Across India, many farmers contend that synthetic nitrogenous fertilizers do more than impact soils, but also lead to tasteless food crops and weakened bodies more susceptible to aches, pains, and diseases. Although these complaints, long-documented across South Asia, have been theorized as embodied critiques of development or as reflecting hybrid epistemologies, there has been strikingly little focus on the potential biophysical currents that may underpin these perceptions of fertilizer harm. This paper works to fill this gap, analyzing qualitative data collected from farmers in two remote eastern Indian districts using an “integrated” political ecology of health (PEH) framework that utilizes two main approaches to examine bodily materiality and health. In particular, the framework looks at the multi-scalar political economies, cultural forms of meaning-making, as well as the visceral, affective ways that respondents come to see synthetic fertilizers as the cause of barren lands, tasteless foods, and weakened bodies. The article then deploys a critical reading of bioscientific literature to interpret respondent narratives and zoom in onto potential bio-social mechanisms that may help illuminate claims of fertilizer harm in new ways. In particular, I present evidence around how phytochemicals—literally chemicals produced by plants—may shift due to chemical fertilizer use in ways that may matter for hunger and health. Yet, not losing sight of the affective ways crops are grown, consumed, and discussed, I also highlight research examining how beliefs and perceptions measurably modify physiological responses to food in positive or adverse ways through the still ill-understood placebo/nocebo effect. The goal of such analysis is not to present a tidy conclusion to questions of fertilizer–health connections but demonstrate how a PEH that remains attentive to power, discourse, and materiality can bring disparate streams of thought together to forge pathways for transdisciplinary research and practice.