Independent Activity Research Articles

Полихудожественное взаимодействие обучающихся во время построения лингвокультурных сценариев как средство обогащения тематического словарного запаса студентов – будущих переводчиков (на примере английского языка)

The purpose of the study is to determine the influence of poly-artistic methodological support for the study of linguistic and cultural scenarios on the formation of lexical and grammatical foreign language skills among students at the Faculty of Translation. The initial understanding of the cognitive approach to teaching foreign languages in a narrow sense (only as a system-theoretical support for processes) led to its underestimation and oblivion. The article examines the current trends towards borrowing individual components of the cognitive approach for the development of a communicative method of learning foreign languages. The scientific novelty of the research consists in the introduction of a poly-artistic approach in the training of students – future translators through the adaptation of professional highly specialized exercises for the training of future actors, directors and theater critics for their subsequent integration into the process of studying English-language frame models and scenarios, which had not previously become the object of research. The relevance of the study lies in the fact that, despite many years of experience using a communicative approach in teaching foreign languages, many students still face difficulties activating passive thematic vocabulary and grammatical rules and, as a result, a language barrier. As a result of the study, it was found that in conditions of meaningful operation of language and speech skills, students present the educational process not as a set of rules or a set of information, but as a toolkit for independent creative language activity. Using the Kolmogorov-Smirnov λ-criterion and the Fisher φ*-criterion (circular transformation), the beneficial effect of artistic and methodological support for the construction of linguistic and cultural scenarios on the expansion of the thematic vocabulary of students within the framework of the theme “At the Restaurant” has been experimentally confirmed.

A first-in-human study of IK-595, an oral MEK/RAF molecular glue, in patients with RAS- or RAF-altered advanced solid tumors.

TPS3185 Background: Alterations in the RAS/RAF/MEK/ERK pathway are the most common drivers of oncogenesis. MEK is a clinically validated cancer target and despite FDA approval of several MEK inhibitors, their clinical utility has been limited to BRAF V600 mutant cancers and NF1 mutant neurofibromas mostly due to early emergence of resistance and low therapeutic indices. IK-595, a potent novel MEK-RAF molecular glue, is being developed to overcome these limitations. IK-595 traps MEK in an inactive complex with all RAF isoforms and blocks RAF-dependent MEK phosphorylation, thereby alleviating CRAF-mediated MEK reactivation that hinders the efficacy of approved MEK inhibitors in RAS/RAF-driven tumors, in addition to kinase independent CRAF activity. IK-595 exhibits potent single agent activity in a wide range of in vivo cancer models harboring various RAS/RAF alterations, including, but not limited to, lung, pancreatic, colorectal cancer (CRC), melanoma, and AML. The preclinical pharmacokinetic profile of IK-595 also enables flexible dosing schedules resulting in a broader therapeutic window. Methods: This is a phase 1, first-in-human, open-label, multicenter study to evaluate IK-595 as monotherapy in patients with RAS- or RAF-altered advanced solid tumors for whom there are no other further treatment options known to confer clinical benefit. Dose escalation uses a Bayesian Optimal Interval Design (BOIN) in patients with advanced and unresectable, or metastatic solid tumors with confirmed RAS/RAF gene alterations. Backfilling of cleared dose levels with key target indications will initiate upon achievement of efficacious plasma exposures. Dose expansion will occur in genetically defined cohorts, for example NRAS-mutant CRC and malignant melanoma, as well as BRAF non-V600 and KRAS mutant tumors using a Simon 2-stage adaptive design. IK-595 will initially be administered on an intermittent dosing schedule in 30-day cycles. Additional dosing schedules may be explored. Primary objectives of the study are to evaluate safety and tolerability of IK-595 and to determine the recommended phase 2 dose (RP2D) and/or maximum tolerated dose (MTD). Secondary objectives include evaluation of preliminary antitumor activity by RECIST 1.1, pharmacokinetic (PK) parameters, and pharmacodynamic effects of IK-595 on pERK in paired tumor biopsies. Key exploratory endpoints include changes in pERK in peripheral blood cells, changes in pERK target genes in tumor biopsies, and assessment of candidate baseline response biomarkers. The study began in December 2023 and enrollment in Cohort 1 was completed with no DLTs; dose escalation continues to enroll. Clinical trial information: NCT.

IMPLEMENTATION OF INTERDISCIPLINARY CONNECTIONS OF PHYSICS, MATHEMATICS, COMPUTER SCIENCE IN A PEDAGOGICAL UNIVERSITY AND SCHOOL

The article discusses the general problems of using information technologies in physics and mathematics lessons in pedagogical universities and schools. The stages of the development of modern science are characterized by the interrelation of sciences. Therefore, the importance of interdisciplinary and intra-subject connections in the educational process becomes an urgent problem. They contribute to the systematization and deepening of students' and students' knowledge and the formation of skills of independent cognitive activity. Therefore, interdisciplinary and intra-subject connections are an important condition and result of an integrated approach in teaching and educating schoolchildren and students. The advantages and disadvantages of some educational programs in natural and mathematical disciplines based on information technologies and digital educational resources are analyzed, which make it possible to implement a competence-based approach in education in order to introduce interdisciplinary classes into the methodological foundations and diversify and integrate means of pedagogical influence on the student. This article emphasizes that the importance of using interdisciplinary connections in teaching physics is very high.The article also discusses the definition of interdisciplinary connections in the courses of physics, mathematics, computer science for deep assimilation of knowledge, theic approach, the unity of the material world, and the relationship of natural phenomena and society.

Application of Foot Massage Therapy to Reduce Pain Scale of Old Age with Rheumatoid Arthritis in Perumnas Public Health Center Working Area Lubuklinggau City 2023

Arthritis in RA patients causes pain, swelling, and decreased joint range of motion. It can lead to decreased independence and limited activities, reducing the quality of life. The process of foot massage also impacts the process of vasodilation and increased blood circulation. It increases the activity of the autonomic nervous system, which stimulates increased production of endorphins, which is expected to reduce pain. The case study used a descriptive method with two old older adults with Rheumatoid Arthritis, using the family nursing care assessment and pain scale assessment. The application of foot messages is carried out for 20 minutes for three days. After applying foot massage for three consecutive days, the study showed a decrease in pain intensity between before and after the intervention was given to the two subjects. The subject's pain intensity decreased from moderate pain intensity to mild pain. Applying foot massage effectively reduces the intensity of Rheumatoid Arthritis pain.

Efficacy and safety of combination therapy with binimetinib, encorafenib, and cetuximab for BRAF non-V600E mutated metastatic colorectal cancer: Results from a phase 2 BIG BANG trial (EPOC1703).

3585 Background: BRAF mutations which are found in 8-12% of metastatic colorectal cancer (mCRC) can be classified into three groups; Class 1 and 2 tumors do not respond to anti-EGFR antibody therapy because of the RAS independent activity, while previous studies suggested potential anti-tumor activity of anti-EGFR antibody for class 3 tumor. Combination therapy with binimetinib, encorafenib, and cetuximab showed the substantial efficacy for BRAF V600E mutated mCRC in the BEACON CRC trial, however, the clinical activity of these triplet therapy for BRAF non-V600E mutated mCRC is unknown. Here, we conducted a multicenter phase 2 trial to assess the efficacy and safety of combination therapy with binimetinib, encorafenib, and cetuximab in patients with BRAF non-V600E mutated mCRC. Methods: We enrolled patients with RAS wild-type and BRAF non-V600E mutated mCRC, refractory or intolerant to at least one fluoropyrimidine-based chemotherapy, and no prior history of anti-EGFR antibody (primary analysis cohort) or refractory to prior anti-EGFR antibody (anti-EGFR antibody refractory cohort). Enrolled patients receive binimetinib (45 mg BID), encorafenib (300 mg QD), and cetuximab (initially 400 mg/m2 and subsequently 250 mg/m2, weekly) until disease progression or unacceptable toxicity. The primary endpoint was investigator-assessed confirmed objective response rate (ORR) in the primary analysis cohort with sample size of 21 patients. Results: Between May 2018 and March 2023, 12 and 20 patients were enrolled in the primary analysis cohort and the anti-EGFR antibody refractory cohort, respectively (same order in the following abstract). 7 and 19 patients had a history of ≥ 2 lines of previous chemotherapy, respectively. The most frequent mutation overall was BRAF D594G (n=14, 43.8%). There were each 2 responders in both cohorts, resulting in 16.7% (95%CI, 2.1-48.4%) and 10.0% (95%CI, 1.2-31.7%) of confirmed ORR, respectively. Among 7 patients harboring class 1 or 2 tumors in both cohorts combined, there were 2 responders (ORR 28.6%). Median progression-free survival was 3.3 months and 3.0 months, respectively. Grade 3 or higher adverse events occurred in 4 and 10 patients, respectively, and no new safety signals were identified. Conclusions: The combination therapy with binimetinib, encorafenib, and cetuximab showed modest efficacy for BRAF non-V600E mutated mCRC, with a manageable safety profile, although there was not enough statistical power due to slow accrual. Circulating-tumor DNA analyses at the timepoint of before and after treatment are ongoing. Clinical trial information: UMIN000031857. [Table: see text]

의사결정나무분석을 이용한 우리나라 노인의 낙상위험요인 기여도예측 모형

This study reviewed the factors affecting falls based on the results of National survey of Older Koreans in 2017(n=10,235) and2020(n=10,097) before and after COVID-19, and analyzed the structural relationships of risk factors for falls through decision tree analysis. The incidence of falls was 15.9% in 2017 and 6.4% in 2020. The decrease in reported incidents of falls during the COVID-19 pandemicis attributed to the reduced outdoor activities and restrictions on mobility, which naturally result in fewer opportunities for falls to occur. In summarizing the decision tree analysis findings from 2020 and 2017, it is evident that hospitalization, low health satisfaction, and challengesin performing independent activities of daily living are factors associated with an increased risk of falling. Additionally, depression, includingspousal factors, which may contribute to decreased physical activity, is also linked to falls. Recognizing these significant factors allowsfor the early identification of high-risk groups for falls and enables the implementation of interventions aimed at preventing falls more effectively.

AR-NAVIS: Mobility Application for Blind and Deaf Students Based on Augmented Reality

Students with disabilities, especially those with visual and hearing impairments, face challenges in navigating through the campus environment. Hence, the development of AR-NAVIS as an Augmented Reality (AR)-based mobility orientation application stands as a significant innovation in providing services for them. This application aims to assist disabled students in moving within the campus environment, both indoors and outdoors. AR-NAVIS identifies the safest and most efficient routes, enabling disabled students to engage in independent activities and enhancing both their academic and non-academic performance. The application development process involves analyzing students' needs, prototype design, model validation, trials, and dissemination. Its features include AR-based 3D guidance, directional text, voice, vibration mode, and hazard information. The app is expected to provide accurate information about buildings or locations that are the destination for disabilities students. The result show that application development can guide disabilities user move between buildings smoothly. The experiment found that there was an increase in student activity after having this application.

Use of Antivibration Technology to Reduce Demands for In-Home Nursing Care and Support in Rural Settings for Persons with Essential Tremors: A Qualitative Study.

With the increased integration of technologies in the healthcare sector, it is important to understand the benefits emerging technologies may play to reduce demands on the health care system. The Steadiwear antivibration glove shows promise for enhancing the independence in functional abilities for persons with essential tremors and for alleviating the need for support from the health care system. The objective of this study was to examine Registered Nurses' (RN) perceptions of the potential for the Steadiwear antivibration glove to reduce the need for in-person support from community healthcare workers. Eleven RNs, experienced in providing care in rural communities, participated in a semi-structured interview sharing their perspectives towards use of the Steadiwear antivibration glove in community practice settings. Thematic analysis guided by Braun and Clarke was undertaken. Nurses described the value of this technology to reduce client needs for support for activities of daily living (e.g., dressing, feeding) and independent activities of daily living (e.g., banking, transportation). Enhanced access to this technology may reduce the need for nursing and personal care support from the health system. Therefore the Steadiwear antivibration glove also shows potential to delay and/or prevent the need for more intensive support and mitigate the need for transition to a long-term care facility.

PRACTICAL ASPECTS OF DEVELOPING SKILLS AND ABILITIES OF INDEPENDENT WORK OF FUTURE HISTORY TEACHERS

An important task of the educational process in a higher institution of pedagogical education is the purposeful formation of the readiness of students ‒ future teachers for professional self-education as a comprehensive characteristic of their personality, which includes the needs and motives of self-education, professionally significant qualities, as well as necessary knowledge, skills and abilities. A student’s ability to self-education is developed in the process of learning. Self-education skills require purposefulness, systematicity, consistency, and self-motivation of the subject of education. One of the factors contributing to the development of this ability can be research and creative tasks for independent performance in the content of methodological disciplines.The article reveals various types of independent work aimed at the formation of self-educational competence of higher education students, the ability to learn throughout life. Examples of practical tasks from the course “Theory and teaching methods of civic education” are given, which form cognitive and operational- procedural components of the independent activity of higher education students. In the course of the study, the technical conditions for the performance of the tasks, their procedural characteristics, and examples of the implementation of metacognitive strategies in the formation of the subject-methodical competence of future history teachers are given. It was found that independent work allows students to build their educational and professional trajectory and is an area of mutual responsibility of subjects of the educational process.

Evaluation of the accelerate stunting reduction program through stunting care houses (Rumah Pesta) Wakatobi district

Wakatobi Regency as an island region in 2022 has a stunting prevalence of 29.9%, higher than the average prevalence rate for Southeast Sulawesi province of 27.7%. This regency has a high commitment to accelerating the reduction of stunting prevalence through the strategic initiative of stunting care home innovation activities (Rumah Pesta). Serving as a venue for organizing the mobilization and execution of internalizing the acceleration of the reduction of stunting through synchronization and cooperation between stakeholders, village administrations, and agencies. To evaluate the stunting reduction acceleration program through the Stunting Care House (Rumah Pesta) Wakatobi Regency. Qualitative descriptive research, content analysis was carried out on the conditions of natural objects from the context in which the event occurred in an effort to describe the incident through key informants, main informants and supporting informants based on knowledge about the stunting reduction acceleration program policy. This research uses in-depth interviews with tools in the form of recording devices, interview guides, review of rules and documents to answer research objectives using the CIPP model evaluation approach. In the context evaluation, the regional stunting reduction acceleration program policy has influenced the prevalence of stunting through the the Stunting Care House or Rumah Peduli Stunting (Rumah Pesta) innovation program which was implemented through the Decree of the Head of the P2 & KB Department. Input evaluation: The main budgetary support for activities comes from self-help, including the APBN and APBD budgets through related SKPD intermediaries who are directly involved in stunting activities. Human resource capacity is inadequate and there is no support for sustainable training programs through Rumah Pesta. Support for facilities and infrastructure for service activities in the building is inadequate, there are facilities to support stunting activities. Evaluation process: Activity planning house party activities are participatory in nature as a form of implementation of policies to accelerate stunting reduction to realize the mobilization of strategic initiative steps by the relevant SKPD leaders in the form of innovation activities, referring to 29 main indicator service coverage designed through creativity in the form of independent activities with at-risk families, local cultural approaches. Product Evaluation: Contributing directly to reducing the prevalence of stunting in Wakatobi district through interventions through assistance activities for at-risk families which are still ongoing today, Sustainability of programs or activities to accelerate stunting reduction requires synergy and support from data sources, use of accurate data through a good human resource availability approach, supporting infrastructure that meets standards at all levels of implementation of activities to accelerate stunting reduction.

Comparing Redox and Intracellular Signalling Responses to Cold Plasma in Wound Healing and Cancer.

Cold plasma (CP) is an ionised gas containing excited molecules and ions, radicals, and free electrons, and which emits electric fields and UV radiation. CP is potently antimicrobial, and can be applied safely to biological tissue, birthing the field of plasma medicine. Reactive oxygen and nitrogen species (RONS) produced by CP affect biological processes directly or indirectly via the modification of cellular lipids, proteins, DNA, and intracellular signalling pathways. CP can be applied at lower levels for oxidative eustress to activate cell proliferation, motility, migration, and antioxidant production in normal cells, mainly potentiated by the unfolded protein response, the nuclear factor-erythroid factor 2-related factor 2 (Nrf2)-activated antioxidant response element, and the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) pathway, which also activates nuclear factor-kappa B (NFκB). At higher CP exposures, inactivation, apoptosis, and autophagy of malignant cells can occur via the degradation of the PI3K/Akt and mitogen-activated protein kinase (MAPK)-dependent and -independent activation of the master tumour suppressor p53, leading to caspase-mediated cell death. These opposing responses validate a hormesis approach to plasma medicine. Clinical applications of CP are becoming increasingly realised in wound healing, while clinical effectiveness in tumours is currently coming to light. This review will outline advances in plasma medicine and compare the main redox and intracellular signalling responses to CP in wound healing and cancer.

Evaluation of the Implementation of Pre-Primary Education in the South-East Geopolitical Zone of Nigeria

Pre-primary education is globally recognized as important stage in the life of a growing child. This is because experiences at this stage have far-reaching effects on the behaviour of the child as adult member of the society. This study is an evaluation research which focused on the implementation of pre-primary education using policy stipulations as the standards. It is also a survey study because the researchers went to the field to meet the things on the ground with instruments that enable data collection and reports are presented as seen without manipulations. The area of the study is Imo State in the South-East geopolitical zone of Nigeria. The population of teachers in the four hundred and seventy threee-primary schools in the State is Five Hundred and Forty One. The sample size is One Hundred and seventy eight teachers in 38 pre-primary schools drawn using proportionate cluster random sampling techniques. This is to achieve a good spread across the three education zones of the state and each zone was represented in the sample according to its school population. Instruments for data collection were school records, interview and observation checklists and a proforma for abstracting the teachers qualifications. Four research questions guided the study. Findings include that 93.26% of the teachers were not trained to teach in the pre-primary education level, teaching and learning materials were far inadequate, and the teachers focused more on getting the pupils learn to carry out written works, thus maintaining strict academic work and strong discipline as opposed to independent activities that boost initiatives and creativity. It was recommended that teachers should be sponsored to go back to school and get training in the early childhood education among other recommendations.

AI-powered smart assistants: Your key to self-learning success

This research aims to develop a prototype of a smart assistant system for independent learning activities based on Artificial Intelligence. Web-based instructional design (WBID) approach is used in research to develop intelligent assistant systems. Artificial Intelligence-Learning Analytics helps students make important decisions and creates an effective and efficient learning environment while still building learning independence. The method used is a research and development (R&D) approach. The findings of this research are an intelligent assistant system in independent learning activities assisted by artificial intelligence in the form of the AILA ChatBot application. In the end, this research concludes that the ChatBOT application developed in this research is used to provide recommendations for using AI applications to students, which are then implemented and integrated into SPOC/MOOC.

Abstract PO3-27-02: A novel PTK6 PROTAC degrader induces apoptosis of drug resistant breast cancer cells

Abstract Background. PTK6/Brk, a non-receptor tyrosine kinase, is an oncogenic driver for several tumor types, including breast, prostate, liver, and pancreatic cancers. PTK6 is expressed in all breast cancer subtypes and higher levels of expression are associated with worse patient outcomes. The optimal approach to targeting PTK6 for therapeutic benefit has not been established. Although several inhibitors of PTK6 kinase activity have been developed, none have thus far been successfully translated to clinical trials. This may be in part due to kinase activity-independent functions of PTK6, for which there is growing evidence, that are not effectively targeted by traditional small molecule kinase inhibitors. Downregulation of PTK6 using shRNA inhibits growth, invasion/migration, survival and metastasis of breast cancer cells, including those that are resistant to standard therapies. PTK6 kinase inhibitor treatment phenocopies effects of PTK6 downregulation with respect to some, but not all PTK6-driven oncogenic activities. Moreover, growth of PTK6 CRISPR-targeted cells can be rescued either with wild type or catalytically inactive PTK6, supporting kinase activity-independent activities of PTK6 in regulating growth and viability of breast cancer cells. Therefore, PROTAC degraders may be a better way to chemically target and downregulate PTK6 expression in cancer, thereby phenocopying the effects of PTK6 shRNA. Methods. We developed a first-in-class PTK6 degrader using PROTAC (proteolysis-targeting chimeric) technology to target PTK6 expression in breast cancer cells of diverse subtypes. Degrader controls were also synthesized to assess specificity of MS105’s effects. Results. PTK6 degrader, but not degrader controls, potently downregulates PTK6 expression in multiple breast cancer cell types. Proteomic and kinome profiling confirm the specificity of our PTK6 degrader. PTK6 PROTAC degrader inhibits viability and induces apoptosis of PTK6-expressing breast cancer cells, whereas treatment with parent kinase inhibitor or degrader controls that do not engage PTK6 or E3 ligase have minimal effect. Treatment with PTK6 degrader, but not kinase inhibitor or degrader controls, induces expression of pro-apoptotic Bim, phenocopying the effects observed with PTK6 shRNA. In contrast, PTK6 degrader and kinase inhibitor are comparably effective in inhibiting cell migration, supporting the differential kinase dependency of PTK6-dependent oncogenic functions. Therefore, our PTK6 PROTAC degrader effectively inhibits both kinase-dependent and independent oncogenic activities of PTK6. Our studies support the development of PTK6 PROTAC degraders as a preferred approach to clinically targeting PTK6 in cancer. Citation Format: Hanna Irie, Criseyda Martinez, Yan Xiong, Alison Bartkowski, Jessica Byerly, Jian Jin. A novel PTK6 PROTAC degrader induces apoptosis of drug resistant breast cancer cells [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO3-27-02.

After-School Activities of Japanese Elementary School Children: Comparison of Children Who Attend Lessons and Cram Schools With Those Who Do Not.

This study examined the after-school activities of Japanese elementary school children in which little information is available for understanding the process by which participation in organized activities leads to the decrease in children's independent mobility. One thousand eight hundred and twenty-four mothers of elementary school children participated in an online survey. The mothers responded to the questions on the number of lessons (or cram schools) their children attended weekdays, as well as their children's behavior after classes, and parents providing transportation when their children go out to play. The proportion of children attending lessons and/or cram schools increased as their grades progressed. A significant interaction existed between the degree of parental transportation and grade in terms of whether or not the children attended lessons and/or cram schools. Parental involvement included pick up or drop-off for a large percentage of younger children without lessons, whereas the degree of parental involvement was greater for older children attending lessons. In other words, parents of children without attending lessons or cram schools tended to allow children to engage in independent activities when they reached the higher grades, whereas parents of children who frequently attended lessons and cram schools tended to remain involved in transporting their children, even when they reached the higher grades. The results suggested that the participation of children in organized activities leads to a routine of parental pickup and/or drop-off, which renders difficult the facilitation of opportunities for children to independently participate in play activities.

Neuropeptide Y affects B-cell activation functions

Introduction: Sympathetic nerves secrete neurotransmitters in response to pathogenic organisms in various immunological contexts. Most studies have focused on norepinephrine (NE) which has shown numerous immunomodulatory effects involving pro- and anti-inflammatory responses. However, sympathetic neurons contain also varicosities where neuropeptides, mainly neuropeptide Y (NPY), are stored. NPY play roles in various physiological processes, including regulating metabolism, vascular function, and immune function but little is known on its action during bacterial respiratory infection. The regulation of its secretion and its impact on the immune system during infection remains unclear. We investigated the role of NPY in B-cell responses during bacterial infection. Methods: Naïve B-cells isolated from mice splenocytes (2M/2F) were stimulated with IL-4 and LPS, along with NE or NPY. After 96 hours, cells were stained and analyzed by flow cytometry and transcripts were isolated for quantitative real-time PCR. Media was collected until immunoglobulin analysis. To investigate NPY role during infection, we used a mice model of bacterial lung infection. Mice were intranasally exposed twice with streptococcus pneumoniae (serotype 19F on day 0: 104 CFU and on day 9: 108 CFU); experiments took place 16 hours later. Control animals were infused with vehicle only. Results: Apart from beta2-adrenergic receptor, isolated B-cells were found to express alpha2- and beta1-adrenergic receptor transcripts. In vitro stimulation of B-cell with IL-4 and LPS (T-cell independent activation) downregulated beta-adrenergic and upregulated alpha2-adrenergic, as well as NPY receptors (Npy1r, Npy2r, Npy4r, Npy5r). Unlike NE, NPY has shown to affect B-cell proliferation and drastically increases IgG positive-cells during stimulation. However, neither NE nor NPY seem to regulate IgG release in this condition. In vivo experiments indicate that NPY level increased in the lung in response to streptococcal challenge, contrasting with the unchanged levels of NE. Conclusion: Our findings contribute to our understanding of how sympathetic neurotransmitters regulates B-cell expansion, memory, and antibody production during infection. Furthermore, our research gives new insights into the function(s) and antimicrobial capacity of neuropeptide Y. These findings allow for the development of new and more effective therapeutic strategies for invasive bacterial infections. 1R21AI159221, UCOP TRDRP T32KT4708. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

Improving tertiary education via remote learning: Insights from students and educators

Relevance. The growing adoption of distance learning in higher education necessitates an understanding of the pedagogical conditions that facilitate its effective implementation. Purpose. This study aimed to identify the pedagogical conditions that support successful integration of distance learning technologies in higher education. Methodology. A questionnaire survey was conducted among 206 first- to fourth-year pedagogy students, complemented by interviews with 28 teachers. The survey and interviews focused on experiences, advantages, and disadvantages of distance learning from both students� and teachers� perspectives. Results. The findings revealed that 89% of students favoured distance learning, highlighting benefits such as time and budget savings, comfortable home learning environments, easy access to necessary information, and flexible learning schedules. However, 11% of students reported dissatisfaction due to issues like internet outages, perceived lower quality of education, and lack of communication with peers and instructors. Teachers identified several challenges, including students� information assimilation, their own adaptation to teaching in distance formats, and administrative hurdles. Conclusions. Distance learning technologies, distinct from traditional methods, emphasize independent student activities and the use of information technology for knowledge exchange. Addressing the identified challenges and leveraging the benefits can significantly enhance the distance learning experience. Keywords: student adaptation; self-education; network technologies; digitalisation in education; pedagogical conditions

New Developments in the Taxation of the Income from Independent Activities for Which the Net Income is Determined on a Real Basis

New Developments in the Taxation of the Income from Independent Activities for Which the Net Income is Determined on a Real Basis

Determining the relationship of p16INK4a and additional molecular markers of aging with clinical frailty in hematologic malignancy

PurposeOlder adults with hematologic malignancies (HM) have unique challenges due to age and fitness. The primary aim of this pilot study was to benchmark the ability of multiple biomarkers of aging (p16, epigenetic clocks, T cell gene expression profiles, and T cell receptor excision circles (TREC) to identify frailty as measured by a clinical impairment index (I2) in patients with HM.Methods70 patients newly diagnosed with HM had peripheral blood T lymphocytes (PBTL) analyzed for p16INK4a expression using the OSU_Senescence Nanostring CodeSet. PBTL epigenetic age was measured using 7 epigenetic clocks, and TREC were quantified by qRT-PCR. A composite clinical impairment index (I2) was generated by combining values from 11 geriatric metrics (Independent Activities of Daily Living (iADL), physical health score, Short Physical Performance Battery (SPPB), Body Mass Index (BMI), Eastern Cooperative Oncology Group (ECOG) performance status, self-reported KPS, Blessed Orientation Memory Concentration (BOMC), polypharmacy, Mental Health Inventory (MHI)-17, Medical Outcomes Study (MOS) subscales). Clinical frailty was defined as a score of 7 or greater on the I2.ResultsAge-adjusted p16INK4a was similar in newly diagnosed patients and healthy controls (p > 0.1). PBTL p16INK4a levels correlated positively with the Hannum [r = 0.35, 95% CI (0.09–0.75); p adj. = 0.04] and PhenoAge [r = 0.37, 95% CI (0.11–0.59); p adj. = 0.04] epigenetic clocks. The discrimination ability of the I2 model was calculated using the area under the receiver operating characteristic curve (AUC). After adjusting for chronologic age and disease group, baseline p16INK4a [AUC = 0.76, 95% CI (0.56–0.98); p = 0.01], Hannum [AUC = 0.70, 95% CI (0.54–0.85); p = 0.01], PhenoAge [AUC = 0.71, 95% CI (0.55–0.86); p = 0.01], and DunedinPACE [AUC = 0.73, 95% CI (0.57–0.88); p = < 0.01] measures showed the greatest potential to identify clinical frailty using the I2.ConclusionsOur pilot data suggest that multiple blood-based aging biomarkers have potential to identify frailty in older adults with HM.Implications for Cancer SurvivorsWe developed the I2 index to quantify impairments across geriatric domains and discovered that PBTL p16, Hannum, PhenoAge, and DunedinPACE are promising indicators of frailty in HM.

Недопустимость ограничения или устранения конкуренции как принцип государственной политики и правового регулирования отношений в сфере высшего образования

The principle of inadmissibility of restricting or eliminating competition in the field of education in relation to public policy implies either the creation of equal conditions for competition, or non-interference of authorities in the processes of competition in the field of education, and the establishment of rules of conduct and legal mechanisms to ensure their compliance with legal regulation. The field of educational services is segmented by types of educational services (education levels, specialties, etc.), each of which represents a separate commodity market. Competition exists between educational organizations, and between educational programs, faculties, departments, scientific schools and other structural elements of the educational process as an activity. The application of the term “competition” to the educational sphere is conditionally permissible, in the field of education it is important to ensure not so much the development of competition as an independent activity of educational organizations, as to create a mechanism for determining the leadership of educational institutions and their structural elements, ensuring fair and non-discriminatory access to those educational services in which a particular consumer is interested.