Event Abstract Back to Event Early postnatal handling attenuates excessive behavioural disinhibition/hyperactivity and spatial learning deficits in 3xTgAD mice for Alzheimer disease Antoni Canete-Ramirez1*, Gloria Blazquez1, Adolf Tobena1, Frank LaFerla2, Alberto Fernandez-Teruel1 and Lidia Gimenez-Llort1 1 Autonomous University of Barcelona, Spain 2 University of California, United States Behavioural and psychological symptoms of dementia (BPSD) are commonly seen in patients with Alzheimer's disease. BPSD have a serious impact on the quality of life of dementia patients, as well as on that of their caregivers and yet have been relatively ignored in murine models. In the present study, (4 month-old) 3xTgAD triple-transgenic mice (hPS1 M146V, hAPP Swe and htau P301L,) showed higher levels of disinhibitory behaviour than non-transgenic controls, as measured in the elevated plus-maze and dark-light box test (spend more time visiting the open arms and light box), as well as by their increased 24-h spontaneous activity in the home cage. Likewise 3xTgAD mice showed signs of hyperactivity in the hexagonal tunnel maze (an ethological anxiety test). Moreover, 3xTgAD mice showed as compared to controls an impaired spatial learning capacity and a marked increase in swimming speed (i.e. hyperactivity). On the other hand, early postnatal handling (PH, tactile stimulation administered from postnatal days 1 to 21) is an early-life treatment known to produce profound and long-lasting behavioural and neurobiological effects. Emotionality, reactivity to stressors and exploratory behaviour as well as the functionality of several neurotransmitter systems can be enduringly altered by this procedure. The present study was aimed at describing the effects of PH on the behavioural profile of male and female 3xTgAD mice at early stages of the disease. The results show that PH treatment reduced the excessive disinhibitory behaviours observed in the male 3xTgAD and attenuated anxiety in females. Moreover PH improved the acquisition of place learning in the Morris water maze in both sexes. While the PH also decreased (excessive) swimming speed in 3xTgAD mice. Therefore, the results clearly indicate that postnatal handling may exert a preventive effect on both emotional and cognitive alterations characteristic of AlzheimerÎs disease. Thanks to Fundacio Marato de TV3 nº 062930 Conference: 41st European Brain and Behaviour Society Meeting, Rhodes Island, Greece, 13 Sep - 18 Sep, 2009. Presentation Type: Poster Presentation Topic: Poster presentations Citation: Canete-Ramirez A, Blazquez G, Tobena A, LaFerla F, Fernandez-Teruel A and Gimenez-Llort L (2009). Early postnatal handling attenuates excessive behavioural disinhibition/hyperactivity and spatial learning deficits in 3xTgAD mice for Alzheimer disease. Conference Abstract: 41st European Brain and Behaviour Society Meeting. doi: 10.3389/conf.neuro.08.2009.09.104 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 08 Jun 2009; Published Online: 08 Jun 2009. * Correspondence: Antoni Canete-Ramirez, Autonomous University of Barcelona, Barcelona, Spain, antoni.canete@uab.cat Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Antoni Canete-Ramirez Gloria Blazquez Adolf Tobena Frank LaFerla Alberto Fernandez-Teruel Lidia Gimenez-Llort Google Antoni Canete-Ramirez Gloria Blazquez Adolf Tobena Frank LaFerla Alberto Fernandez-Teruel Lidia Gimenez-Llort Google Scholar Antoni Canete-Ramirez Gloria Blazquez Adolf Tobena Frank LaFerla Alberto Fernandez-Teruel Lidia Gimenez-Llort PubMed Antoni Canete-Ramirez Gloria Blazquez Adolf Tobena Frank LaFerla Alberto Fernandez-Teruel Lidia Gimenez-Llort Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.
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