This research aims to examine the Effect of Job Stress and Coping Strategies on Job Satisfaction Mediated by Work Family Conflict. This type of research is explanatory research. The populations in the study were all police personnel in the Kendari Police detective field. The number of samples determined was 130 respondents. The analysis method uses structural equation modeling (SEM) using the AMOS 4.01 program package to obtain results of causal relationships between the variables developed in the model. The test results show that: Job stress from the results of this research is proven to have a negative and significant effect on the job satisfaction of police personnel; Coping strategies directly have a positive and significant effect on job satisfaction of police personnel, Work-family conflict directly has a negative and significant effect on job satisfaction, Job stress has a positive and significant effect on work conflict; (5) Coping strategies have a negative and significant effect on work-family conflict. Work stress has an influence on job satisfaction and can be significantly mediated by work-family conflict, so it can be said that work conflict has a significant influence as a mediator variable in this research and strategy. Coping has a significant influence on job satisfaction. The influence on job satisfaction variables can be significantly mediated by conflict. family work. This means that reducing work stress will have an impact on increasing job satisfaction through reducing work conflict, as well as better coping strategies will have an impact on increasing job satisfaction through work conflict.