Indian Journal Research Articles

Cassia occidentalis Potentiates wound Healing Process in Type-2 Diabetic Rats

Indian Journal of Natural Products,2022,36,1,52-57.DOI:10.5530/ijnp.2022.1.8Published:February 2023Type:Original ArticleAuthors:Rajesh Singh Pawar, Avinash Singh Mandloi, Umesh Kumar Patil, and Shweta Kumar Author(s) affiliations:Rajesh Singh Pawar1,2,*, Avinash Singh Mandloi1, Umesh Kumar Patil3, Shweta Kumar4 1Pharmacognosy and Phytochemistry Laboratory, Faculty of Pharmacy, VNS Group of Institutions, Bhopal, Madhya Pradesh, INDIA. 2Department of Pharmacy, Truba Institute of Pharmacy, Bhopal, Madhya Pradesh, INDIA. 3Department of Pharmacognosy, Department of Pharmaceutical sciences, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, Madhya Pradesh, INDIA. 4Department of General Medicine, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, INDIA. Abstract:Introduction: This work is focus on a cost-effective herbal hydrogel formulation comprising of extract, from the leaves of Cassia occidentalis L. (Caesalpiniaceae). The formulation is highly effective for delayed wound healing due to diabetes. Background: Cassia occidentalis (CO) is extensively used in folklore medicine system. It is a common weed scattered from foothills of Himalayas to West Bengal, South India, Burma and Srilanka. Objectives: The study aimed to explore the role of Cassia occidentalis (leaf) for wound healing potential in diabetic rats using the excision wound model. Materials and Methods: The characterization of the phytoconstituents and bioavailability profiles of methanolic extract of CO (MCO) were investigated using High-Performance Liquid Chromatography-Photodiode Array Detector analysis. Insulin resistance was induced in rats by feeding them a diet rich in fructose and hyperglycemia was induced by injecting streptozotocin (STZ) at a dose of 40 mg/kg body weight (bw), intraperitoneally (ip). After confirmation of diabetes fasting blood glucose level, the wound was induced. Excision wound healing activity was examined on Wistar rats. Results: The hydrogel of MCO (5 and 10%) reduced significantly wound size. Significant mean epithelialization period, higher hydroxyproline content and tensile strength were revealed at the concentrations of MCO hydrogel of 5 and 10% compared to the diabetic wound control group. Conclusion: These results provide promising baseline information for the wound healing potential of MCO in type-2 diabetes treatment. Keywords:Biochemical parameters, Cassia occidentalis, Hydrogel, Hydroxyproline, HyperglycemiaView:PDF (906.38 KB)

Chromatographic Studies on Extracts of Ganoderma lucidum

Indian Journal of Natural Products,2022,36,1,28-38.DOI:10.5530/ijnp.2022.1.5Published:February 2023Type:Original ArticleAuthors:Alok Nahata, and Vinod Kumar Dixit Author(s) affiliations:Alok Nahata1,*, Vinod Kumar Dixit2 1Ying Zhi Agricultural and Industries Sdn Bhd., Jalan Guar Napai, Kampung Cerok Mokkan, Jitra, Kedah, MALAYSIA. 2Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Central University, Sagar, Madhya Pradesh, INDIA. Abstract:Ganoderma lucidum is considered to be a natural medicine that promotes longevity and maintains the vitality of human beings. Its beneficial clinical effects in patients with hepatitis, hyperglycemia, chronic bronchitis, cancer, muscular dystrophy, arteriosclerosis, hypertension, hypercholesterolemia, and leukopenia have been confirmed in pharmacologic studies in recent years. The fruiting bodies, mycelia, and spores have recently received more and more attention not only as home remedies but also as new drug sources. Being an important medicinal mushroom, it was thought necessary to scan the mushroom for its chemical constituents and to work out it’s chromatographic profile via thin layer chromatographic and high-performance thin layer chromatographic approaches. Present work sheds light on the qualitative chemical examination of Ganoderma extracts and their further chromatographic analysis. Standard marker viz., beta-sitosterol was used in the process. Some major phytoconstitents found to be present were triterpenoids and polysaccharides which have been held responsible for most of the pharmacological activities of the mushroom. Keywords:Ganoderma lucidum; TLC; HPTLC; Phytochemistry; Polysaccharides; Triterpenoids.View:PDF (1.29 MB)

Biotransformation of Carvedilol Using Plant Cell Culture of Decalepis hamiltonii and Nicotiana tabacum

Indian Journal of Natural Products,2022,36,1,39-43.DOI:10.5530/ijnp.2022.1.6Published:February 2023Type:Original ArticleAuthors:Ch. Raja Shekar, Ajmera Rama Rao, Umesh K Patil, and Ciddi Veeresham Author(s) affiliations:Ch. Raja Shekar1, Ajmera Rama Rao1, Umesh K Patil2, Ciddi Veeresham1,* 1University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Telangana, INDIA. 2Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar, Madhya Pradesh, INDIA. Abstract:The biotransformation reaction of cell suspension cultures produced from Decalepis hamiltonii and Nicotiana tabacum leaves were investigated, using Carvedilol drug. Interestingly, the cell suspension cultures showed biotransformation of racemic carvedilol. There is noticeable conversion of S-enantiomer to R-enantiomer of Carvedilol. The bio-conversion was detected and quantified by Chiral HPLC. The ideal biotransformation was achieved with the concentration of 0.1mg/ml Carvedilol at pH 5.8. The optimum incubation time was observed to be 15 days The Decalepis hamiltonii and Nicotiana tabacum cell culture have shown the capacity to convert S-isomer to R-isomer, because it has enzymes specific for conversion from S to R form. Among the two plants Decalepis hamiltonii have shown better biotransformation when compared to Nicotiana tabacum. Keywords:Bio transformation, Carvedilol, HPLC, Nicotiana tabacum, Plant cell culturesView:PDF (1019.25 KB)

Prevalence and determinants of neonatal near miss in Ethiopia: A systematic review and meta-analysis.

Neonatal near miss is a condition of newborn infant characterized by severe morbidity (near miss), but survived these conditions within the first 27 days of life. It is considered as the first step to design management strategies that can contribute in reducing long term complication and mortality. The aim of this study was to assess prevalence and determinants of neonatal near miss in Ethiopia. The protocol of this systematic review and meta-analysis was registered at the Prospero with a registration number of (PROSPERO 2020: CRD42020206235). International online databases such as PubMed, CINAHL, Google scholar, Global Health, Directory of open Access journal and African Index Medicus were used to search articles. Data extraction was undertaken with Microsoft Excel and STATA11 was used to conduct the Meta-Analysis. Random effect model analysis was considered when there was evidence of heterogeneity between the studies. The overall pooled prevalence of neonatal near miss was 35.51% (95%CI: 20.32-50.70, I2 = 97.0%, p = 0.000). Primiparity (OR = 2.52, 95%CI: 1.62, 3.42), referral linkage (OR = 3.92, 95%CI: 2.73, 5.12), premature rupture of membrane (OR = 5.05, 95%CI: 2.03, 8.08), Obstructed labor (OR = 4.27, 95%CI: 1.62, 6.91) and maternal medical complications during pregnancy (OR = 7.10, 95%CI: 1.23, 12.98) had shown significant statistical association with neonatal near miss. The prevalence of neonatal near miss in Ethiopia is evidenced to be high. Primiparity, referral linkage, premature rupture of membrane, obstructed labor and maternal medical complications during pregnancy were found to be determinant factors of neonatal near miss.

Alternative therapies applied to oncological patients for pain management

INTRODUCTION: Alternative therapies consist of a set of techniques and methods used for the treatment or prevention of diseases, especially in the mind, body and person, providing a balance between the environment and the cancer patient. OBJECTIVE: Analyze the application of alternative therapies in cancer patients for pain management. METHODOLOGY: This is a qualitative, cross-sectional bibliographic review, based on articles found in indexed journals of great academic prestige. The analysis of the information aims to publicize each of the alternative therapies that are used in a cancer patient to treat pain. DISCUSSION: Each of the alternative therapies that have been more effective in relieving pain, such as acupuncture and therapeutic massage, are mentioned in comparison to the others; which are based on managing pain in cancer patients and other symptoms during the course of conventional treatment. CONCLUSION: Each said therapy has its own advantages, from which it is concluded that alternative therapies are effective for pain management in patients with oncological diseases despite the fact that there is little scientific evidence.

Academic publication activities and perspectives of rheumatology practitioners in the COVID-19 pandemic.

This study aimed to analyze the research, publication activities, and perspectives on clinical practices of rheumatology practitioners during the coronavirus disease 2019 (COVID-19) pandemic. The survey-based cross-sectional study was designed online and included 24 closed-ended questions. After performing a pilot test and validation of survey, it was conducted among clinicians between September 2021 and December 2021. One-hundred fifteen clinicians (54 males, 61 females; 78.1% in rheumatology practice for at least five years) responded to the survey. The respondents indicated that they worked in coronavirus-related departments, comprising inpatient service (50.4%), consultancy (42.6%), and outpatient clinic (27.8%). Around 40% of clinicians stated they spent less time on scientific research (43.1%) and clinical learning activities (43.2%), while almost the same proportion of them spent more (41.1% and 45.0%, respectively). This study revealed that 53.5% published at least one paper covering mostly COVID-19 in the scientific citation index (SCI) or SCI-expanded (SCI-E) indexed journals. However, nearly half of them did not have any papers published in the SCI/SCI-E (46.5%) or non-SCI/SCI-E indexed (44.6%) journals. Regarding the perspectives of clinicians about clinical practices, they considered fewer biological (57.0%) and nonbiological (55.0%) drug usage, reported fewer outpatient clinic visits (88.2%), more newly diagnosed rheumatic diseases (62.5%), and more disease exacerbations (31.2%). Most of the clinicians (range, 76.2 to 86.3%) thought they accurately managed their patients during the COVID-19 pandemic. Clinicians published mostly coronavirus-related papers in the pandemic era, and in the self-assessment, clinicians thought that they correctly manage their patients. In addition, this study reflected the frequency of academic publications and clinicians' work routines during the pandemic.

COVID-19 spread algorithm in the international airport network-DetArpds.

Due to COVID-19, the spread of diseases through air transport has become an important issue for public health in countries globally. Moreover, mass transportation (such as air travel) was a fundamental reason why infections spread to all countries within weeks. In the last 2 years in this research area, many studies have applied machine learning methods to predict the spread of COVID-19 in different environments with optimal results. These studies have implemented algorithms, methods, techniques, and other statistical models to analyze the information in accuracy form. Accordingly, this study focuses on analyzing the spread of COVID-19 in the international airport network. Initially, we conducted a review of the technical literature on algorithms, techniques, and theorems for generating routes between two points, comprising an analysis of 80 scientific papers that were published in indexed journals between 2017 and 2021. Subsequently, we analyzed the international airport database and information on the spread of COVID-19 from 2020 to 2022 to develop an algorithm for determining airport routes and the prevention of disease spread (DetARPDS). The main objective of this computational algorithm is to generate the routes taken by people infected with COVID-19 who transited the international airport network. The DetARPDS algorithm uses graph theory to map the international airport network using geographic allocations to position each terminal (vertex), while the distance between terminals was calculated with the Euclidian distance. Additionally, the proposed algorithm employs the Dijkstra algorithm to generate route simulations from a starting point to a destination air terminal. The generated routes are then compared with chronological contagion information to determine whether they meet the temporality in the spread of the virus. Finally, the obtained results are presented achieving a high probability of 93.46% accuracy for determining the entire route of how the disease spreads. Above all, the results of the algorithm proposed improved different computational aspects, such as time processing and detection of airports with a high rate of infection concentration, in comparison with other similar studies shown in the literature review.

Stigma against contraceptive seeking behavior in unmarried women- Experienced or perceived?

Stigma against contraceptive seeking behavior in unmarried women- Experienced or perceived? - IJOGR- Print ISSN No: - 2394-2746 Online ISSN No:- 2394-2754 Article DOI No:- 10.18231/j.ijogr.2023.024, Indian Journal of Obstetrics and Gynecology Research-Indian J Obstet Gynecol Res

The rhetorical density of authorial emotiveness and voice passiveness in abstract compositions

The study sought to examine authorial emotiveness and passive tone of academic writing in academic research abstracts (RAs) to appeal to the Aristotelian pathos. Based on the integrated framework of Contrastive Rhetoric and Domain of Emotional Tone, this study investigated the overall demonstration of emotional appeal through quantitative content analysis of two rhetorical items - emotive phrases and passive voice in subtly ‘colouring’ the academic tone of research abstracts. Four hundred eighty (480) research abstracts (RAs) of the international non-native English writers (INE) and Malaysian non-native English writers (MNNE) were sampled from 88 national and international indexed journals. Two quantitative analysis tools were used to auto-generate the frequency percentages, which were then analysed with SPSS. It was found that MNNE RAs showed a significantly denser level of overall emotional appeal than INE RAs. The authorial tones of emotiveness and passiveness were also distinctly heavier in academic MNNE RAs than INE RAs. These were concluded as the marked rhetorical features of non-native English writers, deflecting them from the ones used by native English writers. In terms of research implication, the common trend of these features was not to be misconstrued by MNNE writers as the main rhetorical appeal of research composition.

Scientific Production on Monkeypox in Dentistry: A Bibliometric Analysis.

To analyze the characteristics and visibility of the scientific production of monkeypox in dentistry. A bibliometric study was carried out with the publications indexed in the Scopus database up to 22 September 2022. A search strategy was developed using Boolean operators "AND" and "OR," in addition to the MeSH term "monkeypox virus" (MPXV) in the subarea of dentistry. The bibliometric indicators were measured objectively with the SciVal program. Of the publications identified, 40% were indexed in first-quartile journals. India and Brazil are the countries with two published papers, while India has more views than the rest. Banaras Hindu University, Varanasi, Uttar Pradesh, India and Dr. Ram Manohar Lohia Hospital, New Delhi, India are the institutions with the highest number of citations with respect to the world average (FWCI: 2.74). The International Dental Journal has a publication on monkeypox in the field of dentistry. India is the country with the most authors (06) who have published about the study. Samaranayake Lakshman Perera is the most productive and high-impact author. In the area of dentistry, scientific production on monkeypox is still scarce; however, the publications identified are mainly in high-impact indexed journals (Q1 and Q2). It is necessary to prioritize this disease as a line of research, in addition to articulating efforts between dental teams from different institutions. It is necessary to demonstrate the characteristics of scientific publications on monkeypox in dentistry worldwide in order to have a panoramic view of the dynamics of scientific articles in this area.

Effects of Microencapsulated Essential Oils on Equine Health: Nutrition, Metabolism and Methane Emission.

This review examines the available data regarding the positive effects of microencapsulated essential oils (EOs) on the nutrition, metabolism, and possibly the methane emission of horses. A literature review was conducted on the effect of microencapsulated (EOs) on the health of horses. The information comprises articles published in recent years in indexed journals. The results indicate that mixtures of microencapsulated EOs may be beneficial to equine health due to their antimicrobial and antioxidant activity, as well as their effects on enteric methane production, nutrient absorption, and immune system enhancement. Moreover, encapsulation stabilizes substances such as EOs in small doses, primarily by combining them with other ingredients.

Hypovitaminosis D among athletes and its impact on athletic performance: Protocol for a scoping review

Varying evidence shows a surge in the prevalence of insufficient serum Vitamin D levels among athletes. Further exploration is incumbent to identify the influence of Vitamin D on athletic performance and various factors such as recovery from musculoskeletal pain and fatigue, improving muscle strength, reducing frequency and duration of illness, and lowering the production of pro-inflammatory markers. This systematic scoping review will identify the rate of occurrence of lower levels of Vitamin D and analyze if it impacts athletic performance. The methodology prescribed by Arksey and O’Malley and the methodological advancement by Levac will be followed. The authors will search electronic databases PubMed, Cochrane Central Register of Controlled Trials, Embase (through Cochrane), Ovid Emcare, and Google Scholar for original research and will include studies published in English between 1981 and 2021. Two reviewers will screen the title and abstracts of the identified literature, and the studies that meet the inclusion criteria will be moved to full text screening. The same reviewers will screen the full text of the selected literature and studies that meet the inclusion criteria will be used for data extraction. Extracted data will be reported as a comprehensive summary. The final manuscript is intended for submission to an indexed journal in January 2023. The scoping review will help to address the prevalence of hypovitaminosis D and combine evidence on its impact on performance among athletes. This scoping review was registered with Open Science Framework.

Evaluation of Low- and Middle-Income Country Authorship in the Global Orthopaedic Literature.

Extensive research collaborations exist between high-income countries and low- and middle-income countries (LMICs), although prior work has raised concerns regarding equitable representation among LMIC authors. The goal of this bibliometric analysis was to characterize LMIC authorship among indexed orthopaedic journals and identify factors contributing to disparities in representation. We identified all articles appearing in orthopaedic journals indexed in MEDLINE and Journal Citation Reports with a focus on LMICs or cohorts between 2009 and 2018. All articles describing research conducted in LMICs or research focused on applications to cohorts in LMIC(s) were included. Author affiliation, article characteristics, and impact factor were assessed for 1,573 articles. Logistic regression models created to identify predictors of LMIC authorship. We identified few studies published in indexed journals focused exclusively on LICs. Funded studies were less likely to have LMIC last authors. Compared with articles published in lower impact factor journals, those in journals with a higher impact factor were less likely to have a LMIC first or last author. The greater the number of countries represented per study, the less likely it had a LMIC first or last author. Our study highlights persistent disparities in authorship from LMICs in indexed orthopaedic journals.

Is cognitive reserve associated with the prevention of cognitive decline after stroke? A Systematic review and meta-analysis.

To conduct a systematic review and meta-analyses of the effect of socio-behavioral cognitive reserve (CR) proxies on cognitive decline after stroke. Three journal search and indexing databases (PubMed, Scopus and Web of Sciences) were crossed to examine the scientific evidence systematically. In addition, meta-analytic techniques, using mixed-effect methods, were carried out to estimate the impact (pooled effect size) of CR proxies on either dementia incidence or cognitive decline after stroke. Twenty-two studies were included in the systematic revision, whereas nineteen of them were eligible for the meta-analysis. The findings showed that high education is associated with a decreased rate of post-stroke dementia. Moreover, other CR proxies (e.g., occupation, bilingualism or social interaction) demonstrate a protective effect against non-dementia cognitive decline after stroke, although some inconsistencies were found in the literature. Regarding the meta-analysis, occupational attainment and education) showed a protective effect against post-stroke cognitive impairment diagnosis in comparison with a mixed category of different CR proxies. Second, a main cognitive change effect was found, pointing to greater cognitive change after stroke in those with low vs. high CR. Our findings emphasize that CR may prevent cognitive decline after stroke, but this effect can be modulated by different factors such the CR proxy and individual characteristics such as age or type of lesion. The methodological divergences of the studies (i.e., follow-up intervals, cognitive outcomes) need unification to diminish external sources of variability for predicting rates of cognitive decline after stroke.

Message by Editor-in-Chief, Western Supplement of Indian Journal of Anaesthesia.

Message by Editor-in-Chief, Western Supplement of Indian Journal of Anaesthesia.

Message by the Editor-in-Chief, Indian Journal of Anaesthesia; Way forward for Science - More opportunities for researchers to publish.

Message by the Editor-in-Chief, Indian Journal of Anaesthesia; Way forward for Science - More opportunities for researchers to publish.

The Research Trends and Scientometric Assessment of Rheumatoid Arthritis in India During 2016-2021.

Rheumatoid arthritis (RA) is a chronic autoimmune disorder that affects the synovial joints, causing swelling and joint damage. RA has become a major public health concern, harming more than 1500 people per lakh of the world's population. This inflammatory disorder is more common in females in comparison to males (3:1). In the present work, a scientometric analysis of published articles on RA during the last five years [1st January 2016 to 2021] on 19/08/2021 in the Scopus database is performed and investigates the contribution of India. In this study, the top most productive countries and the contribution of India in this field were analyzed. The different journals, funding agencies, and productive authors from India who contributed to this field are also recognized. The average citation impact is 10 citations per paper. A total of 61% share was found for the International collaboration in India's publication on rheumatoid arthritis. In India's output on rheumatoid arthritis, medicine produced the largest percentage of paper (60 percent). The top 15 journals publishing the maximum number of Indian papers contribute 1% share of global rheumatoid arthritis research (The highest number of papers (95 papers) published by the Indian Journal of Rheumatology). During the period 2016-2021, the top 10 highly cited papers got a total of 7045 citations, averaging 705 citations per publication. India was found to have a 5% (1974 publications) share of global output (42312 publications). In conclusion, there is a small number of researches on rheumatoid arthritis in a country, which holds the 2nd position in population across the world. There is a need for more research on rheumatoid arthritis in India.

Perkembangan Kajian Pendidikan Karakter Religius: Analisis Jurnal Bilbiometrik pada Database Scopus

This study aims to analyze religious character education using bibliometric analysis on the Scopus database. Bilbiometric analysis is a popular method for analyzing scientific data. This article discusses religious character education which is concretely based on the values of the teachings of each religion and the implementation of religious character education that can be carried out in schools, families and communities synergistically in shaping the religious character of students and in this article uses bilbiometric analysis which uses Scopus indexed journal on the development of religious character education studies: Bilbiometric analysis on the Scopus database. The purpose of the bilbiometric analysis in this study was to find out the top 5 year developments related to the development of religious character education studies. Specifically, this article aims to find out the development of religious character education literature from 2018 to 2022, major journals, authors, affiliates, countries and documents in the field of character education, trending topics related to religious character education, classifications and future character education topics that will provide more research opportunities. Data collected from the Scopus database using the keyword "religious character education". The author uses bilbioshiny software to analyze and visualize the database that has been obtained. The results of this study indicate that the citation analysis shows the number of citations per year from 2018-2022, namely 1,102 documents. Keane, W is a researcher who has the greatest productivity, namely 78 citations.

JACEP open annual report 2022.

JACEP open annual report 2022.

The Issue of Gender Bias Represented in Authorship in the Fields of Exercise and Rehabilitation: A 5-Year Research in Indexed Journals.

Despite progress made in recent decades, gender bias is still present in scientific publication authorship. The underrepresentation of women and overrepresentation of men has already been reported in the medical fields but little is known in the fields of exercise sciences and rehabilitation. This study examines trends in authorship by gender in this field in the last 5 years. All randomized controlled trials published in indexed journals from April 2017 to March 2022 through the widely inclusive Medline dataset using the MeSH term "exercise therapy" were collected, and the gender of the first and last authors was identified through names, pronouns and photographs. Year of publication, country of affiliation of the first author, and ranking of the journal were also collected. A chi-squared test for trends and logistic regression models were performed to analyze the odds of a woman being a first or last author. The analysis was performed on a total of 5259 articles. Overall, 47% had a woman as the first author and 33% had a woman as the last author, with a similar trend over five years. The trend in women's authorship varied by geographical area, with the higher representation of women authors in Oceania (first: 53.1%; last: 38.8%), North-Central America (first: 45.3%; last: 37.2%), and Europe (first: 47.2%; last: 33.3%). The logistic regression models (p < 0.001) indicated that women have lower odds of being authors in prominent authorship positions in higher-ranked journals. In conclusion, over the last five years, in the field of exercise and rehabilitation research, women and men are almost equally represented as first authors, in contrast with other medical areas. However, gender bias, unfavoring women, still exists, especially in the last authorship position, regardless of geographical area and journal ranking.