PurposeThe existing literature reflects that the connection between enablers of Industry 4.0 (I4.0), Supply Chain (SC) sustainability and reliability is understudied. To cover this gap, the purpose of this study is to identify and benchmark the enablers of I4.0 for SC sustainability to build a Reliable Supply Chain (RSC).Design/methodology/approachThis study benchmarks the I4.0 enablers for SC sustainability for building a RSC and analyses them with a multi-method approach. The identified potential enablers are validated empirically. A multi-method approach of Analytical Hierarchy Process (AHP), Decision Making Trial and Evaluation Laboratory (DEMATEL) and Preference Ranking for Organization Method for Enrichment Evaluation (PROMETHEE-II) was used to investigate the influence of the identified benchmarking enablers and develop an interrelationship diagram among the identified enablers.FindingsThis study benchmarks the potential enablers of I4.0 to achieve high ecological-economic-social gains in SCs considering the Indian scenario. Digitalization of the supply chain, decentralization, smart factory technologies and data security and handling are the most prominent enablers of I4.0 for SC sustainability to build a RSC.Originality/valueThe findings from the study may benefit managers, practitioners, specialists, researchers and policymakers interested in I4.0 sustainability applications.