Indices Of Contractile Function Research Articles

Contractile function of the heart and its reactivity to noradrenal in during adaptation to medium altitudes

Acute experiments on rats adapted for 1 month to an altitude of 2100 m showed that in the early period of exposure at this altitude the systolic pressure in the left ventricle and the rate of its development and fall were considerably greater than the corresponding indices in control experiments in Moscow. the indices of contractile function subsequently stabilized gradually. Four weeks later the hearts of the adapted animals showed a much greater rise in the indices of contractile function in response to injection of adrenalin and greater stability of this function at very high heart rates.