Independent Approaches Research Articles

Some Aspects of Researching Quality of Life in Pediatrics

The article is devoted to a discussion of the most important aspects of studying the quality of life in children as an independent approach to assessing child health at the present stage. The work examines the main features of the methodology for assessing the quality of life of a child, presents the areas of children's healthcare in which the use of the method of assessing the quality of life in children is the most popular and promising today and in the near future

Revitalizing Banking: An In-Depth Analysis of Business Model Performance in Indonesian Digital Banking – Neo-Banks Vs Unit Business Banks

The study uses the Independent Test Analysis approach to calculate the business model bank performance of Indonesian commercial banks, focusing on digital banks. The research uses quarterly reports from 2020 to 2023 to collect secondary data. The study includes Digital Banks in Indonesia, including 4 neo-banks and 14 unit business banks. The results show a significant difference in bank business model performance between unit business banks and neo-banks. The Non-Interest Income (NII) results show no significant difference, but the mean results show a slight difference in performance. The author assumes that unit business banks have a diverse and comprehensive ecosystem in banking activities due to their wider scope of business activities compared to neo-banks.

CO2 Capture and Enhanced Hydrogen Production Enabled by Low-Temperature Separation of PSA Tail Gas: A Detailed Exergy Analysis

Hydrogen from natural gas reforming can be produced efficiently with a high CO2 capture rate. This can be achieved through oxygen-blown autothermal reforming as the core technology, combined with pressure-swing adsorption for hydrogen purification and refrigeration-based tail gas separation for CO2 capture and recirculation of residual hydrogen, carbon monoxide, and methane. The low-temperature tail gas separation section is presented in detail. The main objective of the paper is to study and quantify the exergy efficiency of this separation process in detail. To achieve this, a detailed exergy analysis is conducted. The irreversibilities in 42 different process components are quantified. In order to provide transparent verification of the consistency of exergy calculations, the total irreversibility rate is calculated by two independent approaches: Through the bottom-up approach, all individual irreversibilities are added to obtain the total irreversibility rate. Through the top-down approach, the total irreversibility rate is calculated solely by the exergy flows crossing the control volume boundaries. The consistency is verified as the comparison of results obtained by the two methods shows a relative deviation of 4·10−7. The exergy efficiency of the CO2 capture process is calculated, based on two different definitions. Both methods give a baseline exergy efficiency of 58.38%, which indicates a high degree of exergy utilisation in the process.

Effects of maternal and perinatal factors on human milk fat globule membrane proteome: A data independent acquisition approach

Milk fat globule membrane proteins (MFGMP) are essential for supporting infants’ growth and development. The composition of MFGMP may vary depending on maternal and perinatal factors. However, there is a lack of research on the effects of parity, maternal age, and mode of delivery on MFGMP. This study attempts to address this knowledge gap by utilizing a data-independent acquisition (DIA) approach to perform proteomics comparisons of human MFGMP. Mature human milk (MHM) was collected from Chinese women with different parities (multiparous vs. primiparous, MP vs. PP), maternal reproductive ages (age ≥30 vs. age <30, MA1 vs. MA2), and delivery modes (cesarean delivery vs. vaginal delivery, CD vs. VD). We found variations in MFGMP between different cohorts. Differentially expressed proteins (DEP) in MHM of primiparous and multiparous women were mostly related to innate immune response which provides the first line of defense against pathogens. Higher abundances of these DEP were found in the MHM of multiparous women. Meanwhile, DEP in MHM of women with different delivery modes were primarily related to inflammatory response and innate immune response. We postulate that upregulation of the defense response-related DEP in MHM of women who had cesarean delivery was in relation to modulation of the cesarean delivery-induced inflammatory response and to strengthen the immune defense of newborns.

Tip Growth Defective1 interacts with the cellulose synthase complex to regulate cellulose synthesis in Arabidopsis thaliana.

Plant cells possess robust and flexible cell walls composed primarily of cellulose, a polysaccharide that provides structural support and enables cell expansion. Cellulose is synthesised by the Cellulose Synthase A (CESA) catalytic subunits, which form cellulose synthase complexes (CSCs). While significant progress has been made in unravelling CSC function, the trafficking of CSCs and the involvement of post-translational modifications in cellulose synthesis remain poorly understood. In order to deepen our understanding of cellulose biosynthesis, this study utilised immunoprecipitation techniques with CESA6 as the bait protein to explore the CSC and its interactors. We have successfully identified the essential components of the CSC complex and, notably, uncovered novel interactors associated with CSC trafficking, post-translational modifications, and the coordination of cell wall synthesis. Moreover, we identified TIP GROWTH DEFECTIVE 1 (TIP1) protein S-acyl transferases (PATs) as an interactor of the CSC complex. We confirmed the interaction between TIP1 and the CSC complex through multiple independent approaches. Further analysis revealed that tip1 mutants exhibited stunted growth and reduced levels of crystalline cellulose in leaves. These findings suggest that TIP1 positively influences cellulose biosynthesis, potentially mediated by its role in the S-acylation of the CSC complex.

A15 LEVERAGING CULTURE-DEPENDENT AND -INDEPENDENT METAGENOMICS TO IDENTIFY ENTEROBACTERIACEAE GENES ASSOCIATED WITH ACTIVE ULCERATIVE COLITIS

Abstract Background Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) that is restricted to the large intestine and is characterized by mucosal inflammation. There is evidence that pathogenic bacteria contribute to UC pathogenesis in at least some patients and the bacterial family Enterobacteriaceae are prime suspects. Some strains of Enterobacteriaceae carry virulence genes important for colonizing the gut (e.g. fimH) and disrupting the intestinal epithelium (e.g. hemolysins). We hypothesize that key virulence genes carried by strains of many Enterobacteriaceae species contribute to disease activity in some UC patients. As we predict virulence genes are strain-specific, the detection of the species alone (e.g. Escherichia coli) is insufficient to predict pathogenic potential and this has confounded previous studies to identify infectious agents in UC. Aims We aim to use culture-dependent and -independent sequencing approaches to identify Enterobacteriaceae genes in the UC gut microbiome associated with active disease. Methods UC patient stool samples collected throughout enrolment in randomized control trials of fecal microbiota transplantation (FMT) for adult UC (n=10) and microbiome studies in early-onset pediatric UC (n=25) were cultured on MacConkey (MAC) agar to enrich for Enterobacteriaceae. Strains were isolated from baseline stool samples cultured on MAC agar for whole genome sequencing and virulence gene characterization. Baseline and post-treatment stool samples cultured on MAC agar were sent for metagenomic sequencing. Using a subset of 11 pediatric patients, I developed a metagenomic pipeline to identify Enterobacteriaceae genes enriched during active UC compared to periods of remission or milder disease. Results Known virulence genes, including fimH and hemolysins, were present in some strains across multiple Enterobacteriaceae species. Using an unbiased metagenomic approach with the pediatric cohort, we identified 42 genes enriched at baseline with the criteria they must be elevated in at least three of the 11 patients. The majority of the 42 genes were distributed into six gene clusters, including a small plasmid. Conclusions Our approach allows us to identify genes enriched in active UC that have not been previously described in the literature and our analysis will be repeated with our adult cohort. Genes that are enriched in active UC in the pediatric and/or adult cohort will be validated in publicly available metagenomic datasets that consist of both IBD patients and healthy controls. Furthermore, culture-dependent approaches allow us to test mechanisms in vivo that are informed by our bioinformatics. Leveraging microbiome and clinical data provides a unique window to guide future diagnostics and treatments to improve outcomes for UC patients. Funding Agencies CIHROGS

Kepler Multitransiting System Physical Properties and Impact Parameter Variations

We fit a dynamical model to Kepler systems that contain four or more transiting planets using the analytic method AnalyticLC and obtain physical and orbital parameters for 101 planets in 23 systems, of which 95 are of mass significance better than 3σ, and 46 are without previously reported mass constraints or upper limits. In addition, we compile a list of 71 Kepler objects of interest that display significant transit impact parameter variations (TbVs), complementing our previously published work on two- and three-transiting-planet systems. Together, these works include the detection of significant TbV signals of 130 planets, which is, to our knowledge, the largest catalog of this type to date. The results indicate that the typical detectable TbV rate in the Kepler population is of order 10−2 yr−1 and that rapid TbV rates (≳0.05 yr−1) are observed only in systems that contain a transiting planet with an orbital period less than ∼20 days. The observed TbV rates are only weakly correlated with orbital period within Kepler’s ≲100-day-period planets. If this extends to longer periods, it implies a limit on the utility of the transit technique for long-period planets. The TbVs we find may not be detectable in direct impact parameter measurements, but rather are inferred from the full dynamics of the system, encoded in all types of transit variations. Finally, we find evidence that the mutual inclination distribution is qualitatively consistent with the previously suggested angular momentum deficit model using an independent approach.

Optical properties of two-dimensional Dirac–Weyl materials with a flatband

The emergence of a flatband in Dirac–Weyl materials offers new possibilities for electronic transitions, leading to stronger interaction with light. As a result, the optical conductivity can be significantly enhanced in these flatband materials as compared with graphene, making them potentially better candidates for optical sensing and modulation. Recently, a comprehensive theory for the optical conductivity of a spectrum of flatband Dirac–Weyl materials has been developed, with explicit formulas for both the real and imaginary parts of the conductivity derived through two independent approaches. This Perspective offers a review of the development. An understanding of the optical properties of the flatband Dirac–Weyl materials paves the way for optical device applications in the terahertz-frequency domain.

Model independent dark matter properties from cosmic growth

Dark matter dominates the matter budget of the universe but its nature is unknown. Deviations from the standard model, where dark matter clusters with the same gravitational strength as baryons, and has the same pressureless equation of state as baryons, can be tested by cosmic growth measurements. We take a model independent approach, allowing deviations in bins of redshift, and compute the constraints enabled by ongoing cosmic structure surveys through redshift space distortions and peculiar velocities. These can produce constraints at the 3-14% level in four independent redshift bins over z = [0,4].

Finding tau rhythms in EEG: An independent component analysis approach.

Tau rhythms are largely defined by sound responsive alpha band (~8-13 Hz) oscillations generated largely within auditory areas of the superior temporal gyri. Studies of tau have mostly employed magnetoencephalography or intracranial recording because of tau's elusiveness in the electroencephalogram. Here, we demonstrate that independent component analysis (ICA) decomposition can be an effective way to identify tau sources and study tau source activities in EEG recordings. Subjects (N = 18) were passively exposed to complex acoustic stimuli while the EEG was recorded from 68 electrodes across the scalp. Subjects' data were split into 60 parallel processing pipelines entailing use of five levels of high-pass filtering (passbands of 0.1, 0.5, 1, 2, and 4 Hz), three levels of low-pass filtering (25, 50, and 100 Hz), and four different ICA algorithms (fastICA, infomax, adaptive mixture ICA [AMICA], and multi-model AMICA [mAMICA]). Tau-related independent component (IC) processes were identified from this data as being localized near the superior temporal gyri with a spectral peak in the 8-13 Hz alpha band. These "tau ICs" showed alpha suppression during sound presentations that was not seen for other commonly observed IC clusters with spectral peaks in the alpha range (e.g., those associated with somatomotor mu, and parietal or occipital alpha). The choice of analysis parameters impacted the likelihood of obtaining tau ICs from an ICA decomposition. Lower cutoff frequencies for high-pass filtering resulted in significantly fewer subjects showing a tau IC than more aggressive high-pass filtering. Decomposition using the fastICA algorithm performed the poorest in this regard, while mAMICA performed best. The best combination of filters and ICA model choice was able to identify at least one tau IC in the data of ~94% of the sample. Altogether, the data reveal close similarities between tau EEG IC dynamics and tau dynamics observed in MEG and intracranial data. Use of relatively aggressive high-pass filters and mAMICA decomposition should allow researchers to identify and characterize tau rhythms in a majority of their subjects. We believe adopting the ICA decomposition approach to EEG analysis can increase the rate and range of discoveries related to auditory responsive tau rhythms.

Comparison of two methods simulating inter-track interactions using the radiobiological Monte Carlo toolkit TOPAS-nBio

Objective. To compare two independently developed methods that enable modelling inter-track interactions in TOPAS-nBio by examining the yield of radiolytic species in radiobiological Monte Carlo track structure simulations. One method uses a phase space file to assign more than one primary to one event, allowing for inter-track interaction between these primary particles. This method has previously been developed by this working group and published earlier. Using the other method, chemical reactions are simulated based on a new version of the independent reaction time approach to allow inter-track interactions. Approach. G-values were calculated and compared using both methods for different numbers of tracks able to undergo inter-track interactions. Main results. Differences in the G-values simulated with the two methods strongly depend on the molecule type, and deviations can range up to 3.9% (H2O2), although, on average, the deviations are smaller than 1.5%. Significance. Both methods seem to be suitable for simulating inter-track interactions, as they provide comparable G-values even though both techniques were developed independently of each other.

PERBEDAAN EFEKTIFITAS PIJAT LAKTASI DENGAN PERAWATAN PAYUDARA TERHADAP KEBERHASILAN MENYUSUI DI PMB KOTA PEKANBARU

International Guidelines, which are based on scientific data about the advantages of breast milk for infants, moms, families, and nations, advise exclusive breastfeeding for six months. The sensation of having inadequate or too little breast milk, breast swelling, flat or painful nipples, clogged breast milk ducts, and mastitis are issues that nursing moms often face. Breast care and lactation massage are two of the numerous strategies that may be used to boost breast milk supply. The purpose of this study is to ascertain how lactation massage and breast care vary in their ability to support successful breastfeeding in PMB Pekanbaru City. The study design used was two group independent approach design, and the research methodology was quasi experimental (quasi experimental). Mothers who had given birth within two hours and were nursing in the Pekanbaru Midwife Independent Practice Work Area made up the study population. The present study used the independent T test for analysis in order to ascertain the impact of lactation massage and breast care on postpartum moms' success in breastfeeding. The average amount of breast milk provided to moms who undergo lactation massage is 5.47 months, with a standard deviation of 0.837, according to the findings of statistical data processing using the Independent Samples Test. Breastfeeding moms give birth to their children for 4.6 months on average, with a standard deviation of 1,352. Breast milk is delivered to women who do breast care

Engineering peroxisomal biosynthetic pathways for maximization of triterpene production in Yarrowia lipolytica

Constructing efficient cell factories for product synthesis is frequently hampered by competing pathways and/or insufficient precursor supply. This is particularly evident in the case of triterpenoid biosynthesis in Yarrowia lipolytica, where squalene biosynthesis is tightly coupled to cytosolic biosynthesis of sterols essential for cell viability. Here, we addressed this problem by reconstructing the complete squalene biosynthetic pathway, starting from acetyl-CoA, in the peroxisome, thus harnessing peroxisomal acetyl-CoA pool and sequestering squalene synthesis in this organelle from competing cytosolic reactions. This strategy led to increasing the squalene levels by 1,300-fold relatively to native cytosolic synthesis. Subsequent enhancement of the peroxisomal acetyl-CoA supply by two independent approaches, 1) converting cellular lipid pool to peroxisomal acetyl-CoA and 2) establishing an orthogonal acetyl-CoA shortcut from CO2-derived acetate in the peroxisome, further significantly improved local squalene accumulation. Using these approaches, we constructed squalene-producing strains capable of yielding 32.8 g/L from glucose, and 31.6 g/L from acetate by employing a cofeeding strategy, in bioreactor fermentations. Our findings provide a feasible strategy for protecting intermediate metabolites that can be claimed by multiple reactions by engineering peroxisomes in Y. lipolytica as microfactories for the production of such intermediates and in particular acetyl-CoA-derived metabolites.

Cyber insurance risk analysis framework considerations

PurposeIn recent years, the frequency and severity of cybersecurity incidents have prompted customers to seek out specialized insurance products. However, this has also presented insurers with operational challenges and increased costs. The assessment of risks for health systems and cyber–physical systems (CPS) necessitates a heightened degree of attention. The significant values of potential damages and claims request a solid insurance system, part of cyber-resilience. This research paper focuses on the emerging cyber insurance market that is currently in the process of standardizing and improving its risk analysis concerning the potential insured entity.Design/methodology/approachThe authors' approach involves a quantitative analysis utilizing a Likert-style questionnaire designed to survey cyber insurance professionals. The authors' aim is to identify the current methods used in gathering information from potential clients, as well as the manner in which this information is analyzed by the insurers. Additionally, the authors gather insights on potential improvements that could be made to this process.FindingsThe study the authors elaborated it has a particularly important cyber and risk components for insurance area, because it addresses a “niche” area not yet proper addressed in specialized literature – cyber insurance. Cyber risk management approaches are not uniform at the international level, nor at the insurer level. Also, not all insurers can perform solid assessments, especially since their companies should first prove that they are fully compliant with international cyber security standards.Research limitations/implicationsThis research has concentrated on analyzing the current practices in terms of gathering information about the insured entity before issuing the cyber insurance policy, level of details concerning the cyber security posture of the insured entity and way such information should be analyzed in a standardized and useful manner. The novelty of this research resides in the analysis performed as detailed above and the proposals in terms of information gathered, depth of analysis and standardization of approach made. Future work on the topic can focus on the standardization process for analyzing cyber risk for insurance clients, to improve the proposal based also on historical elements and trends in the market. Thus, future research can further refine the standardization process to analyze in more depth the way this can be implemented and included in relevant legislation at the EU level.Practical implicationsProposed improvements include proposals in terms of the level of detail and the usefulness of an independent centralized approach for information gathering and analysis, especially given the re-insurance and brokerage activities. The authors also propose a common practical procedural approach in risk management, with the involvement of insurance companies and certification institutions of cyber security auditors.Originality/valueThe study investigates the information gathered by insurers from potential clients of cyber insurance and the way this is analyzed and updated for issuance of the insurance policy.

The art of effective oversight: unravelling the success of Israel's Cabel Inquiry Committee

ABSTRACT Legislative oversight of the executive branch is a fundamental mechanism for ensuring government accountability, good governance, and enhancing democracy. However, formal oversight powers alone are insufficient, and the practical application eventually determines effectiveness. In contemporary times, a distinct set of political phenomena exists, notably the emergence of populism and polarisation, a deep-seated crisis of representation, and a systematic decline in public trust regarding diverse branches of government, coupled with the personalisation of politics and the weakening of political parties. In light of these developments, it is essential to engage in a meticulous examination of the means by which legislatures can enhance their capacity to effectively oversee governments. This article examines the parliamentary committee of inquiry led by Knesset Member Eitan Cabel in Israel from 2017 to 2019, which focused on credit arrangements for large business borrowers. This committee's rigorous investigation into financial system failures makes it an exemplary case of robust oversight in action. The article analyses the Committee establishment, composition, mandate, systematic meeting-planning and questioning process, unique physical setting, report publishing, and other details. The analysis of the Committee's work reveals important insights regarding effective oversight, and isolates the practices which made its work such an augmented performance of legislative oversight. Factors such as the committee's activeness, cooperation, independence, preparation, respectful yet critical approach, transparency, accurate use of media, and precise procedure, created an exceptional performance of legislative oversight. The article concludes that while legislative oversight relies partly on formal mechanisms, it is primarily driven by how political actors apply them, and reveals the importance and centrality of the human factor. This single case analysis, focusing on the committee's oversight practices can inform comparative learning on delivering robust oversight beyond Israel's context, and derive widely applicable insights into key practices for effective legislative supervision of the executive branch.

Developing gene‐independent approaches for retinal dystrophies

Inherited retinal dystrophies (IRDs) display remarkable genetic heterogeneity, with over 300 retinal disease genes mapped and/or identified. Profound vision loss and blindness, often from birth, is a common occurrence in these clinically heterogeneous disease conditions. The therapeutic options for IRDs are currently very limited but recent advancements in understanding mechanisms of retinal degeneration and technological progress paved the way towards development of novel therapies. Much progress has been made in moving from gene discovery to gene therapy. However, the genetic heterogeneity of IRDs represents a significant challenge for development of gene therapy.Many studies from our group have demonstrated that the survival of cones (responsible for diurnal and high‐resolution vision) depends on the presence of rods (responsible for vision at low light levels) that secrete a diffusible trophic factor identified as rod‐derived cone viability factor (RdCVF). The discovery of RdCVF, of its receptor and mechanism of action, and the demonstration of its mutation‐independent therapeutic potential in several animal models of IRDs paved the way to the development (with the start‐up company Sparing Vision) of RdCVF neuroprotective gene therapy that entered in clinical trial in 2023.IRDs destroy photoreceptors but leave intact and functional a significant number of inner retinal cells. Using viral vectors, light‐sensitive microbial opsins can be expressed in these remaining cells, making possible their conversion into ‘artificial photoreceptors’. Our group in Paris, together with Botond Roska (IOB, Basel) and the biotech company GenSight, demonstrated that this technology, named optogenetics, can restore vision in secondary retinal neurons which can survive years after the degeneration of photoreceptors. Our groups established the foundation for the first‐in‐man clinical trial (NCT03326336) with the photoactivatable optogene ChrimsonR (developed by Ed Boyen at MIT) delivered in the eye via adeno‐associated viral vectors and electronic goggles to intensify the light and provide adaptation. We demonstrated (Nat Med 2021) that optogenetics is a remarkably effective way to restore partial vision and provide useful vision restoration in blind people.Gene‐independent approaches such as neuroprotection and optogenetics would allow for the treatment of a broad spectrum of retinal dystrophies, even at advanced stages of disease, giving hope for vision rescue and vision restoration to approximately 2 million people with IRDs worldwide.

Social aspects of long-distance travel - a study of two survey designs

Major parts of transportation research focus on everyday travel, including qualitative, quantitative and mixed-methods approaches. However, to find strategies to reduce transport-related emissions on a global scale, studies on long-distance travel require greater consideration. This paper presents and compares two independent mixed-methods research approaches exploring social aspects of long-distance travel. While one study is qualitative dominant and focuses on relational aspects of travel decisions, the other is quantitative dominant and originates from the individuals’ needs. Both studies highlight motivational factors as important stimuli for long-distance travel patterns and that part of long-distance travel is due to social commitment.

Spatial Coherence Approaches to Distinguish Suspicious Mass Contents in Fundamental and Harmonic Breast Ultrasound Images.

When compared to fundamental B-mode imaging, coherence-based beamforming, and harmonic imaging are independently known to reduce acoustic clutter, distinguish solid from fluid content in indeterminate breast masses, and thereby reduce unnecessary biopsies during a breast cancer diagnosis. However, a systematic investigation of independent and combined coherence beamforming and harmonic imaging approaches is necessary for the clinical deployment of the most optimal approach. Therefore, we compare the performance of fundamental and harmonic images created with short-lag spatial coherence (SLSC), M-weighted SLSC (M-SLSC), SLSC combined with robust principal component analysis with no M-weighting (r-SLSC), and r-SLSC with M-weighting (R-SLSC), relative to traditional fundamental and harmonic B-mode images, when distinguishing solid from fluid breast masses. Raw channel data acquired from 40 total breast masses (28 solid, 7 fluid, 5 mixed) were beamformed and analyzed. The contrast of fluid masses was better with fundamental rather than harmonic coherence imaging, due to the lower spatial coherence within the fluid masses in the fundamental coherence images. Relative to SLSC imaging, M-SLSC, r-SLSC, and R-SLSC imaging provided similar contrast across multiple masses (with the exception of clinically challenging complicated cysts) and minimized the range of generalized contrast-to-noise ratios (gCNRs) of fluid masses, yet required additional computational resources. Among the eight coherence imaging modes compared, fundamental SLSC imaging best identified fluid versus solid breast mass contents, outperforming fundamental and harmonic B-mode imaging. With fundamental SLSC images, the specificity and sensitivity to identify fluid masses using the reader-independent metrics of contrast difference, mean lag one coherence (LOC), and gCNR were 0.86 and 1, 1 and 0.89, and 1 and 1, respectively. Results demonstrate that fundamental SLSC imaging and gCNR (or LOC if no coherence image or background region of interest is introduced) have the greatest potential to impact clinical decisions and improve the diagnostic certainty of breast mass contents. These observations are additionally anticipated to extend to masses in other organs.

HOW DOES THE GEOPOLITICAL POSITION OF DJIBOUTI INFLUENCE ITS RELATIONS WITH GREAT POWERS?

Djibouti gained independence in 1977 after being ruled by France for nearly a century. However, Djibouti remained under French influence for a long time due to both the military agreement with France and the economic aid provided by this country. Moreover, it had to act more distant when establishing relations with other countries. However, under the leadership of Omar Guelleh, who came to power in 1999, a new process was entered in foreign policy with the adoption of the principle of multilateralism in diplomatic relations. Djibouti, which has become a center of attraction for great powers such as the USA, China and Russia, as well as France, has started to cooperate with these countries in different fields. This study points out that Djibouti’s geopolitical position is the main factor that determines its relations with these great powers and prompts these countries to cooperate with Djibouti. It is also observed that Djibouti has turned its geopolitical position into a tool of its development strategy.

استنباط ِ احکام میں امام شوکانی ؒکے مخصوص اسالیب (ایک تحقیقی و تجزیاتی مطالعہ)

Imam Shukani was skilled not only in hadith and jurisprudence but also in various other sciences and arts. This is the reason why his biographers have given him the status of Muhaddith and Faqeeh, as well as Mufassir (مفسر), Usooli (اصولی), Mua`rrikh (مؤرخ), Adeeb (ادیب), Nahvi (نحوی) and logician (منطقی). Since our subject in the present paper is related to his jurisprudential derivation, ten important styles of his derivation of rulings have been selected and copied here, and here they are: He decides on the basis of argument in deriving jurisprudential rulings. Consider the apparent meaning of the text as much as possible. He is convinced of the collection and implementation of arguments. In deriving rulings, it relies on the principles and rules of the Arabic language. Convinced to combine Furoo` (فروع) with principle. Where necessary, he makes inferences from rational reasoning. It also pays attention to the practical aspects and the prevailing situation of the problem, keeping in view the social foundations. Respect the objectives of Sharia. In jurisprudence, he adopts the approach of independence. These points will be presented in detail in this paper.