This paper studies the microstructural features and mechanical properties of friction stir welds with dissimilar alloys and different thicknesses. The welds are produced in five different thickness/material combinations from 2024-T3 and 7075-T6 sheets with different thicknesses. A parametric study is conducted to optimize the welding parameters such that the different configurations can be compared. The paper is divided into two chapters: microstructural features and mechanical properties. In the first chapter, a study of the chemical composition and microstructure of the welds shows that a narrow chemical mixing zone is present in the dissimilar-alloy welds and that the stirring zone embodies the union rings and exhibits heterogeneous texture for most configurations. Study of the hardness, tensile properties and fracture surfaces in the second chapter shows that an asymmetric softened region, which is harder at the advancing side and extends more into the retreating side, is formed in the stirring zone and that the mechanical properties decrease as the thickness ratio increases. The fracture was partially ductile and partially brittle for all configurations.