Production Index Research Articles

Soil Recycling of Waste Biomass in the Production of Malus domestica Fruit Tree Seedlings

The production of fruit tree seedlings generates waste wood biomass, which results from the pruning of budded rootstocks in the first year of the two-year production cycle. This study proposes a new method of managing this biomass by recycling the wood chips (2, 3 and 5 t ha−1) back into the soil. The impact of different wood chip doses on selected physicochemical soil properties after the production process (especially soil organic carbon content (SOC), as well as the quantity and quality of the produced Malus domestica fruit tree seedlings, was determined. The recycling of waste biomass contributed to enriching the soil with additional components, mainly organic carbon with the potential for biotransformation into humic substances. The applied doses of wood chips, in amounts of 2, 3, and 5 t ha−1, resulted in an increase in SOC content compared to the control by 21.5%, 22.5%, and 35.8%, respectively. Additionally, the recycling of waste biomass introduced other compounds important for plant growth and development into the soil, particularly iron, zinc, magnesium, and manganese. It should be noted that the proposed method of managing waste biomass generated during the apple tree seedling production stage resulted in reduced production costs while maintaining high production indices.

Geochemical characterization of Upper Cretaceous organic-rich deposits: Insights from the Azraq Basin in Jordan

Cretaceous sedimentary successions in Jordan are among the most promising unconventional global petroleum resources. The Upper Cretaceous deposits in the Azraq Basin in Jordan were analyzed using Rock-Eval pyrolysis, stable carbon isotopes, vitrinite reflectance, and biomarkers, as well as 1D basin modeling. This study aims to evaluate source input, depositional environment, burial history and potential for hydrocarbon generation of the Upper Cretaceous organic-rich deposits in Jordan. The Upper Cretaceous samples exhibit variable source rock potential. Maastrichtian samples are very good, primarily oil-prone, while Campanian and Cenomanian samples range from fair to poor, with Turonian samples showing good petroleum generation potential. Thermal maturity analysis of Cretaceous samples reveals higher maturity in Turonian and Cenomanian samples compared to the thermally immature Maastrichtian and Campanian samples based on the maximum temperature of pyrolytic hydrocarbons generation, vitrinite reflectance, production index and biomarker indicators. The molecular fossils data suggest that the organic matter of these source rocks was primarily of marine phytoplankton origin, with considerable contributions from microbial biomass, and deposited under oxygen-depleted bottom water conditions. Additionally, the resemblance in molecular composition between Cretaceous source rocks and crude oil samples suggests a common origin for the hydrocarbons. The highest contents of organic matter have been recorded at the top of the Maastrichtian and at the bottom of the Turonian sections. These findings correspond with Maastrichtian upwelling deposits in North Africa and the Middle East, as well as with deposits from the Cenomanian-Turonian Oceanic Anoxic Event (OAE2).

Engineering Escherichia coli for l-Threonine Hyperproduction Based on Multidimensional Optimization Strategies.

Exploring effective remodeling strategies to further improve the productivity of high-yield strains is the goal of biomanufacturing. However, the lack of insight into host-specific metabolic networks prevents timely identification of useful engineering targets. Here, multidimensional engineering strategies were implemented to optimize the global metabolic network for improving l-threonine production. First, the metabolic bottleneck for l-threonine synthesis was eliminated by synergistic utilization of NADH and an enhanced ATP supply. Carbon fluxes were redistributed into the TCA cycle by rationally regulating the GltA activity. Subsequently, the stress global response regulator UspA was identified to enhance l-threonine production by a transcriptomic analysis. Then, l-threonine productivity was improved by enhancing the host's stress resistance and releasing the inhibitory reaction of glucose utilization. Eventually, the l-threonine yield of THRH16 reached 170.3 g/L and 3.78 g/L/h in a 5 L bioreactor, which is the highest production index reported. This study provides rational guidance for increasing the productivity of other chemicals.

Hydrothermal alkaline treatment of lignocellulosic biomass for microcrystalline cellulose generation at subcritical water

Like lignocellulosic biomass, wood waste sawdust is rich in cellulose and can potentially be used as a source of microcrystalline cellulose (MCC) production via removal of hemicellulose and lignin constituents. Under hydrothermal alkaline treatment (100 to 140 °C), the breaking in the linkages of lignin and hemicellulose groups may happen, resulting in the solid residue, which is known as a cellulose-rich solid product. Results of FTIR analysis indicated that the removal of non-cellulosic constituents improved with increasing operating temperature and/or the prolonged treatment time. The XRD diffractogram pattern proved that improving the operating parameters (temperature and/or time) may also improve the crystallinity index of the solid product. On the contrary, the yield of the solid product decreases with increasing operating temperature and/or the prolonged treatment time.

Regional differences in reimbursement rates from Medicare, Medicaid, and FAIR Health across common procedures for neurological surgeons.

FAIR Health-a nonprofit, state-funded database-was created as an independent repository of healthcare claims paid data to address allegations of price fixing. Many insurers have forced physicians to negotiate payments based on Medicare rates, rather than utilizing FAIR Health. The authors' objective was to provide an overview of regional differences in reimbursement rates per several sample neurosurgical Current Procedural Terminology (CPT) codes and to compare Medicare, Medicaid, and usual, customary, and reasonable rates via FAIR Health rate estimates. The authors compared FAIR Health rates for three common neurosurgical CPT codes: 61510 (removal of bone from skull for removal of upper brain tumor), 22630 (fusion of lower spine bones with removal of disc, posterior approach, single interspace), and 62223 (creation of a brain fluid drainage shunt, ventriculoperitoneal, ventriculopleural, or other terminus), with Medicare and Medicaid reimbursement to evaluate differences in five different regions in the US. Medicare and Medicaid reimbursement rates were consistently and significantly lower than FAIR Health in-network rates across all three CPT codes evaluated (p < 0.001 for all). Significant regional differences exist per census data in median age, median income, employment rates, and degree of health coverage (p < 0.001, p = 0.002, p = 0.002, and p = 0.001, respectively). Reimbursement estimates were found to have regional variation: Medicare/Medicaid rates were significantly lower than FAIR Health in-network rates for all codes across regions with a region-based interaction for reimbursement for code 62223 (p = 0.020). Medicare and Medicaid rates did not significantly vary across regions. Inherent differences exist between cities and states, including median income, employment rates, and health coverage. Despite geographic cost practice indices for Medicare and state-specific production of Medicaid, Medicaid/Medicare reimbursement rates did not vary across regions but were consistently and significantly lower than FAIR Health estimates throughout the US. Locale-specific variation in FAIR Health may further indicate a better accounting of regional differences in cost of practice.

Assessing the therapeutic role of trehalose and hyaluronic acid: implications for patient care.

This Systematic review aims to assess the efficacy of trehalose and hyaluronic acid in enhancing ocular recovery post-cataract surgery, focusing on their impact on tear film stability, ocular surface integrity, and patient-reported outcomes. A comprehensive search was conducted across MEDLINE, PubMed, and Cochrane Library databases to identify randomized controlled trials investigating the efficacy of trehalose, hyaluronic acid, or their combination in post-cataract surgery care. The inclusion criteria focused on peer-reviewed studies in English, detailing outcomes relevant to ocular recovery such as tear film stability, ocular surface integrity, patient-reported discomfort, or visual acuity (VA). The quality of the included studies was assessed using the Cochrane Risk of Bias Tool and synthesized the data qualitatively. Four qualitative investigations met the inclusion criteria. The studies collectively assessed the efficacy of a 3% trehalose and 0.15% hyaluronic acid eye drop solution in reducing postoperative eye symptoms compared to various control solutions. Parameters measured included tear break-up time (TBUT), Fluorescein staining, tear production (Schirmer test), and Ocular Surface Disease Index (OSDI) scores. The results indicated significant improvements in tear film stability and ocular surface health for the treatment groups compared to controls, with a notable decrease in patient-reported discomfort. The study showed an improvement of - 18 (± 14.6) in the treatment group compared to - 7 (± 8.0) in the control group for OSDI. For TBUT, the treatment group improved by 3 (± 1.2) s, whereas the control group improved by 0.3 (± 0.71) s. VA, measured on a scale of 0-100, increased to 17 (± 0.7) in the treatment group compared to 15 (± 1.1) in the control group. Trehalose and hyaluronic acid may be beneficial in the postoperative period by enhancing tear film stability and ocular surface health. While the results are promising, further research is needed to confirm these findings, understand the mechanisms of action, and explore broader applications.

Standardization of Various Chemical Seed Priming on Seed Quality Parameters in Black Gram (Vigna mungo)

Black gram is an important pulse crop in India. It is a major source of dietary protein for the poor people and provides nutritional security. It is mostly grown by the small and marginal farmers under resource constraints situation particularly in rainfed and rice fallow conditions. Seed priming is one such effective technology to achieve high growth, vigor, better stand establishment. The current study aimed to study the standardization of various chemical on crop growth in black gram. A laboratory experiment was conducted in Factorial Completely Randomized Design (FCRD) with three replications using various concentrations (1%, 2%, 3% and 4 %) as first factor and different durations (4 and 6 h) of priming as second factor and different chemicals such as ZnSO4, MnCl2, MgSO4, CaCl2, KCl and KNO3 as third factor. Seeds were primed with different chemicals in different concentrations and in different duration evaluated for its quality parameters to find out suitable seed priming technique. Among all treatments seed priming with ZnSO4 1% for 6 hours recorded higher germination (98%), longest root length (22.17 cm), shoot length (19.15 cm), higher seedling dry matter production (0.93 g seedlings-10), fresh weight (8.93 g seedlings-10) and vigor index (4004) than control under laboratory experiment. The results indicate that use of ZnSO4 1% for 6 hours enhances the seed performance regarding seed quality characters.

Navigating Ghana's economic waters: Exploring the impact of Fiscal and Monetary policies on stock market performance

This study leverages the Autoregressive Distributed Lag (ARDL) and Exponential Generalized Conditional Heteroscedasticity (EGARCH) models to conduct a thorough examination of the impact of fiscal and monetary policies on the Ghanaian stock market from 1990 to 2022. Key findings indicate that government spending and tax revenue, as components of fiscal policy, are positively associated with stock returns, contrasting with the negative influence of the industrial production index. On the monetary policy front, interest rates are found to negatively affect stock performance, while exchange rates and the money supply exert positive influences. In the short term, government spending enhances stock returns, although the effects of GDP and the industrial production index are inconsistent, with exchange rates and money supply demonstrating a negative impact. The study underscores the profound sway that policy decisions have on stock market dynamics, underscoring an urgent need for investors and policymakers to closely monitor policy shifts and their market reverberations. A pivotal policy recommendation emerging from this research is the strategic synchronization of fiscal and monetary policies by policymakers to underpin stock market stability and growth. Such harmonization can counteract the adverse effects of policy-induced volatility, cultivating an investment-friendly climate. Investors and policymakers are encouraged to draw upon a spectrum of credible sources, encompassing financial news, governmental releases, and market analyses, to remain abreast of policy evolutions. This research offers precious perspectives on the nexus between economic policies and market movements, offering value for academic inquiry and informing practical decision-making strategies.

Environmental Enrichment Attenuates Reproductive Adversity in a Mouse Model of Parkinson Disease

Environmental enrichment is the provision of different substrates to mimic an animal’s natural environment and encourage natural, species-specific behavior. However, the use of enrichment to improve breeding efficiency in mouse models for neurologic conditions is not well described. There are reports that diminished environmental stimuli and chronic isolation can result in the early expression of the Parkinson phenotype in mice with a genetic predisposition to the disease. In this study, we compared the provision of crinkle paper, DietGel, and their combination on reproductive parameters in B6.Cg-Tg(THY1-SNCA*A53T)M53Sud mice. We found that enhanced enrichment combined with enhanced nutrition increased dam weight and decreased the interlitter intervals. In addition, enhanced enrichment increased the production index, number of pups born, pups weaned, and the percent survival of pups. This study underscores the importance of incorporating enrichment to enhance the reproductive parameters in mice that are models of Parkinson disease.

Comparative Analysis of Economic Forces and Stock Market Movements: The U.S. and Indonesia

The economies of many developed and developing countries are experiencing instability, characterized by a decline in economic performance. In a macroeconomic context, global instability affects several key indicators such as production indices, exchange rates, interest rates, and inflation rates. The occurrence of shocks to macroeconomic indicators certainly increases the volatility of a country's capital markets. This quantitative research examines the correlation of shocks to each key indicator of capital market performance in Indonesia and the United States. This research uses the VECM method. The research shows that the influence of macroeconomic indicators tends to fluctuate in the short term and is stable in the long term. Where the production and inflation indices have a positive and significant effect on the IDX Composite and the DJI, this is different from interest rates, which negatively impact the IDX Composite and DJI. Meanwhile, the exchange rate indicator has no significant effect on IDX Composite or DJI. The research also found that the IDX Composite was predominantly influenced by exchange rates and inflation, while the DJI was predominantly influenced by production index indicators, inflation, and interest rates.

Association between severe headache or migraine and lipid accumulation product and visceral adiposity index in adults: a cross-sectional study from NHANES

BackgroundExisting literature on the impact of lipid accumulation product (LAP) and visceral adiposity index (VAI) on severe headache or migraine is limited. This study aims to elucidate the association between LAP and VAI and the prevalence of migraine.MethodsData for this study were sourced from the 1999–2004 National Health and Nutrition Examination Survey (NHANES). A database-self-administered questionnaire was used to assess severe headache or migraine. A weighted logistic regression model was employed to assess the relationship between LAP and VAI with migraine prevalence. Complementary analytical approaches included subgroup analysis, restricted cubic spline (RCS), and threshold effect analysis to validate the findings.ResultsIn the end, 4572 people were recruited for the research, including 880 with migraine and 3692 without migraine. Following adjustment for the relevant covariables, weighted logistic regression analysis (OR = 1.409, 95% CI: 1.054, 1.883, P = 0.022; OR = 1.288, 95% CI: 1.010, 1.642, P = 0.042) revealed significantly elevated odds of migraine prevalence in participants within the highest tertile (T3) of LAP and VAI than those in the lowest tertile (T1). The nonlinear association between migraine prevalence and both VAI and LAP was further elucidated through a restricted cubic spline. The threshold analysis pinpointed 2.142 (log-likelihood ratio = 0.016) as the critical inflection point for VAI. Subgroup analysis and interaction testing revealed the significant association was independent in different subgroup factors.ConclusionsThe data indicate a robust association between higher levels of LAP and VAI and an increased prevalence of migraine.

Red cell size factor is a sensitive index in the early diagnosis of nondigestive tract cancer-related anemia: An observational study.

Cancer-related anemia (CRA) is a common comorbidity in cancer patients, and it can lead to a worse prognosis. The aim of this cross-sectional study is to investigate the clinical value of the red cell size factor (Rsf) in the early diagnosis of nondigestive tract CRA. A total of 231 patients with nondigestive tract solid cancer were included, and they were divided into anemic and nonanemic subjects according to the hemoglobin (Hb) levels. A BC-7500 blood analyzer was used to detect the indices of red blood cell and reticulocyte, and the mean corpuscular volume (MCV), mean reticulocyte volume (MRV), reticulocyte hemoglobin (RHE) content, and reticulocyte production index were observed. Subsequently, the Rsf was calculated. Receiver operating characteristic curve analysis was used to evaluate the identifying power of Rsf for anemia diagnosed by the combination of RHE and reticulocyte production index. The adjusted-multivariate analysis and quartiles were used to assess the relation of reduced Rsf level with the risk and incidence of anemia diagnosed by combining the MCV, MCH, and mean corpuscular hemoglobin concentration (MCHC), respectively. Rsf levels showed no statistical differences between anemia and nonanemia subjects grouped by Hb (P > .05). Rsf has a high correlation with the RHE level (R > 0.900, P < .001), or MCV, mean corpuscular hemoglobin (MCH), and MCHC in anemia patients (r: 0.435-0.802, P < .001). Receiver operating characteristic curves showed that Rsf had the highest overall area under curve of 0.886 (95% confidence interval: 0.845-0.927) in identifying anemia of cancer patients (P < .001). When the optimal cutoff values of Rsf were set at 97.05 fl in males and 94.95 fl in females, the sensitivity and specificity were 0.94 and 0.76, and 0.98 and 0.75, respectively. Being treated as a categorical variable, Rsf had a highest odds ratio value of 30.626 (12.552-74.726; P < .001) for the risk of anemia. The increment of Rsf quartiles was highly associated with the decreased incidence of overall anemia (P trend < 0.001). The study suggests that decreased Rsf level is a potentially powerful predictor of overt anemia in nondigestive tract cancer, and it can be used as a convenient, practical, cost-free, and sensitive index in early diagnosis of nondigestive tract CRA.

The impact of the Russian-Ukrainian War on the food security of the Kingdom of Saudi Arabia

The economic and social impact of the Russian-Ukrainian war was the focus of this study, which aimed to assess its effect on the food security of the Kingdom of Saudi Arabia. To achieve its objectives, the study utilized published data, food security index measures, and standard economic analysis. The findings revealed that the Kingdom's food security environment index increased from 58.1% in 2012 to 69.9% in 2022, indicating moderate food security throughout this period. The index was lower than the estimated counterpart for the rest of the Gulf Cooperation Council countries but exceeded the global average (113 countries) by 12.38% in 2022. Furthermore, the study demonstrated that a 10% increase in the estimated food production index and real per capita income led to a 2.72% and 6.55% increase in the food security index, respectively. Conversely, a 10% rise in the estimated consumer price index for foodstuffs resulted in a 1.74% decrease in the food security index. Despite the challenges posed by the Russian-Ukrainian war, the food security index is projected to improve for the Kingdom of Saudi Arabia, expected to increase from 72.4% in 2024 to 75.6% in 2030, attributed to the country's policy of investing in agriculture abroad and focusing on local agricultural investments such as vertical expansion, protected agriculture, and agricultural practices. This strategic approach ensures high-quality produce and facilitates significant financial surpluses, enhancing the country's capacity to import goods from overseas.

Optimal fertilization of Marandu grass with gelatin industry sludge

This study determined optimal fertilization levels for Marandu grass (Urochloa brizantha cv. Marandu) as a forage using sludge from the gelatin industry. The experiment was performed in a greenhouse with five treatments: three rates of gelatin sludge application (0, 200, and 300 m3 ha-1), an organo-mineral (100 m3 ha-1 + mineral: 60 mg dm-3 N), and pure mineral fertilizer (100 mg dm-3 N) with six replicates. Plant and stem height, number of tillers, leaves, leaves/tiller, chlorophyll index, dry mass (leaves, roots, and residue), crude protein, neutral and acid detergent fiber, macronutrient, and micronutrient concentrations were measured. Plant and stem height, number of tillers, leaves, and biomass production increased linearly as gelatin sludge dosage increased. There was a linear increase in crude protein with reduction in neutral detergent fiber and acid detergent fiber with increasing gelatin sludge fertilization. Gelatin sludge dosage did not affect the contents of P, Mg, S, Cu, and Fe. Only Mn had a positive linear response to gelatin sludge with reduction at the highest rate. The 300 m3 ha-1 dosage of gelatin sludge increased biomass production and chlorophyll index. In contrast, the organo-mineral fertilizer promoted higher crude protein and lower neutral detergent fiber concentrations in grass. The gelatin sludge dosage of 300 m3 ha-1 improved the nutritive value of Marandu grass compared to mineral fertilizer. Gelatin sludge is a promising pasture amendment for growing Marandu grass as it recycles industrial animal waste for a more integrated livestock-cropping system.

Tiered maize and wheat nutrient removal coefficients estimated from available data

AbstractEstimates of cropland nutrient budgets at national to global scale generally rely on regional or global mean coefficients for quantifying nutrients removed in crop yield and by-products. Use of such mean values masks the variability in these coefficients. Using maize and wheat as examples, we assessed variation in nutrient removal coefficients, namely harvest index (HI), nitrogen (N), phosphorus (P) and potassium (K) concentrations of crop products (Grain N, Grain P and Grain K respectively) and N, P and K concentrations of crop residues (Residue N, Residue P, and Residue K respectively). Variation in these coefficients was assessed by three categories (Tiers) of estimation. Statistical (mixed-effects) and machine learning (random forest regression) models (Tier 3) were used to predict the coefficients using generally available predictor variables at a global level. Mean prediction accuracies (R2) of the mixed-effects and random forest models were 0.32 for maize coefficients and 0.45 for wheat coefficients when based on a random sub-selection of mainly replicated field experiment data. When predictions were applied to on-farm data only, prediction accuracies were lower (mean R2 values of 0.08 and 0.36 for maize and wheat respectively). Variation in, and dearth of on-farm data for the coefficients contributed to these poor prediction accuracies. Until the limitations of on-farm data are overcome, it is recommended to use Tier 2 (regional) coefficient estimates in country and global cropland nutrient balance and nutrient use efficiency estimates. Where Tier 2 values are not available, then global average (Tier 1) coefficients can be used.

Impact of digital financial inclusion on economic growth: a study on Bangladesh

PurposeThe purpose of the study is to find out the impact of Digital Financial Inclusion (DFI) on economic growth [(Industrial Production Index (INDP)] of Bangladesh.Design/methodology/approachUsing the monthly data over the period 2018 M12 to 2021 M12, this study applied the Auto-regressive Distributed Lag (ARDL) model to assess the effect of DFI indicators on INDP. The secondary data was collected from the Bangladesh Bank and CEIC Global Economic Data.FindingsThe study found that the majority of DFI indicators are positively associated with INDP. From the short-run ARDL, it is seen that one unit positive increase in Point of Sales Transactions (POST) can increase the INDP by 0.055 units. From the long-run ARDL, it is seen that POST and e-commerce transactions (ECOMT) have a significant positive impact, while Automated Teller Machine Transactions (ATMT) have a significant negative effect on INDP. One unit increase in POST and ECOMT increases INDP by 0.13544 and 0.11611 units, respectively.Research limitations/implicationsDuring the era of the fourth industrial revolution, the findings will be beneficial for policymakers, financial technology service providers, manufacturers, consumers, corporations and investors as they pave the way for a more inclusive approach to financial transactions for economic growth.Originality/valueThe study’s novelty is that it explored the influential DFI indicators and shed light on both short-run and long-run relationships between the indicators and macro-economy from the context of a developing nation.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-04-2023-0306

Relationship between Body Adiposity Indices and Reversal of Metabolically Unhealthy Obesity 6 Months after Roux-en-Y Gastric Bypass.

The factors determining the reversal of metabolically unhealthy obesity (MUO) to metabolically healthy obesity (MHO) after Roux-en-Y gastric bypass (RYGB) are not completely elucidated. The present study aims to evaluate body adiposity and distribution, through different indices, according to metabolic phenotypes before and 6 months after RYGB, and the relationship between these indices and transition from MUO to MHO. This study reports a prospective longitudinal study on adults with obesity who were evaluated before (T0) and 6 months (T1) after RYGB. Bodyweight, height, waist circumference (WC), BMI, waist-to-height ratio (WHR), total cholesterol (TC), HDL-c, LDL-c, triglycerides, insulin, glucose, HbA1c and HOMA-IR were evaluated. The visceral adiposity index (VAI), the conicity index (CI), the lipid accumulation product (LAP), CUN-BAE and body shape index (ABSI) were calculated. MUO was classified based on insulin resistance. MUO at T0 with transition to MHO at T1 formed the MHO-t group MHO and MUO at both T0 and T1 formed the MHO-m and MUO-m groups, respectively. At T0, 37.3% of the 62 individuals were classified as MHO and 62.7% as MUO. Individuals in the MUO-T0 group had higher blood glucose, HbA1c, HOMA-IR, insulin, TC and LDL-c compared to those in the MHO-T0 group. Both groups showed significant improvement in biochemical and body variables at T1. After RYGB, 89.2% of MUO-T0 became MHO (MHO-t). The MUO-m group presented higher HOMA-IR, insulin and VAI, compared to the MHO-m and MHO-t groups. CI and ABSI at T0 correlated with HOMA-IR at T1 in the MHO-t and MHO-m groups. CI and ABSI, indicators of visceral fat, are promising for predicting post-RYGB metabolic improvement. Additional studies are needed to confirm the sustainability of MUO reversion and its relationship with these indices.

Combined effects of alcohol and lead on cerebrospinal fluid production

Currently, due to the development of industry, a high incidence of heavy metal salt poisoning is observed, especially in people with alcohol dependence. The study aims to investigate the combined effects of these pathogens on the central nervous system. The study demonstrates changes in intracranial pressure and cerebrospinal fluid production in isolated and combined poisoning of lead and ethanol based on experimental models on 10 and 40 days of exposure, 3 main groups were formed – the group of lead salts, ethanol, combined intoxication, after which the main indicators were measured. The effect of separate and combined action of alcohol and lead on cerebrospinal fluid production and haemodynamic indices in experimental animals was studied. It was found at 40-day intoxication indices remained above normal, systemic arterial pressure was 131.8 mmHg, and the rate of cerebrospinal fluid production was 0.073±0.002 ml/min. Combined 10-day combined action of alcohol and lead enhances their excitatory effect, which is characterised by an increase in systemic arterial pressure (to the level of 135.6 mmHg) and general psycho-somatic agitation, the rate of cerebrospinal fluid production was 0.077±0.008 ml/min. The 40-day co-exposure manifested mainly toxic effects of lead, as shown by a decrease in cerebrospinal fluid production of 0.049±0.001 ml/min, and a decrease in blood pressure to a level of 93.6 mmHg. The results of this study will make it possible to develop treatment protocols for patients with ethanol and heavy metal salt poisoning, especially in the field of anti-oedema therapy

Association of different obesity indexes with diabetic kidney disease in patients with type 2 diabetes mellitus: a cross-sectional study

The objective of this study is to investigate the association between diabetic kidney disease (DKD) and various adiposity indexes, including the visceral adiposity index (VAI), lipid accumulation product index (LAPI), visceral fat area (VFA), and subcutaneous fat area (SFA) in type 2 diabetes mellitus (T2DM) patients. 1176 T2DM patients was stratified into normoalbuminuria (NO), microalbuminuria (MI), and macroalbuminuria (MA) groups based on their urinary albumin-creatinine ratio (UACR) levels. To analyse the correlation between DKD and VAI, LAPI, VFA, and SFA. Multiple linear, restricted cubic spline (RCS), subgroup analyses, and multinomial logistic regression were employed. After adjusting for confounding variables, UACR levels were positively associated with VAI, LAPI, and VFA. RCS curves demonstrated a J-shaped dose-response relationship between VAI and LAPI levels with UACR levels, while a linear correlation was observed between UACR levels and VFA. Using the NO and MI as reference groups, the MA group was analysed as the observational group. DKD severity was positively associated with VAI, LAPI and VFA. When evaluating DKD prognostic risk, with the low-risk and medium-risk groups serving as reference categories, a significant positive correlation was identified with prognostic risk and VAI, LAPI, and VFA in the high-risk or very high-risk groups. In patients with T2DM, DKD severity and prognostic risk were positively correlated with VAI, LAPI, and VFA levels.

Incidence of deep vein thrombosis and pulmonary embolism in closed foot and ankle fractures treated with conservative versus surgical management: A nationwide analysis

ObjectivesThough there is extensive research on recovery and outcomes of proximal joint fractures, such as hip and knee, there is a paucity of such research in foot and ankle fractures and a lack of uniform data on the incidence of venous thromboembolism (VTE). This is a retrospective cohort study that seeks to investigate the incidence of VTE following surgically versus conservatively treated foot and ankle fractures MethodsThis study included all adult-patient hospitalizations with International Classification of Disease 10th Revision diagnosis codes related to closed foot and ankle fractures as a primary diagnosis in the National Inpatient Sample, an administrative database part of the Healthcare Cost and Utilization Project, for a total of 209,595 cases. Multivariate binary logistic regression was performed to determine the effect of age, gender, past medical history of venous thromboembolism (PMHVTE), Charlson Comorbidity Index, race, surgery, and transfusion of red cell products on the incidence of deep venous thrombosis (DVT) and pulmonary embolism (PE). ResultsOur study found an overall incidence of DVT and PE to be 0.4 % and 0.3 %, respectively, following foot or ankle fracture. Conservative management was found to have an increased relative risk of DVT and PE of 2.02 and 1.15, respectively. This difference persisted on performing inverse probability treatment weighting (IPTW) analysis to account for confounders. PMHVTE and requirement of blood transfusion was associated with an increased odds ratio (OR) of 3.41 and 3.217, respectively. Cases identified as Black and Asian/Pacific Islander also had an increased OR of DVT. ConclusionsThe results of this study demonstrate that surgical management of foot and ankle fractures is associated with a lower relative risk of VTE compared to medical management. PMHVTE and transfusion of red cell products increase the odds of VTE following either form of intervention.