The Effect of Organochlorines on Male Infertility Study (FINS) is an NIH-funded project investigating the effects of exposure to organochlorine compounds (OC) and metals via fish consumption on male infertility. In the Great Lakes (GL) basin, a potential source of exposure to heavy metals, such as mercury, is through the consumption of sport-caught GL fish. The study population is men participating in FINS who submit semen specimens for analysis and provide blood samples for OC and metals testing. Cros-sectional study. The first 184 whole blood specimens collected from FINS participants were analyzed for 12 metals by the Michigan Department of Community Health Bureau of Laboratories. The mean values and ranges () in micrograms per liter were: Arsenic, 9.5 (5.8 - 25.5); Cadmium, 0.3 (0.0 - 2.8); Chromium, 0.21 (0.0 - 3.6); Copper, 928.4 (700.0 - 1397.0); Lead, 2.0 (0.5 - 16.2); Manganese, 13.5 (8.0 - 30.0); Mercury, 1.8 (0.0 - 14.5; Molybdenum, 0.4 (0.0 - 2.0); Selenium, 187.7 (130.0 - 260.0); Thallium, 0.0 (0.0 - 0.0); Uranium, 0.0 (0.0 - 0.02); Zinc, 6940.0 (5077.0 - 9251.0). In a preliminary analysis of questionnaire data from144 FINS participants for whom complete data existed for metal levels, fish consumption history and sperm concentration, motility and morphology, metal levels were examined for associations with semen parameters and fish consumption using correlation analysis and univariate logistic regression models. In these samples, no association was found between sperm concentration or motility and any metal. High mercury level (above the 75th percentile) was positively associated with consumption of any fish within 12 months (odds ratio = 8.14, 95% CI:[1.848, 35.814], p = 0.006), but not consumption of Great Lakes fish exclusively (odds ratio = 2.35, 95% CI:[0.915, 6.032], p = 0.08). Consumption of ocean fish within the past 3 months was most strongly associated with high mercury level (odds ratio = 10.34, 95% CI:[2.358, 45.351], p = 0.002). Mean serum values of heavy metals in infertile men have now been simultaneously determined. Increased fish consumption correlates with serum mercury levels. Serum levels of heavy metals levels did not correlate with semen parameters in this sample.