In this work, the mucoadhesive substances from the fruits and seeds of Dillenia indica (DI), a plant present abundantly in India, have been extracted and utilised to prepare a hydrogel. A synthetically prepared amphiphilic polyphenol (L) has been incorporated within the hydrogel network to enhance the hydrogelation property. Moreover, the DI-L hydrogel's total phenolic content and radical scavenging prospects have been investigated. The DI-L hydrogel has shown good, sensitive, and efficient adsorptive removal of Fe(III) from the aqueous medium with an adsorption capacity of 6.157 mg/g for an initial concentration of 10 mg/L of Fe(III) solution. As a result, these findings elucidate the most innovative application of transforming fruit mucoadhesive into sustainable environmental solutions.