A large amount of dust particles produced by the wind in an open-air pile is one of the important reasons for air pollution. Studying the law of dust diffusion in local areas is of great significance for the atmospheric particulate control. In this study, a pile of sodium carbonate in a large open-air pile in Weifang, China, is regarded as the research object. The dispersion characteristics of dust particles around the pile under the action of unidirectional wind are studied through wind tunnel test and numerical simulation. The complex atmospheric environment is simplified as unidirectional wind, and the influence of different wind speeds on the dispersion of particles with diverse sizes in the pile is studied. Although a large gap exists between the assumption and the real atmospheric environment, this study provides a reference for the evaluation of the pollution scope of blowing dust and prevention and control of pollution. Results show that a high-concentration range of the dust exists near the pile behind the wind direction and may continue to spread to the height due to the influence of a whirlpool, and the dispersion distance and width can increase with the increase in wind speed. The increase in particle diameter increases the kinetic energy loss of particles for the fluid. Under the same starting speed, the dispersion distance of dust decreases with the increase in particle diameter. With the increase in particle diameter, the dust concentration distribution presents the trend of interior hollowing and high-concentration area fragmenting.