During the COVID-19 outbreak – a paradigmatic global health challenge – multiple African countries, including Tanzania, mobilised indigenous forms of healing as both preventive and curative measures to curb the pandemic. However, despite this effort to curtail the crisis, the place of indigenous medical knowledge in decolonising global health interventions remains unexamined. Drawing on ethnographic fieldwork in Tanzania, as well as political speeches and newspaper sources, this paper examines how the government, under the late President John Pombe Magufuli, responded to the COVID-19 pandemic. The paper demonstrates that the late Magufuli’s approach to the pandemic, and especially the mobilisation of local practices of self-care like steaming with nyungu, stirred debates on decolonising global health and the role of African traditional medicines in the COVID-19 pandemic response. Building on scholarship regarding the efforts to promote indigenous healing knowledge in postcolonial states in Africa, I argue that colonial history and postcolonial political positionings towards this history were the ‘cause’ for Magufuli’s resistance towards global health interventions of COVID-19 in Tanzania. This draws our attention to the possibility of new thinking when it comes to how global health, colonialism, national politics, and local practices of self-care like nyungu, interact with one another in contemporary Tanzania.