Indian Medicine Research Articles

History of science, technology, environment, and medicine in India (ed.) by Suvobrata Sarkar, London-New York: Routledge, South Asia Edition, 2022. Pp. XXI + 328. Price Rs. 1595

History of science, technology, environment, and medicine in India (ed.) by Suvobrata Sarkar, London-New York: Routledge, South Asia Edition, 2022. Pp. XXI + 328. Price Rs. 1595

Phytochemical and Pharmacological Attributes of Nerium oleander: A Review

Background: Nerium Oleander is an Indian folk medicine popularly known as oleander, contains numerous phytoconstituents and nutritional agents for the treatment of multiple ailments. Objective: The prime objective for the current comprehensive review is to focus on the elaboration of phytochemistry along with the Pharmacological significance of N. oleander. Methods: As per literature investigations it was noticed that plant contains various phytochemical constituents, including Oleandric acid, Kaneroside, Cardenolide, Nerizoside, Neritaloside, Odoroside- H,3-Ocaffeoylquinic acid along with structural isomer, 5-Ocaffeoylquinic acid, α-tocopherol, Oleandrin, Digitoxgenin along with nutritional ingredients viz essential fatty acids like omega- 3 fatty acids, and other polyphenols reported in N. oleander. Results: In recent investigations, it was observed that oleander possesses a wide range of medicinal attributes viz. anti-inflammatory, larvicidal, anti-cancer, Antidiabetic, Cellular/humoral immune response, Hepatoprotective, Wound healing, Anti-microbial, Antioxidant, Antinociceptive, Locomotor, Diuretic, and Anti leukemic activities. Conclusion: N. oleander could be an excellent candidate for discovering new medications because of its wide range of pharmacological action and the large diversity of active phytochemicals. However, to disclose the favorable therapeutic, safety, and pharmacological virtues of N. oleander and its phytoconstituents, more clinical and experimental investigations are needed.

Book review: Suvobrata Sarkar, ed., History of Science, Technology, Environment, and Medicine in India

Book review: Suvobrata Sarkar, ed., History of Science, Technology, Environment, and Medicine in India

Characteristics and comparative study of medicinal materials between China and India based on data mining from literatures

Ethnopharmacological relevanceChina and India have unique traditional medicine systems with vast territory and rich medical resources. Traditional medicines in China include traditional Chinese medicine, Tibetan medicine, Mongolian medicine, Uyghur medicine, Dai medicine, etc. In the third national survey of Chinese medicine resources, 12694 medicinal materials were identified. Traditional medicines in India include Ayurveda, Unani, Siddha, Homoeopathy, etc. There are 7263 medicinal materials in India. Aim of the studyTo reveal the characteristics of medicinal materials between China and India respectively, and to compare the similarities and differences in terms of properties, tastes, medicinal parts and therapeutic uses and to promote the exchange of traditional medicine between China and India and the international trade of traditional medicine industry. MethodsThe information of medicinal materials between China and India was extracted from The Chinese Traditional Medicine Resource Records and Pharmacopoeia of the People's Republic of China, as well as from 71 Indian herbal monographs. The information of each medicinal material, such as types, families, genera, properties, distribution, medicinal parts, efficacy, therapeutic uses, dosage form and dosage, was recorded in Excel for statistical analysis and visual comparison. ResultsA total of 12694 medicinal materials in China and 5362 medicinal materials in India were identified. The medicinal materials were mostly distributed in Southwest China and northern India. Plants were the main sources of medicinal materials. The common medicinal parts in China were whole medicinal materials, roots and rhizomes, and India used more renewable fruits, seeds and leaves. They are commonly used in the treatment of digestive system diseases. There were 1048 medicinal materials used by both China and India, which were distributed in 188 families and 685 genera. The Chinese and Indian pharmacopoeias had a total of 80 species of medicinal materials used by both China and India. ConclusionsThe characteristics of medicinal materials between China and India were somewhat different, which was conducive to provide a reference basis for traditional medicine in China or India to increase the medicinal parts and indications when using a certain medicinal material, as well as to expand the source of medicine and introduce new resources. However, there were certain similarities and shared medicinal materials, which can tap the potential of bilateral trade of medicinal materials between China and India, so as to promote the medical cultural exchange and economic and trade cooperation between the two countries.

REVIEW OF COMPREHENSIVE STUDY ON DIFFERENT ACTIVITIES OF PRIYANGU

The chemical components found in plants make them a vital and fundamental component of complementary and alternative medicine. Traditional medicine has made use of plants of the Aglaia genus, the species in the Meliaceae family. the genus Aglaia has more than one hundred. Juss. Aglaia elaeagnoidea In the Western Ghats and other dry regions of India, Benth trees grow in dense, damp woods. Priyangu and chokkala are two of the common names. Rural people use the bark and leaves of this tree, much like they do with other Aglaia species. The Aglaia elaeagnoidea plant's leaves and stem bark are used in Indian medicine, specifically Ayurvedic medicine, to treat a variety of conditions, including skin diseases, tumors, insect repellent, antibacterial, anti-inflammatory, wound-healing, and anti-cancer. Numerous studies have documented the existence of phytoconstituents in plant extracts, providing empirical evidence for the anti-inflammatory, analgesic, anti-tumor, and anti-hypertensive effects of plants. This review includes information on Aglaia elaeagnoidea phytochemistry and pharmacological properties.

Anti-asthmatic activity of Tinospora cordifolia leaves extract against ach and citric acid-induced asthma in rats

Asthma is one of the common clutters experienced in clinical medication in both grown-ups and children are asthma and it is characterized by irritation of the aviation routes which causes aviation route brokenness. Breathed-in bronchodilators and anti-inflammatory drugs are accessible and compelling and they require long term utilize and are related with side impacts. Typically, why elective and complementary medication is being sort after to anticipate these side impacts. A few restorative plants have anti-inflammatory impact and have demonstrated successful within the treatment of asthma. Citric corrosive, Acetylcholine, Histamine is basically utilized for assessing anti-asthmatic movement of specific sedate. Numerous plants gotten from the normal source play a critical part within the wellbeing care framework. Writing overview on home grown drugs has appeared noteworthy anti-asthmatic movement which has not shown any momentous side impact. The pharmacological component that the phytoconstituents creating the hostile to asthmatic action are not clearly caught on till date. A few herbal formulations have been determined from the Ayurveda, conventional framework of Indian medicine and its extra framework of medication, however to be experimentally approved that they have exhibited pharmacological activity against Asthmatic. As it were less number of logical data of conventional medications is accessible for the treatment of Asthmatic. This survey contains list of restorative plant which have been tried for anti-asthmatic action within the Citric corrosive, Acetylcholine actuated asthmatic in Rodent demonstrate. Rats were divided into 4 groups and given each of them individual intervention based on the activity. Tinospora cordifolia leaf extract shows an anti-asthmatic activity in rats. hence, the data given in this inquiry will offer assistance the analysts for the advancement of elective strategies instead of inhalers and verbal anti-asthmatic drugs for the treatment of asthma and COPD which can minimize the complications.

Evaluation of diuretic activity of hydroalcoholic extract of Leptadenia pyrotechnica in rats

In traditional Indian medicine, the whole plant of Leptadenia pyrotechnica (Asclepiadaceae) is said to have a strong diuretic effect. The aim of this study was to evaluate the diuretic potential of the hydroalcoholic extract of Leptadenia pyrotechnica (HALPE) in rats. Group I, control (0.5% CMC saline, 10 ml/kg, b.w.), group II, furosemide (10 mg/kg b.w.) as a standard drug, and different concentrations of L.P. (100, 200, and 400 mg/kg b.w.) were administered intraperitoneally (n = 5 per treatment group) to hydrated rats, and their urine output was monitored at 6 h, 12 h, and 18 h after drug administration. The diuretic effect of the extract was highly significant compared to control animals. Halpe at a dose of 400 mg/kg shows a significant increase in urine volume with increased urine output. This study suggests that the active component of L.P. had a diuretic effect similar to that of furosemide. These results confirm the traditional use of Leptadenia pyrotechnica as a diuretic agent. Since ancient times, medicinal plants, sometimes called herbs, have been used in various traditional medical procedures. Leptadenia pyrotechnica is a plant commonly known as the chimp. It is traditionally used in rural areas for the treatment of many diseases, such as antifungal, antibacterial, anticancer, antioxidant, wound healing, anthelmintic, atherosclerosis, hypolipidemia, diuretic, diabetes, and hepatoprotective. In rural areas, this plant is also used as medicine and as a vegetable. First, the plants are dried and turned into powder, which is then used as a paste for ringworm, antifungal, wound treatment, and new plants for many other diseases.

Insights into the potential dual-antibacterial mechanism of Kelisha capsule on Escherichia coli

Traditional Chinese medicine (TCM), AYURVEDA and Indian medicine are essential in disease prevention and treatment. Kelisha capsule (KLSC), a TCM formula listed in the Chinese Pharmacopoeia, has been clinically proven to possess potent antibacterial properties. However, the precise antimicrobial mechanism of KLSC remained unknown. This study aimed to elucidate the dual antibacterial mechanism of KLSC using network pharmacology, molecular docking, and experimental validation. By analyzing the growth curve of Escherichia coli (E. coli), it was observed that KLSC significantly inhibited its growth, showcasing a remarkable antibacterial effect. Furthermore, SEM and TEM analysis revealed that KLSC damaged the cell wall and membrane of E. coli, resulting in cytoplasmic leakage, bacterial death, and the exertion of antibacterial effects. The network pharmacology analysis revealed that KLSC exhibited an effect on E. coli ATP synthase, thereby influencing the energy metabolism process. The molecular docking outcomes provided evidence that the active compounds of KLSC could effectively bind to the ATP synthase subunit. Subsequently, experimental findings substantiated that KLSC effectively suppressed the activity of ATP synthase in E. coli and consequently decreased the ATP content. This study highlighted the dual antibacterial mechanism of KLSC, emphasizing its effects on cell structure and energy metabolism, suggesting its potential as a natural antibacterial agent for E. coli-related infections. These findings offered new insights into exploring the antibacterial mechanisms of TCM by focusing on the energy metabolism process.

From petals to healing: consolidated network pharmacology and molecular docking investigations of the mechanisms underpinning Rhododendron arboreum flower's anti-NAFLD effects.

Rhododendron arboreum: Sm., also known as Burans is traditionally used as an anti-inflammatory, anti-diabetic, hepatoprotective, adaptogenic, and anti-oxidative agent. It has been used since ancient times in Indian traditional medicine for various liver disorders. However, the exact mechanism behind its activity against NAFLD is not known. The aim of the present study is to investigate the molecular mechanism of Rhododendron arboreum flower (RAF) in the treatment of NAFLD using network pharmacology and molecular docking methods. Bioactives were also predicted for their drug-likeness score, probable side effects and ADMET profile. Protein-protein interaction (PPI) data was obtained using the STRING platform. For the visualisation of GO analysis, a bioinformatics server was employed. Through molecular docking, the binding affinity between potential targets and active compounds were assessed. A total of five active compounds of RAF and 30 target proteins were selected. The targets with higher degrees were identified through the PPI network. GO analysis indicated that the NAFLD treatment with RAF primarily entails a response to the fatty acid biosynthetic process, lipid metabolic process, regulation of cell death, regulation of stress response, and cellular response to a chemical stimulus. Molecular docking and molecular dynamic simulation exhibited that rutin has best binding affinity among active compounds and selected targets as indicated by the binding energy, RMSD, and RMSF data. The findings comprehensively elucidated toxicity data, potential targets of bioactives and molecular mechanisms of RAF against NAFLD, providing a promising novel strategy for future research on NAFLD treatment.

A Biochemical and Molecular Insight to Wound Healing Properties of Traditional Indian Medicines in Normal and Diabetic Rats

A Biochemical and Molecular Insight to Wound Healing Properties of Traditional Indian Medicines in Normal and Diabetic Rats

Qualitative and quantitative metabolomics of Pamburus missionis Swingle – a medicinal tree taxon

Since ancient times, Plant based medicine is a well-known oldest form of healthcare to mankind. Even the commercial medications used for the treatment of various ailments today, contains a large proportion of plant derived chemical compounds. Hence chemical profiling of medicinal plants gained a key role to use them in pharmaceuticals as well as commercial industries. Pamburus missionis is one of the medicinal plants used in the Indian and Srilankan traditional medicine system to reduce kapha dosha. The ayurvedic physicians used its leaves to treat swelling, piles, fractures, fistula, puerperal diseases and as serpent venom. Therefore, the present study was undertaken to reveal the phytocompounds from various parts of this plant. Metabolomics revealed the presence of primary and secondary metabolites like carbohydrates, lipids, proteins, alkaloids, phenols, flavonoids, steroids etc. From the aqueous extract, Alkaloid content is almost same in leaf, stem and bark extracts with around 1.2 to 1.3 g (w/v%) and completely absent in the fruit. Phenolic content and steroids are notably high in leaf extract with 112.77±0.34 mg/g of extract and 17.91±0.26 mg respectively, where the flavonoid content in fruit extract with 44.69±0.30 mg/g of extract and the tannin content in bark extract with 62.37±1.75 mg/g of extract.

Genesis of People’s Medicine Centre (PMC) for popularisation of generic medicine: A critical qualitative inquiry

IntroductionThe concerns of inaccessibility to essential medicines in India are well-studied and documented. Pradhan Mantri Bhartiya Janaushadhi Priyojana (PMBJP) is one of the policy initiatives to address the inaccessibility of essential medicine. Janaushadhi Kendra (People's Medicine Centre), which is part of PMBJP is being enquired in a limited way to understand its effectiveness. The province of Odisha has been chosen as the study area for the evaluation of People's Medicine Centres. ObjectiveThe present study intends to inquire into the nature of People's Medicine Centre ownership, pharmacists' motivations and incentives to engage in business, perceived customers' trust and satisfaction, scheme beneficiaries, and challenges. MethodsA qualitative research approach has been adopted to evaluate the broader subjective accounts of the pharmacists and People's Medicine Centre. An open-ended interview guide was used. The topics of ownership, motivation, incentives, trust, satisfaction, perceived benefits, and challenges has been recorded from the participants. A total of seventeen in-depth interviews were conducted in the province of Odisha, India. ResultsThe study found that the ownership of People's Medicine Centre was of two types in the province of Odisha: public-NGO-owned People's Medicine Centres and public-private-owned People's Medicine Centres. The financial incentive provisions in the scheme attracted the private pharmacists. Pharmacists highlighted about the lower price of generic medicines compared to branded medicines, which is very popular among patients. They also pointed out that there is no difference in the efficacy of both medicines. The attitude of physicians, especially private physicians, were considered problematic for popularity and acceptance. ConclusionThe People's Medicine Centres in Odisha established themselves as trusted outlets despite physicians' unfavourable attitudes. Although the centres have not reached the required geographical coverage, economically developed regions have large number of centres, while backward regions have minimal presence. The scheme needs to be more conducive to the welfare of the masses living in remote and rural areas.

Pharmacognostical Study of Root Bark of <I>Erythrina indica</I> Lam. Paribhadra

Paribhadra, one of the reputed drugs of the indigenous system of medicine, is equated with Erythrina indica Lamk. Syn. E. variegata Linn. var. orientalis Linn., Family Fabaceae. Some other species of Erythrina viz. E. suberosa Roxb. and E. stricta Roxb., have also been mentioned as 'Paribhadra in different text books on Indian Medicine and are used as substitutes for the genuine drug, Erythrina indica.The pharmacognostical study is made of the root and root bark of E. indica Lamk., as based on material collected from authentic specimens and covers macro- and microscopical characters highlighting the diagnostic features, micro-chemical tests, examination of the powdered drug and preliminary phytochemical investigation.

Cytological Studies in some Indian Medicinal Plants

Meiotic chromosome numbers of 12 taxa of medicinal plants are reported. Chromosome counts for Colebrookea oppositifolia n=16, Cyathula prostrata n=21, Aerva lanata n=8, Trema orientalis n=20, Girardinia zeylanica n=10 and Streblus asper n=13 are new records for these genera. Chromosome number for Ophiorrhiza mungos n=11, Plumbago zeylanica n=14, Clerodendrum viscosum n=24, Polygonum chinense n=11, Acalypha indica n=10 and A. paniculata n=10 are reported for the first time.

Amla (Emblica officinalis) alleviates doxorubicin-induced cardiotoxicity and nephrotoxicity in rats

IntroductionDoxorubicin (DOX) is a widely used anticancer drug known for its significant cardiotoxic and nephrotoxic effects. Seeking remedies to mitigate these adverse effects is crucial. This study investigates the potential of Emblica officinalis (Amla) extract, a prominent component in Chinese and Indian traditional medicine systems, in alleviating DOX-induced cardiotoxicity and nephrotoxicity. MethodsDOX (20 mg/kg i.p., once) was given to rats to cause acute cardiotoxicity and nephrotoxicity. Rats received 16 similar and cumulative doses of DOX (1.25 mg/kg, i.p.) on alternate days for chronic cardiotoxicity and nephrotoxicity. Biochemical and histological evaluations were done to confirm the onset of cardiotoxicity and nephrotoxicity. ResultsThe cardioprotective and nephroprotective effects of Amla extract (AE) (150 mg/kg p.o. and 300 mg/kg p.o) were evaluated in comparison to Vitamin E (25 mg/kg p.o.). The treatment with AE (300 mg/kg/day, p.o.) considerably prevented DOX-induced cardiotoxicity, nephrotoxicity, and oxidative stress by positively altering the integrity of glomeruli, restoring the tissue GSH and decreasing serum TBARS. AE (300 mg/kg) was found to be more cardioprotective and nephroprotective than Vitamin E (25 mg/kg p.o.). DiscussionIt may be concluded that the induction of cardiotoxicity and nephrotoxicity in rats may be due to DOX-induced oxidative stress, and chronic treatment with AE (300 mg/kg) is an effective way to alleviate the cardiotoxic and nephrotoxic adverse effects of DOX in rats. Moreover, given Amla's historical and contemporary significance in Chinese and Indian traditional medicine systems, its potential therapeutic role merits further exploration in clinical settings.

Ethnopharmacological Survey of the Iranian Coastline of Makran Based on the Unani Medicine

Background:: Makran is a semi-desert coastal strip that extends from southeastern Iran to Baluchestan, Pakistan, on the coast of the Oman Sea. This region has a special place in the country and enjoys the cultural diversity of the Baluch people. Aim:: As no specific ethnopharmacological data are available for the Makran coastline, the present work was undertaken to document and analyze traditional knowledge of medicinal approaches used by Baluch communities (Chabahar and Konarak counties) during 2021-2023 in the Sistan and Baluchestan province. Methods:: Data were collected through direct observations during comprehensive field surveys, comprehensive questionnaires, and interviews with local traditional practitioners, herbal healers, and grocery and itinerant sellers of medicinal plants and minerals. Results:: Because of its strategic location, ethnomedicine knowledge of this area has been influenced by Indian and Pakistani medicine and has been endowed with a marvelous diversity of therapeutic approaches, such as Unani or Ayurvedic systems of traditional medication for the treatment of different diseases. Herbal integration, mineral (kushtas), mud, and music and heat therapy are examples of medicinal approaches utilized in the study area. A total of 74 potential medicinal plants belonging to 41 families and 6 mineral drugs have been identified to be traditionally used for remedial measures against special diseases. The inventory of medicinal plants showed that Fabaceae, Solanaceae, and Malvaceae dominated other plant families. Out of the total documented species in this area, some species were used as medicine in at least two or further forms in the local communities. The results have shown that musculoskeletal (SKE-L), digestive (GAS-D), and respiratory (RES-R) diseases have high ICF (>0.90). In terms of temperament, 37% of the medicinal plants used in this region have been found to be hot and dry, 28% hot and moist, and 25% cold and dry. Also, 77% of the medicinal plants have been found to have two degrees of toxicity. Spearman's correlation showed a moderate correlation between temperament and phytochemical compounds (r=0.31). Comparing our data with ethnopharmacological references in Iran revealed that applications of minerals (kushtas) have not been investigated in other provinces and are significant in this region. Conclusion:: The culture of the coast of Makran is rich in the local knowledge of traditional medicine. In addition to herbal medicines, mineral substances are also used in this area, which are a good source for the treatment of various ailments. The Unani medical system and the composition of herbal medicine (multi-ingredients) are the main features of medicinal methods used at the Makran coastline. The variety of treatment methods used by the Baluch people can suggest a suitable candidate for finding drugs.

Vaidyaratna Captain G. Srinivasa Murthy: A legend who revived Indian Medicine

Abstract Captain Dr. G. Srinivasa Murthy, born in 1887, was a multifaceted personality with a strong background in both Allopathic and Indian systems of medicine. He played a significant role in the recognition and encouragement of indigenous systems of medicine. Dr. Murthy was a member of the Usman Committee formed to report on how the indigenous systems of medicine could be best developed. He produced a report, “The Science & the Art of Indian Medicine,” for the committee as his magnum opus. He founded the School of Indian Medicine in 1925 and developed an integral system combining Ayurveda and Allopathy. He was the founder president of the Indian Medical Practitioners Co-operative Pharmacy & Stores. His unselfishness and passion inspired the younger generation in the field of Indian medicine. Dr. V Narayana Swamy, a disciple of Murthy, founded the Captain Srinivasa Murthy Research Institute in 1963, which later became part of the Central Council for Research in Ayurvedic Sciences.

Sida cordifolia L.: Ethnobotany, Phytochemistry, Phytonanotechnology, and Commercial Application.

After a period of prolonged indifference, where synthetic drugs were preferred, interest in the biological aspects and bioactive ingredients of plants accountable for therapeutic potential has been explored eminently. Sida cordifolia L. is a perennial herb that has been widely utilized in Indian (Ayurveda, Unani, and Siddha), American, and Chinese folk medicine and herbalism practice for curing a wide range of ailments in human beings. The goal of this review is to elucidate indigenous knowledge parallelly with the pharmacotherapeutics potential of Sida cordifolia L. against various diseases. It is also intended to display pertinent information related to nanoparticle profiling. In the current comprehensive study, web-based searches were performed by using several databases, such as Google Scholar, PubMed, ResearchGate, Science Direct, and Scopus, to figure out relevant research work and data published in academic journals from 1930 to July, 2023 using single or combination of keywords listed herewith. More than 50 chemical constituents, including quinazoline and phenethylamine alkaloids, flavones, flavonol, phytosterol, fatty acids, etc., were reported to be found in different parts of healthy plants. Apart from traditional claims and pharmacological aspects, several marketed herbal formulations and granted patents were also described. Several in-vitro and in-vivo studies validated the usage of S. cordifolia as antiinflammatory, antibacterial, antifungal, antiprotozoal, anthelmintic, anticancer, antiulcer, cardioprotective, hypoglycemic, etc. agent. Few patents are also related to S. cordifolia, and more research work needs to be carried out for its potential granted to use as an antiviral agent and other new drug discovery molecules.

The nutrition and therapeutic potential of millets: an updated narrative review.

Millets are ancient small grains grown in arid and semiarid regions of the world. They are staple food for many people in Asia and Africa. They are abundant sources of minerals and vitamins, giving them the name Nutricereals. Moreover, millets contain valuable phytochemicals that impart therapeutic properties for various disorders and diseases, thus giving them nutraceutical value. A wide array of biochemical compounds are present in the plant parts as well as the grains. In the oldest texts of medicine in India and China, millets are mentioned for use for their medicinal value. There has been expanding interest and emerging facts about millets and their therapeutic uses. Ample evidence shows that consumption of millets amounts to correction of life style and metabolic disorders. Therapeutic properties of millets can be viewed in two ways, supplementary nutrition through minerals and vitamins, and therapeutic value through the presence of phytochemicals and specialty compounds that include flavonoids, phenolics, anthocyanidins and others that have antioxidant potential. Millets are gluten free, have low glycemic index and the phytochemicals aid in correction of lifestyle disorders and prevention of ailments like carcinogenesis. Supplementary benefits include treatment of anemia and calcium deficiency especially for pregnant women and young children. With the improvements in analytical methods for detection of various compounds, it is possible to identify the compound-specific genotypes in millets that can cater to the pharmacy industry. End-use specific genotypes can be bred to meet the demand. Millets being climate resilient, can contribute to a healthier life and better world through economic usage of natural resources.

In silico Assessment of Efficacy Against the Zoonotic Parasite Echinococcus granulosus, Pharmacokinetic and Toxicity Predictions for the Siddha Formulation Murukkanvithai Mathirai

Background: Thioredoxin glutathione reductase (TGR) is essential for survival of the zoonotic tapeworm Echinococcus granulosus. Albendazole is the only promising drug for the treatment of cystic echinococcosis. To avoid the development of resistance to albendazole in the parasite, an herbal alternative to albendazole is the need-of-the-hour to combat the development of resistance. Aim: This study aimed to identify active compounds against the parasite Echinococcus granulosus from Murukkan Vithai Mathirai, an anthelmintic formulation used in Siddha practice. Objectives: To evaluate the efficacy of Murukkan Vithai Mathirai (MVM), a Siddha formulation against Echinococcus granulosus, a tapeworm of carnivores, by molecular docking, and to evaluate its ADMET properties using in silico tools. Materials and Methods: The 3D structure of Echinococcus granulosus-thioredoxin-glutathione systems (egTGR) and the phytoconstituents of Piper nigrum, Zingiber officinalis, Piper longum, Cuminum syminum, Coptis teeta, Butea monosperma, and Croton tiglium were obtained from a curated database of Indian Medicinal Plants, Phytochemistry and Therapeutics (IMPPAT). 12 promising phytocompounds were selected based on their physicochemical properties, drug-likeness, bioavailability scores, and medicinal chemistry properties. These phytochemicals were docked individually with the egTGR using Autodock vina and binding affinity (kcal/mol) was recorded for each compound and compared with albendazole, a positive control drug. The results of docking were read using the Biovia Discovery studio visualizer. The ADMET properties of the phytochemicals were analysed using pkCSM and VEGA-QSAR tools. The toxicity score for each phytochemical was calculated by assigning weightage to the toxicities predicted and the weighted average was calculated to compare with the albendazole's weighted average. The geometric mean of NOAELs predicted for MVM phytochemicals was compared with the predicted NOAEL of albendazole. Results: The binding affinity (G) scores of the selected phytocompounds were found to be higher than the albendazole and the phytocompounds with G > -8.0 are as follows, aristolodione, berberastine and pluviatilol of Piper longum, apigenin of Cuminum syminum and prunetin of Butea monosperma, whereas the G of albendazole was -6.7. The calculated toxicity score for MVM (0.56) was significantly lower than albendazole (1.08) and the predicted NOAELs was significantly higher (26.63 mg/kg) than albendazole (3.49), indicating that MVM is less toxic than albendazole. Conclusion: Murukkan Vithai Mathirai is a promising and safe anthelmintic in in silico studies, however, it needs to be validated by in vitro and in vivo studies.