Constructing buildings above subway tracks exploits urban-area space intensively by adopting the three-dimensional overlapping development mode, which is one of the important measures for solving the contradictions among urban population increase, land resource shortage, and environmental protection. However, the vibration generated by the frequent train operations is transmitted to the upper buildings through the track structure and ground soil, which can cause structural vibrations and radiated noise and bring physical and mental side effects to occupants within the buildings. Subway projects are often located in geologically sensitive areas, while the influences of the encountered geological problems on the generation and propagation of structural vibration and structure-radiated noise within the buildings are not yet clear. Hence, this paper presents a method of studying the train-induced vibration transmission from the ground up into the buildings and the structure-radiated noise within the building. The method consists of a train-track model, track-soil-building model, and structure-radiated noise simulation. The impact of soil properties on the building vibration and structure-radiated noise is analyzed and ground-improvement measures are proposed in order to mitigate vibration and structure-radiated noise within buildings. The results show that the interaction between soil and structure has a great impact on vibration transmission from the ground into the building. Good foundations reduce vibration transmission from ground soil up into the building and lead to a lower level of structure-radiated noise. Ground improvements increase the impedance of ground soil, thereby weakening the vibration transmission and lowering the structure-radiated noise.