Purpose. To establish technical efficiency of fungicide Propuls 250 SE against a complex of soybean diseases (sclerotium, rust, phomopsis, septoriose, alternaria, gray rot, cercosporosis).Methods. Field, laboratory.Results. The technical efficiency of fungicide Propulse 250 SE which provides disease control of soybean crops has been investigated. Thus, at the Bila Tserkva Research Breeding Station, in the treatments with fungicide Propulse 250 SE, development of sclerotium was 4.5 times less intensive at the application rate of 0.8 L/ha and 5.7 times less intensive at the application rate of 1.0 L/ha, as compared to control. The spread of septoriose for the use of the formulation also decreased to 30.5–31.3% or 1.5 times, and the disease development was almost 4 times lower than in the control treatment (7.2–6.4% vs. 25.7%). It was noted that the use of Propulse 250 SE contributed to a decrease in the spread of rust by 7.1–7.9%, and decreased the disease development 5–6 times compared to control. The distribution of alternaria and cercosporosis was also lower than in the control 1.2 and 1.8 times, respectively, while the disease was reduced by 4 and 5 times, respectively. The efficiency of Propulse 250 SE on soybean was quite high and ranged from 100% (gray rot) to 75.1% (septoriose). In particular, the efficiency of the formulation against rust was 83.5%, cercosporosis 82.2%, sclerotium 82.5%, alternaria 80.1%, and septoriose 75.1%. Under the conditions of Veselyi Podil Research and Breeding Station, the use of fungicide Propulse 250 SE at the application rate of 1.0 L/ha reduced the occurrence of rust from 19.3 to 18.5%, and affection from 3.8 to 3.6%, septoriose from 30.6 to 27.2% and 7.1 to 6.4%, alternaria from 11.2 to 8.7% and 5.5 to 4.9%, cescosporosis from 19.3 to 15.5% and 5.2 to 3.8%, respectively, compared to the application rate of 0.8 1 L/ha. At the same time, it should be noted that the use of this fungicide completely removed the manifestation of damage by sclerotium, gray rot and other diseases, its efficiency ranged from 71.1 to 88.9%. It must be pointed out that the use of this fungicide completely removed the manifestation of sclerotium and gray rot and other diseases, its efficiency varied between 71.1 and 88.9%.Conclusions. Experimental studies indicate that the technical efficiency of the fungicidal Propulse 250 SE against the complex of soybean diseases on the average was as follows: sclerotium 88.2%, rust 81.5%, septoriose 73.3%, alternaria 73.8%, gray rot 100% and cercosporosis 79.0%. The high efficiency of fungicide Propulse 250 SE against the complex of soybean diseases has affected yield. Thus, the use of fungicide at both stations contributed to an increase in soybean yield by an average of 1.0–1.5 t/ha compared to control treatment.