Abstract Background Approx. 14% of adolescents experience mental health disorders. Mindfulness-based interventions (MBIs) could be one way to support adolescents’ well-being. We investigated the effectiveness of a 9-week school-based mindfulness intervention on adolescents’ well-being, moderated by gender, grade, and independent practice. Methods In total 3519 Finnish adolescents (aged 12 - 15) from 56 schools were randomized into intervention, active (relaxation), and inactive (normal school curriculum) control groups. Well-being was assessed with two life satisfaction measures (Life Satisfaction [OECD] and The Satisfaction with Life Scale-Child [SWLS-C]) and positive and negative affects (Positive and negative affects [PANAS]) at baseline, at 9 weeks and 26 weeks and analyzed using multilevel linear modeling. Results Significant improvement in life satisfaction (SWLS-C) was found at 9 weeks in the MBI group (β = 0.38, 95 % CI 0.08-0.68, p = 0.009) compared to the active control. Furthermore, MBI demonstrated an increase in life satisfaction (OECD) among boys (β = 0.25, 95 % CI 0.04-0.46, p = 0.016) and 6th graders (β = 0.26, 95 % CI 0.04-0.49, p = 0.015) at 9 weeks compared to the active control. Additionally, MBI participants engaging in independent practice at least once a week had a higher increase in positive affect at week 26 compared to both the active (β = 3.01, 95 % CI 0.55-5.47, p = 0.009) and inactive control groups (β = 2.81, 95 % CI 0.23-5.40, p = 0.026). Those practicing MBI almost daily also demonstrated a higher increase in positive affect at week 26 compared to the active control group (β = 2.95, 95 % CI 0.28-5.62, p = 0.023). Conclusions MBI in the school context seems to have the potential to increase the well-being of adolescents, especially those who commit to regular independent mindfulness practice. Gender and grade may moderate the effects of MBI. Therefore, we need to better understand how gender and age influence the effectiveness of MBI. Key messages • The findings indicate the need to further examine potential mediators and moderators that may influence the effectiveness of MBI on adolescents. • According to this study, regular mindfulness practice in schools appears to be a promising way to improve well-being of adolescents.
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