You have accessJournal of UrologyProstate Cancer: Markers1 Apr 20112288 PROGNOSTIC IMPACT OF INHERITED GENETIC VARIATIONS IN SRD5A AND ANDROGEN INACTIVATING UGT2B GENES IN PROSTATE CANCER AFTER PROSTATECTOMY Yves Fradet, Etienne Audet-Walsh, Judith Bellemare, Geneviève Nadeau, Louis Lacombe, Pierre Douville, Hugo Girard, Chantal Guillemette, and Eric Lévesque Yves FradetYves Fradet Quebec, Canada More articles by this author , Etienne Audet-WalshEtienne Audet-Walsh Quebec, Canada More articles by this author , Judith BellemareJudith Bellemare Quebec, Canada More articles by this author , Geneviève NadeauGeneviève Nadeau Quebec, Canada More articles by this author , Louis LacombeLouis Lacombe Quebec, Canada More articles by this author , Pierre DouvillePierre Douville Quebec, Canada More articles by this author , Hugo GirardHugo Girard Quebec, Canada More articles by this author , Chantal GuillemetteChantal Guillemette Quebec, Canada More articles by this author , and Eric LévesqueEric Lévesque Quebec, Canada More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.2533AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The relationship between genetic variations in androgen biosynthesis (SRD5A) and inactivating (UGT2B) genes and the risk of biochemical recurrence (BCR) after prostatectomy remains an unexplored area. METHODS We studied a cohort of 526 men with organ-confined and locally advanced cancer with a median follow-up of 7.4 years. RESULTS After adjusting for all clinicopathologic risk factors, we found a strong association between the risk of BCR and 7 SNPs in SRD5A genes. The combination of 2 SNPs respectively in SRD5A 1 and SRD5A 2 were highly favourable, reducing drastically the risk of BCR for carriers of 3–4 alleles (HR=0.34; 95% CI=0.18–0.64; P=9×10-4). Other variations in the SRD5A 2 gene were associated with an increased rate of BCR, namely the cSNPs rs523349 with a HR of 2.12 (95% CI, 1.21–3.75; P=0.009) and reaching 4.97 when combined with deleted copies of UGT2B genes (95% CI, 2.38–10.36; P=0.00002). Further, BCR-free survival rate was significantly reduced to 27% in patients with unfavourable genotypes compared to 75% for patients with favourable genotypes (P=7×10–6). CONCLUSIONS In conclusion, inherited polymorphisms in the SRD5A and UGT2B genes are independent predictors of biochemical recurrence after radical prostatectomy. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e917-e918 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Yves Fradet Quebec, Canada More articles by this author Etienne Audet-Walsh Quebec, Canada More articles by this author Judith Bellemare Quebec, Canada More articles by this author Geneviève Nadeau Quebec, Canada More articles by this author Louis Lacombe Quebec, Canada More articles by this author Pierre Douville Quebec, Canada More articles by this author Hugo Girard Quebec, Canada More articles by this author Chantal Guillemette Quebec, Canada More articles by this author Eric Lévesque Quebec, Canada More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...