Increase In Rate Research Articles

Abstract 6750: Validation of a platform to develop new dendritic cell vaccines for cancer immunotherapy

Abstract Osteosarcoma is the most common malignant form of bone cancer that generally causes patients to die of pulmonary metastasis. If detected before the tumor has metastasized, osteosarcoma has a 75% survival at 5 years after the conventional therapy with surgery and chemotherapy. However, most osteosarcomas are high-grade tumors that grow quickly and spread before being detected, lowering patient survival to 20%. Our unique protocol using the human platelet lysate PLTMax® allows establishing tumor cell lines without genetically modifying cells and with minimal genetic drift. The use of PLTMax® and allogeneic tumor cell cultures has proven to be a major advantage for the generation of large amounts of rich tumor antigen libraries for dendritic cell (DC) vaccines. This protocol was used in an autologous dendritic cell/allogeneic tumor lysate vaccine developed at the Mayo Clinic and licensed to Mill Creek Life Sciences (MCLS) to treat newly diagnosed glioblastoma (GBM), which normally has a poor survival rate at only 2%. The technology was used in a phase I clinical trial (MC1272) performed at the Mayo Clinic. The clinical outcomes proved over a 10 time increase in survival rate of patients that received the DC vaccine after the conventional therapy, providing over 20% three-year survival rate. Our technology differs from other clinically used DC vaccines in three primary ways: a) Highly efficient cell line establishment: The unique method for generating tumor cell lines uses Mill Creek Life Sciences’ PLTMax®, a media supplement derived from human platelets. PLTMax® more closely mimics the native microenvironment of tumors and is used to reduce genetic drift and senescence. b) High genetic fidelity: GBM tumor cells expanded via PLTMax® maintain genetic fidelity and TAA expression—a feat that has not been previously achieved by any other GBM cell culture method. c) Reduction of treatment delays and inclusion of all patients that qualify for treatment: Because we will use allogeneic tumor cell lines, we will be able to avoid delays in treatment caused by the time required to culture autologous tumor cell lines, and all patients may receive treatment without exclusion. Through our preliminary work we transferred the technology from a labor-intensive, small-scale approach, to an automated scalable system. Our ultimate goal is to apply this strategy to not only osteosarcoma, but also several other tumor types to validate it as a platform. Like osteosarcoma, there are other therapy-refractory cancers that we believe can benefit from the use of our platform technology, through the use of DC vaccines that offer an immune response against a wider panel of tumor antigens. Citation Format: Vanesa Alonso-Camino, William Mirsch. Validation of a platform to develop new dendritic cell vaccines for cancer immunotherapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 6750.

An adaptive threshold based gait authentication by incorporating quality measures

In this paper, an adaptive threshold-based gait authentication model is proposed, which incorporates the quality measure in the distance domain and maps them into the gradient domain to realize the optimal threshold of each gait sample, in contrast to the fixed threshold, as most of the authentication model utilizes. For accessing the quality measure of each gait, a gait covariate invariant generative adversarial network (GCI-GAN) is proposed to generate normal gait (canonical condition) irrespective of covariates (carrying, and viewing conditions) while preserving the subject identity. In particular, GCI-GAN connects to gradient weighted class activation mapping (Grad-CAMs) to obtain an attention mask from the significant components of input features, employs blending operation to manipulate specific regions of the input, and finally, multiple losses are employed to constrain the quality of generated samples. We validate the approach on gait datasets of CASIA-B and OU-ISIR and show a substantial increase in authentication rate over other state-of-the-art techniques.

Molecular dynamics simulation of mechanical properties of decagonal quasicrystal approximate phase Al2Fe

By using the molecular dynamics method, the tensile and elastic mechanical properties of Al2Fe (tI6 and oF24) alloys for decagonal quasicrystals approximation are simulated. Structural models for tI6 and oF24 are first established and then the appropriate embedded atom method (EAM) potential function is selected to analyze the effects of temperature and strain rate on the stress-strain relation, atomic structure and deformation mechanism. Furthermore, all the elastic constants Cij of tI6 and oF24 are calculated by the molecular dynamics explicit deformation method, and the crystal structure and stability of tI6 and oF24 are also judged. Besides, the elastic mechanical properties of tI6 and oF24 including bulk modulus, shear modulus, elastic modulus, and Poisson's ratio, are derived by means of both the general formula and the independent crystal system formula. The results show that the elastic modulus and tensile strength of tI6 and oF24 almost decrease linearly with increasing temperature. An increase of strain rate has little effect on the elastic modulus of tI6 and oF24, but it can result in an obvious increase of the tensile strength and ultimate strain. By calculating, tI6 possesses a stable tetragonal crystal structure and oF24 has a stable orthorhombic crystal structure, which are consistent with the previous results derived by the first-principle. The Young's modulus, shear modulus and Poisson's ratio display high anisotropy except for the bulk modulus. The anisotropic of oF24 is higher than that of tI6, while the stiffness and hardness of tI6 are greater than those of oF24. The present work can provide a theoretical reference for analyzing the mechanical properties of the approximate phase of decagonal quasicrystal as well as a novel numerical calculation method for determining the mechanical properties of related materials.

Experimental study and mechanism analysis of high-pressure water jet for mud cake cutting during shield tunneling

When the opening rate of the cutter head of tunnel boring machines is insufficient for the removal of excavated soil in a timely manner, the soil tends to accumulate in front of the cutter head and inside the earth or slurry chamber, leading to mud caking. High-pressure water jetting is an effective method for removing mud cakes. This study explored the influence of high-pressure water jet parameters on the efficiency of mud cake cleaning by using highly weathered argillaceous siltstone as experimental materials. Mud cake compaction equipment and high-pressure water jetting devices were developed. In addition, the impact of jetting parameters such as jet pressure and flow rate on the mud cake cutting performance was investigated. The results indicated that with an increase in the erosion distance, the cutting width of the mud cake first increased and then gradually decreased to zero, while the cutting depth progressively diminished. Under the same jet pressure, when the flow rate increased from 49.1 L/min to 110 L/min, the cutting width of the high-pressure water jet increased. With further increase in the flow rate from 110 L/min to 202.8 L/min, the cutting width decreased and the cutting depth increased. Under the same jet flow, the increase in water pressure resulted in greater cutting width and depth.

Numerical simulation of single-well enhanced geothermal power generation system based on discrete fracture model

This study proposes a single-well enhanced geothermal system (SEGS) to mitigate the high-risk of traditional Enhanced Geothermal Systems (ESGs) with two or more wells and enhance the general applicability. A detailed thermodynamic model that couples the wellbore, reservoir, and organic Rankine cycle is built. For the reservoir, a three-dimensional flow and heat transfer model featuring a discrete fracture network is employed. The effects of injection flow rate, injection temperature, branch well length, and branch well spacing on net output work, pump power consumption, thermal efficiency, and exergy efficiency have been investigated. The results indicate that an increase in the injection flow rate improves the shaft power of the expander and the power consumption of the injection pump. An optimal flow rate of 30 kg/s is identified, which maximizes the annual net power output to 1221.2 kW. Additionally, an increase in the injection temperature is found to enhance the buoyancy effect, thereby improving both thermal and exergy efficiency, and reducing the power consumption of the injection pump. The maximum net output power is achieved at an injection temperature of 60 °C. The study also notes that the branch well length has a negligible effect on thermal and exergy efficiency and expander shaft work. However, a longer branch well length contributes to a decrease in the power consumption of the injection pump and an increase in the net power output. Finally, it is observed that increasing the lateral well spacing slows the rate decay of the production temperature. A spacing of 360 m is found to yield a maximum annual net output power of 1259.4 kW. In conclusion, this study offers significant insights and practical guidance for the development and utilization of SEGS, demonstrating its potential as an effective alternative to conventional EGS methodologies.

Physiological and metabolic aspects of adaptation to special physical loads of the organism of sports walkers

Purpose: to evaluate the efficiency of the use of interval training loads by athletes specialising in race walking in different periods of training using biochemical and physiological indicators. Methodology. In solving the tasks of increasing the functionality of training of the organism of sports walkers, the progressive method of training, which is aimed at improving special endurance through the use of certain physical activities, is crucial, taking into account specific periods of training. Their rational use contributes to the growth of functional capabilities and metabolism, which ensures the growth of sports performance. According to the literature, interval training loads are one of the most effective ways to accelerate speed potential and special speed endurance in cyclic sports. The interval training method is characterised by the repeating of physical exercises in a strict sequence, where the intervals are planned in advance, and the speed of passing certain distance segments with a strictly regulated break - a rest interval - is also provided for. At the same time, the interval training method can be composed with little changes, where rest intervals can vary in time, and the length can be variable, increasing with each subsequent segment. The value of this method, according to the literature, is that it increases the heart's capacity almost twice as fast as by covering distances using the continuous method. Scientific novelty. In addition to the available scientific data, we proposed the effectiveness of the use of interval training loads in the preparatory and competitive period. Conclusions. The tasks of our researches were the analysis of efficiency of the use of interval training loads (2000m x7 times) and performance of tempo work of 10 km of specially-preparatory and competitive periods. It was established that the use of interval training, accompanied by the accumulation of lactate up to 12 mmol·l-1 in the blood and an increase in heart rate over 180 beats∙min -1, leads to an improvement in sports result, which indicates an improvement in the speed capabilities and high-speed endurance of athletes in the competitive period compared to the preparatory period. The used interval loads confirm the correct choice of the training load programme, which has shown its effectiveness in the competitive period of training in comparison with the preparatory period: it contributed to the improvement of test results, speed capabilities and high-speed endurance of athletes.

Heralded Entanglement Distribution Between Two Spin‐Wave Memories Using Temporally Multiplexed Scheme

AbstractThe elementary link, which is formed by entanglement between two remote atomic ensembles, is a fundamental component of Duan–Lukin–Cirac–Zoller (DLCZ) quantum repeater. For practical realization of quantum repeaters, it is required that entanglement between two atomic‐ensemble‐based memories can be generated with high rates and retrieved with high efficiencies. However, so far, such quantum‐repeater links remain challenge in experiments. Here, heralded entanglement distribution between atomic‐ensemble‐based memories is demonstrated via temporally multiplexed scheme. A train of 12 write pulses in time is applied to a cloud of cold atoms along different directions, which generates temporally multiplexed pairs of Stokes photons and spin waves via DLCZ processes. The Stokes fields propagating in the two spatial modes, which are paired with two spin waves are combined to perform a single‐photon Bell‐state measurement. A successful detection projects the two spin waves into a single‐excitation entanglement, which represents entanglement distribution in an elementary link. Compared with single‐mode storage scheme, the temporally multiplexed scheme gives rise to a 11.8‐fold increase in entanglement generation rate. By using cavity‐enhanced scheme, spin waves stored in the atoms are retrieved on demand and the retrieval efficiencies are up to 70%, which is beneficial for the subsequent entanglement swapping between adjacent links.

THE EXCHANGE RATE PASS-THROUGH EFFECT IN TÜRKİYE: FOURIER SHIN COINTEGRATION APPROACH (2006-2023)

In this research, the relationship between currency exchange rates and inflation in the context of Türkiye is investigated, covering the period 2006:Q1-2023:Q1. To achieve this objective, unit root tests on the variables are conducted using both Fourier KPSS and Standard KPSS methods. Additionally, Fourier SHIN and Standard SHIN cointegration tests are employed to determine the presence of a long-term connection between these variables. Furthermore, DOLS, FMOLS, and CCR estimators are utilized to estimate both long-term and short-term coefficients. The findings, which are obtained through all three estimation techniques, consistently indicate that increases in the exchange rate lead to higher inflation levels, whether in the long-term or the short-term. This result underscores the significant impact of exchange rates on inflation rates within the Türkiye economy. When Türkiye's economic structure is examined, it becomes evident that there is a substantial reliance on foreign exchange. This underscores the critical importance of maintaining exchange rate stability. Ultimately, the results emphasize the necessity of not only preserving exchange rate stability but also strengthening efforts to generate foreign exchange.

Investigating the potential of nanobonechar toward climate-smart agriculture.

Extreme climates and the unpredictability of the weather are significant obstacles to agricultural productivity. This study is the first attempt to explore the capacity of nanobonechar (NBC) for promoting climate-smart agriculture. A pot experiment was performed on maize (Zea mays L.) under a deficit irrigation system (40, 70, and 100% irrigation rates) using different soil application rates of the NBC (0, 0.5, 1, and 2% wt/wt). Additionally, the CO2-C efflux rate and cumulative CO2-C were measured in an incubation experiment. The results indicated the best performance of the 1% NBC treatment under a 70% irrigation rate in terms of the fresh and dry weights of maize plants. Total PO43- and Ca2+ were significantly higher in the plants grown in the NBC-amended soil as compared to the control, showing a gradual increase with an increase in the NBC application rate. The improved productivity of maize plants under a deficit irrigation system was associated with enhanced water-holding capacity, organic matter, and bioavailability of cations (Ca2+, K+, and Na+) and anions (PO43- and NO3-) in the soils amended with NBC. The CO2-C efflux rate and cumulative CO2-C emissions remain higher in the NBC-amended soil than in the un-amended soil, pertaining to the high contents of soil organic matter emanating from the NBC. We conclude that NBC could potentially be used as a soil amendment for promoting maize growth under a water stress condition.

An experimental investigation and flow-system simulation about the influencing of silica–magnesium oxide nano-mixture on enhancing the rheological properties of Iraqi crude oil

This study aims to investigate the effects of introducing a 50/50 mixture of silica and magnesium oxide nanoparticles (SNP + MgONP) to the viscosity of Al-Ahdab crude oil (Iraq) at varied concentrations and temperatures. It is observed that the viscosity value drops from 38.49 to 7.8 cP. The highest degree of viscosity reduction is measured to be 56.91% at the maximum temperature of 50 °C and the greatest concentration of 0.4 wt% SM4. The Bingham model can be used to classify the behavior of the crude oil before the Nano-mixture is added. The liquid behavior grew closer to Newtonian behavior once the Nano-mixture was added. Along with a rise in plastic and effective viscosity values, the yield stress value decreases as the concentration of the Nano-mixture increases. The numerical data demonstrate that when the volume proportion of nanoparticles increases, the pressure distribution decreases. Furthermore, as the nanoparticle volume fraction increases, the drag decrease would also increase. SM4 obtains a maximum drag reduction of 53.17%. It is discovered that the sample SM4 has a maximum flow rate increase of 2.408%. Because they reduce the viscosity of crude oil, nanoparticles also reduce the friction factor ratio.

Association of Depression and Antidepressant Use With Driving Behaviors in Older Adults: A LongROAD Study.

Older adults aged 70 and older who drive have higher crash death rates per mile driven compared to middle aged (35-54years) adults who drive in the US. Prior studies have found that depression and or antidepressant medication use in older adults are associated with an increase in the vehicular crash rate. Using data from the prospective multi-site AAA Longitudinal Research on Aging Drivers Study, this analysis examined the independent and interdependent associations of self-reported depression and antidepressant use with driving behaviors that can increase motor vehicle crash risk such as hard braking, speeding, and night-time driving in adults over age 65. Of the 2951 participants, 6.4% reported having depression and 21.9% were on an antidepressant medication. Correcting for age, race, gender, and education level, participants on an antidepressant had increased hard braking events (1.22 [1.10-1.34]) but self-reported depression alone was not associated with changes in driving behaviors.

The economics of waste oil recycling in the EU

ABSTRACT In 2018, 1.6 million tonnes of waste oil were collected in the European Union. About 61% of the waste oil was regenerated – i.e. it was turned into base oil again – and 39% followed energy recovery pathways either in the form of conversion to fuel or via direct incineration. Although the life-cycle literature largely agrees that regeneration outperforms energy recovery in the EU in terms of greenhouse gas emissions and societal costs, policies to boost regeneration and their socio-economic impacts remain underexplored. We fill this gap by discussing policies for managing waste oil flows and by systematically assessing their socio-economic impacts. We analyse different policies that would induce an increase in the regeneration rate of waste oil from the current 61% to either 70% or 85% and assess how the type and magnitude of impacts as well as their distribution across different actors varies, depending on the policy design. The policies lead to a net saving in terms of avoided societal costs and to moderate gains in employment. However, when accounting for estimated administrative costs, these benefits are likely insufficient to justify regulatory intervention.

Early onset type 2 diabetes mellitus: an update.

The incidence and prevalence of type 2 diabetes mellitus (T2DM) in young individuals (aged <40 years) have significantly increased in recent years, approximating two to threefold increase in the respective rates. Numerous risk factors including severe obesity, family history, ethnicity, maternal diabetes or gestational diabetes, and female sex contribute to a younger age of onset. In terms of pathogenesis, impaired insulin secretion is the key operating mechanism, alongside with ectopic adiposity-related insulin resistance. T2DM diagnosis in a young adult requires the exclusion of type 1 diabetes mellitus (T1DM), latent autoimmune diabetes of adults (LADA) and maturity-onset diabetes of the young (MODY). The establishment of such diagnosis is critical for prognosis, because early-onset T2DM is associated with rapid deterioration in pancreatic β-cell secretory function leading to earlier initiation of insulin therapy. Furthermore, mortality and lifetime risk of developing complications, especially microvascular, is increased in these patients compared to both later-onset T2DM and T1DM patients; also, the latter are often developed earlier in the course of disease. The management of early-onset T2DM follows the same guidelines as in later-onset T2DM; yet patients aged 18-39 years are underrepresented in the big clinical trials on which the development of guidelines is based. Finally, young people with T2DM face significant challenges associated with social determinants, which compromise their adherence to therapy and induce diabetes distress. Future research focusing on the pathogenesis of β-cell decline and complications, as well as on specific treatment shall lead to better understanding and management of early-onset T2DM.

Titania/graphene nanocomposites from scalable gas-phase synthesis for high-capacity and high-stability sodium-ion battery anodes

In sodium-ion batteries (SIBs), TiO2 or sodium titanates are discussed as cost-effective anode material. The use of ultrafine TiO2 particles overcomes the effect of intrinsically low electronic and ionic conductivity that otherwise limits the electrochemical performance and thus its Na-ion storage capacity. Especially, TiO2 nanoparticles integrated in a highly conductive, large surface-area, and stable graphene matrix can achieve an exceptional electrochemical rate performance, durability, and increase in capacity. We report the direct and scalable gas-phase synthesis of TiO2 and graphene and their subsequent self-assembly to produce TiO2/graphene nanocomposites (TiO2/Gr). Transmission electron microscopy shows that the TiO2 nanoparticles are uniformly distributed on the surface of the graphene nanosheets. TiO2/Gr nanocomposites with graphene loadings of 20 and 30 wt% were tested as anode in SIBs. With the outstanding electronic conductivity enhancement and a synergistic Na-ion storage effect at the interface of TiO2 nanoparticles and graphene, nanocomposites with 30 wt% graphene exhibited particularly good electrochemical performance with a reversible capacity of 281 mAh g−1 at 0.1 C, compared to pristine TiO2 nanoparticles (155 mAh g−1). Moreover, the composite showed excellent high-rate performance of 158 mAh g−1 at 20 C and a reversible capacity of 154 mAh g−1 after 500 cycles at 10 C. Cyclic voltammetry showed that the Na-ion storage is dominated by surface and TiO2/Gr interface processes rather than slow, diffusion-controlled intercalation, explaining its outstanding rate performance. The synthesis route of these high-performing nanocomposites provides a highly promising strategy for the scalable production of advanced nanomaterials for SIBs.

Sound waves alter the viability of tobacco cells via changes in cytosolic calcium, membrane integrity, and cell wall composition.

The effect of sound waves (SWs) on plant cells can be considered as important as other mechanical stimuli like touch, wind, rain, and gravity, causing certain responses associated with the downstream signaling pathways on the whole plant. The objective of the present study was to elucidate the response of suspension-cultured tobacco cells (Nicotiana tabacum L. cv Burley 21) to SW at different intensities. The sinusoidal SW (1,000 Hz) was produced through a signal generator, amplified, and beamed to the one layer floating tobacco cells inside a soundproof chamber at intensities of 60, 75, and 90 dB at the plate level for 15, 30, 45, and 60 min. Calibration of the applied SW intensities, accuracy, and uniformity of SW was performed by a sound level meter, and the cells were treated. The effect of SW on tobacco cells was monitored by quantitation of cytosolic calcium, redox status, membrane integrity, wall components, and the activity of wall modifying enzymes. Cytosolic calcium ions increased as a function of sound intensity with a maximum level of 90 dB. Exposure to 90 dB was also accompanied by a significant increase of H2O2 and membrane lipid peroxidation rate but the reduction of total antioxidant and radical scavenging capacities. The increase of wall rigidity in these cells was attributed to an increase in wall-bound phenolic acids and lignin and the activities of phenylalanine ammonia-lyase and covalently bound peroxidase. In comparison, in 60- and 75 dB, radical scavenging capacity increased, and the activity of wall stiffening enzymes reduced, but cell viability showed no changes. The outcome of the current study reveals that the impact of SW on plant cells is started by an increase in cytosolic calcium. However, upon calcium signaling, downstream events, including alteration of H2O2 and cell redox status and the activities of wall modifying enzymes, determined the extent of SW effects on tobacco cells.

Analysis of Dynamic Mechanical Properties and Energy Consumption of Fractured Sandstone under Dynamic–Static Combination Conditions

Under dynamic loads, such as blasting, excavation, or quarrying, rocks with fissures are the first to sustain damage, leading to instability in the engineering rock mass. To investigate the kinetic properties of fractured rocks, fractured coal mine sandstone specimens underwent impact compression tests using a dynamic–static combination SHPB (split Hopkinson pressure bar) test device at different loading rates under combined dynamic and static conditions. The damage characteristics of the specimens were analyzed from an energy point of view. The results show that under the dynamic and static combined condition, when five impact loading air pressures are used for loading at different impact rates, the trends of the dynamic stress–strain curves of prefabricated fissured rock samples under various impact pressures were discovered to be similar and were mainly categorized into three main stages of elasticity, yield, and destruction; the specimen’s dynamic compressive strength increases according to a power function relationship; as the average strain rate increases, the dynamic strain increases linearly and the dynamic modulus of elasticity increases in a quadratic relationship, all of which show a significant strain rate effect. The incident energy is a power function of the loading rate. The reflected, transmitted, and absorbed energies by the sample increase with the incident energy. The degree of the sandstone specimen fragmentation gradually grows with increasing impact loading rate and incident energy, as evidenced by a decrease in the scale of the fragments. The absorbed energy in the sample is mainly used for the deformation damage of the rock, and the more intense the fragmentation of the specimen, the more absorbed energy is required.

A Multifactor Combination Optimization Design Based on Orthogonality for a Two-Degree-of-Freedom Floating Machine Gun Vibration System

This paper introduces a novel type of floating machine gun that can be simplified as a self-balancing two-degree-of-freedom mechanical system with distinct vibration characteristics. The model accounts for intricate motion patterns and encompasses numerous potential influencing factors. Multifactor combination optimization of the system represents a pressing engineering challenge. After establishing a simulation model for the machine gun and validating it experimentally, seven factors were chosen as optimization variables. The maximum recoil displacement of the inner receiver (MRD) and the firing rate were chosen to be indicators. Orthogonal combinations and variance analyses were used, and the effects of multiple factors were analyzed using SPSS software; these processes led to a determination of the optimal combination. The results indicated that the piston cylinder pressure, the bi-directional buffer spring energy storage, and the inner receiver mass significantly affected the MRD. Furthermore, the automaton mass and the reset spring energy storage were found to substantially affect the firing rate. Careful analysis of the variance results facilitated the determination of the optimal combination of parameter values. Remarkably, the optimal combination chosen resulted in an MRD reduction of approximately 20.2% and a firing rate increase of approximately 26.6%.

Nebulization and In Vitro Upper Airway Deposition of Liposomal Carrier Systems.

Liposomal carrier systems have emerged as a promising technology for pulmonary drug delivery. This study focuses on two selected liposomal systems, namely, dipalmitoylphosphatidylcholine stabilized by phosphatidic acid and cholesterol (DPPC-PA-Chol) and dipalmitoylphosphatidylcholine stabilized by polyethylene glycol and cholesterol (DPPC-PEG-Chol). First, the research investigates the stability of these liposomal systems during the atomization process using different kinds of nebulizers (air-jet, vibrating mesh, and ultrasonic). The study further explores the aerodynamic particle size distribution of the aerosol generated by the nebulizers. The nebulizer that demonstrated optimal stability and particle size was selected for more detailed investigation, including Andersen cascade impactor measurements, an assessment of the influence of flow rate and breathing profiles on aerosol particle size, and an in vitro deposition study on a realistic replica of the upper airways. The most suitable combination of a nebulizer and liposomal system was DPPC-PA-Chol nebulized by a Pari LC Sprint Star in terms of stability and particle size. The influence of the inspiration flow rate on the particle size was not very strong but was not negligible either (decrease of Dv50 by 1.34 μm with the flow rate increase from 8 to 60 L/min). A similar effect was observed for realistic transient inhalation. According to the in vitro deposition measurement, approximately 90% and 70% of the aerosol penetrated downstream of the trachea using the stationary flow rate and the realistic breathing profile, respectively. These data provide an image of the potential applicability of liposomal carrier systems for nebulizer therapy. Regional lung drug deposition is patient-specific; therefore, deposition results might vary for different airway geometries. However, deposition measurement with realistic boundary conditions (airway geometry, breathing profile) brings a more realistic image of the drug delivery by the selected technology. Our results show how much data from cascade impactor testing or estimates from the fine fraction concept differ from those of a more realistic case.

Studying Plastic Deformation Mechanism in β-Ti-Nb Alloys by Molecular Dynamic Simulations

Using molecular dynamics (MD) simulations, the transition of the plastic deformation mechanism of Ti-Nb alloys during the tensile process was studied, and the effects of temperature, Nb composition, and strain rate on the deformation mechanism were also investigated. The results show that the deformation process of Ti-Nb alloys involves defect formation, followed by twinning and ω-phase transition, and ultimately, dislocation slip occurs. The &lt;111&gt;{112} slip makes the ω-phase easily overcome the transition energy barrier, inducing the phase transition in the twinning process. Increasing temperature will enhance the plasticity and reduce the strength of the material, while increasing Nb composition will have the opposite effect on the deformation. The simulations show a competition between twinning and dislocation slip mechanisms. With the increase in Nb content, the plastic deformation mechanism of the alloy will change from twinning to dislocation slip. In addition, the plastic strain range increases with the increase in the deformation rate in Ti-Nb alloys. At a higher strain rate, the alloy’s plastic strain range is affected by various deformation mechanisms, which significantly influence the plasticity of the material. The findings of this study provide further insights into the design of Ti-Nb-based alloys.

Incidence, mortality and survival rates of lip, oral cavity and salivary glands cancers in Singapore: A half-century time trend analysis (1968-2017).

To examine trends in incidence and mortality and evaluate overall survival (OS) of oral cancer in Singapore between 1968 and 2017. All diagnosed oral cancers by anatomical sites and population size were extracted from the Singapore Cancer Registry and the Department of Statistics Singapore. The trend of age-standardized incidence rate (ASIR) and mortality rate (ASMR) (per 100 000 person-years) of the lip, oral cavity and salivary gland cancers were evaluated by Prais-Winsten regressions for each ethnicity and gender. Kaplan-Meier curves were performed to evaluate the OS by anatomical sites in each age group by ethnicity and sex. Overall, 49, 3494 and 1066 people were diagnosed, and 28, 2310 and 476 died from lip, oral cavity and salivary gland cancers, respectively. The oral cavity cancer ASIR and ASMR reduced from 3.07 (1968-1972) to 2.01(2008-2012) and from 2.06 (1978-1982) to 1.21 (2013-2017) per 100 000 person-years, respectively, with both highest in Indians throughout the whole period. Male:Female ratio ranged from 3.43 (1973-1977) to 1.75 (2013-2017) and from 3.41 (1978-1982) to 2.40 (2013-2017) for ASIR and ASMR, respectively. However, both salivary gland cancer ASIR and ASMR increased from 0.50 (1968-1972) to 0.80 (2008-2012) and from 0.18 (1968-1982) to 0.42 (1988-1992) per 100 000 person-years, respectively, with both higher in males since 1993. Oral cavity cancer ASIR decreased for males aged ≥60, and Indian females ≥25, but increased among Chinese females aged ≥60. Oral cavity cancer ASMR decreased among Chinese aged 25-59, and among Malay males and Indian females. Salivary gland cancer ASIR increased among Chinese males aged ≥60 and Malay males aged 25-59; while ASMR increased among Chinese males aged ≥60. The median OS for oral cavity, lip and salivary gland cancers were 3.0, 9.3 and 18.1 years, respectively, with females surviving longer than males. Singapore has experienced a decline in the incidence and mortality of lip, oral cancer, an increase in in the incidence and mortality of salivary gland cancer, with an increase in the median overall survival rate. Monitoring the magnitude of oral cancer burden and the demographic, and temporal variations is necessary for tailoring health planning and setting priorities for future clinical care and research.