Salt fog originating from the offshore zone can easily accumulate in the semi-enclosed space (called the gridiron space) formed by the beams and slabs of a pile-supported wharf. Such accumulation can lead to the premature failure of the durability of the wharf’s substructure. Previous works have mainly focused on material-level measures to eliminate the adverse effects of salt fog accumulation, such as the use of anti-corrosion concrete and anti-corrosion coatings, which could result in increased construction costs. In fact, salt fog can be extracted from a gridiron by natural ventilation in some cases, so it is important to examine the flow characteristics of the gridiron space. In this work, a numerical simulation was conducted with natural ventilation and auxiliary ventilation groups. The critical value of the shield ratio (defined as the height ratio of edge stringer to air inlet) that led to the weakest turbulence of airflow inside the gridiron was studied in the natural ventilation group. In addition, the effect of various configurations of vents was discussed; in accordance with the results, design recommendations were proposed to enhance the durability of a pile-supported wharf.