Independent Intellectual Property Rights Research Articles

New Catalysts for Coal to Ethylene Glycol

Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences has achieved the industrialization of the first generation catalysts for coal to ethylene glycol for the first time in 2009. However, there are still lots of aspects to be improved, such as high noble metal loading and toxic Cr in catalyst of ester hydrogenation. To improve the catalysts, we have done systematic deep research about the nanostructures of catalysts, and revealed facet effect, size effect, synergistic effect, support effect, and so on. A series of catalysts preparation technologies have been developed to achieve the efficient utilization of noble metals. The Pd loadings of dehydrogenation catalyst and CO oxidative coupling catalyst have been dropped from 2.5% to 0.9% and 2.0% to 0.13%, respectively, while the catalytic performances are enhanced greatly. The toxic Cu‐Cr in ester hydrogenation catalyst has been upgraded to green Cu‐Si. The new catalysts for coal to ethylene glycol with advancement have been successfully developed with independent intellectual property rights.

Serum thioredoxin reductase 1 as a diagnostic marker for non-small cell lung cancer.

e23069 Background: Non-invasive diagnostic markers for patients with suspicious non-small cell lung cancer (NSCLC) may provide needed guidance on invasive diagnostic and therapeutic decisions. Thioredoxin reductase 1 (TrxR1) is a pivotal intracellular redox sensor and antioxidant enzyme, and plays an important part in tumor growth, progression, metastasis, and chemotherapy resistance. The goal of this study is to test the feasibility of developing plasma TrxR1 as a novel diagnostic marker for NSCLC. Methods: The plasma TrxR1 activity was determined spectrophotometrically by monitoring the NADPH-dependent production of 2-nitro-5-thiobenzoate at 412nm and at 37℃. All detection kits and automatic analyzer possess independent intellectual property rights, and have been widely used in breast cancer screening. Results: In this study, the plasma levels of TrxR1 were measured in 109 treatment-naïve resectable NSCLC patients and 15 individuals with benign tumor-like pulmonary diseases. Taking plasma TrxR1 activity of 5.0 as reference, the overall concordance rate was 58.1%, while those of CEA, CA199, CA125, NSE, CYFRA21-1 and SCC were 19.2%, 8.2%, 2.1%, 45.9%, 25.3% and 9.5%, respectively. Furthermore, using TNM staging (AJCC 7th ed.) as classifier, the concordance rates of TrxR1 in benign tumor-like pulmonary diseases, local and regional stage NSCLC subgroups were 53.3% (8/15), 57.5% (46/80) and 63.0% (17/27), respectively. A multipoint linear fitting correlation model was created, and the equation was TrxR1 = 5.716 + 0.4898*Stage. Conclusions: Our data suggest that plasma TrxR1 activity is a useful non-invasive diagnostic marker for NSCLC, and there may be a linear correlation between TrxR1 activity and pathological stage.

Research advances of electrochemical micro/nanofabrication based on confined etchant layer technique

Compared with mechanical machining, ECM has several advantages, such as avoiding tool wear, none thermal or mechanical stress on machining surfaces, as well as high removal rate. Moreover, ECM is capable of making complex three-dimensional structures and is appropriate for flexible, fragile, or fissile materials even materials harder than the machining tool. Thus, ECM has been widely used for various industrial applications in the fields of aerospace, automobiles, electronics, etc. ECM methods can be classified usually as electrolytic machining based on anodic dissolution and electroforming based on cathodic deposition of metallic materials. Recently, high technology industry, such as ultralarge scale integration (ULSI) circuits, microelectromechanical systems (MEMS), miniaturized total analysis systems (μ-TAS) and precision optics, has developed more and more rapidly, where miniaturization and integration of functional components are becoming significant. Nowadays, the feature size of interconnectors in ULSI circuits has been down to 20 nanometers, predicted by Moore’s law. Confined etchant layer technique (CELT) was proposed in 1992 to fabricate three-dimensional micro- and nanostructures (3D-MNS) on different metals and semiconductors, which has been developed an effective machining method with independent intellectual property rights. Generally, there are three procedures in CELT: (1) generating the etchant on the surface of the tool electrode by electrochemical or photoelectrochemical reactions; (2) confining the etchant in a depleted layer with a thickness of micro- or nanometer scale; (3) etching process when the tool electrode is fed to the workpiece, which applicable for 1D milling, 2D polishing, and 3D microfabrication with an accuracy at micro or nanometer scale. External physical-field modulations have recently been introduced into CELT to improve its machining precision. In this review, the advances of CELT in principles, instruments and applications will be addressed as well as the prospects.

Research on the Internationalized Operation Strategy of Small and Medium-Sized Enterprises in China in the New Era

The international operation of small and medium-sized enterprises is the development of the small and medium-sized enterprise to a certain stage of the objective needs, and it is the important sign of the small and medium-sized enterprise to mature. With the deepening of economic globalization, the pace of internationalization of Chinese enterprises to gradually accelerate. This paper analyzes the existing problems of the international operation of small and medium-sized enterprises in China from the aspects of talents, capital, independent intellectual property rights, and then analyzes brands, localization operation, information construction and other aspects of China's small and medium-sized international business development strategy.

Development trends of environmental protection technologies for Chinese steel industry

Chinese steel industry has made significant progress on reducing fresh water consumption and CO2/SO2/COD (chemical oxygen demand)/dust emissions, and improving comprehensive utilization of solid waste. Some steel companies have become topped worldwide. However, due to the large output quantity of crude steel, the whole steel industry is still a huge source of pollutants. At present, environmental protection standards are encountering challenges of lack of technical support, taxation policy and other issues. Steel industry is currently facing enormous environmental pressure. The development trends of environmental protection technologies were studied by summarizing different development stages. To realize the development targets, the industry needs to carry out its research with independent intellectual property rights, develop comprehensive management systems and establish ecological chain with other industries. This can not only raise the level of environmental protection in a broader range, but also improve the energy efficiency of iron and steel plants and increase added value of waste utilization. Finally, 23 environmental protection technologies were proposed and 4 new environmental protection practices were studied.

A study on natural recovery of tassel fertilization and doubling method in maize haploids.

Doubling method is the technical barriers in maize haploid breeding. It was very important to establish the independent intellectual property rights for doubling method. In this experiment, the maize haploid inducer, TG15, was used for producing maternal haploids. Also, haploids were obtained from two kinds of maternal genotypes involved in the experiment, including high-oil type and common type. Significant differences were observed among offspring of various genotypes in the recovery of haploid fertilization. In 21 hybrid offspring haploids, the average powder rate was 8.28%, and the seed setting rate was 4.98%. The experimental results showed that when the hybrids were treated with 0.08% colchicine, the average powder rate and seed setting rate of offspring haploids were 35.53 and 20.30%, respectively, which were significantly higher than the hybrids with natural recovery ability. This study primarily established the doubling method of haploids called "bud seedling method" in China which was very practicably in maize doubled haploid breeding.

Research on the Automation Control Information System Model based on the Chaos and Nonlinear Transformation

In this paper, we conduct research on the automation control information system model based on the Chaos and nonlinear transformation. Electronic control automation system in the process of social and economic development plays the key role is obvious, it can effectively encourage industry automation level is improved greatly, at the same time, electronic automation system control to the larger extent on saving the cost of enterprise. Electronic systems control automation industrial enterprises should also improve their in technical innovation ability, to have independent intellectual property rights of electronic automation engineering control system. This paper combines the chaos and nonlinear transformation principles to optimize the traditional system that is meaningful.

Radiometric calibration of tempospatially modulated polarization interference imaging spectrometer.

The tempospatially modulated polarization interference imaging spectrometer (TSMPIIS) nominated by the Ministry of Scence and Technology, takes part in the "Eleventh Five-Year National Science and Technology Exhibition." In order to improve the detecting precision of the TSMPIIS, its radiometric calibration scheme is proposed on the basis of the solar simulator, integrating sphere, monochromator, and spectroradiometer. Under the conditions of changing the exposure time and radiant brightness, the CCD linear responses for the TSMPIIS were first tested to validate the reliability of the radiometric calibration performed with a linear response model, and the linear errors were less than 0.15% and 1.15%, respectively. A novel method is put forward to calibrate the nonuniformity of CCD pixels, and the least squares method can commendably correct the uneven effect in the spatial direction. Besides, the absolute radiometric calibration establishes a corresponding relation between the dimensionless intensity output from the TSMPIIS and the target radiant brightness. The study lays the foundation for the engineering application of the TSMPIIS, such as remote sensing detection, and has an important significance for the development of our instrument and equipment technology with independent intellectual property rights.

Applications, opportunities and challenges of molecular probes in the diagnosis and treatment of major diseases

Minimally invasive treatment of cancer can significantly reduce surgery risks due to many advantages, such as no laparotomy, small wound and early recovery and so on. Especially, it is suitable for patients who cannot be operated on due to tumor distant metastasis, oldness, weakness, and major organ dysfunction. According to clinical statistics, more than 60% of patients with mid-advanced cancer can be cured by employing minimally invasive surgery. Malignant tumors often show invasive growth and unclear boundary, resulting in partial removal of healthy tissue during surgery, hence postoperative sequelae and dysfunction. In order to carry out minimally invasive surgery and targeted elimination of tumor, the size and location of the tumors must be accurately identified before therapy, which requires the imaging guidance. By using optical molecular imaging, we can find a small tumor less than ~1mm. Therefore, the molecular imaging navigation provides a great opportunity for the development of minimally invasive interventional therapy for cancer. Especially, the cancer specific probes are emerging as one of the key technologies of molecular imaging. Compared with small molecular probes, nanoprobes show longer imaging time, remarkable signal multiplication and drug loading capacity. There, specific nanoprobes become the development direction of the molecular imaging navigation technology. Aiming at accuracy, high efficacy and minimal invasiveness of cancer treatments, we need solve two key scientific issues including identification of tumor boundary and predictability of lymph node metastases, and develop three key technologies including: high accumulation of nanoprobes at tumor sites, high sensitivity of nanoprobes to cancer cells, high precision imaging methods based on nanoprobes. This project will design and construct a variety of safe and efficient nanoprobes and related nanomaterials with independent intellectual property rights. For example, ultra pH (or enzyme)-sensitive fluorescent nanoprobes will be fabricated for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals. Multifunctional nanoprobes will be developed for simultaneous molecular imaging and interventional therapy of cancer. Fluorescent/ultrasound nanoprobes will be prepared to achieve a bimodal imaging with excellent signal sensitivity and high spatial resolution. Theranostic nanoprobes will be produced for both targeted imaging (diagnosis) and interventional therapy (laser, ultrasound, microwave, radiofrequency or combination etc.). In addition, we will establish a practical and feasible technology platform for large-scale production of nanoprobes, and in vivo and in vitro evaluation systems for the clinical applications of nanoprobes. It is of crucial importance to investigate the biological influence of nanoprobes on cell division, proliferation, apoptosis and signal transduction pathways, assess in vivo transport mechanism across biological barriers, and evaluate biosafety of nanoprobes, such as acute toxicity, long-term toxicity, nervous system toxicity and immunogenicity. Moreover, fluorescence confocal microendoscope and minimally invasive therapeutic devices will be developed based on nanoprobes. Finally, we will assess invasion depth and lymph node metastasis in early gastric cancer, as well as retroperitoneal lymph node metastasis of ovarian cancer by using nanoprobes in combination of fluorescence confocal microendoscope and molecular imaging navigation system. The sensitivity and specificity of molecular imaging nanoprobes are evaluated by using pathology as the gold standard. The precise interventional therapy (photodynamic, photothermal and sonodynamic etc.) will be implemented by irradiating the tumor tissue using laser or ultrasound under the guidance of nanoprobe-enhanced molecular imaging. It is essential to investigate the evaluation methods of therapeutic efficacy. We will explore the synergistic, anti-metastatic and overcoming drug resistance effects of interventional therapy combined with chemotherapy. In conclusion, molecular imaging nanoprobes can be used not only for imaging and diagnosis, but also for the minimally invasive interventional treatments. In particular, the research and application of nanoprobes will promote the development and application of fluorescence confocal microendoscope, molecular imaging navigation systems and minimally invasive interventional therapy systems. This will accelerate the breakthrough in the key technology of major medical equipment. Undoubtedly, the accomplishment of the project would enhance the innovation capability and international competitiveness of China in nanobiomedicine and medical equipment.

Review of application of biomimetics for designing soil-engaging tillage implements in Northeast China

The reduction of water resources and soil fertility in Northeast China will have a requirement on higher working efficiency of agricultural soil-engaging components. The adhesion and resistance are main problems for soil-engaging tillage components. However, the soil-burrowing or soil-digging animals give inspirations to resolve those problems. Their fair, claw, toe, textured surface and scales have functions of anti-adhesion or resistance reduction. Those results provide a way to realize the sustainable development of modern agriculture by developing novel biomimetic agricultural machinery systems with independent intellectual property rights to meet conservation tillage requirements in the Northern China region. Biological structures of some soil-burrowing or soil-digging animals, such as beetle, mole cricket, earthworm, mole, vole, pangolin, and snake, as well as their mechanisms of anti-adhesion or reducing resistance were reviewed in this paper. Bioinspired applications in Northeast China were also presented in the paper, including moldboard, subsoiler components, furrow opener, roller, and biomimetic rototilling-stubble-breaking blade. In addition, the existed problems in agricultural engineering and the future development trends were discussed. Keywords: review, agricultural engineering, biomimetics, soil-engaging tillage implements, conservation tillage DOI: 10.3965/j.ijabe.20160904.1437 Citation: Zhang Z J, Jia H L, Sun J Y. Review on application of biomimetic for designing soil-engaging tillage implements in Northeast China. Int J Agric & Biol Eng, 2016; 9(4): 12－21.

Clinical Analysis of Icotinib on Beneficiary of Advanced Non-small Cell Lung Cancer with EGFR Common Mutation

背景与目的靶向治疗已经成为晚期非小细胞肺癌（non-small cell lung cancer, NSCLC）治疗中不可或缺的重要手段，表皮生长因子受体（epithelial growth factor receptor, EGFR）的酪氨酸激酶抑制剂（tyrosine kinase inhibitor, TKI）可显著延长晚期携带EGFR基因突变肺癌患者生存期。埃克替尼是我国第一个拥有自主知识产权的EGFR-TKI。本研究旨在探讨埃克替尼治疗EGFR敏感突变的晚期NSCLC获益患者的临床特点，对获益患者[无进展生存时间（progression-free survival, PFS）≥6个月]进行回顾性资料收集并分析相关影响因素。方法收集2011年9月1日-2015年9月30日浙江省肿瘤医院经埃克替尼片治疗的231例EGFR敏感突变的晚期NSCLC获益患者的生存情况。结果经埃克替尼治疗后，一线治疗组1年获益率达67.9%，二线及以上组为53.6%，具有统计学意义（P=0.027）；一线治疗组2年获益率对比二线及以上组亦有统计学差异（18.7%和9.3%，P=0.047）。一线患者和二线及以上患者的中位PFS分别为16.7个月和12.4个月，且差异具有统计学意义（P=0.006）。其中有无脑转移（P=0.010）、埃克替尼治疗时机（P=0.001）、美国东部肿瘤协作组（Eastern Cooperative Oncology Group, ECOG）评分（P=0.001）为影响预后的主要因素。主要不良反应为皮疹51例（22.1%），腹泻27例（11.7%）。结论埃克替尼是EGFR基因敏感突变的晚期NSCLC患者有效的治疗方案，其优势人群除无脑转移者及ECOG评分好的患者外，一线治疗患者疗效明显优于二线及以上者。敏感突变患者采用埃克替尼可得到较好的临床获益，并具有较好的耐受性。

The General Design and Technology Innovations of CAP1400

ABSTRACT The pressurized water reactor CAP1400 is one of the sixteen National Science and Technology Major Projects. Developed from China's nuclear R&D system and manufacturing capability, as well as AP1000 technology introduction and assimilation, CAP1400 is an advanced large passive nuclear power plant with independent intellectual property rights. By discussing the top design principle, main performance objectives, general parameters, safety design, and important improvements in safety, economy, and other advanced features, this paper reveals the technology innovation and competitiveness of CAP1400 as an internationally promising Gen-III PWR model. Moreover, the R&D of CAP1400 has greatly promoted China's domestic nuclear power industry from the Gen-II to the Gen-III level.

Wirelessly programmed deep brain stimulation of the bilateral subthalamic nucleus for the treatment of primary Parkinson′s disease: study protocol for a multicenter, randomized, parallel-controlled optimal-efficiency trial

Background: Deep brain stimulation (DBS) is a commonly used neurosurgical approach for the debilitating motor symptoms of Parkinson's disease (PD). A number of neurostimulation products have been developed, including the Medtronic implantable neurostimulator (Medtronic USA, Inc., USA) and a wirelessly programmed implantable neurostimulator (Sceneray Co. Ltd., China) with protection by independent intellectual property rights in China. This study will validate the safety and efficacy of implantable neurostimulators in the treatment of primary PD. Methods/Design: This is a prospective, single-blind, randomized parallel-controlled optimal-efficiency trial, which will be performed in five research centers. Sixty-four patients with middle-stage and advanced-stage idiopathic PD will be randomly assigned to an experimental group and a control group according to a 1:1 ratio. An implantable neurostimulator will be implanted in each participant in both groups, but the stimulator will be activated within 1 month of surgery in the experimental group, while the patients in the control group will not receive stimulation until 3 months after implantation. After 3 months, patients in both groups will receive stimulation from the implanted neurostimulator. Beginning 6 hours after implantation, all participants will receive anti-PD drugs such as dopamine receptor agonists and compound levodopa. The primary outcome measure in this study will be changes in motor function score (Unified Parkinson's Disease Rating Scale (UPDRS)-III), relative to the baseline value, in patients from each group upon withdrawal of medications for 12 hours at 3 months after surgery. The secondary outcome measures for this study include (1) changes in UPDRS-I, II, III, and IV scores in patients from each group under the influence of medication at 3, 6, 9, and 12 months after surgery relative to baseline values; (2) changes in UPDRS-III scores upon withdrawal of medications 12 months after surgery in stimulation on and off modes relative to baseline value; (3) patient satisfaction. Safety indices are the numbers and incidences of adverse events. Discussion: This study is the first to investigate the safety and efficacy of a wirelessly programmed implantable neurostimulator enforced with protection by independent intellectual property rights in China through a randomized controlled trial. If safe and effective outcomes are acquired, this implantable neurostimulator will become a new option for treatment of PD patients. Trial registration: This trial was registered at http://www.chictr.org.cn (registration number ChiCTR-INR-16008951) on 1 August 2016. Ethics: The study protocol has been approved by the Ethics Committee of Tangdu Hospital of the Fourth Military Medical University of China (approval number: 2012009); Ethics Committee of Changhai Hospital of China (approval number: CHEC2012-044); Clinical Trial Ethics Committee, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine of China (approval number: 2012-67); Clinical Trial and Biomedical Ethics Committee of West China Hospital of Sichuan University of China (approval number: 2012-7); Ethics Committee of First Affiliated Hospital of Guangzhou Medical University of China (approval number: 2013-8). The study protocol will be performed in strict accordance with the Declaration of Helsinki, formulated by the World Medical Association. Informed consent: Signed informed consent will be obtained from the patients or their relatives.

Research progress in magnetocaloric effect materials

Magnetocaloric effect（MCE) is the intrinsic property of a magnetic material near transition temperature and the magnetic refrigeration based on MCE has been demonstrated as a promising alternative to the conventional gas compression or expansion refrigeration due to its high energy efficiency and environmental friendliness. The development of magnetic refrigeration technology depends on the research progress of magnetic refrigerant materials with large MCEs. Lots of researches of material exploration and material optimization have promoted the progress of magnetic refrigeration technology in recent decades. In this paper, we introduce the basic theory of MCE and the development of refrigeration technology, review the research progress of large MCE materials both in low temperature range and in room temperature range, and specifically focus on the latest progress of some MCE materials. Low temperature MCE materials mainly include those rare earth based materials with low transition temperatures, such as binary alloys（RGa, RNi, RZn, RSi, R3Co and R12Co7), ternary alloys（RTSi, RTAl, RT2Si2, RCo2B2 and RCo3B2), and quaternary alloys（RT2B2C), where R denotes the rare earth and T represents the transition metal. Those materials mainly possess the second-order phase transitions and show good thermal hysteresis, magnetic hysteresis, and thermal conductivities. Room temperature MCE materials are mainly Gd-Si-Ge intermetallic compounds, La-Fe-Si intermetallic compounds, MnAs-based compounds, Mn-based Heusler alloys, Mn-based antiperovskite compounds, Mn-Co-Ge intermetallic compounds, Fe-Rh compounds, and perovskite-type oxides. The above materials usually have the first-order phase transitions and most of these materials possess the large MCEs in room temperature range, therefore they have received much attention home and abroad. Among those room temperature MCE materials, the La-Fe-Si series is considered to be the most promising magnetic refrigerant materials universally and our country has independent intellectual property rights of them. The further development prospects of MCE materials are also discussed at the end of this paper.

Research on Innovation of Science and Technology Investment and Financing of SMEs in Intellectual Property

With the development of the knowledge economy, the intellectual property is more and more important. The intellectual property is the core lifeline of an enterprise. High-tech SMEs owe the independent intellectual property rights, but they have financing problems. How to use intellectual property to invest and finance will be the focus of future development of high-tech SMEs. This paper will focus on the characteristics of intellectual property for investment and financing, the development paths and put forward in the course of management and policy innovation of investment and financing.

A large LNG tank technology system “CGTank®” of CNOOC and its engineering application

LNG tanks are complex in design and building process and high in costs, so LNG tank technology is one of the most advanced ones in the field of energy, which has been monopolized by foreign companies for a long time. In order to work out LNG tank technology domestically, China National Offshore Oil Corporation (CNOOC for short), the largest LNG importer in China, develops a LNG tank technology system “CGTank®” successfully in reference to the design and construction experience of domestic and foreign companies, after years of scientific research in tackling difficult problems. This system presents four traits as follows. First, a set of calculation software is developed independently by CNOOC, and the tanks in all operating conditions are calculated after 3D hologram and multi-point contact model of fluid-solid coupling effect is built up. Second, earthquake effect research and inner tank check research are improved innovatively by means of response spectrum analysis after European standards are introduced. Third, it is put forward for the first time that the stress strength discrimination standard is based on the principal stress which is obtained by means of the maximum shearing failure theory. And fourth, a large LNG full-capacity tank technology package with completely independent intellectual property right is established. The “CGTank®” system was first applied in the Tianjin LNG demonstration project, which has passed all indicator tests and is now in operation smoothly. The project is provided with the core tank design technology by CNOOC Gas and Power Group and with the EPC by CNOOC Engineering Co., Ltd. The independent LNG tank technology can be applied in a wide scope and it is favorable for impelling domestic production of LNG industry completely.

Research and Application of Work Roll Contour Technology on Thin Gauge Stainless Steel in Hot Rolling

Shape control is the key technology for thin gauge stainless steel in hot rolling. Because of high rolling force, work roll can suffer from serious uneven wears, edge drop of strip temperature and so on. And in turn these imperfections lead to defects in thin gauge stainless steel production, such as big crown value, quarter wave, edge profile anomalies, poor rolling stability. In order to improve shape the control ability, one will have to eliminate the quarter wave, make roll wear uniform, increase rolling stability in the thin gauge stainless steel production, use high performance variable crown technology in upstream stands, use mixed variable crown technology in last stand, and use conventional work roll with variable shifting stroke strategy in other downstream stands. The above technologies have been successfully applied in several stainless steel productions, which have completely independent intellectual property rights, and the crown control precision of thin gauge stainless is 98.1%, flatness control precision is 97.5%, also a 1260 mm × 1.6 mm ultra-thin gauge stainless steel was successfully developed.

Development and application of ZM-2 drilling fluid density adjustment mixing device

High-pressure shallow (gas/water) flow is often hidden in the deepwater seabed, so penetrating shallow flow in drilling without BOP will be highly risky. In this case, the conventional well killing method to balance the formation pressure with back pressure generated by well head equipment is no longer suitable. Based on the analysis of structural characteristics of domestic and foreign multi-phase mixing systems, a ZM-2 drilling fluid density adjustment mixing device with independent intellectual property right was developed according to the principles of dynamic well killing. The device is mainly composed of a throttle valve, a high-precision electromagnetic flowmeter, a mixer, dumbbell-shaped nozzles, connecting pipes and other components. Fixed on the mixer are three inlets to fill heavy mud, seawater and additives. Opposed jetting is adopted to realize rapid and uniform mixing of fluids with different densities. A laboratory test was conducted to work out the relationship between throttle opening and injection flow rate and establish a linear relationship between killing fluid density and heavy mud flow. The results of field test conducted in the Nanhai No.8 drill ship showed that the mixing device was stable in operation and excellent in mixing performance. The density difference of ingredient mixture could be controlled within 0.05 g/cm3 after the mixture flowed out of the mixing chamber of the mixer of about 0.3 m long, so such high precision can meet the requirement of dynamic well killing.

Development of the 1.2 T~1.5 T Permanent Magnetic Resonance Imaging Device and Its Application for Mouse Imaging

By improving the main magnet, gradient, and RF coils design technology, manufacturing methods, and inventing new magnetic resonance imaging (MRI) special alloy, a cost-effective and small animal specific permanent magnet-type three-dimensional magnetic resonance imager was developed. The main magnetic field strength of magnetic resonance imager with independent intellectual property rights is 1.2~1.5 T. To demonstrate its effectiveness and validate the mouse imaging experiments in different directions, we compared the images obtained by small animal specific permanent magnet-type three-dimensional magnetic resonance imager with that obtained by using superconductor magnetic resonance imager for clinical diagnosis.

Research and Progress of Hot Stamping in China

This paper introduced the significance of hot stamping on developing lightweight technology and safety property enhancement in China Automotive industry, as well as the research status and progress and market prospect of hot stamping process, Materials and equipments. Key technology and focus of hot stamping are analyzed, direction of hot stamping further development were proposed. Hot stamping process, technology and equipments with completely independent intellectual property rights were developed surrounding energy saving, process stability, quality consistency, flexible distribution of components’ strength , high cost-effective production and so on, which is of important for development of hot stamping in China.