Indicator Of Progression Research Articles

MiR-132-3p, miR-106b-5p, and miR-19b-3p Are Associated with Brain-Derived Neurotrophic Factor Production and Clinical Activity in Multiple Sclerosis: A Pilot Study.

Introduction: Brain-derived neurotrophic factor (BDNF) levels are reduced in advanced stages of multiple sclerosis (MS) and may be associated with reduced regenerative capability in progressive MS. This has brought increased attention to factors regulating BDNF production in MS. Our aim was to investigate the link between neurotrophin-regulating microRNAs (miRNA) and disease progression in MS. Materials and Methods: Serum levels of BDNF and peripheral blood mononuclear cell (PBMC) expression levels of miR-132-3p, miR-106b-5p and miR-19b-3p were respectively measured by ELISA and real time PCR in twelve relapsing remitting MS (RRMS) patients, seven secondary progressive MS (SPMS) patients and fourteen healthy controls. Results: Serum BDNF levels were significantly reduced in SPMS patients, while selected miRNAs were significantly upregulated in PBMC of RRMS and SPMS patients. miR-106b-5p and miR-19b-3p respectively showed the highest sensitivity and specificity for MS diagnosis by receiver operating characteristic curve analysis. There was a negative correlation between levels of BDNF and the miRNAs in RRMS. Likewise, levels of BDNF and the investigated miRNAs showed positive and negative correlations respectively with the expanded disability status scale in RRMS and SPMS patients. miR-132-3p and miR-106b-5p levels showed positive correlations with the progression index in SPMS patients. Conclusion: Our results suggest that increased disability is associated with downregulation of miR-132-3p, miR-106b-5p and miR-19b-3p in RRMS patients and putatively promotes increased production of neuroprotective BDNF as a compensatory mechanism. This link between the investigated miRNAs and BDNF in RRMS does not appears to hold for SPMS. This might be one of the factors contributing to reduced regenerative ability in the progressive stage of MS.

Study of Quasispecies Complexity and Liver Damage Progression after Liver Transplantation in Hepatitis C Virus Infected Patients.

Cirrhosis derived from chronic hepatitis C virus (HCV) infection is still a common indication for liver transplantation (LT). Reinfection of the engrafted liver is universal in patients with detectable viral RNA at the time of transplant and causes fast progression of cirrhosis (within 5 years) in around one-third of these patients. To prevent damage to the liver graft, effective direct-acting antiviral (DAA) therapy is required as soon as possible. However, because of post-LT clinical instability, it is difficult to determine the optimal time to start DAAs with a low risk of complications. Evaluate changes in quasispecies complexity following LT and seek a predictive index of fast liver damage progression to determine the timing of DAA initiation. HCV genomes isolated from pre-LT and 15-day post-LT serum samples of ten patients, who underwent orthotopic LT, were quantified and sequenced using a next-generation sequencing platform. Sequence alignments, phylogenetic trees, quasispecies complexity measures, biostatistics analyses, adjusted R2 values, and analysis of variance (ANOVA) were carried out. Three different patterns of reinfection were observed (viral bottlenecking, conserved pre-LT population, and mixed populations), suggesting that bottlenecking or homogenization of the viral population is not a generalized effect after liver graft reinfection. None of the quasispecies complexity measures predicted the future degree of liver damage. Higher and more uniform viral load (VL) values were observed in all pre-LT samples, but values were more dispersed in post-LT samples. However, VL increased significantly from the pre-LT to 15-day post-LT samples in patients with advanced fibrosis at 1-year post-LT, suggesting that a VL increase on day 15 may be a predictor of fast liver fibrosis progression. HCV kinetics after LT differ between patients and are not fibrosis-dependent. Higher VL at day 15 post-LT versus pre-LT samples may predict fast liver fibrosis progression.

The Road to Cognitive Skill Acquisition: Psychometric Evaluation of the Competencies of Cognitive Therapy Scale.

Cognitive therapy (CT) skills are an index of treatment progress. They predict changes in patients' acute depressive symptoms and symptom relapses. However, the psychometric properties of the various measures of CT skills are poorly understood. This study aimed to investigate the factor structure of the Competencies of Cognitive Therapy Scale-Self Report (CCTS-SR) and assess its concurrent validity. The psychometric properties of the CCTS-SR were explored by using data from a panel of online respondents (N=410). The fit of a one-factor solution was explored by using a confirmatory factor analysis. Exploratory bifactor analyses (EBFA) were then conducted to determine other possible factor structures. The one-factor solution did not fit the data well. Results of the EBFA suggested that the factor structure of the CCTS-SR may be characterized by a single underlying dimension capturing the general use of CT skills as well as by more specific factors the authors labeled "behavioral activation" and "CT comprehension." The variance captured by the factor initially labeled as CT comprehension was correlated with measures of depression and emotional dysregulation, suggesting that these items do not capture CT comprehension and should be removed from the scale. The CCTS-SR seems to be characterized by more than a single factor, and items that seemingly compose CT comprehension (i.e., items 13 and 14) may need to be removed. Although the CCTS-SR may be a valid index of therapy progress, more attention needs to be paid to its psychometric properties.

Biomarker signatures for progressive idiopathic pulmonary fibrosis.

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease in which circulatory biomarkers have the potential for guiding management in clinical practice. We assessed the prognostic role of serum biomarkers in three independent IPF cohorts: Australian Idiopathic Pulmonary Fibrosis Registry (AIPFR), Trent Lung Fibrosis (TLF) and Prospective Observation of Fibrosis in the Lung Clinical Endpoints (PROFILE). In the AIPFR cohort, candidate proteins were assessed by ELISA as well as in an unbiased proteomic approach. LASSO (least absolute shrinkage and selection operator) regression was used to restrict the selection of markers that best accounted for the progressor phenotype at 1 year in the AIPFR cohort, and subsequently prospectively selected for replication in the validation TLF cohort and assessed retrospectively in the PROFILE cohort. Four significantly replicating biomarkers were aggregated into a progression index model based on tertiles of circulating concentrations. 189 participants were included in the AIPFR cohort, 205 participants from the TLF cohort and 122 participants from the PROFILE cohort. Differential biomarker expression was observed by ELISA and replicated for osteopontin, matrix metallopeptidase-7, intercellular adhesion molecule-1 and periostin for those with a progressor phenotype at 1 year. Proteomic data did not replicate. The progression index in the AIPFR, TLF and PROFILE cohorts predicted risk of progression, mortality and progression-free survival. A statistical model incorporating the progression index demonstrated the capacity to distinguish disease progression at 12 months, which was increased beyond the clinical GAP (gender, age and physiology) score model alone in all cohorts, and significantly so within the incidence-based TLF and PROFILE cohorts. A panel of circulatory biomarkers can provide potentially valuable clinical assistance in the prognosis of IPF patients.

Efficacy of plum blossom acupuncture on alopecia areata – A case report

Alopecia areata (AA) is a complex autoimmune condition that causes non-scarring hair loss and may present at any age. It typically presents with sharply demarcated round patches of hair loss. AA presents heterogeneously and is influenced by both environmental and genetic factors. There is no effective pharmacological treatment currently available for this disorder so far. We had an opportunity to treat a patient with AA using acupuncture. The patient was a 23-year-old male who presented to us with a complaint of sudden hair loss in patches in two demarcated round areas in a diameter of 2–3 cm on the back of the head for the past year. He was diagnosed as AA by AA progression index. After a long treatment course of about 3 months with acupuncture, this patient showed significant hair growth.

Оценка изменения биомеханических свойств роговицы при кератэктазиях

Purpose. To make a comparative analysis of topographic, tomographic and biomechanical values, measured by Pentacam HR and Corvis ST, in healthy multirefractive cohort versus patients with keratectasia of various severity. Material and methods. The prospective study comprised 237 patients aged from 18 to 47 years, subdivided into three groups. The first group included 174 healthy persons with various refraction (174 eyes). The second and the third group embraced 63 patients with keratoconus: 36 patients (36 eyes) with keratoconus of the I degree and 27 eyes with keratoconus of the II and III degrees. Besides the conventional comprehensive ocular examination the following studies were performed in all the patients: evaluation of topographic, tomographic and biomechanical corneal properties with application of Pentacam HR and Corvis ST (OCULUS Optikgerate GmbH; Wetzlar, Germany). Results. It was revealed that the following biomechanical values, assessed by means of Pentacam HR and Corvis ST, exhibited statistically significant changes (p<0,001) in all degrees of ketatoconus: a relative corneal thickness by Ambrosio, inverted radius of applanation curvature (IntRadius), DA Ratio Coefficient, values of corneal rigidity – SP-A 1 and SSI. Conclusion. The detected parameters may be applied as indicators, allowing to evaluate corneal biomechanics, to define early features of ectatic process, to assess effectiveness of the performed corneal collagen crosslinking and intralamellar keratoplasty with implantation of corneal segments. Key words: keratoconus, corneal biomechanics, pachymetry, index of pachymetric progression, corneal viscoelasticity.

Social solidarity in healthcare: The Israeli case

While solidarity is at the basis of all social health insurance systems, little has been done to define and analyze it empirically. Equity in the delivery of medical care and progressivity of its finance are socially important, but miss the main principle of social health insurance systems – mutual help. The present study views social solidarity not as a value but as cross-subsidies among individuals, which are necessary to achieve a separation between finance and delivery of care in order to make healthcare affordable universally. A solidarity index, derived from the Kakwani Progressivity Index, is suggested and applied to the Israeli national health insurance system in 2010. The observed solidarity index for 2010 Israel is 0.242. Adjusting for possible barriers in use does not change the index. About 85% of the solidarity index originates from income solidarity. If the entire health budget was financed by the general revenue, the solidarity index would rise to 0.259. The level of solidarity in Israel is close to the one found in Canada, Finland and France. More comparative results over time and over systems will enable further insights and uses. The sustainability of solidarity requires, however, some altruism among the rich with respect to the health state of the poor.

Correlation of Country Characteristics and Government Response Measures With COVID-19 Mortality During the First Phase of the Global COVID-19 Pandemic: A Worldwide Ecological Study

IntroductionIt is valuable to know if country demographic, educational, healthcare and other socioeconomic factors were correlated with the COVID-19 mortality rate during the initial phase of the coronavirus disease 2019 (COVID-19) worldwide pandemic (January 1st - August 31st, 2020). Similarly, it is worthwhile understanding whether a country’s geographic location or the measures instituted by governments, such as lockdowns and mask-wearing, were associated with an increased or decreased mortality rate.Materials and methodsTo assess these correlations, we conducted an ecologic study of 178 countries using time-matched data from the Social Progress Index (www.socialprogress.org, produced by the Social Progress Imperative), population data from the World Bank (data.worldbank.org), government response indices from Our World In Data (ourworldindata.org/policy-responses-covid), and COVID-19 mortality data from the Johns Hopkins University CSSE COVID-19 Data repository (github.com/CSSEGISandData/COVID-19), accessed on November 22nd, 2020. Pearson correlation coefficients were derived between potential predictors and countries’ COVID-19 population-adjusted crude mortality rates. Select variables were entered in a multivariable regression model. Countries with no data in the social progress index database or those with no COVID-19 cases were excluded (20 in total). ResultsThe highest positive correlations were found between the proportion of the population older than 75 (Pearson correlation coefficient 0.321), country distance from the equator (0.267), gross domestic product per capita (0.218), health and wellness score (0.388), water and sanitation score (0.384), environmental quality (0.237), and the days between the first reported COVID-19 case and the initial government response (0.238). A previously unreported and unexpected negative correlation was found between gender parity in secondary education attainment and COVID-19 mortality (-0.290). Peak mask-wearing ranging from ‘recommended’ to ‘required outside the home at all times was extremely weakly correlated with lower COVID-19 mortality (-0.046).ConclusionsCrude COVID-19 mortality rates during the first phase of the pandemic in 2020, during which no vaccine or specific treatment was available, were higher in wealthier countries that were further away from the equator and had a higher health and wellness score according to the Social Progress Imperative. They were also higher the longer governments delayed their initial response. Gender parity in secondary education and stringency of mask-wearing guidelines were correlated with lower mortality, though the latter correlation was extremely weak. Our findings are consistent with previously published correlations. The correlation between crude COVID-19 mortality rates and gender parity in secondary education has not been previously reported.

The XXV Años de Paz Española: the invention of a Francoist aesthetics of objectivity and the constitution of a new visual regime of history

ABSTRACT This article explores how the celebration of the XXV Años de Paz in 1964 served as the stage for a new national rhetoric of peace, progress and modernity that allowed the Francoist dictatorship to move away from its fascist past. Through its study of the exhibition España 64 and the movie Franco, ese hombre, this paper explores how the celebration put into circulation what I refer to as a Francoist aesthetics of objectivity – the visual strategies used by the state to create visible indices of progress through statistics and economics as signs of good governmental practice. I challenge this idea with my analysis of the curatorial narrative of the Spanish pavilion at the New York World’s Fair of 1964. Ultimately, this article argues that what took place during the year 1964 was a rearrangement of the national narrative surrounding the Spanish Civil War that allowed the dictatorship to fluctuate between its fascist ideological tenets and pseudo-liberal economic policies and combine them at will. Despite the alleged aperturismo of the 1960s, I propose that the values attached to the Civil War continued to be at the core of the ideology determining the creation and circulation of new national narratives that would constitute a new visual regime of history.

Longitudinal Ankle Brachial Index and Risk of CKD Progression

Longitudinal Ankle Brachial Index and Risk of CKD Progression

Effects of climate change and its impact on some variables that influence the quality of life of populations in Latin America

This article provides a bibliographic review of the effects of climate change on various currently prevailing topics deemed critical. Humanity faces enormous challenges in the areas of agricultural production, food security, sustainable development, the environment, and their relationships and impact on poverty.
 It is essential to adapt the 2030 Agenda for Sustainable Development in Latin American and Caribbean countries in order to fulfill proactive actions for attaining the Sustainable Development Goals (SDGs). Each Country must develop its own solutions according to the best interests of their citizens and country.
 A review of topics including climate change and its affiliation with social progress indexes, unemployment, intensity of deprivation, and indicators of sustainable development are key to inspiring companies to adopt good corporate social responsibility practices. A longitudinal design was applied to the non-experimental research in order to examine changes throughout time over populations of people living in LAC countries. An analysis of the changes that occurred to populations over time was divided into three sections.

CALCULATION OF SUSTAINABLE DEVELOPMENT INDEX IN THE EU AND UKRAINE

It is proposed using certain indicators to assess the sustainable development of the EU countries and Ukraine: for the economic measuring - the global competitiveness index, the global innovation index and the index of economic freedom; for the social measuring - the social progress index, the human development index, quality of life index; for the environmental measuring - environmental performance index. The analysis of each selected indices of the EU countries and Ukraine is carried out. The methodology for calculating the ratio of the economic, social and environmental components of sustainable development for each EU country and Ukraine is presented. Attention is focused on the significant regional diversification of sustainable development and its components in the EU countries and Ukraine; the highest, middle and lowest levels of sustainable development of counties are identified. Impact: the methodology for the study of sustainable development, proposed by the authors on the example of the EU countries and Ukraine, is based on objective international ratings that have a transparent calculation methodology. These international ratings are constantly updated and cover most of the countries of the world. Therefore, the proposed methodology makes it possible to identify countries with the highest level of economic, social and environmental development; calculate the index of sustainable development of any country in the world.

Ubiquitin ligase Wwp1 gene deletion attenuates diastolic dysfunction in pressure-overload hypertrophy.

Heart failure with a preserved left ventricular (LV) ejection fraction (HFpEF) often arises from a prolonged LV pressure overload (LVPO) and accompanied by abnormal extracellular matrix (ECM) accumulation. The E3 ubiquitin ligase WWP1 is a fundamental determinant ECM turnover. We tested the hypothesis that genetic ablation of Wwp1 would alter the progression of LVPO-induced HFpEF. LV echocardiography in mice with global Wwp1 deletion (n = 23; Wwp1-/-) was performed at 12 wk of age (baseline) and then at 2 and 4 wk following LVPO (transverse aortic banding) or surgery without LVPO induction. Age-matched wild-type mice (Wwp1+/+; n = 23) underwent identical protocols. LV EF remained constant and unchanged with LVPO and LV mass increased in both groups but was lower in the Wwp1-/- mice. With LVPO, the E/A ratio, an index of LV filling, was 3.97 ± 0.46 in Wwp1+/+ but was 1.73 ± 0.19 in the Wwp1-/- group (P < 0.05). At the transcriptional level, mRNA for fibrillar collagens (types I and III) decreased by approximately 50% in Wwp1-/- compared with the Wwp1+/+ group at 4 wk post-LVPO (P < 0.05) and was paralleled by a similar difference in LV fibrillar collagen content as measured by histochemistry. Moreover, mRNA levels for determinants favoring ECM accumulation, such as transforming growth factor (TGF), increased with LVPO, but were lower in the Wwp1-/- group. The absence of Wwp1 reduced the development of left ventricular hypertrophy and subsequent progression to HFpEF. Modulating the WWP1 pathway could be a therapeutic target to alter the natural history of HFpEF.NEW & NOTEWORTHY Heart failure with a preserved left ventricular (LV) ejection fraction (HFpEF) often arises from a prolonged LV pressure overload (LVPO) and is accompanied by abnormal extracellular matrix (ECM) accumulation. It is now recognized that the ECM is a dynamic entity that is regulated at multiple post-transcriptional levels, including the E3 ubiquitin ligases, such as WWP1. In the present study, WWP1 deletion in the context of an LVPO stimulus reduced functional indices of HFpEF progression and determinants of ECM remodeling.

Triglyceride/Glucose Index (TyG Index) as a marker of glucose status conversion among reproductive-aged women in Jakarta, Indonesia: The Bogor cohort study (2011–2016)

Background and aimsReproductive-aged women are prone to type 2 diabetes mellitus. This study aims to evaluate the optimal cut off point of Triglyceride/Glucose Index for predicting glucose status conversion among women of reproductive age. MethodsThis study involved normoglycemic and prediabetes women aged 20–49 years from the Bogor Non-Communicable Diseases Cohort Study (West Java, Indonesia) conducted from 2011 to 2016. Statistical analysis was performed using Receiver Operating Characteristics curve analysis with STATA version 15. ResultsAmong prediabetes subjects (n = 371), the cut-off point of TyG index for regression from prediabetes to normoglycemic subjects was <4.51 [sensitivity, specificity, AUC (95%CI) 83.9%, 80.1%, 0.913 (0.875–0.943), respectively] and the cut-off point for progression from prediabetes to diabetes was >4.54 [80.0%, 73.1%, 0.858 (0.807–0.900)]. Among normoglycemic subjects (n = 1300), the cut-off point of TyG index for progression to prediabetes and diabetes were >4.44 [80.1%, 71.1%, 0.834 (0.812–0.854)] and >4.47 [80.6%, 80.8%, 0.909 (0.890–0.926)] respectively. ConclusionBased on sample of subjects evaluated between 2011 and 2016, TyG index appears to be a promising marker for glucose status conversion among reproductive-aged women in Jakarta, Indonesia.

Productivity of Public Theatres in the Times of COVID-19: The Example of Polish Theatres

Purpose: Our article aims to analyze the changes in the productivity of cultural institutions during the Covid -2019 pandemic. We studied how much productivity has changed and saw which indicator was targeting the influx. The number of visitors in the theatre in a given year is taken as productivity. The research period is the years 2016-2020. We hypothesize that the productivity index in 2020 depended on most on the technology change. Design/Methodology/Approach: The proper study was focused on Polish Public Theatres. The verification of the assumptions was conducted through the Malmquist index -Total Factor Productivity. Findings: As a result of the research, it was found that the hypothesis was positively verified. The value of the Malmiqusita index shows significant changes in productivity between 2020-2019 and 2019-2016. In particular, the considerable increase of the technological progress index is worth noting. In 2020-2019, the annual change regarding this index was as high as 1208.8%, while the technical efficiency decreased to 13.9% and TFP was 168.2% - the highest level over the whole period considered. Practical implications: We noticed that for individual theaters, the productivity results were different. It means that not all of the theatres studied coped with the new conditions. Depending on the organization, the effects of using digital technologies may be different. This proves that each unit should be analyzed individually. Originality/value: These results seem to fully reflect the pandemic reality in which the technological factor was of crucial importance, an innovative research to describe the pandemic in the theatre sector.

Serum levels of leptin and adiponectin in patients with multiple sclerosis

BackgroundThe role of adipokines such as leptin and adiponectin in regulating the immunity has been documented, however data concerning their consequence on multiple sclerosis (MS) Egyptian patients are deficient. The aim of this study is to demonstrate the serum levels of leptin and adiponectin in MS patients and to assess their association with disease disability and severity. A case–control study including 60 subjects (30 MS patients and 30 age, sex and body mass index-matched healthy controls) was performed.ResultsSerum leptin level was significantly higher among MS patients than controls (P < 0.001) while adiponectin was not significantly elevated in MS patients (P = 0.24). There was a significant positive correlation between leptin levels with MS disability (Expanded Disability Status Scale) (r = 0.678; P < 0.001), severity (Multiple Sclerosis Severity Score) (r = 0.631; P < 0.001) and progression (progression index) (r = 0.461; P = 0.01). There was no statistically significant correlation between adiponectin with disease disability, severity or progression.ConclusionsMS patients had significantly higher serum leptin levels and insignificant adiponectin levels compared to controls. Leptin has a potential role in multiple sclerosis disability and severity. However, adiponectin is not useful as a biomarker of MS disease, disability and severity.

Evaluation analysis on industrial green total factor productivity and energy transition policy in resource-based region

Based on the input-output panel data of industrial sectors of Shanxi Province, which is the only province-wide resource-based region in China, this paper uses the non-parametric DEA model and the Malmquist productivity index to construct the DEA-Malmquist model for evaluation analysis of the green total factor productivity (GTFP) and its decomposition value of the sub-sector, and then through fixed effect panel regression model studies the ways of energy transition of the SDG’s. The results show that the technological progress index has the greatest contribution to the growth of GTFP, while the scale efficiency index has the lowest contribution. And the amount of investment in environmental pollution control has a significant positive relationship with the GTFP of the three major polluting industries in Shanxi. Among them, investment in environmental pollution control has the greatest positive effect on the GTFP of light polluting industries characterized by high technology, high added value and low emissions; investment in environmental pollution control has the largest positive effect on the GTFP of heavy polluting industries with heavy chemical industry and pollution-intensive industries; investment in environmental pollution control has the weakest positive effect on the GTFP of the medium polluting industries that manufacture life service products and some heavy industrial products. Based on these results, the paper puts forward effective policy for the energy transition of resource-based regions.

Impact of comorbidities on the disability progression in multiple sclerosis.

Investigation of the comorbidity burden in persons with multiple sclerosis (PwMS) has become increasingly important. The aim of this study was to investigate the relationships of cardiovascular disease (CVD) comorbidities and type 2 diabetes with the disability progression. The retrospective cohort study was conducted at the Clinic of Neurology, Belgrade. The Belgrade MS population Registry, which comprises 2725 active MS cases, was used as the source of data. The mean duration of the disease was 21.6 ± 12.5years. Expanded Disability Status Scale (EDSS) was followed in all PwMS in the Registry. In the statistical analysis, the Cox proportional hazard regression analysis and Kaplan-Meier curve were performed. Hypertension statistically significantly contributed to more rapid reaching investigated levels of irreversible disability (EDSS 4.0, 6.0, and 7.0), while the presence of any of the investigated CVD comorbidities and type 2 diabetes significantly contributed to faster reaching EDSS 4.0 and EDSS 6.0. In a multivariable model, progression index (PI) was singled out (HR=3.171, p<.001), indicating that higher progression index (PI) was an independent predictor of CVD occurrence in MS patients. In the case of type 2 diabetes, PI (p<.001) and MS phenotype (p=.015) were statistically significant in multivariable Cox regression analysis. Our study confirms the impact of CVD comorbidities and type 2 diabetes in MS on the progression of disability as measured by EDSS in the large cohort of PwMS from the population Registry.

The impact of depression and post-traumatic stress symptoms on physical health perceptions and functional impairment among sexual minority men living with HIV with histories of trauma

ABSTRACT Mental health symptoms may compromise health-related quality of life (HRQOL), including among men who have sex with men (MSM) living with HIV, who experience high rates of trauma and other stressors. This study sought to examine the relative contributions of post-traumatic stress disorder (PTSD) symptoms, depression symptoms, and biological indices of HIV disease status on HRQOL in this population. Participants were 79 MSM with HIV (49% White; 35% Black; 8% Hispanic/Latinx) with trauma histories (52% met current PTSD diagnostic criteria). HRQOL outcomes were general perceptions of health (0–100 visual analog scale) and functional disability (WHODAS 2.0). Dominance analysis was applied to examine the relative share of variance in these outcomes accounted for by PTSD symptom severity, depression symptom severity, viral suppression status, and CD4 count. Depression symptom severity accounted for 70% and 92% of variance in perceived health, respectively, across models (p’s < 0.05). Both PTSD symptom severity (45%) and depression symptom severity (43%) scores also accounted for significant variance in functional disability (p’s < 0.05). Medical indices of HIV disease progression did not explain significant variance in HRQOL in any model. A trauma-informed approach may aid clinicians in interpreting reports of health and physical functioning in MSM with HIV.

Tax Rate of Management Control: The Mexican Income Tax Rates System for Resident and Non-Residents

The aim of this study is to show the tax rate of management control of the legislation according to the tax residence of the people who obtain income from wages. The questions considered here are: Is the income tax rate applied to national resident workers and to residents abroad proportionally? Under the same circumstances, in both cases do they pay similar amounts? The empirical analysis was based on the evaluation of the income tax and tax rate of management control in Mexico based on the Suits progressivity index. It was found that, under similar conditions, the amount of the tax to be paid by a resident abroad is less than that paid by a national resident.