Increase In Adhesion Strength Research Articles

A Microwave-Strengthened Supramolecular Adhesive: from Flexible Pressure Sensitive Bonding to Strong and Muti-Reusable Hot Melt Bonding.

A microwave-strengthened supramolecular adhesive by introducing maleic acid amide bonds into the cross-linked networks of catechol-based monomers and iron oxide nanoparticles is reported. Under microwave irradiation, the supramolecular adhesive can be rapidly heated up, causing the transformation from maleic acid amide bonds to maleimide bonds and thus the increase of its cohesive strength. The supramolecular adhesive can flexibly bond substrates like pressure sensitive adhesives during the bonding procedure and shows an adhesion strength of 0.5MPa toward ceramic. After microwave strengthening, it can strongly bond substrates like hot melt adhesives and shows a dramatically increased adhesion strength of 5.0MPa, 10 times stronger than the original value. Moreover, the microwave-strengthened supramolecular adhesive can be reused 3 times with negligible loss in adhesion strength, exhibiting outstanding multiple reusability. By combining both high flexibility and high adhesion strength, it is anticipated that the supramolecular adhesive can be of great potential in cultural relics restoration and microelectronics.

Smart Mechanical Structures and Design for Advanced Adhesives: A Review

Abstract Smart adhesives with engineered mechanical structures have emerged as a transformative technology with broad applications in fields such as wearable healthcare devices, bioengineering, and soft robotics. By integrating advanced mechanical architectures like kirigami, tessellations, and multilayered designs, these adhesives exhibit enhanced surface and mechanical properties that lead to superior interfacial adhesion. Such designs offer critical advantages—improved stretchability, substrate conformability, and increased adhesion strength—over conventional adhesives. This review explores the range of engineered structures used in smart adhesives and demonstrates how these innovations address the limitations of traditional adhesives. Additionally, we discuss their applications in wearable healthcare devices, flexible electronics, and robotics.

Enhanced adhesion strength of copper deposited epoxy composite films for chip substrates by tuning copper oxide and internal stress

Copper oxides and internal stress have an obvious influence on adhesion strength of copper deposited polymer composites. However, the effect of the evolution behavior of copper oxides and internal stress on adhesion force of chip substrates is no clear and rare far. Herein, the copper deposited epoxy-phenolic/silica composite film with different desmear time was fabricated by using wet chemistry and electrochemistry methods. The chemical structure, surface roughness, morphology, surface chemical state, crystal structure and adhesion strength of copper and epoxy resin substrate were characterized by scanning electron microscope (SEM), interference microscope, X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR). The adhesion strength of samples is increased from 3 N/cm to 4.7 N/cm. The effect of the evolution behavior of copper oxides and internal stress on adhesion strength of copper deposited epoxy resin composite films at the interfaces was systematically investigated, the mechanisms and reason of increasing adhesion strength and interfacial adhesion failure for copper deposited epoxy resin composite substrates were revealed. This work will provide a guidance in theory and experiment to enhance interfacial adhesion force of epoxy resin composite films for advanced substrate in the future.

Recycled PET Fibers with Dopamine Surface Modification for Enhanced Interlayer Adhesion in 3D Printed Concrete.

Three-dimensional printed concrete (3DPC) is increasingly recognized in the construction industry for its high design flexibility and the elimination of conventional formwork. However, weak interlayer adhesion remains a significant challenge. The potential of recycled polyethylene terephthalate (PET) fibers for reinforcing 3DPC is being explored, driven by their environmental sustainability and economic advantages. However, there is an inadequate interfacial adhesion between these recycled fibers and the 3DPC matrix. This study investigated the use of dopamine modification to address this issue and enhance the interlayer adhesion of fiber-reinforced 3DPC. Recycled PET fibers were surface-modified using dopamine treatment, forming a polydopamine (PDA) film that improved surface roughness and hydrophilicity. Both unmodified and modified fibers were incorporated into 3DPC at various volume fractions (0.1%, 0.3%, 0.5%). The effects on interlayer adhesion strength, compressive strength, and flexural strength were systematically evaluated and compared. The results showed that the inclusion of 0.3 vol% dopamine-modified fibers resulted in a 22.5% increase in interlayer adhesion strength compared to the control group, and a 14.8% improvement over unmodified fibers at the same content. Additionally, the compressive strength and flexural strength of 3DPC with 0.3 vol% MPET fibers increased by 22.5% and 27.6%, respectively, compared to the control group. Microstructural analysis using SEM and XRD revealed that the dopamine modification significantly improved the interfacial adhesion between fibers and the concrete matrix, explaining the superior performance of modified fibers. This study demonstrates that recycled PET fibers modified with dopamine can effectively enhance the interlayer adhesion of 3DPC. The findings affirm that surface modification techniques can significantly elevate the utility of recycled PET fibers in 3DPC, contributing to the sustainable advancement of construction materials.

Effect of carbon fibers modification on joint adhesion steel-epoxy resin-aluminum

The combination of high-performance steel with aluminum or aluminum alloys shows a wide range of application in high technologies field like aerospace, smart materials, etc. The problem in using of adhesive bonding technology for these substrates is the weak mechanical occlusion between steel/aluminum and common coatings. In this study, different methods of treatment of carbon fiber were employed to enhance the adhesion strength in steel-epoxy resin filled with carbon fiber-aluminum triplex. The treatment of carbon fibers with 3-glicidyloxypropyl-trimetoxysilane after their oxidation in 65 wt.% nitric acid leads to the additives which improve the adhesion strength of epoxy resins at 15 wt.% contain on 67.5% in comparison with neat epoxy up to 20 MPa. This result can be explained by the change of failure mechanism from “cohesive’ to “adhesive” that leads to an increase of adhesion strength to steel and aluminum. The SEM study shown that 60–80 nm thick two-layer interphase formed between carbon fiber and epoxy matrix. The mechanical strength of this interphase governs the mechanical and adhesion performance of steel-epoxy resin-aluminum triplex. Taking into account the mechanical properties and adhesive strength of these composites, it emerges as a potential candidate for advanced materials.

Self-Growing Hydrogel Bioadhesives for Chronic Wound Management.

Hydrogel bioadhesives have emerged as a promising alternative to wound dressings for chronic wound management. However, many existing bioadhesives do not meet the functional requirements for efficient wound management through dynamically mechanical modulation, due to the reduced wound contractibility, frequent wound recurrence, incapability to actively adapt to external microenvironment variation, especially for those gradually-expanded chronic wounds. Here, a self-growing hydrogel bioadhesive (sGHB) patch that exhibits instant adhesion to biological tissues but also a gradual increase in mechanical strength and interfacial adhesive strength within a 120-h application is presented. The gradually increased mechanics of the sGHB patch could effectively mitigate the stress concentration at the wound edge, and also resist the wound expansion at various stages, thus mechanically contracting the chronic wounds in a programmable manner. The self-growing hydrogel patch demonstrated enhanced wound healing efficacy in a mouse diabetic wound model, by regulating the inflammatory response, promoting the faster re-epithelialization and angiogenesis through mechanical modulation. Such kind of self-growing hydrogel bioadhesives have potential clinical utility for a variety of wound management where dynamic mechanical modulation is indispensable.

INFLUENCE OF TANGENTIAL SLIDING ON THE CONTACT AREA OF A MACROSCOPIC ADHESIVE CONTACT

Influence of tangential force on the adhesive contact, in particular on the adhesive strength and the contact area have been a subject of investigation and discussions for many years. Depending on the system under consideration, both increase and decrease of adhesion strength due to shearing of an adhesive contact have been reported. The same is valid for change of the contact area. While it is generally accepted that the contact area decreases when applying tangential traction, also opposite behaviour is possible. In the present paper we study theoretically and experimentally the conditions under which the contact area may increase or decrease due to shear.

Enhancement of adhesion strength in viscoelastic unsteady contacts

We present a general energy approach to study the unsteady adhesive contact of viscoelastic materials. Under the assumption of infinitely short-range adhesive interactions, we exploit the principle of virtual work to generalize Griffith’s local energy balance at contact edges to the case of a non-conservative (viscoelastic) material, subjected to a generic contact time–history. We apply the proposed energy balance criterion to study the approach–retraction motion of a rigid sphere in contact with a viscoelastic half-space. A strong interplay between adhesion and viscoelastic hysteretic losses is reported which can lead to strongly increased adhesion strength, depending on the loading history. Specifically, two different mechanisms are found to govern the increase of pull-off force during either approach–retraction cycles and approach – full relaxation – retraction tests. In the former case, hysteretic losses occurring close to the circular perimeter of the contact play a major role, significantly enhancing the energy release rate. In the latter case, instead, the pull-off enhancement mostly depends on the glassy response of the whole (bulk) material which, triggered by the fast retraction after relaxation, leads to a sort of ‘frozen’ state and results in a flat-punch-like detachment mechanism (i.e., constant contact area). In this case, the JKR theory of adhesive contact cannot be invoked to relate the observed pull-off force to the effective adhesion energy, i.e. the energy release rate G, and strongly overestimates it. Therefore, a rigorous mathematical procedure is also proposed to correctly calculate the energy release rate in viscoelastic dissipative contacts.

Improving additive manufacturing for housing construction

The use of additive manufacturing in construction can significantly reduce the speed of construction of an object, labor costs, waste, reduce the risks of industrial injuries, etc. Despite a number of existing advantages of these technologies, their implementation in construction is associated with various problems, one of which is the need to ensure the required adhesion strength of printed layers. There are a number of studies devoted to solving this problem and creating effective materials for additive construction production, mainly based on cement binders; to a much lesser extent, these studies are available in the field of mixtures based on gypsum and mixed (gypsum-cement-pozzolanic) binders. The purpose of this work is to develop a scientifically based technological solution for improving additive technologies for low-rise housing construction using gypsum-cement-pozzolanic mixtures (GCPS) by regulating recipe-technological factors that provide increased adhesion strength of printed layers. Based on the results of the research, a technological solution has been developed to improve the technology of additive construction production of GCPM by regulating the kinetics of the increase in plastic strength of the mixture when it is modified with a multifunctional complex additive, which makes it possible to ensure the viability of the mixture required for 3D printing in the range of 0–50 minutes, significantly reduce the defectiveness of the extrudate during the 3D printing process, and increase the adhesion strength of the printed layers. It has been established that the adhesion strength of layers printed without a technological break from the GCP concrete mixture, modified with multifunctional complex additive, is 65% higher compared to the base composition, and when a technological break lasts 6 hours, it is 25% higher, which confirms its effectiveness in additive manufacturing.

How Static and Cyclic Loading Affect the Mechanical Properties of the Porcine Annulus Fibrosus.

This study sought to evaluate the effects of prolonged cyclic loading on the tissue-level mechanical properties of the spinal annulus fibrosus. Functional spinal units (FSUs) were obtained from porcine cervical spines at the C3-C4 and C5-C6 levels. Following a 15-min preload of 300 N of axial compression, the FSUs were split into three groups: the cyclic loading group cycled between 0.35 MPa and 0.95 MPa for 2 h (n = 8); the static loading group was compressed at 0.65 MPa for 2 h (n = 10); and a control group which only underwent the 300 N preload (n = 11). Following loading, samples of the annulus were excised to perform intralamellar tensile testing and interlamellar 180 deg peel tests. Variables analyzed from the intralamellar test were stress and strain at the end of the toe region, stress and strain at initial failure (yield point), Young's modulus, ultimate stress, and strain at ultimate stress. Variables evaluated from the interlamellar tests were lamellar adhesion strength, adhesion strength variability, and stiffness. The analysis showed no significant differences between conditions on any measured variable; however, there was a trend (p = 0.059) that cyclically loaded tissues had increased adhesion strength variability compared to the static and control conditions. The main finding of this study is that long-duration axial loading did not impact the intra- or interlamellar mechanical properties of the porcine annulus. A trend of increased adhesion strength variability in cyclically loaded samples could indicate a potential predisposition of the annulus to delamination.

Fully Recycled Polyolefin Elastomer-Based Vitrimers with Ultra-High, Universal, Stable, and Switchable Adhesion.

Achieving both robust adhesion to arbitrary surfaces and thermal-switchable/recyclable properties has proven challenging, particularly for commodity polyolefins. Herein, a simple and effective route is reported to transform polyolefins elastomer (POE) into a fully recycled epoxy-functionalized POE vitrimers (E-POE vit) with ultra-high, universal, stable, and switchable adhesion via facile free radical grafting and dynamic cross-linking. The resultant E-POE vit exhibits increase in adhesion strength on glass exceeding three to ten times compared to those commonly used polymers, due to the synergy of dense hydrogen (H)-bonds and strong interfacial affinity. In addition, E-POE vit also displays strong adhesion on diverse surfaces ranging from inorganic to organic while maintaining good stability in various harsh environments. More importantly, temperature-sensitive H-bonds allow E-POE vit to switch between attachment-detachment at alternating temperatures, resulting in reversible adhesion without adhesion loss, even after 10 cycles. Moreover, E-POE vit is able to be fully recycled and reused more than ten times via thermo-activated transesterification reactions with negligible change in structure and performance. This work may unlock strategies to fabricate high-performance commercial polymer-based adhesives with adhesion and recyclable features for intelligent and sustainable applications.

Effect of multiple environmental conditions on the formation process and adhesion strength of ice on asphalt binder surface

Road icing caused by freezing rain significantly impacts driving safety. Since asphalt binder plays a pivotal role in pavement infrastructure, understanding the formation process and adhesion strength of ice on asphalt binder surfaces is crucial for assessing road icing risk. This work investigated the effect of different environmental conditions on asphalt-ice interface adhesion strength via a self-designed low-temperature adhesion testing system. In addition, the icing process on asphalt binder surfaces was observed to analyze the asphalt-ice adhesion strength formation mechanism. Results show that the completion time of water-ice phase transition signified the initial development of asphalt-ice adhesion strength. Moreover, as the internal structure of the ice evolved from transparent to needle-like fine lines to dense, the asphalt-ice adhesion strength gradually increased until it reached stability. At asphalt-ice adhesion began forming after 40 min and stabilized after 80 min, whereas at −8°C, adhesion strength started forming after 20 min and stabilized by 60 min. The growth rates of asphalt-ice adhesion strength for temperatures ranging from −2°C to −10°C were approximately 7.92 kPa/°C, 6.56 kPa/°C, 5.14 kPa/°C, 3.29 kPa/°C, and 1.49 kPa/°C, respectively, showing a positive correlation with temperature and a negative correlation with time. According to heterogeneous nucleation theory, the influence mechanism of temperature and water depth on the nucleation icing process and asphalt-ice adhesion strength is analyzed. lower temperatures lead to asphalt-ice adhesion strength increase originating from the larger supercooling, which reduces the critical nucleation energy and thus accelerates the ice nucleation rate. In addition, the increase in water depth promotes the formation of nucleation sites and further enhances the asphalt-ice adhesion strength. Finally, an asphalt-ice adhesion strength prediction model was developed, with PSO-SVM-G achieving over 90 % accuracy. These results provide insights for evaluating ice adhesion behavior on asphalt surfaces and designing anti-icing asphalt materials.

Effect of Cow Dung Additions on Tropical and Mediterranean Earth Mortars-Mechanical Performance and Water Resistance.

Cow dung (CD) is a material that has been used for millennia by humanity as a stabilizer in earth building techniques in vernacular architecture. However, this stabilization has been little addressed scientifically. In this study, the effect of CD additions was assessed on earth mortars produced with one type of earth from Brazil and two other types from Portugal (from Monsaraz and Caparica). The effect of two volumetric proportions of CD additions were assessed: 10% and 20% of earth + sand. The German standard DIN 18947 was used to perform the physical and mechanical tests, and classify the mortars. In comparison to the reference mortars without CD, the additions reduced linear shrinkage and cracking. An increase in flexural and compressive strengths was not observed only in mortars produced with earth from Monsaraz. In mortars produced with the earth from Caparica, the addition of 10% of CD increased flexural strength by 15% and compressive strength by 34%. For mortars produced with the earth from Brazil, the addition of 10% of CD increased these mechanical strengths by 40%. The increase in adhesive strength and water resistance promoted by the CD additions was observed in mortars produced with all three types of earth. Applied on ceramic brick, the proportion of 10% of CD increased the adherence by 100% for the three types of earth. Applied on adobe, the same proportion of CD also increased it more than 50%. For the water immersion test, the CD additions made possible for the mortar specimens not to disintegrate after a 30 min immersion, with the 20% proportion being more efficient. The effects of the CD on mechanical performance, including adhesion, were more significant on the tropical earth mortars but the effects on water resistance were more significant on the Mediterranean earthen mortars. CD has shown its positive effects and potential for both tropical and Mediterranean earthen plasters and renders tested, justifying being further studied as an eco-efficient bio-stabilizer.

Mitigation mechanisms of ash deposition and adhesion by different coatings on heated surfaces at macro and molecular scales

Research on the mitigation of ash deposition on coals rich in alkali and alkaline earth metals using coatings is limited. Existing research methods, mainly focusing on ash composition and melting characteristics, cannot fully elucidate the key mechanisms underlying ash adhesion properties on various coated surfaces. Therefore, this study explored the mitigation mechanisms of nickel and chromium coatings on ash deposition using a drop tube furnace, custom-made ash adhesion strength tester, and molecular dynamics. The results revealed that nickel and chromium coatings effectively mitigated ash deposition, with a more significant effect at temperature less than 1000 °C. Above 1000 °C, the ash melting led to a significant increase in ash adhesion strength, diminishing the inhibitory effect of coatings. The key minerals, Na2SO4, Ca2MgSi2O7, and Ca2Al2SiO7, mainly physically adsorbed onto the NiO(001) and Cr2O3(001) surfaces. The binding energy of these minerals with NiO(001) and Cr2O3(001) was significantly lower than that on α-Fe2O3(110) surfaces. The α-Fe2O3(110) system was more stable, and minerals readily adhered to the α-Fe2O3(110) surface, whereas none of these minerals readily bound to NiO(001) and Cr2O3(001), maintaining their adhesion state. Consequently, nickel and chromium coatings demonstrated excellent resistance to ash adhesion and deposition, with nickel coatings being more effective.

3D printing of thick film NTC thermistor from preceramic polymer composites for ultra-high temperature measurement

Integrating thick/thin film sensors into component systems has emerged as a prevalent approach for monitoring in extreme environments. However, traditional vapor deposition methods face obstacles, including complex fabrication processes and the degradation of sensitive materials at extremely high temperatures. This work delineates the development of a polysilazane composite dual-layer thick-film Negative Temperature Coefficient (NTC) thermistor characterized by its suitability for extreme temperatures and robust bond strength achieved through an advanced near-net-shape printing methodology. High-temperature resistant La(Ca)CrO3/polysilazane films were printed as the sensitive layer, while a dense layer formed by Cr2O3/polysilazane was used as the protective layer. The bilayer structure resulted in a 2.5-fold increase in adhesion strength compared to the single-layer La(Ca)CrO3/polysilazane films. Experimental results indicate that the dual-layer thick-film NTC thermistor can be operated long-term at 1300 °C with a resistance drift rate of 0.9 %/h and survive short-term exposure to temperatures up to 1550 °C. As a proof of concept, this work applied 3D printing technology to fabricate a polysilazane composite dual-layer thick-film NTC thermistor on the surface of turbine blades and demonstrated its functionality under flame impingement at nearly 1300 °C. Such flexible 3D printing techniques pave the way for a new paradigm in manufacturing sensors capable of withstanding ultra-high temperatures.

Модифицирующая добавка для повышения качества асфальтобетона

The paper describes the production of modifying additive on the basis of waste - deferrization sludge of waste groundwater of Nekrasovskoye settlement, Yaroslavl region. The authors found that the predominant components of this waste are trivalent and divalent colloidal iron in the ratio of 3:1. The authors propose to use this waste as a modifier of asphalt concrete mixture to increase the adhesion of bitumen to mineral components of asphalt concrete based on the study of its physical and chemical properties. The authors have conducted studies of asphalt concrete mixes of various grades and selected optimal conditions for the use of deferrization sludge in the technological process of asphalt concrete production. The use of modifying additive allows to increase shear stability and water holding capacity of asphalt concrete, which indicates the increase of adhesive strength of bitumen bond with mineral components of asphalt concrete.

Probing local adhesion: A miniaturized multi-photon lithography design demonstrated on silanized vs. untreated surfaces

As multi-photon lithography technology matures, advanced integrated device design concepts become possible, positioned onto small surfaces, such as optical fibres. Only local adhesion anchors the printed object on the surface and ensure proper print-development without structure loss and long-term usability. Although surface treatments such as silanization are well known to considerably increase adhesion strength, quantification of adhesion is not straightforward and commonly assessed indirectly by surface characteristics and technological methods. The present work aims to quantify adhesion on a micrometer scale through SEM in situ tension experiments, that utilize a newly developed specimen geometry. Multiple specimens, with various footprints, were manufactured on both silanized and untreated fused silica substrates, allowing the comparable quantification of adhesion stresses between different surface conditions. Specimens on an untreated substrate failed with a high scatter in detaching force, whereas specimens on a silanized substrate tend to fail within the photoresist, either at the gauge section or just above the substrate, rather than at the interface itself. Thus, the adhesion stress was increased at least by a factor of 1.4 by the silanization treatment. Generally, a novel approach was developed, that can quantify local adhesions properties in realistic packaging or integrated circuits.

A Single-Component Janus Zwitterionic Hydrogel Patch with a Bionic Microstructure for Postoperative Adhesion Prevention.

The development of anti-adhesion hydrogels for preventing postoperative adhesions is an ongoing challenge, particularly in achieving a balance between exceptional antifouling properties and effective in situ tissue retention. In this study, we propose a unique approach with the design of a single-component Janus zwitterionic hydrogel patch featuring a bionic microstructure. The Janus patches were prepared through free radical polymerization of sulfobetaine methacrylate with N, N'-methylenebis(2-propenamide) as the cross-linker. The incorporation of hexagonal facets separated by interconnecting grooves on one side imparts durable and reliable in situ retention capabilities to the Janus hydrogel patch when it is applied to traumatized tissues. The opposing flat surface exhibits outstanding resistance to bacteria, proteins, and cell adhesion, due to the superhydrophilicity and excellent antifouling characteristics of zwitterionic polymers. This dual functionality empowers the Janus hydrogel patch to mitigate adhesions between traumatized and surrounding tissues. The hexagonal and groove bionic microstructures facilitate rapid drainage, promoting swift contact with the tissue for increased adhesion strength, while independent hexagonal microfacets enhance the peeling energy. In an in vivo setting, Janus zwitterionic hydrogel patches with surface microstructures form mutually embedded structures with the cecum surface, minimizing the likelihood of slippage and detachment. Remarkably, in vivo experiments involving abdominal wall cecum injuries illustrate the Janus zwitterionic hydrogel patch's superior anti-adhesion effectiveness compared to commercial controls. Thus, the Janus hydrogel patch, distinguished by its bionic microstructure surface, presents substantial potential in the biomedical field for averting postoperative adhesions.

Impact of Screw Geometry and Solids Content on the Properties of Continuously Produced Si Anodes

Within the realm of lithium‐ion batteries, there is a growing emphasis on achieving high energy density and environmentally friendly production at a low cost. To address these demands, the battery slurries in this study incorporate the high‐energy anode material silicon. They are systematically produced through continuous extrusion, aiming to realize cost reductions by significantly reducing the overall process time. In this study, it is demonstrated that the choice of screw configuration and solids content during kneading influences the specific energy input and the stress intensity during processing significantly. The stress intensity, represented here by the specific torque, has a great influence on the slurry properties as well as the electrochemical performance of the battery. An increased stress intensity leads to an increase in adhesive strength and ionic resistance. In the results, it is indicated that carbon black decomposition increases significantly, but when a critical specific stress intensity in form of the specific torque is reached, delamination and fracture of the graphite particles occur, leading to a loss of lithium‐ion storage capacity, favoring lithium plating and severely degrading both capacity by up to 40% at 1C and long‐term performance by up to 10% after 50 cycles.

Disulfiram Reduces Atherosclerosis and Enhances Efferocytosis, Autophagy, and Atheroprotective Gut Microbiota in Hyperlipidemic Mice.

Pyroptosis executor GsdmD (gasdermin D) promotes atherosclerosis in mice and humans. Disulfiram was recently shown to potently inhibit GsdmD, but the invivo efficacy and mechanism of disulfiram's antiatherosclerotic activity is yet to be explored. We used human/mouse macrophages, endothelial cells, and smooth muscle cells and a hyperlipidemic mouse model of atherosclerosis to determine disulfiram antiatherosclerotic efficacy and mechanism. The effects of disulfiram on several atheroprotective pathways such as autophagy, efferocytosis, phagocytosis, and gut microbiota were determined. Atomic force microscopy was used to determine the effects of disulfiram on the biophysical properties of the plasma membrane of macrophages. Disulfiram-fed hyperlipidemic apolipoprotein E-/- mice showed significantly reduced interleukin-1β release upon invivo Nlrp3 (NLR family pyrin domain containing 3) inflammasome activation. Disulfiram-fed mice showed smaller atherosclerotic lesions (~27% and 29% reduction in males and females, respectively) and necrotic core areas (~50% and 46% reduction in males and females, respectively). Disulfiram induced autophagy in macrophages, smooth muscle cells, endothelial cells, hepatocytes/liver, and atherosclerotic plaques. Disulfiram modulated other atheroprotective pathways (eg,efferocytosis, phagocytosis) and gut microbiota. Disulfiram-treated macrophages showed enhanced phagocytosis/efferocytosis, with the mechanism being a marked increase in cell-surface expression of efferocytic receptor MerTK. Atomic force microscopy analysis revealed altered biophysical properties of disulfiram-treated macrophages, showing increased order-state of plasma membrane and increased adhesion strength. Furthermore, 16sRNA sequencing of disulfiram-fed hyperlipidemic mice showed highly significant enrichment in atheroprotective gut microbiota Akkermansia and a reduction in atherogenic Romboutsia species. Taken together, our data show that disulfiram can simultaneously modulate several atheroprotective pathways in a GsdmD-dependent as well as GsdmD-independent manner.