You have accessJournal of UrologyKidney Cancer: Evaluation and Staging1 Apr 2011960 HIGH PREOPERATIVE PLASMA FIBRINOGEN IS AN INDEPENDENT PREDICTOR OF DISTANT METASTASIS AND POOR PROGNOSIS ON RENAL CELL CARCINOMA Jun Du, Jianhua Zheng, Peng Peng, and Xin Yao Jun DuJun Du Tianjin, China, People's Republic of More articles by this author , Jianhua ZhengJianhua Zheng Tianjin, China, People's Republic of More articles by this author , Peng PengPeng Peng Tianjin, China, People's Republic of More articles by this author , and Xin YaoXin Yao Tianjin, China, People's Republic of More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.928AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The prognostic ability of the TNM staging system, tumor size, Fuhrman grade and symptom classification is good but not ideal in patients treated with partial or radical nephrectomy for all stages of renal cell carcinoma. Therefore, the investigators have been working on to find available biomarkers from body fluid to predict postoperative metastasis and survival prognosis. The objective of this study was to evaluate the association of preoperative plasma fibrinogen levels with clinicopathologic parameters, disease-free survival and overall survival in patients after nephrectomy for renal cell carcinoma. METHODS We retrospectively studied 286 patients with renal cell carcinoma who underwent radical nephrectomy from 2000 to 2003 at our institution. The plasma fibrinogen were routinely determined before operation in all patients. Preoperative plasma fibrinogen levels were correlated with clinicopathologic findings by t-test or ANOVA methods. As well, univariate and multivariate analysis were used to determine the association of preoperative level of plasma fibrinogen and survival duration. RESULTS Elevated level of plasma fibrinogen was positively related with tumor size (P=0.000), T stage (P=0.000) and the risk of distant mestasis after operation (P=0.000), but it was negative with histologic type (P=0.266). Univariate analysis showed that tumor size, T stage and plasma fibrinogen level were significantly correlated with disease-free survival (P=0.004, P=0.000, P=0.008) and overall survival (P=0.008, P=0.000, P=0.000). However, plasma fibrinogen level is remained as independent prognostic factors for disease-free survival (P=0.004, P=0.042) and overall survival (P=0.004, P=0.001) by multivariate analysis. CONCLUSIONS High preoperative plasma fibrinogen level is an independent predictor of distant metastasis and survival prognosis after radical nephrectomy for the patients with renal cell carcinoma. Variable Number of patients Mean preoperative plasma fibrinogen levels (mg/dl) P-value Sex 0.157 Female 101 304.7>75.1 Male 185 319.7>90.9 Age(y) 0.020 ≤50 85 297.2>84.5 50–60 99 311.2>76.5 ≥60 102 313.8>92.8 Histologic type 0.243 Clear cell 238 312.2>84.9 Non-clear 48 328.1>89.2 Tumor size(cm) 0.000 ≤4 32 270.9>61.3 4–7 132 301.2>75.2 8–10 84 339.0>89.5 ≥10 38 350.0>111.2 T stage 0.000 T1 166 293.7>69.5 T2 55 336.0>94.8 T3 52 358.8>103.6 T4 13 389.6>75.5 Postoperative distant mestasis 0.000 Negative 227 304.3>80.5 Positive 59 353.2>95.2 © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e386-e387 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jun Du Tianjin, China, People's Republic of More articles by this author Jianhua Zheng Tianjin, China, People's Republic of More articles by this author Peng Peng Tianjin, China, People's Republic of More articles by this author Xin Yao Tianjin, China, People's Republic of More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...