Multiple Indicators Research Articles

The Spillover Effects of Public Attention and Real Estate Market: A Case Study from Shanghai, China

The real estate industry is closely linked to the national economy, and fluctuations in house prices have long been a major focus of public attention. This study explores the relationship between public attention and the real estate market, using public attention as a focal point. It systematically explains how public attention affects investment decisions in real estate. Taking Shanghai as a case, this study empirically examines the dynamic time-varying relationship between public attention and house prices, sales, investment and floor space completed by building a Time-Varying Parameter Vector Autoregression (TVP-VAR) model with data from 2011 to 2024.The research shows that the spillover index of house prices on public attention is positive and house prices acting as the sender of the shock, with rising house prices boost public attention. Conversely, the spillover index of public attention on house prices is negative, with public attention acting as the receiver of the shock. Based on the empirical results, it is recommended to incorporate public attention into the real estate market monitoring system, observe the real estate industry using multiple indicators, and enhance the regulation of online media to ensure policy transparency.

Intelligent Optimization and Impact Analysis of Energy Efficiency and Carbon Reduction in the High-Temperature Sintered Ore Production Process

The coordinated optimization of energy conservation, efficiency improvement, and pollution reduction in the sintering production process is vital for the efficient and sustainable development of the sintering department. However, previous studies have shown shortcomings in the multi-objective collaborative optimization of sintering systems and the quantification of pollutant impacts. To address these, this paper proposes a multi-objective optimization method integrated with the NSGA-III algorithm and establishes an integrated system optimization model for sintered ore production and high-temperature waste heat recovery. The results demonstrate significant improvements: energy utilization efficiency increased by 0.67%, energy consumption decreased by 17.3 MJ/t, production costs were reduced by 11.45 CNY/t, and the emissions of CO2, SO2, and NOx were reduced by 0.464 kg/t, 0.034 kg/t, and 0.008 kg/t, respectively. Additionally, the study identified optimal configuration parameters and analyzed the quantitative impact of several key factors on multiple indicators. The results also show that reducing the water content of the mixture, decreasing the middling coal content in the fuel, and increasing the thickness of the material layer are effective strategies to reduce energy consumption and pollutant emissions in the sintering process. Overall, implementing these optimizations can bring significant economic and environmental benefits to the steel industry.

Percutaneous transhepatic biliary drainage in patients with cholestasis following liver transplantation.

Biliary strictures are among the most common complications following liver transplantation (LT). If endoscopic retrograde cholangiography fails, percutaneous transhepatic biliary drainage (PTBD) may serve as an alternative approach. Description of clinical important short- and long-term outcomes as well as outcome prediction following PTBD after LT are scarce. We analyzed outcomes of 56 liver-transplanted adults with biliary complications receiving a PTBD. We described the safety and longitudinal laboratory changes. We analyzed as endpoints, incidence of biliary complications, need for surgical biliary revision/re-LT and overall-survival at 12- and 60-months. We used simple comparison tests accordingly and performed competing risk analysis and multivariate competing risk regression as well as log-rank test and cox proportional hazard regression for further analysis. PTBD procedures had a high technical success rate (98%) and tolerable safety profile. Multiple laboratory indicators improved during follow-up (37 patients with complete biochemical follow-up). Incidence of subsequent biliary complications was highly dependent on the nature of present biliary strictures (Anastomotic stricture (AS): adjusted SHR: 0.26, 95% CI: 0.09-0.78, p = 0.016). Need for surgical biliary revision/re-LT remained below 15%. 12-month survival was significantly better, if drainage into the small intestine was achieved at first attempt compared to completely external drainage (internal: 92.9 vs. external: 67.9%, p = 0.018). Patients with AS had a numerically higher long-term-survival and higher C-reactive-protein (CRP) and lower body-mass-index (BMI) at baseline were significantly associated with inferior short- and long-term-survival. PTBD for biliary complications following LT had a high technical success and a tolerable safety profile. Incidence of subsequent biliary complications was highly dependent on the nature of biliary strictures and increased mortality was found in patients with higher CRP, lower BMI and failure of initial PTBD internalization.

High-precision IFM receiver based on random forest algorithm

Abstract The six-port network-based Instantaneous Frequency Measurement (IFM) receiver is widely utilized in industrial applications for signal frequency demodulation. However, current IFM receivers face the issue of low algorithmic demodulation accuracy (ACC). According to the four-channel output characteristics of the IFM receiver, we use the Random Forest algorithm to extract features, train and test the output voltage data set, and recognize frequency labels. The experimental results show that the ACC of the proposed algorithm reaches 0.9583, which is 13.99% higher than that of the traditional polynomial fitting algorithm. To evaluate the noise reduction performance of the algorithm, we add Gaussian white noise to the original data and demodulate the signal with noise. Comparative tests prove the advantages of the algorithm in high stability and flexibility. Finally, multiple model evaluation indicators demonstrate that the algorithm features strong applicability and robustness to the experimental data with IFM receiver.

Giardia antagonizes beneficial functions of indigenous and therapeutic intestinal bacteria during protein deficiency

ABSTRACT Undernutrition in children commonly disrupts the structure and function of the small intestinal microbial community, leading to enteropathies, compromised metabolic health, and impaired growth and development. The mechanisms by which diet and microbes mediate the balance between commensal and pathogenic intestinal flora remain elusive. In a murine model of undernutrition, we investigated the direct interactions Giardia lamblia, a prevalent small intestinal pathogen, on indigenous microbiota and specifically on Lactobacillus strains known for their mucosal and growth homeostatic properties. Our research reveals that Giardia colonization shifts the balance of lactic acid bacteria, causing a relative decrease in Lactobacillus spp. and an increase in Bifidobacterium spp. This alteration corresponds with a decrease in multiple indicators of mucosal and nutritional homeostasis. Additionally, protein-deficient conditions coupled with Giardia infection exacerbate the rise of primary bile acids and susceptibility to bile acid-induced intestinal barrier damage. In epithelial cell monolayers, Lactobacillus spp. mitigated bile acid-induced permeability, showing strain-dependent protective effects. In vivo, L. plantarum, either alone or within a Lactobacillus spp consortium, facilitated growth in protein-deficient mice, an effect attenuated by Giardia, despite not inhibiting Lactobacillus colonization. These results highlight Giardia’s potential role as a disruptor of probiotic functional activity, underscoring the imperative for further research into the complex interactions between parasites and bacteria under conditions of nutritional deficiency.

Empowerment through technology: domestic violence acceptance among Iraqi women in an intersectional context

BackgroundAcceptance of domestic violence against women refers to the belief that violence can be justified. Women’s attitudes towards domestic violence shape societal acceptance, victimization, disclosure, and help-seeking behaviors. This study explored the role of gender, socio-economic status, regional disparities, and empowerment in domestic violence acceptance among Iraqi women.MethodsUsing data from the 2018 Iraq Multiple Indicator Cluster Survey (MICS 6) with 19,443 married Iraqi women, this cross-sectional study employed logistic regression analyses to investigate individual, interpersonal, community, and societal determinants of domestic violence acceptance.Results48.4% of married Iraqi women accepted domestic violence, with higher acceptance in South/Central regions (62–73%). Factors associated with higher acceptance included lower education (aOR = 0.39, 95% CI: 0.35–0.45 for upper secondary education compared to preprimary or non), functional difficulties (aOR = 1.60, 95% CI: 1.40–1.83), marriage to blood-related spouses (aOR = 1.45, 95% CI: 1.36–1.54), and rural residence (aOR = 1.20, 95% CI: 1.15–1.33). Conversely, owning a mobile phone (aOR = 0.47, 95% CI: 0.44–0.50) and using a computer/tablet (aOR = 0.34, 95% CI: 0.30–0.38) were associated with lower acceptance.ConclusionThese findings, given the lack of research on domestic violence among Iraqi women, highlight the urgent need for policy discussions supporting Sustainable Development Goals on gender equity and well-being. Enhanced access to technology could help women have better access to resources, support systems, and information, which would lower acceptance for domestic violence.

What determines the accessibility of early childhood education in Bangladesh?

This paper aims to understand the potential factors influencing the accessibility of early childhood education (ECE) in Bangladesh. Utilising data from the Multiple Indicator Cluster Survey (MICS) 2019, this study explored the influence of individual, household, socio-economic as well as geographical variables on ECE enrollment. It employed a comprehensive approach, which involved using descriptive statistics for univariate analysis, chi-square and t-statistics for bivariate analysis, and the logit model for multivariate analysis. The findings revealed that a child’s likelihood of attending an ECE program increases with their age, while those with functional difficulties and larger household sizes exhibit lower odds of attendance. Children with mothers possessing higher education levels demonstrated increased odds of ECE enrollment. Wealthy households and urban or Mymensingh division residency were associated with higher odds of ECE enrollment, while Barishal, Rajshahi, and Sylhet divisions indicated lower odds. To enhance ECE accessibility, the study recommends implementing a roadmap for ensuring universal early childcare and early education with an emphasis on socioeconomically underprivileged children, particularly in rural areas. Proposed strategies may include providing financial assistance to poor households and fostering public–private partnerships for ECE provision in remote regions like Barishal, Rangpur, Rajshahi, and Sylhet divisions. Moreover, it is crucial to make parents and communities aware about the significance of ECE in order to make sure that children ages 3–5 years are involved in ECE programs.

Fathering Promotes Child Development in Low- and Middle-Income Countries Through Specific “Active Ingredient” Caregiving Activities

SYNOPSIS Objective. We do not know which specific paternal caregiving practices are associated with more advanced child development in understudied low- and middle-income countries (LMICs). The current investigation attempts to identify such caregiving practices. Design. Maternal reports of six specific paternal caregiving practices which may be uniquely associated with early childhood development were examined in a sample of 159,959 families with 3- to 4-year-old children from 51 LMICs. Both father caregiving practices and early childhood development scores were quantified using measures from UNICEF’s Multiple Indicator Cluster Surveys. Linear regression models examined which paternal caregiving practices were associated with early childhood development after controlling for the contributions of mothers and children’s other caregivers engaging in the same practices as well as father residence in the home and multiple aspects of the physical home environment and national context. Results. When fathers read to their children, named/counted/drew with their children, or sang to their children, their children demonstrated more advanced overall development. When fathers read, named/counted/drew, and told stories to their children, their children also demonstrated more advanced development in literacy/numeracy and approaches to learning. Some effects depended on whether fathers resided in the home. Fathers naming/counting/drawing with their children was associated with more advanced child development in approaches to learning, and fathers reading to their children was associated with more advanced child socioemotional development only if fathers resided in the child’s home. Conclusions. Fathers reading to their children, naming/counting/drawing with their children, and singing to their children appear to be specific “active ingredients” that promote child development in LMICs. Some of these ingredients only actively promote child development when fathers reside in the child’s home environment. These practices should be supported and encouraged in policy and practice. Fathers’ caregiving matters for child development across a wide swath of LMICs in the world.

High-affinity T cell receptor ImmTAC® bispecific efficiently redirects T cells to kill tumor cells expressing the cancer testis antigen PRAME

Abstract PRAME (Preferentially expressed Antigen in Melanoma) is a cancer testis antigen expressed in several tumor indications, representing an attractive anti-cancer target. However, its intracellular location limits targeting by traditional methods. PRAME peptides are presented on the surface of tumor cells by human leukocyte antigen (HLA) molecules, indicating that a T cell receptor (TCR)-based strategy that redirects T cells to kill PRAME+ tumors could be a novel immunotherapeutic option. We confirm that PRAME protein is expressed in cutaneous melanoma, including rare subtypes with limited treatment options, as well as primary and metastatic lung, breast, endometrial and ovarian tumors. Furthermore, PRAME is expressed homogeneously across tumors with distinct oncogenic mutations, mutation burden, PD-L1 expression, immune infiltration and features of immune checkpoint resistance. Immunopeptidomic analysis of primary tumors detected HLA class I-restricted PRAME peptides. A TCR recognizing PRAME peptide SLLQHLIGL was engineered to high affinity and fused to a CD3 engaging domain to create a TCRxCD3 bispecific molecule (Immune mobilizing monoclonal TCR Against Cancer, ImmTAC®) with the ability to redirect polyclonal T cells to efficiently kill PRAME+ cells. The degree of T cell activation was positively correlated with peptide-HLA abundance, with as few as 10 epitopes per cell sufficient for target cell killing. Impaired ImmTAC®-redirected cytotoxicity of exhausted T cells was rescued using an anti-PD-1 antibody, supporting the use of a combination strategy to treat tumors with active PDL1-PD1 axes. Our data demonstrate selective and efficient T cell activation and killing by a PRAME-directed TCRxCD3 bispecific, supporting further investigation in multiple cancer indications.

Optimizing Pediatric Sedation: Evaluating Remimazolam and Dexmedetomidine for Safety and Efficacy in Clinical Practice.

Daily, children undergo countless investigations and interventions, which require sedation and immobilization to ensure safety and accuracy. This remains associated with a persistent risk of sedation-induced life-threatening events as children are particularly vulnerable to adverse medical events and complications. Consequently, there is an urgent need to increase the safety of pediatric sedation and anesthesia. An ideal approach involves the use of drugs with fewer intrinsic side effects. In this context, on the basis of their pharmacokinetic properties, remimazolam (RMZ) and dexmedetomidine (DEX) were evaluated for their suitability as ideal sedatives. RMZ and DEX, both of which are currently available in pediatric medicine, have shown great promise in initial publications. To date, only very limited data concerning RMZ in small children are available. RMZ is a novel, ultrashort-acting benzodiazepine that is metabolized by tissue esterase, largely independent of organ function. It has a context-sensitive half-life of approximately 10 min, with minimal accumulation even with prolonged use. Its effects can be completely reversed with flumazenil. DEX, an isomer of medetomidine, is a potent α2-receptor-agonist with multiple indications in anesthesia and intensive care medicine. It has coanalgesic potential, allows for 'arousal sedations' and has a low profile for cardiorespiratory side effects. DEX is metabolized in the liver and is predominantly excreted renally. Both drugs show potential in the prevention and treatment of delirium, with DEX having additional neuroprotective effects. DEX and RMZ possess several properties of an optimal sedative, including clinically insignificant main metabolites and a broad dosage range, indicating their potential to reduce the incidence of sedation-related life-threatening events in children. However, further clinical research is necessary to better evaluate their potential risks.

Boosting the Development and Management of Wind Energy: Self-Organizing Map Neural Networks for Clustering Wind Power Outputs

Aimed at the information loss problem of using discrete indicators in wind power output characteristics analysis, a self-organizing map neural network-based clustering method is proposed in this study. By identifying the appropriate representativeness and topological structure of the competition layer, cluster analysis of the wind power output process in four seasons is realized. The output characteristics are evaluated through multiple evaluation indicators. Taking the wind power output of the Hunan power grid as a case study, the results underscore that the 1 × 3-dimensional competition layer structure had the highest representativeness (72.9%), and the wind power output processes of each season were divided into three categories, with a robust and stable topology structure. Summer and winter were the most representative seasons. Summer had strong volatility and small wind power outputs, which required the utilization of other power sources to balance power supply and load demand. Winter featured low volatility and large wind power outputs, necessitating cooperation with peak-shaving power sources to enhance the power grid’s absorbability to wind power. The seasonal clustering analysis of wind power outputs will be helpful to analyze the seasonality of wind power outputs and can provide scientific and technical support for guiding the power grid’s operation and management.

Resource selection by a megaomnivore in a marine foraging habitat

AbstractHabitat‐based approaches to animal conservation are bolstered by an understanding of resource selection, that is, use of resources (i.e., habitat features) relative to their availability in the environment. Quantifying resource selection is especially valuable when data characterizing animal space use are limited, as is often the case with mobile and/or cryptic species. Documenting associations with habitat features can better inform management in space in time, while also revealing key insight into movement ecology and behavior. Here, we evaluate resource selection by a megaomnivore whose highly mobile nature within marine habitats has resulted in an incomplete understanding of drivers of space use. We used satellite telemetry to track 29 green turtles (Chelonia mydas) from an eastern Pacific foraging aggregation in San Diego Bay, California, USA during 2013–2023. Tracking produced 5023 Fastloc‐GPS points which we used to model selection for local environmental resources relative to their availability. We employed logistic models to evaluate associations with seagrass, bathymetry, and water temperatures, implementing a framework that additionally allowed us to explore the roles of season, diel period, and turtle body size. Our methods demonstrate an approach for down‐weighting observations according to assumed telemetry error and autocorrelation. Results from fine‐scale resource selection models provide evidence that green turtles in San Diego Bay select for eelgrass meadows (Zostera marina), particularly during the warmest months of the year, but the strength of this selection changes from day to night. We additionally found day–night shifts in depth and temperature selection that changed with turtle body size and season. We discuss these findings in the context of diel patterns in resting and foraging behavior in addition to seasonal changes in thermally sensitive metabolic rates. Our study documents resource associations and provides quantitative information for the management of sea turtle foraging populations and their habitats. We offer key insight into habitat use by green turtles in the eastern Pacific at a pivotal time when multiple indicators point to population growth and expansion within the region.

Multivariate Evaluation of Flash Drought Across the United States

AbstractThis study uses the flash drought intensity index (FDII) to develop a multivariate flash drought climatology for the contiguous U.S. using data from 2001 to 2021. The FDII method uses the rate of intensification (FD‐INT) and subsequent drought severity (DRO‐SEV) to determine when a flash drought occurred and the strength of the event. Overall, the results showed that flash drought occurrence and severity varied with season and region and were sensitive to the drought indicator used to compute the FDII. Precipitation‐based indicators identified more flash droughts across the western U.S. whereas soil moisture (SM) and evapotranspiration indicators identified more flash droughts across the central and eastern U.S. When assessed over the entire U.S., the most flash droughts were found when using an evaporative demand indicator. Though FD‐INT was larger than DRO‐SEV across the U.S. for most indicators, regional patterns were also evident in their relative importance. For example, a distinct east‐west gradient was present in the SM and evapotranspiration FD‐INT, with relatively large values in the central and eastern U.S. A combined data set synthesizing information from multiple indicators showed that the strongest flash droughts from a multivariate perspective were located in the central and southeastern U.S. A seasonal analysis revealed a distinct seasonal cycle in flash drought onset across the western and central U.S. Together, the results illustrate the need to use a multivariate framework to identify and characterize the occurrence and severity of flash droughts.

An evaluation of measurement invariance of Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition borderline personality disorder criteria across heterosexual, lesbian, gay, and bisexual adults.

There is a robust, yet poorly understood relationship between nonheterosexual orientation and borderline personality disorder (BPD), with lesbian, gay, and bisexual individuals evidencing greater BPD symptoms compared to heterosexual individuals. Recent evidence suggests possible psychometric bias in BPD diagnostic criteria leading to greater endorsement among sexual minority individuals, which hinders researchers' ability to make valid group comparisons. The present study utilized an epidemiological sample of 35,995 men and women to evaluate the extent of differential item functioning (DIF) among BPD criteria across sexual orientation groups using a multiple indicators multiple causes approach. All criteria except affective instability and emptiness indicated DIF for at least one sexual minority focal group, although both demonstrated DIF in sensitivity analyses. DIF was most consistently indicated for suicidality, efforts to avoid abandonment, and impulsivity. Contrary to predictions, DIF was mostly nonuniform with greater item discrimination for sexual minority groups compared to their heterosexual counterparts. Finally, all estimated effect sizes were small, suggesting that DIF was not practically meaningful and unlikely to impact the validity of group comparisons for BPD criteria across heterosexual and nonheterosexual men and women. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Anxiety, depression, and fear of cancer recurrence in head and neck cancer.

Patients with head and neck cancer (HNC) report some of the highest levels of psychological distress amid managing their disease as well as debilitating and disfiguring treatment side effects. Fear of cancer recurrence (FCR) is a top unmet need and concern of patients with HNC. Prior research suggests elevated symptoms of anxiety and depression are potential antecedents to FCR, but findings have been limited in HNC populations. The aim of the present study was to examine the early level and change in symptoms of anxiety and depression in relation to later change in FCR among patients with HNC. The study is a secondary analysis of data collected from 2011 to 2014 through the Head and Neck 5000 Study in the United Kingdom. A sample of 4,891 patients completed self-report longitudinal assessments of anxiety and depression symptoms at baseline, 4, and 12 months and FCR at 4 and 12 months. Utilizing multiple indicator latent change score modeling, results revealed baseline anxiety and increases in anxiety from baseline to 4 months were both positively associated with increases in FCR from 4 to 12 months. Neither baseline depression nor change in depression from baseline to 4 months were significantly associated with FCR change. Findings indicate that early level and increases in symptoms of anxiety were markers of increased FCR in patients with HNC. Future research may consider anxiety as a unique antecedent and maintaining factor of FCR and targeting anxiety early in the cancer trajectory may have downstream effects on FCR development. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

What factors are associated with early childhood development in Thailand? A cross-sectional analysis using the 2022 Multiple Indicator Cluster Survey.

Early childhood development is essential for lifelong health and well-being. This study aims to assess the proportion of children aged 24-59 months in Thailand who are developmentally on track using the Early Childhood Development Index 2030 (ECDI2030) and to explore associations with household socioeconomic characteristics and environments. A cross-sectional analysis was conducted using data from the 2022 Multiple Indicator Cluster Survey by the Thailand National Statistical Office. The developmental progress of 6557 children was evaluated across health, learning and psychosocial domains using ECDI2030 criteria. Multivariable logistic regression was used to assess associations between developmental status and household and participant characteristics. The study found that 81.3% of children were developmentally on track. Factors positively associated with being on track included being female (adjusted OR (AOR)=1.49), higher maternal education (AOR=2.02 for above secondary education), more books at home (AOR=1.59 for 3-9 books; AOR=2.40 for 10+ books) and increased screen time (AOR=1.68). Living in the Northern (AOR=0.45) and Northeastern (AOR=0.56) regions decreased the likelihood of being on track. Around 20% of children did not meet ECDI2030 milestones, highlighting the need for targeted policy interventions. Gender, region, maternal education, access to books and screen time were significant factors for developmental outcomes. Policies should prioritise support for parents, nurturing care and educational resources, particularly for socioeconomically disadvantaged groups.

Prescription Practices and Usage of Antimicrobials in a Tertiary Teaching Hospital in Rwanda: A Call for Antimicrobial Stewardship

Background: Antimicrobial resistance (AMR) is a global problem that results in high morbidity and mortality, particularly in low- and middle-income countries. Inappropriate use of antimicrobials is a major driver of AMR. This study aimed to evaluate the rate and quality of antimicrobial prescription and use at the University Teaching Hospital of Kigali (CHUK), a tertiary-referral teaching hospital. Methodology: A point prevalence survey (PPS) of antimicrobial prescription was conducted using the Global PPS tool, including a healthcare-acquired infection (HAI) module. Results: On the day of the PPS, 39.3% (145/369) of inpatients were prescribed at least one antimicrobial. Out of the 259 prescribed antimicrobials, 232 (89.6%) were antibacterials, of which 151 (65.1%) belonged to the watch group of the WHO AWaRe classification. The top three antibiotics prescribed were cefotaxime (87; 37.5%), parenteral metronidazole (31; 13.4%), and meropenem (23; 9.9%). Stop or review dates for the prescribed antimicrobials were documented in 27/259 prescriptions (10.4%). Surgical prophylaxis (SP) was prescribed for longer than one day in 83.3% of 61 patients. Samples for culture were sent for 27.1% (63/232) of all the patients prescribed antibiotics. Conclusion: This PPS demonstrates multiple indicators of the poor use of antimicrobials, including the high prevalence usage of watch antibiotics and prolonged surgical prophylaxis and other poor-quality indicators. Thus, there is an urgent need for intervention to improve antimicrobial stewardship.

Groundwater Geochemistry in the Karst-Fissure Aquifer System of the Qinglian River Basin, China

The Qinglian River plays a significant role in China’s national water conservation security patterns. To clarify the relationship between hydrogeochemical properties and groundwater quality in this karst-fissure aquifer system, drilling data, hydrochemical parameters, and δ2H and δ18O values of groundwater were analyzed. Multiple indications (Piper diagram, Gibbs diagram, Na+-normalized molar ratio diagram, chloro-alkaline index 1, mineral saturation index, and principal component analysis) were used to identify the primary sources of chemicals in the groundwater. Silicate weathering, oxidation of pyrite and chlorite, cation exchange reactions, and precipitation are the primary sources of dissolved chemicals in the igneous-fissure water. The most relevant parameters in the karst water are possibly from anthropogenic activities, and other chemicals are mostly derived from the dissolution of calcite and dolomite and cation exchange reactions. Notably, the chemical composition of the deep karst water from the karst basin is mainly influenced by the weathering of carbonate and cation exchange reactions and is less affected by human activities. The hydrogeochemical properties of groundwater in the karst hyporheic zone are influenced by the dissolution of carbonates and silicates, evaporation, and the promotion effect of dissolution of anorthite or Ca-containing minerals. Moreover, the smallest slope of the groundwater line from the karst hyporheic zone among all groundwater groups revealed that the mixing effects of evaporation, isotope exchange in water–rock interaction or deep groundwater recharge in the karst hyporheic zone are the strongest. The methods used in this study contribute to an improved understanding of the hydrogeochemical processes that occur in karst-fissure water systems and can be useful in zoning management and decision-making for groundwater resources.

Multi‐objective optimization of ultrasonic vibration‐assisted drilling in carbon fiber reinforced polyetherketoneketone laminate

AbstractCarbon fiber reinforced polyetherketoneketone (CF/PEKK) possess excellent mechanical properties and also meet low‐carbon environmental standards, leading to their increasingly widespread application in recent years. To ensure the strength of mechanical connections, it is crucial to minimize drilling damage. This paper utilizes Ultrasonic Vibration‐Assisted Drilling (UVAD) to enhance hole‐making quality, comparing multiple drilling performance indicators with Conventional Drilling (CD), including thrust force, drilling temperature, delamination factor, and burr factor. The results demonstrate that UVAD significantly reduces thrust force and drilling temperature, decreases delamination and burring damage, and effectively improves hole quality. To further optimize processing parameters, the Non‐dominated Sorting Genetic Algorithm II (NSGA‐II) was used, targeting thrust force, Material removal rate (MRR), and delamination factor as optimization goals. The reliability of the model was verified through experimentations. This paper provides an effective technical approach for high‐quality drilling in CF/PEKK materials, offering significant practical application value for material processing in aerospace and other fields.Highlights The quality of CF/PEKK processed by CD and UVAD was compared. UVAD can effectively improve the quality of drilling. The drilling parameters were optimized by NSGA‐II. The reliability of the prediction model was verified by experiments.

Temporal trends analysis of emergency obstetric and newborn care availability and readiness index of healthcare facilities in Burkina Faso

BackgroundEnsuring healthcare services are equipped to offer; emergency obstetric and newborn care (EmONC) is crucial for improving the quality of maternal and newborn care in low- and middle-income countries. We assessed the temporal trends of the availability and readiness of the healthcare system to provide EmONC in Burkina Faso.MethodsWe analyzed the data from three national health facilities surveys, conducted in 2014, 2016 and 2018, using the WHO Service Availability and Readiness Assessment tool. We performed multivariable linear regression models to examine the trends.ResultsBetween 2014 and 2018, the percentage of healthcare facilities providing delivery service and blood transfusion significantly decreased (88.1% to 75.4% for delivery services and 67.3% to 50.2% for blood transfusion, p < 0.001). The readiness index of healthcare facilities to provide basic EmONC showed a negative trend according to public healthcare, primary healthcare, and Centre-Nord, Centre-sud, Hauts-Bassins, Nord, Plateau Central and Sud-ouest health regions.ConclusionsWe observed multiple indications of a decline in the readiness of healthcare services to offer EmONC in Burkina Faso from 2014 to 2018. As such, bolstering the capabilities of health facilities to deliver EmONC is essential for hastening the decrease in maternal mortality.