The article discusses the agro-production features of the river valley-escarpment soils of the Republic of Armenia, the negative changes occurring in the soils due to the impact of climate change and the anthropogenic factor, as well as a number of issues related to the ways of increasing soil fertility. According to the Research results, river valley-escarpment soils are in general, characterized by high natural fertility and are widely used in agricultural production as high-quality arable land. Meantime, significant changes in the agro-productive features of soils are observed as well. In order to efficiently use the land, increase and maintain the fertility, it is recommended that scientifically based complex agrotechnical measures in compliance with local conditions are applied.