Incremental Lifetime Cancer Risk Research Articles

Implication of heavy metal(loid)s contamination for human health and preliminary application of water treatment in floodplain area along Mekong River, Lao PDR

Groundwater is widely used for domestic purposes, especially as a reliable source of drinking water in rural areas of the Lao People’s Democratic Republic (Lao PDR). This preliminary study aims to examine heavy metal(loid)s contamination leading to human health risks while also focusing on a method that can improve drinking water quality in floodplain areas along the Mekong River in Lao PDR. Groundwater and surface water samples were collected during the monsoon season in 2022 in Attapeu and Champasak provinces. Heavy metal(loid)s concentrations and human health risks were investigated using inductively coupled plasma mass spectrometry (ICP-MS) and the USEPA method, respectively. A nanofiltration membrane technique was introduced to optimize the quality of groundwater. Results showed that groundwater quality was significantly poor (p < 0.05), particularly in Attapeu province, with high levels of electrical conductivity, total dissolved solids, and manganese, exceeding WHO standards of 400 µS cm−1, 300 mg L−1, and 80 µg L−1, respectively. With the groundwater ingestion pathway, children were found to be more vulnerable to non-carcinogenic risk than adults (Hazard Quotient, Hazard Index >1), but adults had a higher carcinogenic risk (Incremental Lifetime Cancer Risk >1E-04). The removal of fecal bacteria and heavy metal(loid)s was achieved using the nanofiltration membrane, demonstrating its potential as a practical point-of-use technology to provide cleaner water sources and enhance the health status of Lao residents.

Comprehensive assessment of water pollution and health risks in the Angereb Reservoirs, Gondar, Ethiopia

Angereb Reservoirs are experiencing significant levels of pollution due to various anthropogenic activities such as agricultural runoff, untreated sewage discharge and industrial waste, were degrading water quality and causing eutrophication. Communities used Angereb Reservoir water is at increased risk of waterborne diseases; particularly heavy metal causes chronic health problems. However there was lack of comprehensive data on the cause and extent of pollution in the Angereb Reservoir. This comprehensive assessment highlights urgent need for integrated water resource management and effective pollution control strategies. This study was conducted through a multi-faceted and systematic approach involving several key methodologies. Six water samples were collected along the strategic points of the reservoir between May 2023 and March 2024. Different standard analytical methodologies were applied for analysis of water quality parameters including pH, dissolved oxygen, nutrients and heavy metals. The finding indicates that the concentration (mg/L) of heavy metals were Fe (0.01–6.56), Zn (0.67–5.22), Cu (0.009–0.19), Mn (0.0–1.89), Cr (5.06 × 10–5–0.03), Cd (0.029–0.27) and Pb (0.001–2.216). Cd and Pb were exceeded WHO for safe drinking water, heavy metal evaluation index values was > 10. Hazard Quotient (HQ), hazard index (HI) and incremental lifetime cancer risk (ILCR) were calculated. Average HQ values for Cd and Pb were above the risk threshold (HQ>1), indicating significant long-term exposure risks. HI>1 suggested potential non-carcinogenic effects. Furthermore, ILCR values exceeding 10–4 threshold, shows that Cd and Pb were the major risk factor for cancer particularly in children. The findings underscore the urgent need for Cd and Pb removal from Angereb reservoir.

Health Risk Assessment of Toxic Metal(loids) Consumed Through Plant-Based Anti-diabetic Therapeutics Collected in the Northern Divisional City of Rajshahi, Bangladesh.

The present study investigates human health risks upon consumption of herbal medicines in terms of ten toxic metalloids in 20 plant-based anti-diabetic therapeutics. The analysis of metalloids was determined by an atomic absorption spectrometer after microwave-assisted digestion. The computation of hazard quotients (HQ) and hazard indexes (HI) of metalloids leads to the assessment of non-carcinogenic health risks. Carcinogenic risk was assessed based on cancer slope factor (CSF) and chronic daily intake (CDI) values. Comparison with WHO regulatory cut-off points for each metalloid: seven samples for Mn, 12 samples for Hg, three samples for Cu, eight samples for Ni, four samples for Cd, two samples for Pb, one sample for Cr, and eight samples for Zn are unsafe to consume. Non-carcinogenic human health risk is predicted for Mn in seven samples, Fe in one sample, Hg in ten samples, Cu in three samples, Ni in one sample, and Pb in two samples. HI values greater than 1 predict non-carcinogenic health risk in thirteen samples. Incremental lifetime cancer risk (ILCR) remains for As (inorganic) in 12 samples, Cr (+ 6) in one sample, and Pb in no samples. To guarantee consumer safety, the implementation of strict monitoring is suggested.

Determination of trace elements content of fruits from Tehran's market using ICP- OES method: a risk assessment study.

For the first time in Iran, in this study, the amount of 19 trace elements in some types of commonly consumed Iranian fruits (in their peel and pulp) was evaluated by ICP-OES (Inductively coupled plasma-optical emission spectrometry) method. Based on the outcomes, the highest and lowest average detected elements in all fruits samples were related to (Al) aluminum (1842.18) and (V) vanadium (0.28) ppm, respectively. Mercury (Hg) and antimony (Sb) were not detected (ND) in any samples. Also, the maximum mean of elements in quince, lemon, grapefruit, kiwi, orange south, orange north and tangerine samples was related to(Fe) iron (2048.32 ppm), (Zn)zinc(753.45 ppm), Fe (1056.33 ppm), Al (9794.41 ppm), Zn (717.78 ppm), Fe (1334.87 ppm) and Fe (974.93 ppm), respectively. Furthermore, our outcomes revealed, the highest mean of elements in kiwi peel, kiwi pulp, orange North peel, orange North pulp, orange South peel, orange South pulp, quince peel, quince pulp, grapefruit peel, grapefruit pulp, lemon peel, lemon pulp, tangerine peel and tangerine pulp was related to Al (17967.79 ppm), Al (1621.03 ppm), Fe (1350.01 ppm), Al (1457.66 ppm), Zn (934.71 ppm), Fe (728.06 ppm), Fe (2768.11 ppm), Fe (1328.54 ppm), Zn (1008.54 ppm), Fe (1198.00 ppm), Zn (683.35 ppm), Zn (823.55 ppm), Fe (1182.59 ppm), and Fe (767.27 ppm), respectively. Based on the Monte Carlo simulation results, the THQ (target hazard quotient) and ILCR (Incremental Lifetime Cancer Risk) related to exposure to heavy metals via fruits for adults and children showed that there is no significant non-carcinogenic risk (THQ < 1) and carcinogenic risk (ILCR < 1E-4) for adults and children.

Changes in concentrations of potentially toxic and essential elements of Iranian rice using various cooking methods: A probabilistic health risk-assessment study

In the present study, 41 domestic rice samples were analyzed for potentially toxic elements (PTEs) and essential elements (EEs) using inductively coupled plasma-optical emission spectrometry (ICP-OES). Then, a health risk assessment was carried out. Effects of cooking methods, including the rinsed and kateh (unrinsed) methods, on removing PTEs were investigated as another major aim of this study. The rinsed cooking process demonstrated significant efficacy in decreasing concentrations of Pb, Al, and Ba, as well as EEs, including Ca, Fe, K, Mn, Mo, Na, Ni, and Zn. The mean levels of PTEs (Al, As, Ba, Cr, Cd, Pb, and Ti) were respectively 4.532, 0.018, 2.186, 0.425, 0.014, 0.102, and 0.027 mg kg−1. Rinsed the rinsed cooking method included the greatest significant decreases in PTE and EE concentrations. The target hazard quotient (THQ) values of Cr, Cu and Mo were greater than those of safety limits in children but less than 1 U. Using rinsed cooking method, concentrations of PTEs, including Al, Ba and Pb, decreased 2, 3 and 7 folds in rice samples, respectively. Technically, incremental lifetime cancer risk (ILCR) values indicate carcinogenic risks for exposure to As, Cr, and Ni for children and Cr and Ni for adults., and Ni for children, This study provides knowledge that reflects the need to set up food-safety risk management and the importance of promoting further coordinated and focused policy actions to achieve food and nutrition security.

Semi-diurnal distribution of polycyclic aromatic hydrocarbons bound to PM2.5 and PM0.1 during pollution episode in the urban area of Hanoi.

Every year, Hanoi suffers from several episodes (periods with daily concentration of PM2.5 higher than 50µgm-3 during at least two consecutive days). These episodes are of health concern because of the high concentration of PM2.5 and/or PM0.1 and the presence of PM-bound toxic components, such as, PAHs. In this study, the concentrations of PAHs bound to PM2.5 and PM0.1 in night-time and day-time samples during episode and non-episode periods in December 2021 were determined. The concentrations of PAHs bound to PM2.5 were found to increase significantly from day-time samples of 3.24 ± 0.83ngm-3 to night-time samples of 10.8 ± 4.45ngm-3 in episode periods. However, PAHs bound to PM0.1 increased slightly from day-time samples of 0.58 ± 0.12ngm-3 to night-time samples of 0.89 ± 0.30ngm-3 in episode periods. Diagnostic ratios of PAHs indicate that biomass/coal combustion andvehicular emissionare the primary sources of PAHs. The incremental lifetime cancer risk was estimated to vary from 8.7E-09 to 2.5E-08 for children and 6.7E-08 to 2.2E-07 for adults, respectively. Accordingly, loss of life expectancy was estimated at 0.11min and 0.82min for children and adults, respectively. These findings imply that the carcinogenic impact induced by PAHs via inhalation is negligible during the episode period.

Assessment of polycyclic aromatic hydrocarbon (PAH) levels and health risks in kitchen dust from wood, kerosene, and gas cooking systems in Cumilla, Bangladesh

This study investigates the presence of polycyclic aromatic hydrocarbons (PAHs) in kitchen dust from households in the Cumilla District of Bangladesh, utilizing three different cooking systems: wood, kerosene, and gas. Sixty dust samples were collected from various kitchen surfaces and analyzed for 18 PAH compounds. The extraction and analysis of PAHs were performed using gas chromatography-mass spectrometry (GC-MS) with selective ion monitoring (SIM) mode. The results indicated significant variations in PAH concentrations across different cooking systems, with the highest levels observed in kitchens using wood stoves, followed by kerosene and gas stoves. Diagnostic ratios were used to identify the sources of PAHs, revealing a combination of pyrogenic and petrogenic origins. Health risk assessments, including Incremental Lifetime Cancer Risk (ILCR) and Hazard Index (HI), were conducted to evaluate the potential risks associated with PAH exposure. The findings demonstrated a higher carcinogenic risk associated with wood stove systems, while kerosene and gas systems posed comparatively lower risks. The study's findings have practical implications for public health and policy development, as they underscore the need for continuous monitoring of indoor PAH levels and the development of policies to mitigate exposure, highlighting the critical importance of addressing indoor pollution to ensure public health safety.

Health risk assessment of heavy metals in the dust street of Mehran city, as a busy city in religious times, Iran.

The concentration of various potentially toxic metals (Pb, Cd, As, Ni, Zn, and Cr) in street dust samples collected from Mehran city, Iran, was analyzed. The samples were obtained during normal traffic conditions, NTT, prior to the Arbaeen ceremony, as well as after the pilgrims' return, which corresponds to high traffic time, HTT. Street dust samples were analyzed for HM content using ICP-OES, following acid digestion. The subsequent evaluation of the data involved the application of the geo-accumulation index, enrichment factor, and potential ecological risk index (PER) and health risk assessment. The findings demonstrate a notable increase in the levels of HMs during HTT compared to the NTT. The highest enrichment values for Pb and Cd were observed in Mehran Street dust during the HTT. The mean of PER for all sampling points increased to 138.24, indicating a moderate-potential ecological risk at this time. Based on the health risk assessment, it was found that the hazard index for all samples was below one. The incremental lifetime cancer risk was below 10-6. This indicates that the exposed population is not exposed to substantial health risks. Despite the heavy traffic caused by the Arbaeen ceremony in this area and the high enrichment of HMs, along with potential ecological risks, no significant health risks were observed for individuals exposed to street dust. However, it is important to note that the continuation of this trend, in the absence of proper traffic management, could lead to significant environmental and health problems in the future.

Comprehensive Assessment of the Relationship between Metal Contamination Distribution and Human Health Risk: Case Study of Groundwater in Marituba Landfill, Pará, Brazil

Effective management of urban solid waste in the Metropolitan Region of Belém, State of Pará, Brazil is essential for conserving ecosystems and public health in eight cities, emphasizing the municipality of Marituba. Considering the vulnerability of underground water resources in Marituba to pollution due to the possible impact of leachate percolation from the landfill, this study evaluates the quality of groundwater captured in tubular wells from different adjacent locations potentially used for human consumption. For this purpose, the systematic methodologies of the groundwater quality index and human health risk assessment analysis: non-carcinogenic and carcinogenic risk to human health were used based on chronic daily intake of heavy metals by consumption and dermal adsorption of groundwater, measured through risk quotients, risk index, and incremental lifetime cancer risk. To evaluate the interrelationships of pollutants, analysis of variance, hierarchical cluster analysis, and principal component analysis were used based on the spatio-temporal quantification of pH, temperature, electrical conductivity, As, Al, Ba, Co, Cd, Cu, Cr, Fe, Hg, Ni, Pb, Sb, Se, U, and Zn. Residents of the study area are not at potential risk, as the results demonstrate that groundwater is within the potability standards of Brazilian legislation, except for aluminum concentrations, which ranged from 53.12 to 378.01 μg L−1 and 3.82 to 339.5 μg L−1 in the dry and rainy seasons, respectively, exceeding the established limit of 200.0 μg L−1. The quality index for groundwater and the heavy metal pollution index demonstrated that groundwater has good drinking quality with low metal contamination. The risk was considered low at all sampling sites in the non-carcinogenic risk assessment. Principal component analysis indicated that the sources of metal pollution are natural origins and anthropogeny. In this sense, they become worried because aluminum is a recognized neurotoxicant that can interfere with the central nervous system’s critical physiological and biochemical processes. Furthermore, despite complying with potability standards, trace concentrations of highly toxic metals such as As, Pb, Cd, and Ni may indicate initial contamination by landfill leachate.

Profiling and health risk assessment of trace metal contents in bovine tissues: A case study in Gondar City, Ethiopia

This study aimed to determine six trace metal (Cu, Mn, Zn, Cd, Cr, and Pb) concentrations in three bovine tissues (kidney, liver and muscle) from Gondar City abattoir, Ethiopia, and assess associated health risks. Samples were digested with HNO3/HClO4, and metal concentrations were analyzed by Inductively Coupled Plasma Optical Emission Spectroscopy. Zn exhibited the highest concentration in muscle (52.1 mg/kg), whereas Cd was below the LOD (0.6 µg/kg) in all muscle samples. The levels of Cd, Cr, and Mn in liver and kidney tissues, as well as Zn in muscle, exceeded FAO/WHO safety thresholds. Principal component analysis revealed distinct metal accumulation patterns among the tissues where liver is the target organ for accumulation of Pb, Mn and Cu, while kidney appears to be the organ of preference for Cd and Cr accumulation. Zn had the highest chronic daily intake for both children and adults, followed by Cu. Hazard index values for both age groups were below one, indicating no non-carcinogenic risks. However, the incremental lifetime cancer risks and cumulative carcinogenic risks of Cr exceeded the tolerable limit for adults and children, indicating a high cancer likelihood from this trace metal. In contrast, the incremental lifetime cancer risks of Pb for both adults and children were within acceptable limits. In conclusion, cumulative carcinogenic risk values indicate that consuming muscle tissue poses health risks for both adults and children, highlighting the need for stricter cattle feed regulations in the study area to safeguard public health.

The probabilistic health risk assessment and analysis of trace elements in grape and date syrup as a sweet and nutritious alternative

ABSTRACT This study aimed to investigate the levels of essential and toxic elements in the grape and date syrups of Tehran. The concentration of elements in the syrup samples was measured using the acid digestion method and the inductively coupled plasma atomic emission spectrometry (ICP-OES) technique. The grape and date syrup samples were tested for the mean concentrations of 19 elements, namely aluminium (Al), arsenic (As), boron (B), barium (Ba), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), iron (Fe), mercury (Hg), lithium (Li), manganese (Mn), molybdenum (Mo), nickel (Ni), lead (Pb), antimony (Sb), tin (Sn), vanadium (V,) and zinc (Zn). Based on the results, the grape syrup samples showed the highest mean concentration of B (4210 ppb) and the lowest mean concentration of Hg (1.126 ppb). In the date syrup samples, the highest mean concentration was for Zn (4323.40 ppb), while the lowest mean concentration was for V (0.14 ppb). The concentrations of Fe, Mn, Mg, and Zn were observed to be relatively higher compared to the levels of other elements. Health risk assessments indicated that the 95th percentile of the target hazard quotient (THQ) for potentially toxic elements (PTEs) intake from both syrups was below one (THQ <1) for both children and adults. This suggests that the detected concentrations have not yet proposed any short-term health risks. Also, the 95th percentile of incremental lifetime cancer risk (ILCR) among children was between 1E–04 to 1E–06 which is the WHO’s target, so more investigation before taking any action is required. However, among adults, the 95th percentile of ILCR was lower than 1E–6 so more investigation is required. In general, it is necessary to regularly control and monitor the concentration of contaminants in date and grape syrups.

Dietary Intake of Minerals and Potential Human Exposure to Toxic Elements via Coffee Consumption.

In this study, we investigated the levels of macro, minor, and trace elements in roasted ground and instant coffees (n = 56). We assessed dietary mineral intake and health risks associated with potentially toxic elements (PTEs) using deterministic and probabilistic approaches. The limits of detection (LOD) ranged from 0.13 µg/kg for Be to 3.7 mg/kg for K, with corresponding limits of quantification (LOQ) at 0.43 µg/kg and 12.2 mg/kg. The recovery values (R%) ranged from 89 to 107%. The most abundant element was K, followed by Mg, Ca, and Na. Other elements followed this order: Fe > Mn > B > Cu > Sr > Zn > Al > Ba > Ni > Cr > Co > Se > Sn > Pb > Li > Ag > V > As > Cd > Hg > Be. Instant coffees generally exhibited higher K, Mg, and Na levels than ground-roasted coffees. Notably, Hg, Li, and Se were not detected in 34, 2, and 1 samples, respectively. Coffee samples were generally a good source of dietary elements such as Cu, Mn, Cr, and Se. The PTEs found in coffee products posed negligible risks to human health. The total target hazard quotient (TTHQ) remained below 1, and the incremental lifetime cancer risk (ILCR) did not exceed the threshold of 1 × 10-6. Nevertheless, coffee consumption contributed to Pb and As levels below 15% of the benchmark dose lower confidence limit (BMDL) values, and Sn, Hg, and Cd levels below 0.90% of the provisional tolerable weekly intake (PTWI).

Spatial variations and health risk assessment of heavy metal levels in groundwater of Qatar

The present work’s objective is to give a comprehensive overview of the quality of groundwater in Qatar in terms of heavy metals content as well as investigating the cause and effect of the elevation in their levels above the WHO/US-EPA standards. The scope of the study included (1) physical and chemical analysis of 82 groundwater samples collected from various locations around Qatar, (2) development of ArcGIS maps depicting the variations in the levels, (3) assessment of the human health risks associated with the existing levels using three of the most used models which are: Hazard index (HI), Nemerow comprehensive pollution index (NCPI) and Incremental Lifetime Cancer Risk (ILCR). There is no extensive study ever reported to assess the health risks linked with the consumption of groundwater characterized with such heavy metals levels in Qatar. The chronic daily intake (CDI) of the investigated heavy metals (Ag, Mn, Cr, V, Mo and Sr) through ingestion and dermal pathways had a range of 1.4 × 10–5–6.7 × 10–1 mg/kg/day while the NCPI’s range was reported at 0–4.39. Moreover, the HI and ILCR were found to have a range of 0–3.2 and 5.6 × 10–4–5.5 × 10–2, respectively. The assessment of health risks, conducted in the present work, could be beneficial in building the baseline of heavy metals levels in groundwater in Qatar. This will also help in the determination of any future contamination of groundwater.

Characteristics, sources, and health risks of PAHs and their derivatives in indoor dust in Zhengzhou

The occurrence, source, and health risk of polycyclic aromatic hydrocarbons (PAHs), nitro-PAHs (NPAHs), and oxy-PAHs (OPAHs) in indoor dust collected from three types of microenvironments (offices, classrooms, and dormitories) at a university campus in Zhengzhou were analysed. The results showed that the average concentration of the total PAHs was 2403.21 ± 981.99 ng g−1, with PHE (20.06% of Σ18PAHs) and BkF (15.46%) being the dominant species. The average concentrations of total NPAHs and OPAHs were 11.09 ± 5.12 and 385.80 ± 255.27 ng g−1, with 2+3N-FLT (39.15%) and 9-FLO (39.76%) as the most abundant species of NPAHs and OPAHs, respectively. The average concentrations of total PAHs, NPAHs, and OPAHs in different microenvironments displayed obvious spatial specificity with the highest values in dormitories. The main source of PAHs, as identified by diagnostic ratios, was petroleum combustion, coal/biomass combustion and vehicle exhaust emissions. The average incremental lifetime cancer risk (ILCR) for undergraduates exposed to dust in classrooms and dormitories exceeded 10−6, indicating a potential cancer risk. The most important exposure pathway was dermal contact, while the inhalation route was negligible.

Assessing drinking water quality based on water quality indices, human health risk, and burden of disease attributable to heavy metals in rural communities of Yazd County, Iran, 2015–2021

The water quality indices, health risk, and burden of disease attributable to heavy metals in rural communities of Yazd County, Iran during 2015–2021 were studied. The drinking water quality index (DWQI) based on 27 parameters (including heavy metals) and heavy metal pollution index (HPI) were used for assessing drinking water quality. The health risk and burden of disease from heavy metals in drinking water were estimated in terms of hazard quotient (HQ), hazard index (HI), incremental lifetime cancer risk (ILCR), and disability-adjusted life year (DALY). Based on the DWQI scores by community, the drinking water quality in rural communities of Yazd County was characterized as good for 61 %, fair for 25 %, marginal for 2 %, and poor for 12 %. The distribution of the rural communities into the HPI categories was as follows: 43 % for excellent, 36 % for good, 14 % for poor, and 7 % for unsuitable. In about 20 % of the rural communities, the average HI level of heavy metals was higher than the boundary limit of one. The highest average HQ level at the county level was related to arsenic (As) to be 0.44. In all the communities, the total ILCR values of the heavy metals were in the category of significant increased cancer risk (10−6 to 10−4). At the county level, As and cadmium (Cd) exhibited the two highest cancer risk levels to be 1.96 × 10−4 and 1.87 × 10−4 for ILCR, respectively. The DALY rate (per 100,000 people) induced by exposure to the heavy metals via drinking water was 13.9, which was considered relatively high as compared to that of other drinking water pollutants obtained in the previous studies. The drinking water quality improvement through decreasing Cd and As levels below the standard values can drastically reduce the attributable burden of disease and promote the public health in the rural communities.

Health Risk Assessment of Lead and Cadmium in Roadside Roasted Corn from Selected Areas of Bwari Local Government Area, FCT, Nigeria

This research examined the presence of lead and cadmium in roasted corn sold by roadside vendors. Five locations (Market Square, Ade Femi Street, Abiola Road, SCC Road, and Primary School) were selected for the research according to the availability of vendors and vehicular activities. Roasted corns were oven-dried at 80°and digested according to standard methods. The concentrations of lead (Pb) and cadmium (Cd) were determined with an Atomic Absorption Spectrophotometer. The data generated was analyzed with the R statistical program version 4.3.0. Lead and cadmium concentrations in the roasted corn varied significantly (p &lt; 0.05) across the study locations. The Pb content of the roasted corn varied from 0.08±0.00 mg Kg-1 – to 0.29±0.00 mg kg-1. While Cd was found to be within the range of 0.006±0.00 mg kg-1 – 0.09±0.00 mg kg-1. Lead levels in roasted corn at Market Square were above WHO limits of 0.2 mg kg-1. However, The Cd levels were within the acceptable limit of 0.1 mg kg-1. The strong positive correlation observed between Pb-Cd pairs in the roasted corn was a strong indication of similarity in the origin of the contamination. The potential risk associated with Pb and Cd exposure in roasted corn was determined by the Average Daily Intake of metals (ADI, Health Risk Index (HRI), and Incremental Lifetime Cancer Risk (ILCR). The risk assessment indices revealed that HRI was &lt; 1, indicating a non-potential health risk for adults and children. Also, the estimated ILCR for Pb and Cd was within the acceptable limit of 1 x 10-4 – 1x 10-6. This study shows that consumers of roasted corn sold at Market Square may be at risk of lead toxicity with continuous exposure.

Environmental Implications of the Soil-to-Groundwater Migration of Heavy Metals in Mining Area Hotspots

Groundwater contamination was studied at several hotspot sites in the Majdanpek copper mining area (Serbia). These sites include a milling facility, a metallurgical wastewater treatment plant, a heavy vehicle service area, and a waste disposal site. In addition to Cu, high concentrations of As and heavy metals (Cd and Pb) were detected in groundwater and soil at the same sampling points. Mining operations and heavy vehicle transport activities have been identified as the main sources of pollution. The migration of metals from soil to groundwater, expressed as a concentration ratio, were the highest for Co and the lowest for Mn. The environmental implications of groundwater pollution were studied using the heavy metal pollution index (HPI), Nemerov pollution index (NPI), hazard index (HI), and incremental lifetime cancer risk (ILCR). HPI and NPI show the high potential of groundwater to have adverse environmental effects. HPI ranges in the following descending order of metals: Cd &gt; Pb &gt; As &gt; Mn &gt; Ni &gt; Cr &gt; Hg &gt; Cu &gt; Zn. NPI exceeds the threshold of 0.7 in 66.7% of the samples. Potential human exposure to the studied groundwater may cause severe health problems in adults, with HI ranging from 0.61 to 5.45 and ILCR from 1.72 × 10−4 to 1.27 × 10−3. Children were more susceptible to non-carcinogenic risk than adults, with HI ranging from 0.95 to 8.27. However, the results indicated that children were less prone to carcinogenic risks, with ILCR ranging from 5.35 × 10−5 to 3.98 × 10−4. Arsenic is the most contributing element to both risks. This research imposes the need for enhanced groundwater monitoring at hotspots in the mining area and the adoption of remediation plans and measures.

Assessment of organic contaminants at a paint manufacturing site: Implications for health risks and source identification

The daily variation of organic contaminants, both gaseous and associated with suspended particulate matter (PM), was investigated within the estate of the National Company of Paintings in Lakhdaria, Algeria, spanning the period 2014-2015. The research emphasizes the chemical characterization of suspended PM, analyzing a range of organic compounds, including n-alkanes, polycyclic aromatic hydrocarbons (PAHs), and highly polar organics (HPOC), such as phthalate esters and heterocyclic compounds. Vapors of PAHs and polychlorobiphenyls (PCBs) were also analyzed. Low molecular weight compounds were primarily associated with the gas phase (two-ring PAHs, approximately 95%; three-ring PAHs, around 70%), while high molecular weight congeners were mainly associated with the particle phase (six-ring PAHs, 55%). The concentrations of PCBs (ranging from 0.6 to 42 ng m–3) were higher than those reported in other cities in Algeria and Europe. The source reconciliation of organic contaminants through principal component analysis (PCA) demonstrated that the primary sources were petroleum combustion, industrial manufacturing, tobacco smoking, and vehicular traffic. The significance of tobacco smoke was further confirmed by the analysis of PAH diagnostic ratios. Differences in the rates of diagnostic ratios between gaseous and particulate PAHs were attributed to distinct contributions from sources such as industrial processes. Health risks for workers exposed to PAHs and PCBs in PM &lt; 10 μm (PM10) were quantitatively assessed in terms of benzo[a]pyrene equivalent concentration and incremental lifetime cancer risk (ILCR). The ILCR presents novel findings showcasing heightened risks among workers exposed to specific PAHs within production areas, whereas those related to PCBs suggested a high potential of health risks for laboratory workers.

Assessment of atrazine contamination in the Sele River estuary: spatial distribution, human health risks, and ecological implications in Southern Europe

BackgroundOveruse of pesticides is a major worldwide problem for the environment and human health. Atrazine (ATR) is a synthetic triazine herbicide that is typically used to manage crops and although it was banned many years ago, it was detected frequently with a high persistence in the aquatic environments. This study assesses the human and environment health risks, temporal patterns and spatial distribution of ATR and its degradation products (DPs) in the Sele River estuary within the Southern European context.. It specifically investigates their occurrence in the water dissolved phase (WDP), suspended particulate matter (SPM), and sediment.ResultsSampling was conducted across 10 sites throughout the year’s four seasons. Amounts of ATR and its DPs detected ranged from 20.1 to 96.5 ng L−1 in WDP, from 5.4 to 60.2 ng L−1 in SPM, and from 4.7 to 19.8 ng g−1 in sediment samples, signifying some pollution levels. Spatial distribution mechanisms revealed a southward movement of ATR and its DPs pollution from the Sele River mouth, intensifying during the rainy season. In this study area, a risk evaluation was also carried out. No sample contained ATR or its DPs in concentrations above the recommended limits, which pose a Non-carcinogenic and Carcinogenic risk. The environmental risk was low. Additionally, the determined Incremental lifetime cancer risk (ILCR) value was within the allowable range.ConclusionDespite its long-standing prohibition, this study investigate ATR levels in the water and sediments of Sele River in Southern Europe. Beyond simply delineating the pollution status of Sele River, this research delineates its ecological repercussions on the Thyrrenian Sea, providing essential data for norms and laws related to water contamination.Graphical

A probabilistic risk assessment of long-term exposure to metals and pesticides residues via consumption of cucurbit crops

Cucurbits contribute significantly to global food and are economically important for farm lands and greenhouses in Iran. The present study assessed the probabilistic risk posed to Iranian consumers through oral exposure to a mixture of pesticides and metals by consumption of cucurbit crops. A total of 180 samples of cucurbit crops including cucumber, courgette, pumpkin, Persian melon, watermelon, and melon were collected from different farm lands (i.e. open fields, 90 samples) and greenhouses (90 samples) in Iran and levels of pesticides and metals were quantified by GC-MS and ICP-OES, respectively. The mean levels of Cd, As, and Ni were above reference dose (RfD) in farmland crops, whereas only Ni levels were above RfD in greenhouse crops. In general, metals mean levels in farmland crops were statistically higher compared to greenhouse cucurbits. Concerning pesticides, in farmland crops, mean concentrations of carbaryl, methomyl, diazinon, malathion, and methamidophos were above the maximum residue limits (MRLs), while in greenhouse crops diazinon and methamidophos were above MRLs. Estimated incremental lifetime cancer risk (ILCR) and hazard index (HI) for metals reflected no health risk for both farmland and greenhouse crops. Based on probabilistic assessment, HI values for carbamates, pyrethroids, and organophosphorus contents in cucurbit crops from farmlands and greenhouses at the 50th, 80th and 95th centiles, indicated no risk for Iranian consumers. Agricultural policies should be updated by using the cultivars types with minimum contaminants-accumulation and raise the general awareness of Iranian farmers about careful use of pesticides and fertilizers in agricultural practices.