Purpose: Physical activity (PA) is important to improve and maintain general health. However, the level of PA is decreasing with age, especially in patients with lifestyle-related diseases such as osteoarthritis (OA). The recommended first-line treatment for patients with hip or knee OA, patient education and exercise therapy, may therefore help not only to relieve OA symptoms but also to improve general health, if PA can be increased. Such an improvement is especially important for patients with low PA level. In this study we aim at identifying the proportion of OA patients who increased and maintained their PA levels after entering a patient education and exercise therapy program. Methods: We used data from the Good Life with osteoArthritis in Denmark (GLA:D®) program, which is a supervised patient education and exercise therapy program delivered in primary care to patients with hip or knee OA. The intervention consists of two patient education and 12 supervised exercise therapy sessions. Patients participating between 2013 and 2019 were included in the study, if they provided information on the University of California, Los Angeles (UCLA) activity scale at three time points (TP): TP0) baseline, TP1) immediately after and TP2) 12 months after entering the program.The outcomes of interest were changes on the UCLA activity scale (1-10, low to high) (Table 1). In this study, we defined patients as ’low active’ if they reported a UCLA activity level of ≤ 3; ‘sometimes participate in mild activities’ or lower at TP0.We calculated the proportion of all and of the ‘low active’ patients, who increased their PA by at least one UCLA activity scale unit, from TP0 to TP1, and from TP0 to TP2. Furthermore, we evaluated the proportion of patients who at least maintained their increased PA level from TP1 to TP2. Finally, we calculated the proportion of ‘low active’ patients, who reached at least UCLA activity level 4 (‘regular participation in mild activities’) at TP1, and at TP2, as well as the proportion of these patients who at least maintained a UCLA activity level of 4 from TP1 toTP2. Results: During the inclusion period, 19,079 patients with hip or knee OA participated in the GLA:D® program and provided complete information on the UCLA activity scales. They were on average 65 years old, had a mean BMI of 28, and 13,683 (72%) were female. 7% (n=1,352) reported low PA at baseline (UCLA activity score ≤ 3) and these patients were on average 65 years old, had a mean BMI of 31 and 936 (69%) were female.In the ‘low active’ patient group, 81% (n=1,092) and 80% (1,086) reported an increased UCLA activity level at TP1 and TP2 compared to TP0, respectively (Figure 1). The increased PA level was maintained by 48% (n=650) of the ‘low active’ patients from TP1 to TP2.When considering all patients, 37% (n=7,103) and 38% (n=7,243) increased their UCLA activity level from TP0 to TP1, and from TP0 to TP2, respectively. 18% (n=3,387) of all included patients had at least maintained their increased PA levels from TP1 to TP2.In the ‘low active’ patient group (level 1-3), 76% (n=1,033) and 75% (n=1,016) reached a PA level of at least 4 on the UCLA activity scale, corresponding to regularly participating in mild activities such as walking, at TP1, and at TP2, respectively (Figure 2). 62% (n=844) of the ‘low active’ patients maintained their increased UCLA PA level of at least 4 from TP1 to TP2. Conclusions: Eight out of ten osteoarthritis patients with low physical activity at baseline reported improved physical activity immediately after and 12 months after entering a supervised patient education and exercise therapy program. About half maintained their increased physical activity level from immediately after to twelve months after the GLA:D® program.View Large Image Figure ViewerDownload Hi-res image Download (PPT)View Large Image Figure ViewerDownload Hi-res image Download (PPT)