Abstract A feedlot study was conducted to evaluate the effect of two feed additives, Prime Force (Furst-McNess Company, Rockford, IL) and Optipartum C+ (AB Vista, Plantation, FL), on finishing cattle performance and carcass characteristics. In this experiment, steers [n = 320; 390 ± 9.5 kg of body weight (BW)] were used and four treatments were evaluated in a total of 32 pens, with 10 steers per pen and 80 steers per treatment. Treatments were arranged in a 2 × 2 factorial and included a control diet with no additives; a diet containing Prime Force targeted at 68 g/steer daily; a diet containing Optipartum C+, targeted at 20 g/steer daily; and a diet containing a combination of both products (68 g/steer Prime Force and 20 g/steer Optipartum C+). Cattle were fed for 151 d, but treatments were imposed the last 67 d before slaughter (i.e., fed control diet to all cattle until d 84). Performance is for the total 151-d feeding period. No interaction between feed additives was observed for performance or carcass traits (P ≥ 0.41), therefore main effects are presented. Feeding Prime Force increased final BW (P < 0.04) when compared with cattle not fed Prime Force. A tendency was observed for greater adjusted final BW (P = 0.06) and ADG (P = 0.08) for cattle fed Prime Force compared with cattle fed no Prime Force. Cattle fed Prime Force had numerically greater intake (P = 0.11) than cattle fed no Prime Force, therefore gain to feed (G:F) was not impacted (P = 0.54). Ribeye area and fat depth were not different (P ≥ 0.17) for cattle fed Prime Force versus cattle that had no Prime Force added to the diet, but marbling was numerically improved (P = 0.11) due to Prime Force. Carcass-adjusted final BW (P = 0.11) was numerically greater for cattle fed Optipartum C+ and ADG tended (P = 0.09) to be greater for cattle fed Optipartum C+ compared with cattle fed no Optipartum C+. Dry matter intake was not different (P = 0.54) for cattle fed Optipartum C+ versus cattle with no Optipartum C+ in the diet, therefore G:F was numerically improved (P = 0.13) by the increase in ADG for cattle fed Optipartum C+. Ribeye area, fat, and marbling were not different (P ≥ 0.30) between cattle fed Optipartum C+ and those that did not receive Optipartum C+ in the diet. Incidence of liver abscesses was not affected by feeding either additive (P = 0.40). Based on results from this study, adding Prime Force to a finishing diet tended to improve BW and ADG compared with cattle not fed Prime Force. Feeding Optipartum C+ tended to increase ADG and improve G:F due to equal DMI when compared with diets with no Optipartum C+ added.