Indoor air quality (IAQ) is a significant concern that affects our health. Recent studies show how poor IAQ amplifies the effects of airborne viruses, which endanger the health of the population relative to the COVID-19. This study aims to find the relationship among IAQ, the location of the air outlet valve and the behavior of the IAQ indicators in the cardiac care unit (CCU) at Namazi Hospital, Shiraz, Iran. In this context, the condition of the air outlet valve can play an important part in preparing a better IAQ. To test the hypothesis, articles based on IAQ guidelines have been studied. Also, certain emissions (CO2, CO, PM2.5 and PM10) have been measured, and the relationship between IAQ, the location of the air outlet valve and the behavior of these emissions in the patient’s room at Namazi Hospital. This room has been analyzed using computational fluid dynamics for the prediction of the specification of incoming air flow particles. Also, a Eulerian–Lagrangian model was used. In constant, the turbulence model (realizable k – ԑ) and discrete particle model were employed. The results show that when the outlet valve is placed on the wall at 20 cm, it decreased particle deposition in the room, and as a result, IAQ will be improved and at the same time, the chances of transmitting infectious diseases will be reduced. It is also indicated that a higher amount of particle deposition fraction (ca. 0.71) obtains when the outlet valve is located on the top of the wall.