Independent Software Research Articles

Validation of clearcalc for efficient patient specific QA.

Uganda's only radiotherapy center is a very busy facility treating about 210 patients daily on three linear accelerators making it sometimes hard to have machine time for pretreatment QAs. This study was aimed at validating an independent calculation software, ClearCalc (ICS) for second checks of the treatment planning system (TPS) calculations. The validation of ICS started with simple phantom test plans consisting of square, irregular, open and wedged fields designed in the TPS and measured in phantoms. Doses and monitor units (MUs) calculated by ICS were compared with TPS calculated doses and with measured doses. ICS was then validated on clinically approved treatment plans: comparison with TPS calculations and with pretreatment QA measurements performed with electronic portal imaging devices (EPIDs) and analyzed using Gamma passing criteria of 3%/3 mm and 3%/2 mm. Results for test plans were within the passing level of 3.0% except for 2 outliers (-3.1% and 3.1%). As for the clinically approved treatment plans, they show good agreement between MUs (0.2 ± 1.8%), reference point doses (0.2 ±1.5%) and mean PTV doses (0.5 ± 1.4%). ICS calculated (3D) mean gamma pass rates were 98.1±1.6% and 98.4±1.0% for 3%/2 mm and 3%/3 mm criteria. No correlation was seen between gamma analysis results from ICS and EPID. This study validated ClearCalc on phantom and clinically approved plans. The result show that ICS based patients specific QA is quick, promising and potentially allows significant time saving that can be utilized for patient treatments.

A computationally efficient semi-analytical model for the dust environment of comets and asteroids

We present a model for the distribution of dust ejected by asteroids and comets. Our model incorporates the effects of solar gravity and radiation pressure. In specific cases it can also account for additional forces and the re-impacts of ejected dust onto the source body. The number density of dust at a given point in space was computed as the sum of contributions from a set of point sources placed along a given trajectory, ejecting dust in a temporal sequence that approximates the motion of the source body. The dust ejection from each source was modeled using continuous distributions of the dynamical parameters the dust grains have at ejection. We developed three methods to solve for the dust number density from a single point source that differ in complexity and applicability. We applied the model to investigate the dust environment of the near-Earth asteroid Phaethon, and estimated the number of dust grains that will be observed by the dust detector on the flyby of the forthcoming DESTINY+ mission by JAXA. Additionally, as an illustrative example, we reconstructed an image of comet C/1996 B2 (Hyakutake) to demonstrate the details of working with the model. The implementation of our model, verified with a comparison to independent software, is freely available as a Fortran-95 package, DUDI-heliocentric.

Tuning a secondary dose verification software for a CT-guided online adaptive delivery system.

Quality assurance (QA) remains unstandardized for CT-guided online adaptive radiotherapy (CTgART) platforms (Ethos, Varian Medical Systems, Inc., Palo Alto, CA), as they become more clinically prevalent. A secondary dose calculation software (Mobius3D, Varian Medical Systems, Inc., Palo Alto, CA) is provided for this closed CTgART system. However, the clinical impact of tuning dosimetric leaf gap (DLG) correction values for specific delivery techniques for CTgART secondary dose calculations remains uninvestigated. Tuning the DLG correction value for different delivery techniques of the independent secondary dose verification software for adaptive online QA. A total of 31 volumetric arc therapy (VMAT) and 13 fixed-gantry intensity modulated radiation therapy (IMRT) plans were selected from representative anatomical sites treated in our clinic. All plans were evaluated on a patient CT dataset and a QA dataset of a solid water phantom with an embedded ion chamber placed at the center in both primary treatment planning systems (TPS) and secondary dose verification software. Primary TPS plan doses were compared with secondary calculation doses on patient CT by calculating 3D gamma passing criteria under different DLG correction values ranging from -2 to 2mm to determine the optimal DLG correction range. Ion chamber verification measurements were then compared to secondary calculation dose to determine the optimal DLG correction value by minimizing the difference for IMRT and VMAT plans, separately. The optimal DLG correction values for VMAT and IMRT techniques were -0.3 and 0.4mm respectively for the selected clinical cohort of patients. The mean gamma passing rate between primary and secondary doses for VMAT and IMRT were 99.0%±1.0% and 99.9%±0.1% with 3%/2mm and excluding 10% low dose criteria. The mean ion chamber agreement for VMAT and IMRT were 0.0%±2.1% and 0.2%±1.4%. DLG correction value should be tuned for each delivery technique (VMAT and IMRT) separately to maximize the robustness of CTgART online QA programs.

Land surface scheme TerM: the model formulation, code architecture and applications

Abstract This paper presents the INM RAS–MSU land surface scheme, extracted from the INM RAS Earth system model into an independent software complex and supplemented with several modules to reproduce new components and processes of the Earth system. The resulting software product is referred to as TerM (Terrestrial Model). The physical and mathematical foundations of the model, the main features of the software implementation, and examples of applications in reproducing components of the terrestrial hydrological and carbon cycles are briefly outlined. Separating the land surface block into a standalone software complex significantly saves computational resources when assessing the impact of global and regional climate changes on natural resources (including hydrological ones), ecosystem dynamics, and emissions of climate-relevant substances with high spatial detalization. Within the TerM modelling complex, the development, validation, and calibration of new parameterizations of physical and biogeochemical processes are being conducted in an autonomous mode for subsequent implementation into the full INM RAS Earth system model.

Retrospective study of left and right ventricular strain mechanics among neonates undergoing therapeutic hypothermia for neonatal encephalopathy

PurposeEarly diagnosis of impaired myocardial function and timely therapeutic hypothermia is vital among patients with Neonatal Encephalopathy (NE). Traditional markers of myocardial function (Left Ventricular Ejection Fraction (LV EF) & LV Fractional Shortening (LV FS) can be variably reduced. Speckle tracking echocardiography (STE) is a more sensitive marker for impairment but remains inadequately studied in this patient population. MethodsA retrospective study of neonates who underwent therapeutic hypothermia (TH) for NE from 2009 to2020 were matched 1:1 with normal neonates with normal echocardiograms performed for indications other than NE. Matching was based on gestational age, birth weight, days of age, and sex. Left ventricular 4 Chamber (4Ch) strain, right ventricular 4 Chamber (RV 4Ch), and RV free wall strain (RV FWS) were measured offline using vendor independent strain software (TomTec, GMBH, Munich, Germany). ResultsNinety pairs of NE patients and controls were studied. Compared to controls, RV 4Ch strain (−17.3 % vs. -19.6 %), RV FWS (−18.8 % vs. -21.9 %), and RV fractional area change (FAC) (35 % vs. 37 %) were lower in NE cases (all p < 0.001), while differences in LV 4Ch strain, LV EF, and LV FS did not reach statistical significance. Moderate/severe NE (72 %) was associated with lower LV 4Ch strain compared to mild NE (−22.2 %/−19.3 % vs. -25.4 %, p = 0.004). RV 4Ch strain (−14.9 % vs. -18.8 %, p = 0.020) and RV FAC (27 % vs. 36 %, p = 0.006) were lower in severe NE compared to mild NE. Lower LV 4Ch was associated with need for chest compressions (−18.5 % vs. -23.3 %), epinephrine at delivery (−19.3 % vs. -23.4 %), and decreased survival to discharge (−15.9 % vs. -22.7 %). ConclusionsRV and LV strain mechanics are impaired in NE patients. Lower RV Strain and LV 4Ch strain were associated with need for increased medical support and decreased survival to discharge.

Large variability in degree of constraint of reverse total shoulder arthroplasty liners between different implant systems.

The liner design is a key determinant of the constraint of a reverse total shoulder arthroplasty (rTSA). The aim of this study was to compare the degree of constraint of rTSA liners between different implant systems. An implant company's independent 3D shoulder arthroplasty planning software (mediCAD 3D shoulder v. 7.0, module v. 2.1.84.173.43) was used to determine the jump height of standard and constrained liners of different sizes (radius of curvature) of all available companies. The obtained parameters were used to calculate the stability ratio (degree of constraint) and angle of coverage (degree of glenosphere coverage by liner) of the different systems. Measurements were independently performed by two raters, and intraclass correlation coefficients were calculated to perform a reliability analysis. Additionally, measurements were compared with parameters provided by the companies themselves, when available, to ensure validity of the software-derived measurements. There were variations in jump height between rTSA systems at a given size, resulting in large differences in stability ratio between systems. Standard liners exhibited a stability ratio range from 126% to 214% (mean 158% (SD 23%)) and constrained liners a range from 151% to 479% (mean 245% (SD 76%)). The angle of coverage showed a range from 103° to 130° (mean 115° (SD 7°)) for standard and a range from 113° to 156° (mean 133° (SD 11°)) for constrained liners. Four arthroplasty systems kept the stability ratio of standard liners constant (within 5%) across different sizes, while one system showed slight inconsistencies (within 10%), and ten arthroplasty systems showed large inconsistencies (range 11% to 28%). The stability ratio of constrained liners was consistent across different sizes in two arthroplasty systems and inconsistent in seven systems (range 18% to 106%). Large differences in jump height and resulting degree of constraint of rTSA liners were observed between different implant systems, and in many cases even within the same implant systems. While the immediate clinical effect remains unclear, in theory the degree of constraint of the liner plays an important role for the dislocation and notching risk of a rTSA system.

MHealth Service Effects for Negative Emotions Among Parents of Preterm Infants: A Systematic Review and Meta-Analysis.

This review aims to ascertain the effects of mHealth on negative emotions among parents of preterm infants and analyze the current state of mHealth services in this context. Caring for preterm infants often engenders negative emotions in parents, such as anxiety, depression, and stress. Mobile Health (mHealth) services offer potential benefits for preterm infant care. However, there are several uncertainties regarding the impact of mHealth services on parental emotions. Randomized controlled trial (RCT) and quasi-RCT were published in English and Chinese until 2023 and are available in the electronic databases of MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINHAHL), Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Wanfang Database, and China Science and Technology Journal Database were reviewed. Review Manager 5.4 was employed for random-effects meta-analysis. Seven RCTs and 6 quasi-RCTs with high risks were included, most of them were based on small sample size and single-centered. Meta-analysis demonstrated that mHealth interventions mitigated negative emotions, including anxiety (standard mean difference [SMD]=-1.07; 95% confidence interval [CI], -1.47 to -0.66; P<0.0001), depression (SMD=-1.94; 95% CI, -3.01 to -0.86; P<0.0001), and stress (SMD=-1.24; 95% CI, -2.07 to -0.40; P<0.0001), among parents of preterm infants. It is recommended to develop independent specialized software for mHealth, enhance theoretical underpinnings, and standardize practical protocols. Incorporating early recognition and screening of negative emotions within mHealth could offer comprehensive support for the mental health of parents with preterm infants. The mHealth-based interventions are needed to focus on the parents' emotional needs and minimize the impacts associated with mental stress.

746: Optimisation of the DLG in Mobius3D independent verification software for Ethos and TrueBeam linacs

746: Optimisation of the DLG in Mobius3D independent verification software for Ethos and TrueBeam linacs

Refining Treatment Planning in STereotactic Arrhythmia Radioablation: Benchmark Results and Consensus Statement From the STOPSTORM.eu Consortium

Background and purposeSTereotactic Arrhythmia Radioablation (STAR) showed promising results in patients with refractory ventricular tachycardia (VT). However, clinical data is scarce and heterogeneous. The STOPSTORM.eu consortium was established to investigate and harmonize STAR in Europe. The primary goal of this benchmark study was to investigate current treatment planning practice within the STOPSTORM project as a baseline for future harmonization. MethodsPlanning target volumes (PTV) overlapping extra-cardiac organs-at-risk and/or cardiac substructures were generated for three STAR cases. Participating centers were asked to create single fraction treatment plans with 25 Gy dose prescription based on in-house clinical practice. All treatment plans were reviewed by an expert panel and quantitative crowd knowledge-based analysis was performed with independent software using descriptive statistics for ICRU report 91 relevant parameters and crowd dose-volume-histograms. Thereafter, treatment planning consensus statements were established using a dual-stage voting process. ResultsTwenty centers submitted 67 treatment plans for this study. In most plans (75%) Intensity Modulated Arc Therapy (IMAT) with 6 MV flattening-filter-free beams was used. Dose prescription was mainly based on PTV D95% (49%) or D96-100% (19%). Many participants preferred to spare close extra-cardiac organs-at-risk (75%) and cardiac substructures (50%) by PTV coverage reduction. PTV D0.035cm3 ranged 25.5-34.6 Gy, demonstrating a large variety of dose inhomogeneity. Estimated treatment times without motion compensation or setup ranged 2-80 minutes. For the consensus statements, strong agreement was reached for beam technique planning, dose calculation, prescription methods and trade-offs between target and extra-cardiac critical structures. No agreement was reached on cardiac substructure dose limitations and on desired dose inhomogeneity in the target. ConclusionThis STOPSTORM multi-center treatment planning benchmark study showed strong agreement on several aspects of STAR treatment planning, but also revealed disagreement on others. To standardize and harmonize STAR in the future, consensus statements were established, however clinical data is urgently needed for actionable guidelines for treatment planning.

Dereplication of 4-Quinolone Alkaloids from Waltheria Indica (Malvaceae) Tissues Using Molecular Network Tools.

Waltheria indica (Malvaceae) is a plant popularly used in folk medicine by traditional African and indigenous communities, and in various countries worldwide, to treat general inflammation. Several biological activities of this plant have been reported, including acetylcholinesterase inhibition and potential anti-human immunodeficiency virus (HIV), antinociceptive, analgesic, antifungal, anticancer, anti-inflammatory, leishmanicidal, trypanocidal, antioxidant, and antibacterial activities. The chemical profile of Waltheria indica was assessed by dereplication analysis using UPLC-MS/MS, and data acquisition was performed using chemoinformatics tools, such as Mass Spectrometry-Data Independent AnaLysis (MS-DIAL) and MS-FINDER softwares. The preprocessed data were sent to the GNPS to build a feature-based molecular network (FBMN). Thirty-three 4-quinolone alkaloids were annotated in the extracts and fractions of stems and roots, whereas 12 were annotated in the extracts and fractions of flowers and leaves. This represents an inaugural chemical investigation study employing UPLC-Q-TOF-MS/MS analysis, along with a molecular network approach, within this species and genus.

HMM-Based Blockchain Visual Automatic Deployment System

The traditional blockchain deployment process is too complicated and has high technical requirements for blockchain deployers. Deploying a blockchain requires building a complex software-dependent environment, being able to use Linux commands for cumbersome parameter configurations, as well as the need to consider whether the hardware meets the requirements for running a blockchain. To address these current challenges in blockchain deployment both domestically and internationally, a web-based automatic deployment system with an interactive front-end and back-end has been developed. This system streamlines the process by automatically configuring and deploying blockchains while providing deployers with a graphical interface to monitor the entire deployment procedure. Meanwhile, in order to improve the efficiency of blockchain deployment, a Hidden Markov Model has been designed for blockchain deployment, which can predict the best deployment method for blockchain deployment under the current software environment. As one of the excellent blockchain platforms in China, Chainmaker has the outstanding features of independent control, flexible assembly, software and hardware integration, open source, and openness. The system takes Chainmaker as an experimental object and after a lot of tests, it can easily build a blockchain network on the server.

Development of a Portable Stand-Alone 20 K Brayton Cycle Helium Refrigeration System

From 2012 to 2015, NASA funded development of the Ground Operations Demonstration Unit for Liquid Hydrogen (GODU-LH2) at Kennedy Space Center that scaled up and matured Integrated Refrigeration and Storage (IRAS) technology. IRAS involves the integration of an external helium refrigeration system with a cryogenic storage tank via an internal heat exchanger and allows advanced operations such as zero boiloff and densification of the liquid. The refrigeration system employed for GODU-LH2 was a Linde LR1620 piston-Brayton cycle machine with an RSX helium compressor. The GODU-LH2 system was installed in two separate shipping containers—one housing the cold-box, compressor, and gas management hardware, and the other the water chiller unit—with 480 VAC and 120 VAC electrical power fed from external hardware at the test site, and data capture and controls achieved using four different, independent software packages. From 2017 to 2019, in support of a densified hydrogen loading test program, the entire system was repackaged into a single, 40’ (12 m) shipping container, including the refrigeration system, water chiller, and electrical power distribution hardware, and controls were consolidated into a single Allen Bradley PanelView. Details regarding the design, build-out, and testing of the system will be presented and discussed.

An intelligent body frame structure modeling and optimization system based on conceptual design

The conceptual design stage is an indispensable and important stage in the development of the modern body. However, due to the lack of sufficient body structure parameter support, the design defects generated at this time are difficult to make up for in the subsequent design stage. Therefore, it is of great significance to develop a conceptual design software for body structure that integrates design, analysis, and optimization. This paper proposes an intelligent body frame structure modeling and optimization system based on conceptual design, S-iVCD (Intelligent System for Conceptual Design of Vehicle Body Structure). Based on deep learning methods and body design sketches, a conceptual model of body structure is quickly established. Based on the data parameters stored in the Excel table, the system is seamlessly connected to the domestic independent finite element software SIPESC to calculate the simulated working conditions. The body structure optimization module is driven by the MMA (method of moving asymptotes), and takes the body structure performance and total mass as the optimization goals or constraints of the mathematical model to achieve body structure performance improvement and lightweight design.

A First Look with JWST Aperture Masking Interferometry: Resolving Circumstellar Dust around the Wolf–Rayet Binary WR 137 beyond the Rayleigh Limit

Abstract We present infrared aperture-masking interferometry (AMI) observations of newly formed dust from the colliding winds of the massive binary Wolf–Rayet system WR 137 with JWST using the Near Infrared Imager and Slitless Spectrograph (NIRISS). NIRISS AMI observations of WR 137 and a point-spread function calibrator star, HD 228337, were taken using the F380M and F480M filters in 2022 July and August as part of the Director’s Discretionary Early Release Science program #1349. Interferometric observables (squared visibilities and closure phases) from the WR 137 “interferogram” were extracted and calibrated using three independent software tools: ImPlaneIA, AMICAL, and SAMpip. The analysis of the calibrated observables yielded consistent values except for slightly discrepant closure phases measured by ImPlaneIA. Based on all three sets of calibrated observables, images were reconstructed using three independent software tools: BSMEM, IRBis, and SQUEEZE. All reconstructed image combinations generated consistent images in both F380M and F480M filters. The reconstructed images of WR 137 reveal a bright central core with a ∼300 mas linear filament extending to the northwest. A geometric colliding-wind model with dust production constrained to the orbital plane of the binary system and enhanced as the system approaches periapsis provided a general agreement with the interferometric observables and reconstructed images. Based on a colliding-wind dust condensation analysis, we suggest that dust formation within the orbital plane of WR 137 is induced by enhanced equatorial mass loss from the rapidly rotating O9 companion star, whose axis of rotation is aligned with that of the orbit.

GenIce-core: Efficient algorithm for generation of hydrogen-disordered ice structures.

Ice is different from ordinary crystals because it contains randomness, which means that statistical treatment based on ensemble averaging is essential. Ice structures are constrained by topological rules known as the ice rules, which give them unique anomalous properties. These properties become more apparent when the system size is large. For this reason, there is a need to produce a large number of sufficiently large crystals that are homogeneously random and satisfy the ice rules. We have developed an algorithm to quickly generate ice structures containing ions and defects. This algorithm is provided as an independent software module that can be incorporated into crystal structure generation software. By doing so, it becomes possible to simulate ice crystals on a previously impossible scale.

Dosimetric evaluation in Helical TomoTherapy for lung SBRT using Monte Carlo-based independent dose verification software.

To elucidate the dosimetric errors caused by a model-based algorithm in lung stereotactic body radiation therapy (SBRT) with Helical TomoTherapy (HT) using Monte Carlo (MC)-based dose verification software. For 38 plans of lung SBRT, the dose calculation accuracy of a treatment planning system (TPS) of HT was compared with the results of DoseCHECK, the commercial MC-based independent verification software. The following indices were extracted to evaluate the correlation of dosimetric errors: (1) target volume, (2) average computed tomography (CT) value of the planning target volume (PTV) margin, and (3) average CT value of surrounding 2-mm area of the PTV (PTV ring). Receiver operating characteristic (ROC) analyses determined the threshold for 5% of differences in PTV D95%. Then, the 38 plans were classified into two groups using the cutoff values of ROC analysis for these three indices. Dosimetric differences between groups were statistically compared using the Mann-Whitney U test. TPS of HT overestimated by more than 5% in the PTV D95% in 16 of 38 plans. The PTV ring showed the strongest correlation with dosimetric differences. The cutoff value for the target volume, the PTV margin, and the PTV ring was 14.7 cc, -754 HU, and -708 HU, respectively. The area under the curve (AUC) for the target volume, the PTV margin, and the PTV ring were 0.835, 0.878, and 0.932, respectively. Dosimetric errors more than 5% were observed when the PTV volume was less than 15 cc or when the CT value around the target was less than -700 HU. The TPS of HT might overestimate the PTV dose by more than 5% if any the three indices in this study were below threshold. Therefore, independent verification with an MC-based algorithm should be strongly recommended for lung SBRT in HT.

LifeWatch ERIC Strategic Working Plan Outcomes

LifeWatch ERIC has embarked on its new destination towards upgrading and (co-)constructing its Infrastructure as a response to the needs of its target communities and stakeholders. Through an industrialisation process, all independent data, software components, publications and other types of research products contributed by the Member Countries will be consolidated and integrated to enable collaborative development. The Technology Readiness Level of LifeWatch ERIC will be raised to level 9. This process is described in its new Strategic Working Plan on its second implementation period (2022-2026). Accordingly, this topical collection of papers includes articles which describe the main outcomes, that is the deliverables of this new Strategic Working Plan. The deliverables published in this topical collection are not of a confidential nature and are developed in the form of a standard, structured template.

Validation and characterization of algorithms and software for photonics inverse design

In this work, we present a reproducible suite of test problems for large-scale optimization (“inverse design” and “topology optimization”) in photonics, where the prevalence of irregular, non-intuitive geometries can otherwise make it challenging to be confident that new algorithms and software are functioning as claimed. We include test problems that exercise a wide array of physical and mathematical features—far-field metalenses, 2d and 3d mode converters, resonant emission and focusing, and dispersion/eigenvalue engineering—and introduce an a posteriori lengthscale metric for comparing designs produced by disparate algorithms. For each problem, we incorporate cross-checks against multiple independent software packages and algorithms, and reproducible designs and their validations scripts are included. We believe that this suite should make it much easier to develop, validate, and gain trust in future inverse-design approaches and software.

Dose Calculation Accuracy of Beam Models in RadCalc for a 1.5 T MR-Linac

The purpose of this study is to evaluate RadCalc, an independent dose verification software, for patient-specific quality assurance (PSQA) in online adaptive planning with a magnetic resonance linear accelerator (MR-linac) of a 1.5 T. Version 7.1.4 of RadCalc to introduce the capability to establish a beam model that incorporates MR field characteristics. A total of six models were established, with one using manufacturer-provided data and the others differing in percentage depth dose (PDD) data sources. Overall, two models utilized PDD data from the treatment planning system (TPS), and three used commissioned PDD data from gantry angles of 0° and 270°. Simple tests on a virtual water phantom assessed dose-calculation accuracy, revealing percentage differences ranging from −0.5% to −20.6%. Excluding models with significant differences, clinical tests on 575 adaptive plans (prostate, liver, and breast) showed percentage differences of −0.51%, 1.12%, and 4.10%, respectively. The doses calculated using RadCalc demonstrated similar trends to those of the PSQA-based measurements. The newly released version of RadCalc enables beam modeling that considers the characteristics of the 1.5 T magnetic field. The accuracy of the software in calculating doses at 1.5 T magnetic fields has been verified, thereby making it a reliable and effective tool for PSQA in adaptive plans.

Three-dimensional Volumetric Visceral and Subcutaneous Fat Analysis on Opportunistic Computed Tomography Imaging of Patients With Greater Trochanteric Pain Syndrome Compared With Those With Predominant Osteoarthritis: A Case-Control Study.

This study aimed to address the gap in knowledge assessing the impact of visceral and subcutaneous body fat on 3-dimensional computed tomography imaging in patients with greater trochanteric pain syndrome (GTPS) in comparison with those primarily diagnosed with osteoarthritis (OA). We evaluated adult patients with a confirmed diagnosis of GTPS from our institutional hip-preservation clinic spanning 2011 to 2022. Selection criteria included their initial clinic visit for hip pain and a concurrent pelvis computed tomography scan. These patients were age- and sex-matched to mild-moderate OA patients selected randomly from the database. Visceral and subcutaneous fat areas were measured volumetrically from the sacroiliac joint to the lesser trochanter using an independent software. Interreader reliability was also calculated. A total of 93 patients met the study criteria, of which 37 belonged to the GTPS group and 56 belonged to the OA group. Both groups were sex and race matched. Average age in GTPS and OA groups was 59.3 years and 56 years, respectively. For GTPS group, average body mass index was 28.9 kg/m 2 , and for the OA group, average body mass index was 29.9 kg/m 2 , with no significant difference ( P > 0.05). Two-sample t test showed no significant differences in the visceral fat, subcutaneous fat, or the visceral fat to total fat volume ratio between the GTPS and OA groups. There was excellent interreader reliability. Our results indicate that there is no significant difference in fat distribution and volumes among GTPS and OA patients. This suggests that being overweight or obese may not be directly linked or contribute to the onset of GTPS. Other factors, such as gluteal tendinopathy, bursitis, or iliotibial band syndrome, might be responsible and need further investigation.