selected the overlapping targets. The networks between overlapping targets and bioactive were visualized, constructed, and analyzed by STRING programme and Cytoscape software. Finally, we implemented a molecular docking test (MDT) using AutoDock Vina to explore key target(s) and compound(s). HR-LC/MS detected hundreds of phytocompounds, and few were accepted by Lipinski's rules after virtual screening and therefore classified as drug-like compounds (DLCs). A total of 464 potential target genes were attained for the nine quantitative phytocompounds and using Gene Cards, OMIM and DisGeNET platforms, 12063 disease targets linked to breast cancer were retrieved. With Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment, a total of 20 signalling pathways were manifested, and a hub signalling pathway (PI3K-Akt signalling pathway), a key target (Akt1), and a key compound (8-Hydroxycoumarin) were selected among the 20 signalling pathways via molecular docking studies. The molecular docking investigation revealed that among the nine phytoconstituents, 8-hydroxycoumarin showed the best binding energy (-9.2kcal/mol) with the Akt1 breast cancer target. 8-hydroxycoumarin followed all the ADME property prediction using SwissADME, and 100 nanoseconds (ns) MD simulations of 8-hydroxycoumarin complexes with Akt1 were found to be stable. Furthermore, D. roylei extracts also showed significant antioxidant and anticancer activity through in vitro studies. Our findings indicated for the first time that D. roylei extracts could be used in the treatment of BC.

A Review Study on Alternative Conservation and Management Methods to Sustain Medicinal Plants in South Africa

The use of indigenous medicinal plants is still prevalent as the most trusted form of health care, predominantly in developing countries. Overuse of medicinal plant resources, coupled with the negative impacts of unpredictable rainfall and rising temperatures, necessitated the development of local methods to conserve medicinal plants. These indigenous conservation methods have proved to be failing and aggravating threats to medicinal plants. This study aimed to review the alternative conservation and management methods to protect medicinal plants in South Africa. A review of the literature presents in situ, ex situ, natural reserves, wild nurseries, botanical gardens, and seed banks as alternative conservation methods proposed and used by scientists to conserve and manage medicinal plant species. These methods are Western practices introduced to the local communities in an effort to conserve and protect the indigenous medicinal plant species for future use and as a cultural heritage. From a qualitative standpoint, this study adopted the interpretivist research design to offer support to employ the systematic review method. Seminal studies on this subject were purposively collected using keywords extracted from the research topic. The collected data was analysed using the inductive Textual Content Analysis (TCA) method. The results of this study reveal that there are various conservation methods that are implemented as strategies to safeguard the existing medicinal plants, and this proves if these methods are implemented correctly these plants will still be available for future use. It is concluded and recommended that the demand for medicinal plants imposes huge threats to their anticipated availabilities, therefore, the relevant stakeholders need to take urgent corrective measures ­concerned parties should be consistently exposed to improved resources, advanced training and better education about the benefits and importance of these plants. Keywords: Medicinal plants, conservation method, In situ, natural resource

Lead biosorption profiling of endophytic Aspergillus flavus SGE34 isolated from Cleome viscosa Linn.

ABSTRACT Lead is an environmental pollutant that causes remarkable damage to various organs in the human body, especially the nervous system. Removal of lead by conventional methods is costly, and therefore, in the current scenario, biosorption using fungi is extensively explored as they provide good metal uptake systems. The present study evaluated the Pb (II) biosorption potential of endophytic fungi Aspergillus flavus SGE34. The fungal isolate was obtained from the root of an indigenous medicinal plant of the Chhattisgarh region named Cleome viscosa Linn. The biosorption potential of dead fungal biomass was optimized at different operating parameters like contact time, pH, and temperature. The maximum biosorption values were found at pH 6.0 with an equilibrium time of 150 minutes at 350C. The Fourier transform infrared spectroscopy study revealed that the pattern of new absorption bands, altered absorption intensity, and shift in wavenumber of functional groups was deduced, due to interaction between metal ions and active sites of biosorbent. The present study concluded that A. flavus SGE34 has high metal tolerance and biosorption capacity; it could effectively remove lead from industrial effluents.

In-vitro antioxidant and cytotoxic activities of ethyl acetate extract of Holigarna ferruginea

Higher plants have long been used as traditional medicines to treat human ailments. Approximately 80% of people worldwide utilize plants as safe sources of medicines to heal human diseases via a totally new medicinal system. Holigarna ferruginea is an indigenous medicinal tree plant in the Anacardiaceae family. The plant has a wide range of physiologically active chemicals. GC-MS was used to screen phytochemical substances, while FTIR was used to identify functional groups. GC-MS study revealed 10 major bioactive phytochemical substances that belong to functional groups such as secondary amines, alcohols, ethers, esters, carboxylic acids, and anhydrides. These diverse active phytochemicals have been discovered to have a wide range of actions that may aid in the prevention of illnesses. Higher quantities of phytochemical substances were found in ethyl acetate extracts of leaves. As a result, the extract possesses anticancer and antioxidant activities against Humans Breast cell lines (MCF-7). The viability was reduced when the concentrations of the ethyl acetate extract of H. ferruginea leaves were increased and it may help in the discovery of an ideal therapeutic agent in novel drugs as well as nutritional supplements.

Preliminary studies on in vitro antioxidant and retardation of essential carbohydrate hydrolysing enzymes by some indigenous South African medicinal plants

Preliminary studies on in vitro antioxidant and retardation of essential carbohydrate hydrolysing enzymes by some indigenous South African medicinal plants

E-DATABASEINFORMATION OF INDIAN MEDICINAL PLANTS AND ITS ACTIVE INGREDIENTS

India is a land of indigenous medicinal plants and diverse wildlife. Since ancient time, Indians are usingthese plants and their extracts as medicine for the treatment of human diseases, and termed as traditional medicine (TM). Ayurveda, an alternative TM system, is well known across the Indian subcontinent. The oldest manuscript on Ayurveda practice is SushrutaSamhitabySushruta,written in 6th century BCE. It emphasises the use of medicinal plants and its parts with healing properties for health practices. The phytochemicals of a medicinal plant encompasses essential oils, flavonoids, saponins, steroids, phenylpropanoids and waxes. These phytochemicals are synthesized by plants as secondary metabolites, but, have numerous industrial applications. Though, we have these ancient medical practicing systems, but their documentation, dosage, inhibitory concentrations, where-abouts and the origin of medicinal plants is still not up to date. Therefore, there is a need for a repository where all the information regarding the medicinal plants and its properties should be listed. Here, we are discussing all the comprehensive information regarding all these databases of indigenous medicinal plants, which will apprehend our knowledge and understanding about Indias vast diverse medicinal flora.