Independent Surveys Research Articles

Spatiotemporal dynamics of Atlantic reef fishes off the southeastern U.S. coast

AbstractUnderstanding the spatiotemporal dynamics of fish species is a central concern in fish ecology and crucial for guiding management and conservation efforts. We constructed a joint species distribution model (JSDM) to simultaneously estimate the spatiotemporal distributions and densities for 21 reef fish species in the southeastern United States (SEUS). The model separately estimates encounter probability and positive density, and accounts for unobserved spatial and spatiotemporal variation using latent factors, where the correlations among species are induced. We applied the model to video data collected from a large‐scale, fishery independent survey. A clustering method was applied to the results of the JSDM to group species based on spatial and spatiotemporal synchrony in encounter probability and positive density. We found strong spatial associations among most of the reef fish species. However, species did exhibit differences in occupied habitat that varied with latitude and/or depth. Within their area of occupied habitat, almost all the species share similar spatial pattern of average density. However, for some species, annual distributions were less correlated with their expected average distributions perhaps due to differing responses to underlying spatiotemporal drivers. Some species show significant declines in abundance, for example, black sea bass, red porgy, and blueline tilefish, while a small number of species showed evidence of shifts in distribution, for example, black sea bass. The findings suggest that spatiotemporal management strategies may be of limited utility for reducing bycatch in these highly mixed reef fisheries due to high spatial correlations in occupied habitat and spatial patterns in density. Species‐specific responses to environmental change may also influence the spatiotemporal structure of reef assemblages. This work suggests management attention is needed for some of the lesser known species as they are showing declining trends in abundance.

#3026 Uncovering the potential of HIF-PH inhibitors to treat renal anemia

Abstract Background and Aims Hypoxia-inducible factor prolyl hydroxylase enzyme inhibitors (HIF-PHis) are a novel class of agents that were developed for the treatment of renal anemia. The agents work by stabilizing the HIF complex and stimulating endogenous erythropoietin production. This research aims to gauge the potential utilization and impact of HIF-PHis based on the perspectives of nephrologists who are based in the EU5. Method Data were collected via an independent online survey of 204 nephrologists based in the EU5 (UK, Germany, Italy, France, and Spain) in November 2023. Results EU5 nephrologists report that most dialysis and CKD non-dialysis patients with renal anemia who are on ESA therapy have an optimal response to treatment; however, a substantial proportion of patients experience a suboptimal response to treatment and up to 13% of patients across dialysis modalities are classified as ESA hypo-responders. Regardless of their geographic location, EU5 nephrologists position HIF-PHis to offer the most value in the CKD non-dialysis patient setting, with a perceived high level of opportunity (80%) for roxadustat to improve renal anemia outcomes among non-dialysis patients. Not surprisingly, the perceived advantages of an oral agent over an injectable medication for the treatment of renal anemia are more substantial for dialysis patients who are receiving home therapies (peritoneal and home hemodialysis) compared to those receiving in-center hemodialysis treatment. EU5 nephrologists also tend to believe that roxadustat represents a high level (64%) of opportunity to improve renal anemia outcomes in dialysis patients, with similar ratings observed for vadadustat (63%) in the same patient population. Specific to the use of HIF-PH inhibitors in the CKD non-dialysis setting, nephrologists are most concerned about patient compliance (51%), followed by safety compared to ESAs in general and as they relate to cardiovascular events (36%). When considering the use of HIF-PH inhibitors in the dialysis setting, nephrologists express similar concerns compared to the non-dialysis setting, with patient compliance (50%) ranked as the top concern, followed by safety compared to ESAs (38%), and the potential for off target effects (33%). Most EU5 nephrologists agree that HIF-PH inhibitors represent a more physiologic way of treating anemia of CKD compared to ESAs (70%) and many would like gain more clinical experience with the class of medications (63%). Current roxadustat treatment rates in dialysis are slowly increasing across the EU5 region, with slightly higher adoption in peritoneal dialysis patients (10%) compared to in-center hemodialysis patients (8%). Meanwhile, their self-reported uptake of roxadustat in CKD non-dialysis patients is also increasing over time, with the largest increase observed in CKD Stage 4 patients (9%). There is little consensus among EU5 nephrologists regarding their expected time to trial vadadustat once it is available, as nearly the same proportion of prescribers project that they will prescribe the agent to their dialysis patients within three months (36%), six months (23%), and within one year (28%). Conclusion With HIF-PHis having more of a physiologic mechanism of action, oral administration, and a similar safety profile compared to ESAs, broader adoption of the novel agents will potentially help address unmet needs and improve patient outcomes in the treatment of renal anemia for both CKD non-dialysis and dialysis patients.

An updated analysis of safety climate and downstream outcomes in two convenience samples of U.S. fire departments (FOCUS 1.0 and 2.0 survey waves)

BackgroundThe Fire service Organizational Culture of Safety (FOCUS) survey is an assessment tool comprised of psychometrically validated metrics of safety climate, safety behavior, and downstream outcomes (organizational and injury) that are specific to the U.S. fire and rescue service.MethodsThis analysis consists of a descriptive summary of two independent survey waves (FOCUS 1.0 and 2.0). The fire departments included in these survey waves were from convenience sampling (n1.0 = 275; n2.0 = 170). In addition to department level characteristics, we examined individual level characteristics for firefighters and EMS providers in participating departments (n1.0 = 22,719; n2.0 = 16,882). We conducted regression analyses to examine the associations between safety climate and safety behaviors, organizational outcomes, and safety outcomes. All analyses were stratified by organization type (career, volunteer).ResultsOur analysis indicated that a majority of respondents were males (90.7%FOCUS 1.0; 90.4%FOCUS 2.0), non-officers (68.4%FOCUS 1.0; 66.4%FOCUS 2.0), and non-Hispanic Whites (70.8%FOCUS 1.0; 69.5%FOCUS 2.0). For both samples there was a higher prevalence of injuries among individuals in career departments (nFOCUS 1.0 = 3778 [17.5%]; nFOCUS 2.0 = 3072 [18.7%]) than volunteer departments (nFOCUS 1.0 = 103 [8.8%]; nFOCUS 2.0 = 34 [7.4%]). We observed an approximate 10-point difference between the mean scores of Management Commitment to Safety for career and volunteer departments in both samples. We observed associations for two organizational outcomes, Safety Behavior and Job Satisfaction, with Management Commitment to Safety and Supervisor Support for Safety overall and when stratified by organization type. We observed a decrease in the odds of injuries associated with a one-unit increase in Management Commitment to Safety (OR1.0 overall: 0.98, 95% CI 0.97–0.99; OR2.0 volunteer: 0.90, 95% CI 0.85–0.95) and Supervisor Support for Safety (OR1.0 overall: 0.95, 95% CI 0.93–0.97; OR1.0 career: 0.95, 95% CI 0.92–0.98).ConclusionsFrom our current study, and a prior analysis of a geographically stratified random sample of U.S. fire departments, we identified that from all the organizational outcomes, job satisfaction was most consistently associated with FOCUS safety climate. Further, firefighters in our samples consistently rated Supervisor Support for Safety higher than Management Commitment to Safety. Future interventions should support fire departments in improving their departmental Management Commitment to Safety and maintaining their Supervisor for Safety.

Fisheries independent surveys in a new era of offshore wind energy development

Abstract Fisheries independent surveys require rethinking because of increasing spatial restrictions and interactions with offshore wind energy development (OWD). Fisheries, protected species, and environmental data collections have been conducted by scientific institutions to meet societal demands for food security, conservation, and other marine uses. These data collections provide information on key resource measures, essential for fisheries, protected species, and ecosystem management. With the increase in pace and magnitude of OWD's industrialization of marine waters, disruptions in these long-term time series can be expected. These disruptions will impact the ability to support current and future management goals and objectives. This paper presents an expert survey on the perceptions of OWD interactions with common survey designs and survey methodologies in Europe and the U.S., along with a selected sample of 75 fisheries independent surveys in the U.S. and Europe providing an initial assessment and description of potential impacts from OWD. About 72% of the surveys sampled record interactions with operational, planned or future OWD. Four case studies demonstrate efforts to address these interactions within European regions that have operational OWD and the U.S. where development has just begun. Finally, we make recommendations for future research important to continue meaningful scientific-based management advice.

Radiation Awareness and X-Ray Use in Cardiology: An International Independent Web-Based Survey

Background. Cardiologists are today exposed to a growing dose of ionising radiation in their practice. Radiation awareness and correct management of X-ray use are the cornerstone to comply with the principles of exposure optimization and justification. Methods and Results. An investigator-initiated international voluntary-based survey including 28 questions was conducted across 19 European countries. 228 cardiologists participated in the survey. Invasive cardiology subspecialties were the most represented (83.6%). Radiation exposure is the cause of personal protective equipment-related orthopaedic injuries (personally or in coworkers) or anxiety in 68.5% and 62.9% of cases, respectively. 38.4% of participants have encountered difficulties in having their institutions recognizing periods off work for exceeding radiation exposure limit (16.3% usually and 22.1% on rare occasions). Gender was not associated with any difference in the answers. Age older than 40 years old was associated with an increased knowledge of personal dosimeter data (71.6% vs. 51.3%, p=0.008). Invasive cardiologists more frequently suffer from orthopaedic injuries (73.0% vs. 44.8%, p=0.006) and show greater participation to radioprotection courses (78.4 vs. 27.6%, p<0.001). Conclusion. European cardiologists show appropriate awareness of the risks associated with X-ray use in medical practice and of the principles guiding a proper management of radiation hazard. However, there is still room for improvement, and institutions should promote risk education policies, which are the basis for the creation and diffusion of a community consciousness on radiation hazard.

Adolescent Digital Self-Harm Over Time: Prevalence and Perspectives

ABSTRACT Digital self-harm, the anonymous online posting, sending, or otherwise sharing of hurtful content about oneself, has not received the same amount of scholarly scrutiny as other forms of self-directed abuse. In the current paper, we analyze three independent national surveys of U.S. teens (aged 13–17, M = 14.96) in repeat cross-sectional studies conducted in 2016 (N = 4,742), 2019 (N = 4,250), and 2021 (N = 2,546) to assess the prevalence of two measures of digital self-harm. We examine demographic differences within each sample (gender, race, and sexual orientation), whether experience with cyberbullying was associated with these behaviors, and changes over time. Overall, the prevalence of digital self-harm has been increasing over time, and changes in demographic influences were observed. Implications for identifying, preventing, and responding to digital self-harm are discussed.

Methodological issues of retrospective surveys for measuring mortality of highly clustered diseases: case study of the 2014–16 Ebola outbreak in Bo District, Sierra Leone

ABSTRACT Background There is a lack of empirical data on design effects (DEFF) for mortality rate for highly clustered data such as with Ebola virus disease (EVD), along with a lack of documentation of methodological limitations and operational utility of mortality estimated from cluster-sampled studies when the DEFF is high. Objectives The objectives of this paper are to report EVD mortality rate and DEFF estimates, and discuss the methodological limitations of cluster surveys when data are highly clustered such as during an EVD outbreak. Methods We analysed the outputs of two independent population-based surveys conducted at the end of the 2014–2016 EVD outbreak in Bo District, Sierra Leone, in urban and rural areas. In each area, 35 clusters of 14 households were selected with probability proportional to population size. We collected information on morbidity, mortality and changes in household composition during the recall period (May 2014 to April 2015). Rates were calculated for all-cause, all-age, under-5 and EVD-specific mortality, respectively, by areas and overall. Crude and adjusted mortality rates were estimated using Poisson regression, accounting for the surveys sample weights and the clustered design. Results Overall 980 households and 6,522 individuals participated in both surveys. A total of 64 deaths were reported, of which 20 were attributed to EVD. The crude and EVD-specific mortality rates were 0.35/10,000 person-days (95%CI: 0.23–0.52) and 0.12/10,000 person-days (95%CI: 0.05–0.32), respectively. The DEFF for EVD mortality was 5.53, and for non-EVD mortality, it was 1.53. DEFF for EVD-specific mortality was 6.18 in the rural area and 0.58 in the urban area. DEFF for non-EVD-specific mortality was 1.87 in the rural area and 0.44 in the urban area. Conclusion Our findings demonstrate a high degree of clustering; this contributed to imprecise mortality estimates, which have limited utility when assessing the impact of disease. We provide DEFF estimates that can inform future cluster surveys and discuss design improvements to mitigate the limitations of surveys for highly clustered data.

The Influence of Personality Traits, Competencies and Organizational Citizenship Behavior on Teacher Performance Which is Moderate by Organizational Culture (Study At Darullughoh Wadda'wah Islamic Boarding School)

This research is motivated by teacher performance. The purpose of this research is to determine the influence of the relationship between personality traits, competence, organizational citizenship behaviour can have an impact on teacher performance is moderated by teacher organizational culture Darulgoh Wadda'wah Islamic Boarding School (Dalwah, Bangil, Pasuruan). Grand theory This research is theoretical Theory of Planned Behavior (TPB). The sampling technique uses a formulaslovinwith an error rate of 5%. The sample in this study was 232 teacher respondents Darulgoh Wadda'wah Islamic Boarding School through an independent survey. This research instrument uses a questionnaire and is analyzed using SEM analysis, the analytical tool for this research is Smart PLS version 3.0. These analytical tools are used to analyzeouter model, inner model and hypothesis testing with usep-value. The research results show the direct influence of personality traits influential significantly against performance of Darulgoh Wadda'wah Islamic Boarding School teachers. Then competence influential significantly against to performance of Darulgoh Wadda'wah Islamic Boarding School teachers. Connection organizational citizenship behaviour influential significantly against to performance of Darulgoh Wadda'wah Islamic Boarding School teachers. The results of this research indicate that there is an influence of the moderating variable, namely organizational culture, on relationships competence dan organizational citizenship behaviour against against performance of Darulgoh Wadda'wah Islamic Boarding School teachers. But organizational culture cannot be a moderating variable connection personality traits against against performance of Darulgoh Wadda'wah Islamic Boarding School teachers. This research shows that practice personality traits, competence, organizational citizenship behaviour and organizational culture plays an important role in encouraging the performance of Darulgoh Wadda'wah Islamic Boarding School teachers.

Meso-scale seabed quantification with geoacoustic inversion

Knowledge of sub-seabed geoacoustic properties, for example depth dependent sound speed and porosity, is of importance for a variety of applications. Here, we present a semi-automated geoacoustic inversion method for autonomous underwater vehicle data that objectively adapts model inference to seabed structure. Through parallelized trans-dimensional Bayesian inference, we infer seabed properties along a 12 km survey track on the scale of about 10 cm and 50 m in the vertical and horizontal, respectively. The inferred seabed properties include sound speed, attenuation, density, and porosity as a function of depth from acoustic reflection coefficient data. Parameter uncertainties are quantified, and the seabed properties agree closely with core samples at two control points and the layering structure with an independent sub-bottom seismic survey. Recovering high resolution seabed properties over large areas is shown to be feasible, which could become an important tool for marine industries, navies and oceanic research organizations.

Integrating the US Caribbean Reef Fish Visual Census into fishery stock assessments

The United States Caribbean Reef Fish Visual Census (RVC) is a fishery-independent survey of the coral reef fish community, comprised of hundreds of species, designed to provide quantitative information for data-poor fisheries to support regional stock assessments. The Caribbean RVC, implemented in 2014 as part of the National Coral Reef Monitoring Program (NCRMP), uses a probabilistic stratified random sampling design capitalizing on the strong mean-variance relationship of population abundance dependent on hardbottom habitats and depths. Here we highlight RVC data for queen triggerfish in Puerto Rico, where survey precision improved from CVs of 20.6% in 2014 to 12.6% in 2021, which produced accurate and cost-effective estimates of key assessment metrics like size- structured relative population abundance and biomass. We estimated a relatively stable exploited-phase average population abundance for 2014–2021 at 2.3 million queen triggerfish with a biomass of 1246 metric tons. To support stock assessments using "statistical catch at age" models, we generated a 2001–2021 time series of several population metrics by a statistical conversion of spatially-restricted, pre- NCRMP data to the RVC frame. To cross-check assessment modeling, we combined 2014–2021 RVC results with life history demographics in an alternative length-based risk analysis (LBRA) model to evaluate stock sustainability consequences using two lifetime growth scenarios. LBRA models indicated low overfishing risks. We concluded that only a few quality fishery-independent surveys are needed to obtain understanding of stock sustainability status, and that RVC not only provides reliable data for single-species stock assessments, but also for design evaluation of marine protected areas and ecosystem-based fishery management.

The relationship of game genres, in-game purchases, and playing duration with probable gaming disorder in two independent, large-scale online surveys of Japanese adults.

Game genres, availability on smartphones, in-game purchases, and playing duration, have been thought to influence Gaming Disorder (GD). However, little research has comprehensively examined their relationships with GD. Therefore, we examined the relationship between GD, in-game purchases, gaming duration via consoles and smartphones, and genres of smartphone games. Study 1 was based on self-reports, and Study 2 included objective data to clarify these associations. We conducted two independent online surveys that collected sociodemographic data, game use patterns, and psychopathological assessment data, including GD severity (Study 1: N = 32,690; Study 2: N = 3,163). General mental illness scores and objective gaming time were also collected in Study 2. In Study 1, in-game purchases, several gaming genres, and subjective gaming duration were positively associated with probable GD. On the other hand, interactions between card games and loot box charges were negatively related to probable GD. In Study 2, objective gaming times of most game genres were not associated with GD. Although the correlation between subjective and objective gaming duration was moderate, their correlations with GD differed. These results suggest the complexity of relationships between GD and in-game purchases, genres, and gaming duration. Results of this study suggest the importance of proper assessment of GD reflecting actual functional impairment in social life. Future studies should improve and update evaluation of assessments for gaming.

Sentinel-2 MSI image time series reveal hydrological and geomorphological control of the sedimentation processes in an Amazonian hydropower dam

Monitoring sediment transport in a run-of-river hydropower dam was investigated to detect and quantify the siltation processes using Sentinel-2/MSI satellite images. We developed a method allowing us to assess the fate of sediment discharge in reservoirs and to map the locations of eroding and silting stream cross sections. This monitoring was achieved by retrieving the seasonal and interannual variation in suspended sediment concentration (SPM) longitudinally and by developing indices to detect local deviations from the overall SPM trend. A comparison between Sentinel-2 reflectance, processed for atmospheric and glint correction, and field measurements showed fine accuracy for the b8a/b4 band ratio (RMSE = 0.23 sr-1, N = 50) as well as a very good SPM retrieval performance for a wide range of concentrations [10–926 mg/L] with an RMSLE of 0.23 mg/L. SPM trend analysis demonstrated that significant (p < 0.001) sedimentation processes (i.e., decreases in SPM concentration upstream to downstream) occur for most parts of the hydrological cycle except during peak flooding when there was no significant SPM siltation. The overall rate of SPM decrease is −0.52 mg/L/km, varying from +0.11 mg/L/km down to −1.10 mg/L/km. We developed a deviation index to detect local anomalies from the overall upstream–downstream satellite-derived SPM trend. A satellite-derived map of eroding and silting reaches is produced evidencing the control of the sediment transport pattern by geomorphological features, such as rapids. Using independent bathymetric surveys, we showed that satellite data allow the locations of eroding and silting river reaches to be correctly mapped.

Coriander (Coriandrum sativum L.) from Alentejo (South Portugal)-Ethnobotany and Potential Industrial Use.

Coriander is a medicinal and aromatic plant (MAP) traditionally cultivated and used in Alentejo, Portugal. However, few publications are available about its ethnobotanical applications. Four independent ethnobotanical surveys were carried out: throughout the region (2002-2003), in three villages (2013), and in city markets (2007 and 2022). Coriander was the most common fresh cultivated MAP (75% of the total area) and also the most representative MAP fresh herb in city markets. The leaves, mostly, were used fresh or frozen or transformed in piso. Some of the recipes have agro-industrial potential, such as piso and aromatized olive oil. Coriander essential oils (EOs) were isolated by hydrodistillation from aerial parts with inflorescence emergence (APIs) and from fruits, and fatty acids (FA) by solvent extraction from the fruits. Gas chromatography and gas chromatography-mass spectrometry analysis showed EOs dominated by n-decanal (21-24%), 2-trans-decenal (12-18%) and n-nonane (10-17%) in APIs, and linalool dominance (73-78%) in the fruits. Petroselinic acid (32-55%) was the dominant fatty acid. A literature survey on conventional and nonconventional extraction techniques showed a constancy in the dominant compounds isolated, highlighted piso as a home-made green-extraction procedure, but also reflected the relevance of coriander as a MAP with diverse industrial potential uses.

Distribution of the invasive ambrosia beetle Anisandrus maiche (Coleoptera, Scolytinae) in Switzerland and first record in Europe of its ambrosia fungus Ambrosiella cleistominuta

Ambrosia beetles are highly successful as invaders because they are often transported internationally with wood packaging and other wood products and because their inbreeding mating systems facilitates establishment of invading populations. In 2022, two independent insect surveys in canton Ticino (southern Switzerland) revealed the widespread occurrence of the invasive ambrosia beetle Anisandrus maiche (Kurentzov, 1941) from southern to central-upper Ticino. This species is native to east Asia and has previously been found as a non-native invasive species in the United States, Canada, western Russia, Ukraine and, in 2021, in northern Italy. Here, we present the results of several trapping studies using different trap types (bottle traps, funnel traps and Polytrap intercept traps) and attractants and a map of the distribution of the species. In total, 715 specimens of A. maiche, all female, were trapped, and the identity of selected individuals was confirmed by morphological and molecular identification based on three mitochondrial and nuclear markers (COI, 28S and CAD). Trap samples from early April to early September 2022 in intervals of two to four weeks showed that flights of A. maiche occurred mainly from June to mid-August. Isolation of fungal associates of A. maiche from beetles trapped alive revealed the presence of four fungal species, including the ambrosia fungus Ambrosiella cleistominuta, the known mutualist of A. maiche. The identity of A. cleistominuta was confirmed by comparing DNA sequences of its nuclear, internal transcribed spacer (ITS) gene with reference sequences in NCBI and BOLDSYSTEMS. This represents the first record of A. cleistominuta in Europe. Of the other fungal associates isolated from A. maiche in Ticino, Fusarium lateritium is of note as there is a possibility that A. maiche could act as a vector of this plant pathogen. We highlight several research needs that should be addressed to gain insight into the potential impact of these non-native species and to overcome problems with heteroplasmy in COI sequences in studies of invasion and population genetics of ambrosia beetles.

Harmonizing culture and consumer psychology: optimizing color schemes for children’s product design inspired by traditional ornaments

Color is one of the vital components of product design and the choice of color combination is a critical factor that affects consumer reaction and purchase decisions. However, the impact of traditional colors on color extraction and product design has seldom been studied. The purpose of this study is to discover suitable colors from traditional patterns to create color schemes that will be used in the design of children’s products. Colors were extracted from five major traditional ornaments obtained from Turkmenistan’s national carpets, each representing one of the main Turkmen tribes, using tools like Photoshop, Adobe Color, and EasyRGB, with the objective of investigating psychological-emotional attachment, reaction, and attitudes towards the colors obtained. This initial extraction provided 124 color data points. Initially, extracted colors were refined and used to develop novel color schemes by two independent survey studies. The first survey, based on a sample of 104 parents of preschool children, identified colors that have a positive emotional effect on consumer preferences and provided the basis to develop color schemes. As a result, 25 colors were identified for use in developing 14 color schemes. The second survey, based on a sample of 48 parents of preschool children, identified which color schemes have an attraction for consumers. The survey indicated that 11 out of these 14 schemes were highly favored by the respondents. Based on these results, this study proposed new color schemes for children’s products, extracted from traditional patterns of Turkmenistan and aligned with the psychological perception of the consumers.

The normatively troubling impact of attitudes toward the role of money in politics on external political efficacy

AbstractObjectiveWe explore whether Americans’ attitudes about the role of money spent on political campaigns and separately their attitudes about the influence of corporations impact their external political efficacy (EE) or perception that the government is responsive to them.MethodsWe conduct three independent sample surveys (total N = 2789) to measure individuals’ attitudes toward the role of money in politics (ARMP), attitudes toward corporations, and EE. We also measure political partisanship to test for moderating effects.ResultsARMP are strongly and positively associated with EE: those who are more favorable of the role money plays in politics view government as more responsive to them. This finding is specific to ARMP and does not extend to corporations, suggesting that public awareness of campaign spending is shaping individuals' views of government responsiveness. We find no evidence that this relationship is moderated by partisanship, despite differing views of money in politics between Democrats and Republicans.ConclusionOur results are normatively troubling and suggest that as campaign spending continues to rise, individuals will increasingly feel that the government is less responsive to their concerns.

Sampling of healthcare professionals' perspective on point-of-care technologies from 2019-2021: A survey of benefits, concerns, and development.

Point-of-care technology (POCT) plays a vital role in modern healthcare by providing a fast diagnosis, improving patient management, and extending healthcare access to remote and resource-limited areas. The objective of this study was to understand how healthcare professionals in the United States perceived POCTs during 2019-2021 to assess the decision-making process of implementing these newer technologies into everyday practice. A 5-point Likert scale survey was sent to respondents to evaluate their perceptions of benefits, concerns, characteristics, and development of point-of-care technologies. The 2021 survey was distributed November 1st, 2021- February 15th, 2022, with a total of 168 independent survey responses received. Of the respondents, 59% identified as male, 73% were white, and 48% have been in practice for over 20 years. The results showed that most agreed that POCTs improve patient management (94%) and improve clinician confidence in decision making (92%). Healthcare professionals were most concerned with potentially not being reimbursed for the cost of the POCT (37%). When asked to rank the top 3 important characteristics of POCT, respondents chose accuracy, ease of use, and availability. It is important to note this survey was conducted during the COVID-19 pandemic. To achieve an even greater representation of healthcare professionals' point of view on POCTs, further work to obtain responses from a larger, more diverse population of providers is needed.

Active tracking measures: Providing targets for youth alcohol use and health behavior interventions.

This study seeks to use examine the utility of recently published, developmentally informed measures of parental active tracking for work on youth health behaviors. Information on parental active tracking and health behaviors were collected in six independent survey studies (n's = 157-408). A series of empirical questions regarding parental active tracking were examined. The recently published measures of parental active tracking in high school and college were shown to have sufficient internal consistency, to be well described by single latent factors, to be empirically distinct from helicopter parenting, to be inconsistently linked with youth risk behaviors, and to demonstrate closer linkages with youth substance use when accounting for parental motivations for tracking. The measures of parental active tracking employed provide face valid, psychometrically sound, and empirically supported indices for use examining parental influences during adolescence and young adulthood.

Machine Learning-Based Prediction of Suicidality in Adolescents With Allergic Rhinitis: Derivation and Validation in 2 Independent Nationwide Cohorts.

Given the additional risk of suicide-related behaviors in adolescents with allergic rhinitis (AR), it is important to use the growing field of machine learning (ML) to evaluate this risk. This study aims to evaluate the validity and usefulness of an ML model for predicting suicide risk in patients with AR. We used data from 2 independent survey studies, Korea Youth Risk Behavior Web-based Survey (KYRBS; n=299,468) for the original data set and Korea National Health and Nutrition Examination Survey (KNHANES; n=833) for the external validation data set, to predict suicide risks of AR in adolescents aged 13 to 18 years, with 3.45% (10,341/299,468) and 1.4% (12/833) of the patients attempting suicide in the KYRBS and KNHANES studies, respectively. The outcome of interest was the suicide attempt risks. We selected various ML-based models with hyperparameter tuning in the discovery and performed an area under the receiver operating characteristic curve (AUROC) analysis in the train, test, and external validation data. The study data set included 299,468 (KYRBS; original data set) and 833 (KNHANES; external validation data set) patients with AR recruited between 2005 and 2022. The best-performing ML model was the random forest model with a mean AUROC of 84.12% (95% CI 83.98%-84.27%) in the original data set. Applying this result to the external validation data set revealed the best performance among the models, with an AUROC of 89.87% (sensitivity 83.33%, specificity 82.58%, accuracy 82.59%, and balanced accuracy 82.96%). While looking at feature importance, the 5 most important features in predicting suicide attempts in adolescent patients with AR are depression, stress status, academic achievement, age, and alcohol consumption. This study emphasizes the potential of ML models in predicting suicide risks in patients with AR, encouraging further application of these models in other conditions to enhance adolescent health and decrease suicide rates.

Leveraging the holistic benefits of biosimilars in Europe – part 2: how payers can safeguard the future of a healthy biosimilar market environment

ABSTRACT Introduction Biosimilars have improved access to biologic medicines; however, historical thinking may jeopardize the viability of future markets. Areas covered An expert panel of eight diverse European stakeholders provided insights about rethinking biosimilars and cost-savings, reducing patient access inequalities, increasing inter-market equity, and improving education. The insights reported here (Part 2) follow a study that provides perspectives on leveraging the holistic benefits of biosimilars for market sustainability based on independent survey results and telephone interviews of stakeholders from diverse biosimilar markets (Part 1). Directional recommendations are provided for payers. Expert Opinion The panel’s market maturity framework for biosimilars has three stages: ‘Invest,’ ‘Expand’ and ‘Harvest.’ Across market stages, re-thinking the benefits of biosimilars beyond cost-savings, considering earlier or expanded access/new indications, product innovations, and re-investment of biosimilar-generated cost-savings should be communicated to stakeholders to promote further engagement. During ‘Expand’ and ‘Harvest’ stages, development of efficient, forward-looking procurement systems and mechanisms that drive uptake and stabilize competition between manufacturers are key. Future biosimilars will target various therapy areas beyond those targeted by existing biosimilars. To ensure a healthy, accessible future market, stakeholders must align their objectives, communicate, collaborate, and coordinate via education, incentivization, and procurement, to maximize the totality of benefits.